Patents
Literature
82 results about "Reference product" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
A reference product is the single biological product, already approved by FDA, against which a proposed biosimilar product is compared. A reference product is approved based on, among other things, a full complement of safety and effectiveness data.
Quality control method and application of traditional Chinese medicine composition containing cassia twig
The invention discloses a content determination method of a traditional Chinese medicine composition containing cassia twig. The determination method comprises the following steps: taking a test solution and a reference solution of the traditional Chinese medicine composition for detection; obtaining content information of a reference substance of the traditional Chinese medicine composition according to a detection result; wherein the traditional Chinese medicine composition comprises cassia twig, radix paeoniae alba, liquorice, ephedra, ginger, bighead atractylodes rhizome, rhizoma anemarrhenae, radices sileris and black prepared aconite root, and the reference substances are mangiferin, paeoniflorin, cimicifugin, 5-O-methylvisammioside, cinnamaldehyde, ammonium glycyrrhizinate and 6-gingerol. The detection method is simple, accurate, efficient, good in stability, high in precision, good in reproducibility, convenient and easy to master, energy can be effectively saved, the analysis cost is reduced, and the technical content is not disclosed in the prior art.
Owner:HUNAN YINENG BIOLOGICAL PHARMA
Method for quantitatively detecting specific activity of MntC antigen in recombinant staphylococcus aureus vaccine or / and stock solution
PendingCN119916034AMaterial analysis by observing effect on chemical indicatorBiological testingReference productStaphyloccocus aureus
The invention discloses a method for quantitatively detecting the specific activity of a MntC antigen in a recombinant staphylococcus aureus vaccine or / and a stock solution. The method comprises the following steps: (1) coating an elisa plate by taking MntC-686 as a capture antibody; (2) adding a sample to be detected into the coated ELISA plate; (3) carrying out a chromogenic reaction by using HRP-MntC-A7, and measuring an OD450 / 630 nm value; and (4) preparing a standard curve by using the MntC reference, and calculating the specific activity of the MntC antigen in the detected sample according to the standard curve. According to the present invention, the fully human monoclonal antibody for specifically recognizing the recombinant staphylococcus aureus vaccine MntC protein is adopted as the coating antibody, and the anti-MntC protein fully human monoclonal antibody is adopted as the detection antibody; the kit can be used for detecting the specificity of the MntC antigen in a staphylococcus aureus vaccine or a stock solution, and has good stability and repeatability.
Owner:CHONGQING YUANLUN BIOTECH
Noninvasive fetal trisomy 21 syndrome prenatal screening kit based on digital PCR
The invention provides a non-invasive fetal trisomy 21 syndrome prenatal screening kit based on digital PCR, and relates to the technical field of fetal trisomy 21 syndrome screening, according to a method for enriching fetal cfDNA in pregnant woman plasma, SPRIselect magnetic beads with low enrichment multiple and silicon hydroxyl magnetic beads are combined for use, and under a certain dosage, the recovery rate of fetal cfDNA short fragments reaches 95%; according to the provided multiple system construction method, positive gDNA and negative gDNA are obtained on the basis of a 21 trisomy positive cell line and a 21 trisomy negative cell line, low-proportion reference substances are prepared and used, internal reference sites and detection sites which are high in detection capacity and stable in detection performance are screened from the beginning, and compared with existing multiple system establishment and verification through direct use of pregnant woman plasma samples, the multiple system construction method has the advantages that the detection efficiency is high, and the detection cost is low. The to-be-detected sample with lower fetal cfDNA content can be stably detected.
