5 results about "Oxcarbazepine" patented technology

The present application provides a detection method and quality control method for related substances in dextromethorphan oral solution, which comprises the following steps: dissolving dextromethorphan oral solution in a solvent to obtain a test solution; and performing high performance liquid chromatography detection on the test solution; the mobile phase used in the high performance liquid chromatography detection comprises mobile phase A and mobile phase B, the mobile phase A comprises a phosphate solution, the mobile phase B comprises acetonitrile, and the concentration of the phosphate solution is 0.1 mM-10 mM. The detection method has good linear relationship between dextromethorphan and related substances, good accuracy and sensitivity, strong specificity, high stability, good separation degree and good reproducibility, and is suitable for wide application.

The invention discloses a cyclization continuous flow synthesis process of iminodibenzyl. 2, 2 '-diamino bibenzyl is used as a raw material, polyphosphoric acid is used as a cyclization agent, toluene is used as a dispersion medium, the efficient heat and mass transfer characteristic of the microchannel reactor is utilized, the reaction temperature is controlled within 85 + / -2 DEG C, meanwhile, the material ratio and the retention time are optimized, generation of high-polymer impurities is inhibited from the source, no remarkable high-polymer impurities exist in reaction liquid, a rectification purification process is not needed, and the production cost is reduced. And washing the toluene layer with phosphoric acid, washing with clear water, and crystallizing to obtain a high-purity qualified product. In the product obtained by the process, the content of high polymer impurities is less than or equal to 0.003 wt%, the residue of 2, 2 '-diamino bibenzyl is less than or equal to 0.0002 wt%, the purity of the product is more than or equal to 99.8%, and the molar yield reaches 93.2%; the toluene solvent recycling rate is greater than or equal to 95%, the discharge amount of three wastes is reduced by more than 70% compared with that of a traditional intermittent process, and the method has the advantages of product quality improvement, production efficiency improvement and environmental protection, and can be directly applied to large-scale production of antiepileptic drug oxcarbazepine and carbamazepine intermediates.

The application provides a synthesis process of an ocinaplon intermediate. S1, petroleum ether, methanol and ethyl formate are mixed to obtain a mixed system, ortho-phenyltoluene and sodium methoxide are added, and reaction is carried out to obtain intermediate 1; S2, intermediate 1 is added into methanol, a palladium-carbon catalyst is added, hydrogen is introduced, and reaction is carried out to obtain intermediate 2; S3, phosphoric acid and a supported catalyst are added into intermediate 2, and reaction is carried out to obtain iminodibenzyl. The problem of low iminodibenzyl yield in the prior art is solved.

1. Name of the designed product: medicine packaging set (Oxcarbazepine). 2. Use of the designed product: for medicine packaging. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: set 1 perspective view 1. 5. Other circumstances needing to be explained: set 1 is an inner packaging box; set 2 is an outer packaging box; set 3 is a packaging bottle.

The invention discloses a synthesis method of oxcarbazepine and analogues thereof, which comprises the following steps: dissolving a dibenzo [b, f] azepine analogue as shown in a formula (I) in an organic solvent under an illumination condition, and carrying out oxidation reaction in an air or oxygen atmosphere under the action of a photocatalyst. And after the reaction is completed, carrying out post-treatment on the reaction liquid to obtain oxcarbazepine shown in the formula (II) and the analogue thereof. The reaction formula is as follows. The method takes light as reaction energy, and has the advantages of high safety, low cost, mild conditions, simplicity and convenience in operation and the like.