Owner:合肥行知生物技术有限公司
Kit and method for detecting klebsiella pneumoniae and drug-resistant gene of klebsiella pneumoniae
PendingCN119842930AMicrobiological testing/measurementMicroorganism based processesK pneumoniaeResistant genes
The invention relates to the technical field of biology, in particular to a kit and a method for detecting klebsiella pneumoniae and a drug-resistant gene of the klebsiella pneumoniae. The kit comprises a nucleic acid amplification reagent, a reference substance and a standard substance, and the nucleic acid amplification reagent contains primers with nucleotide sequences as shown in SEQ ID NO: 1-SEQ ID NO: 6 and probes as shown in SEQ ID NO: 7-SEQ ID NO: 9. Compared with traditional bacterial drug resistance detection, the detection kit and the method can simultaneously detect klebsiella pneumoniae and two multi-drug resistance genes, increase the detection speed and reduce the labor cost, and have the advantages of simplicity, rapidness, high sensitivity, strong specificity and the like.
Owner:HEBEI INST OF ANIMAL HUSBANDRY & VETERINARY MEDICINE
Construction method of specific chromatogram of pinus tabulaeformis knot formula granules, specific chromatogram and application of specific chromatogram
The invention provides a construction method of a specific chromatogram of pinus tabulaeformis nodule formula granules, the specific chromatogram and application of the specific chromatogram. The construction method comprises the following steps: (1) preparing the pinus tabulaeformis nodule formula granules into a test solution; preparing the pinus tabulaeformis knot reference medicinal material into a reference medicinal material reference solution; preparing a silver pinocembrin monomethyl ether reference substance into a reference substance solution; and (2) respectively carrying out ultra-high performance liquid chromatography detection on the test solution, the reference substance solution of the reference medicinal material and the reference substance solution of the reference substance, and obtaining the specific chromatogram of the pinus tabulaeformis knot formula granules according to detection. According to the specific chromatogram constructed by the method provided by the invention, the specific identification of the pinus tabulaeformis formula granules is enhanced, the pinus tabulaeformis medicinal material base can be effectively identified, and a support is provided for ensuring the singleness of the source of the pinus tabulaeformis formula granules medicinal material base. The specific chromatogram constructed by the invention can comprehensively reflect the characteristic peak information of the sample, and the method is stable, high in precision and better in reproducibility.
Owner:BEIJING KANGRENTANG PHARMA
Risk detection method and risk detection equipment for electronic product
PendingCN119723124ACharacter and pattern recognitionSpecial purpose weighing apparatusAlgorithmReference product
The invention provides a risk detection method and risk detection equipment for an electronic product, and is applied to the technical field of ray detection. The method comprises the following steps: determining weight difference information according to obtained product weight information and reference weight information; according to the obtained first image and the second image, the peak signal-to-noise ratio of the ray attenuation degree plane two-dimensional distribution images of the to-be-detected product and the reference product is determined, and the peak signal-to-noise ratio represents the overall similarity between the to-be-detected product and the reference product; according to the obtained first image and second image, the subtraction value of the ray attenuation degree plane two-dimensional distribution image of the product to be detected and the reference product is determined, and the subtraction value represents the local difference between the product to be detected and the reference product; and determining the risk degree of the to-be-detected product according to the weight difference information, the peak signal-to-noise ratio and the subtraction value. According to the invention, the detection cost and the protection difficulty can be reduced through low ray energy and dosage.
Owner:TSINGHUA UNIVERSITY +1
A reagent, method and application capable of simultaneously detecting three common viruses in cichlid
The application discloses a reagent, a method and application of the reagent and the method for simultaneously detecting three common viruses in a fancy carp, and belongs to the technical field of fish quarantine. The application provides a reaction system and a detection method for simultaneously detecting three common viruses in a fancy carp, establishes a multiplex fluorescence PCR method, adopts a full-closed reaction, solves the problem that common PCR is prone to generating aerosols and causing false positive results of tests, has high detection sensitivity, can detect target genes with a copy number of 10 orders of magnitude at the minimum, is suitable for detecting a small amount of viruses carried in normal fancy carp or viruses in water quality environment, and can fully meet the requirements of customs quarantine prevention and control, has strong specificity, has no cross reaction to templates such as IHNV, RSIV and EHNV, and further provides a virus-like particle which can be used as a positive reference product in the multiplex system, is stable in state and beneficial to storage, can monitor an extraction process, and ensures that a test is established.
Owner:XIAN CUSTOMS TECH CENT +1
Method for measuring content of amino acid in periplaneta americana
PendingCN119846090AComponent separationAgainst vector-borne diseasesMedicinal herbsReference product
The invention belongs to the technical field of quality detection of traditional Chinese medicinal materials, and particularly relates to a method for determining the content of amino acid in periplaneta americana. The method comprises the following steps: a, preparation of a test solution: taking American cockroach medicinal material powder, adding water, carrying out ultrasonic treatment, carrying out solid-liquid separation to obtain a separation solution, enabling the separation solution to pass through a cation exchange resin column, soaking, eluting, collecting the eluent, drying by distillation, adding a hydrochloric acid solution, dissolving, filtering, and taking a subsequent filtrate to obtain the test solution; b, preparing a reference substance solution; and c, determination: respectively and precisely sucking the reference substance solution and the test solution, injecting into a high performance liquid chromatograph, determining, and calculating the content by using an external standard two-point method logarithmic equation. The method provided by the invention has good linearity, repeatability, stability and recovery rate, and can effectively monitor the content of various amino acids in periplaneta americana.
Owner:SICHUAN GOODDOCTOR PANXI PHARMA
Application of expression cassette, vector or recombinant cell in screening MR inhibitor or detecting MR inhibitory activity
The invention discloses an application of an expression cassette, a vector or a recombinant cell in screening of an MR inhibitor or detection of MR inhibitory activity, and relates to the technical field of targeted inhibition drugs of a mineralocorticoid receptor. The screening method of the mineralocorticoid receptor inhibitor or the method for detecting the inhibitory activity of the mineralocorticoid receptor has the advantages of good specificity, strong specificity and high accuracy; the precision is high, and the repeatability and the fluorescence presentation degree of a reference product and a test product are good. Therefore, by adopting the method provided by the invention, the biological activity of the MRAs can be simply, accurately and efficiently evaluated, which is of great significance to screening, research and development, quality control and clinical application of the MRAs.
Owner:GUIZHOU MEDICAL UNIV
Automatic classification method and device, storage medium and equipment
Owner:ANT ZHIXIN HANGZHOU INFORMATION TECH CO LTD
Recommendation method and device, equipment, medium and program product
PendingCN119624508Aavoid complexityavoid uncertaintyDigital data information retrievalSpecial data processing applicationsReference productProcess engineering
The invention provides a recommendation method which can be applied to the technical fields of data processing, artificial intelligence and finance. The recommendation method comprises the steps of determining a plurality of reference products matched with a target product based on product attribute information of the target product; on the basis of the current life cycle of the target product, reference operation information, located in the same life cycle as the target product, of the multiple reference products is obtained; the reference operation information comprises reference operation state information and reference operation strategy information of the reference product, and the reference operation state information represents the quality of the reference operation strategy information. And determining a target recommendation strategy of the target product from the reference operation strategy information of the plurality of reference products based on the reference operation state information of the plurality of reference products. The invention further provides a recommendation device, equipment, a medium and a program product.
Owner:INDUSTRIAL AND COMMERCIAL BANK OF CHINA
A single tube quantitative detection of HBV viral load real-time fluorescent quantitative PCR kit
ActiveCN121227955BMicrobiological testing/measurementMicroorganism based processesReference productGenotype
The application discloses a single-tube quantitative detection HBV viral load real-time fluorescent quantitative PCR kit and belongs to the technical field of molecular biological detection. The kit comprises a primer probe combination for single-tube quantitative detection HBV viral load real-time fluorescent quantitative PCR, wherein the primer probe combination comprises a primer pair and a probe for detecting a target gene, and a probe IC-P1 and a probe IC-P2 for detecting an internal standard. The kit can cover various genotypes of HBV viruses, and the minimum detectable viral load is 2.5 IU / mL, the detection sensitivity is high, the repeatability is good, and the quantitative standard curve is constructed without additional quantitative reference products, so that the operation is simplified and the utilization rate of the reagent is improved.
Owner:BORUIYUAN BIOTECHNOLOGY (BEIJING) CO LTD
Method for separating sodium hyaluronate and detecting molecular weight
The invention belongs to the technical field of biological medicine detection, and relates to a method for separating sodium hyaluronate mixtures in different molecular weight ranges and / or measuring molecular weight through gel permeation chromatography. According to the method, sodium hyaluronate mixtures with different molecular weights are subjected to separation and molecular weight determination through a gel chromatography tandem technology, key technical parameters such as selection of reference substances and types of chromatographic columns are comprehensively adjusted in the determination process, a good separation effect on the sodium hyaluronate mixtures is achieved, the accuracy of a molecular weight detection result is high, and the method is suitable for industrial production. Meanwhile, good stability and repeatability are achieved, toxic and harmful chemical reagents are not used in detection, and the safety and practicability of detection are improved.
Owner:HUBEI MAGIC HEALTH TECH CO LTD
A method of preparing ffpe quality control articles with cell lines, reference articles, and kits
ActiveCN120869743BPreparing sample for investigationArtificial cell constructsBiotechnologyParaffin wax
The application provides a method for preparing FFPE quality control products by using cell lines, a reference product and a kit, and belongs to the fields of medicine, clinical laboratory science and biotechnology, and comprises the following steps: culturing cell lines by using microcarriers; mixing different cell lines based on requirements; centrifuging the mixed cell microcarrier suspension in a sealed malt pipe at one end; removing supernatant after the treatment; packaging the two ends of the malt pipe by using a semi-permeable membrane; removing the semi-permeable membrane after fixing, dehydrating and transparentizing the malt pipe by using a formaldehyde solution; separating the cell microcarriers after the wax immersion treatment from the malt pipe; and embedding the cell microcarriers into a paraffin block by using wax. The quality control product can be used in subsequent quality control processes, the mutation frequency of the quality control product can be kept in good uniformity, and batch production and large-scale production of the quality control product can be realized.
Owner:GENETRON HEALTH (BEIJING) CO LTD +3
Internal reference product for quantifying human nucleic acid in metagenome sample, quantifying method and application
PendingCN119433039AStable detectionMicrobiological testing/measurementBiostatisticsReference productGenome
The invention discloses an internal reference product for quantifying human nucleic acid in a metagenome sample, a quantifying method and application, and provides a method for screening the concentration of an internal reference sequence for quantitative detection of the human nucleic acid in the metagenome and an internal reference product for quantitative detection of the human nucleic acid in the metagenome. The invention provides a construction method of a quantitative detection model for the content of human nucleic acid in a metagenome and the quantitative detection model for the content of the human nucleic acid in the metagenome. The invention provides a method for quantitatively detecting human nucleic acid in metagenome based on internal reference, a related system, equipment and a computer readable storage medium.
Owner:BEIJING CAPITALBIO MEDLAB CO LTD
Method and device for determining product replenishment quantity, and computer storable medium
The present disclosure relates to a method and apparatus for determining product replenishment quantities. The method for determining product replenishment quantities includes: obtaining historical data of multiple reference products related to a target product; determining attribute data of product attributes of each reference product based on its historical data, wherein the product attributes include demand attributes, and the attribute data of the demand attributes include the historical demand of the reference product; clustering the multiple reference products based on the attribute data of the product attributes of each reference product and target values of the attribute weights to obtain multiple reference classes, wherein the attribute weights include demand attribute weights; screening reference classes similar to the target product from the multiple reference classes as similar classes; predicting the future demand of the target product in a future cycle based on the attribute data of the demand attributes of each reference product in the similar class; and determining the future replenishment quantity of the target product in the future cycle based on the future demand of the target product.
Owner:BEIJING WODONG TIANJUN INFORMATION TECH CO LTD
Method for quantitatively detecting specific activity of HI antigen in recombinant staphylococcus aureus vaccine or stock solution
ActiveCN119881338AMaterial analysis by observing effect on chemical indicatorBiological testingAntigenStaphylococcus
The invention discloses a method for quantitatively detecting the specific activity of an HI antigen in a recombinant staphylococcus aureus vaccine or stock solution. The method comprises the following steps: (1) coating an elisa plate by using IsdB-318 as a capture antibody; (2) adding a sample to be detected into the coated ELISA plate; (3) carrying out a chromogenic reaction by using an enzyme-labeled Hla-26 monoclonal antibody, and determining an OD450 / 630 nm value; and (4) preparing a standard curve by using the HI reference substance, and calculating the specific activity of the HI antigen in the detected sample according to the standard curve. The specific activity of the HI protein in the recombinant staphylococcus aureus vaccine or stock solution can be quantified, and good stability and repeatability are achieved.
Owner:CHONGQING YUANLUN BIOTECH
Blood chyle degree detection reference product and preparation method thereof
PendingCN120404272APreparing sample for investigationMaterial analysis by optical meansChylomicronReference product
The invention discloses a blood chyle degree detection reference and a preparation method thereof. The reference comprises the following components: triglyceride, cholesteryl ester, free cholesterol, phosphatidylcholine, bovine serum albumin, a buffer solution and an auxiliary agent. The blood chyle degree detection reference product provided by the invention can be stably stored, is low in cost, can be used for instrument calibration, can be used for judging and grading clinical plasma chyle degree and the like, and can unify detection standards and eliminate artificial interference; based on the blood chyle degree detection reference product provided by the invention, detection can be realized by utilizing image gray calculation, and compared with manual visual inspection, the detection accuracy is greatly improved.
Owner:SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
Method, apparatus, server, and storage medium for updating classification status
The present application discloses a method, device, server, and storage medium for updating classification status, belonging to the field of the Internet. The method includes: determining that the status of a product corresponding to a classification has changed; in the case where the status of the product changes from being on the shelf to being off the shelf, if the product is not the reference product corresponding to the classification, then the status of the classification is not updated; if the product is the reference product corresponding to the classification and there is no corresponding reference product on the shelf for the classification, then the status of the classification is updated according to the status of each product corresponding to the classification; if the product is the reference product corresponding to the classification and there is a corresponding reference product on the shelf for the classification, then the status of the classification is not updated; in the case where the status of the product changes from being off the shelf to being on the shelf, if there is no corresponding reference product on the shelf for the classification, then the status of the classification is updated, and if there is a corresponding reference product on the shelf for the classification, then the status of the classification is not updated. By adopting the present application, the classification update efficiency can be improved.
Owner:BEIJING SANKUAI ONLINE TECH CO LTD
Method for preparing sheep-derived positive serum reference of yersinia enterocolitica, obtained positive serum and application thereof
The invention discloses a method for preparing a sheep-derived positive serum reference of yersinia enterocolitica, obtained positive serum and application of the positive serum, and belongs to the field of veterinary medicine products. The invention aims to solve the technical problem of how to obtain the yersinia enterocolitica sheep-derived positive serum reference which is stable in titer and character and can be used for specific detection of brucella diagnostic products. Therefore, the invention provides a method for preparing the yersinia enterocolitica sheep-derived positive serum reference, which comprises the following steps: immunizing a tested sheep by using an immunizing antigen, and collecting serum of the immunized tested sheep to obtain the yersinia enterocolitica sheep-derived positive serum reference. The immune antigen is an inactivated yersinia enterocolitica obtained by inactivating the yersinia enterocolitica. The positive serum reference can be effectively applied to quality control evaluation work of brucellosis related diagnosis products, and plays a positive role in prevention and control of brucellosis.
Owner:CHINA INST OF VETERINARY DRUG CONTROL
A single tube quantitative detection of HCV viral load real-time fluorescent quantitative PCR kit
ActiveCN121272118BMicrobiological testing/measurementMicroorganism based processesReference productCalibration curve
The application discloses a single-tube quantitative detection HCV viral load real-time fluorescent quantitative PCR kit and belongs to the technical field of molecular biological detection. The kit comprises a pair of primers and a probe combination, the primer and the probe combination comprise a primer pair and a probe for detecting a target gene and a probe for detecting an internal standard. The kit can detect HCV 1-6 common types in clinic, covers all types, can stably detect a viral load of 10 IU / mL, has high detection sensitivity and good repeatability, does not need additional quantitative reference product to construct a calibration curve, simplifies operation, improves the utilization rate of reagents, and avoids invalid results and repeated detection caused by the failure of calibration curve construction.
Owner:BORUIYUAN BIOTECHNOLOGY (BEIJING) CO LTD
Method for detecting specific activity of recombinant pseudomonas aeruginosa vaccine rPO stock solution
The application discloses a method for detecting specific activity of recombinant Pseudomonas aeruginosa vaccine rPO stock solution, and comprises the following steps: (1) using OprI-B052 as a capture antibody to coat an enzyme-labeled plate; (2) adding a sample to be detected into the coated enzyme-labeled plate; (3) diluting an enzyme-labeled antibody PcrV-A039 and then performing a color reaction to measure an OD 450 / 630 nm value; and (4) preparing a standard curve by using a rPO reference product, and calculating the specific activity of the rPO antigen in the sample according to the standard curve. In the application, OprI-B052 is used as a coating antibody, and PcrV-A039 is used as a detection antibody. The specific activity of the recombinant Pseudomonas aeruginosa vaccine rPO stock solution can be quantitatively detected, and the application has good stability and repeatability.
Owner:CHONGQING YUANLUN BIOTECH
Packaging box (ginseng gift box)
1. Name of the product in this design: Packaging Box (Class III Gift Box). 2. Purpose of this design: For use as the outer packaging box for reference products. 3. The key design features of this product are the combination of pattern and color. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. The design for which protection is sought includes color.
Owner:JIANGXI HUIREN PHARMA CO LTD
A single tube quantitative detection HIV-1 viral load real-time fluorescence quantitative PCR kit
ActiveCN121272119BMicrobiological testing/measurementMicroorganism based processesReference productGenotype
The application discloses a single-tube quantitative detection HIV-1 virus load real-time fluorescent quantitative PCR kit and relates to the technical field of molecular biology detection. The kit comprises a primer and probe combination; the primer and probe combination comprises a primer pair GAG-1-F / R and a probe GAG-1-P for detecting a first target gene, a primer pair POL-1-F / R and a probe POL-1-P for detecting a second target gene, and probes IC-P1 and IC-P2 for detecting an internal standard. The kit covers various genotypes of HIV-1 viruses, can stably detect a virus load of 15 IU / mL, has high detection sensitivity and good repeatability, does not need additional quantitative reference products to construct a quantitative standard curve, can simplify operations, and improves the utilization rate of reagents.
Owner:BORUIYUAN BIOTECHNOLOGY (BEIJING) CO LTD
Yield prediction method and device for produced product, storage medium and program product
The invention provides a yield prediction method and device of a produced product, a storage medium and a program product, and relates to the technical field of data processing, and on the basis of obtaining reference product information of each reference product and target product information of a target product, clustering processing is performed on each reference product to obtain at least two reference product clustering sets; and for each reference product cluster set, performing multi-head self-attention fusion processing to generate a corresponding product relation degree matrix. And matching a corresponding target reference product cluster set according to the target product information of the target product, and determining the target reference product. In each production time window, training the initial yield prediction model to obtain a target yield prediction model; inputting the product relation degree matrix corresponding to the target reference product cluster set, the target product information of the target product and the future time feature vector into a full-connection neural network layer, and outputting a target predicted yield; the problem of inaccurate yield prediction of newly developed products is solved.
Owner:BEIHANG UNIV
A kit for detecting nutritional iron deficiency in sows and application
ActiveCN116042814BMicrobiological testing/measurementDNA/RNA fragmentationBiotechnologyAnimal science
The present application relates to a kind of kits for detecting sows' nutritional iron deficiency by biomarker quantitative detection evaluation and application, including fluorescent reaction liquid A, fluorescent reaction liquid B, internal standard, negative control, nucleic acid release agent and quantitative reference product, the fluorescent reaction liquid B contains detection primer and probe, the detection primer includes upstream primer and downstream primer, the sequence of upstream primer is 5'-ATCTGGCTTGTAAACCAACA-3', the sequence of downstream primer is 5'-ATCTTAGTTGTGGATTCCGT-3', the fluorescent reaction liquid B also contains primer probe, probe sequence is 5'-TCACCGTCAATTTCGGCTCT-3', 5' end is labeled with reporter fluorescent group, and 3' end is labeled with quenching fluorescent group.The present application effectively improves the accuracy of sows' nutritional iron deficiency detection, and provides scientific guidance for sow nutrition.
Owner:HUNAN GUOCE BIOTECHNOLOGY CO LTD
Reference product for methylmalonic acidemia and use thereof
This invention relates to the fields of molecular biology and human genetic disease detection; specifically, it relates to a reference standard for methylmalonic acidemia and its application. The reference standard comprises positive reference cells with MMACHC gene mutation sites. The genome of the positive reference cells contains one or more combinations of specific mutation sites of the following MMACHC genes: c.609G>A, c.567insT, c.658_660delAAG, c.482G>A, c.1A>G, c.80A>G, c.217C>T, c.315C>G, and c.394C>T. This reference standard provides reliable technical support for the accurate detection of methylmalonic acidemia, especially MMACHC gene-related mutations, and is of great significance in improving detection accuracy and promoting detection standardization.
Owner:SHENZHEN ZHUOYUN HAIZHI TECHNOLOGY CO LTD +2
Glycosylation-like extracellular vesicle as well as preparation method and application thereof
The invention relates to a glycosylation-like extracellular vesicle as well as a preparation method and application thereof. The invention relates to a glycosylated lipidosome which comprises a glycosylated lipidosome outer membrane and nucleic acid wrapped in the glycosylated lipidosome outer membrane, and the glycosylated lipidosome outer membrane comprises cholesterol, phospholipid, cationic lipid and an amphiphilic lipid-PEG-glycosyl compound in a molar ratio of (6-10): (6.5-4.5): (6.5-4.5): 1. According to the method, the glycosylated amphiphilic lipid, the artificially synthesized glycosylated liposome and the simulated glycosylated EVs subgroup are used as a reference substance or a quality control substance of the glycosylated EVs, so that the problem that an existing sugar capture method for extracting the glycosylated EVs subgroup is lack of quality control standards can be solved.
Owner:BEIJING HOTGEN BIOTECH CO LTD +1
Alarm processing method and device
The present specification provides an alarm processing method and device, the method comprises: acquiring a query text, and inputting the query text into a first large language model; generating identification information of a reference product based on the query text by the first large language model; searching in a real-time database based on the identification information of the reference product to obtain real-time related information of the reference product from the real-time database; wherein the real-time database is used to store the corresponding relationship between the identification information and the real-time related information of the product; based on the query text, the identification information and the real-time related information of the reference product, the identification information of the target product related to the query text is determined.
Owner:BEIJING OCEANBASE TECHNOLOGY CO LTD
Method, apparatus and program for identity determination based on artificial intelligence
PendingUS20250239095A1PhotometryCharacter and pattern recognitionFeature extractionReference product
A method of identity determination based on artificial intelligence is disclosed. The method may include: acquiring a first image of a reference product; acquiring a second image of a comparison target product which is a comparison target of the reference product; acquiring a plurality of first features corresponding to the first image and a plurality of second features corresponding to the second image by inputting the first image and the second image to a feature extraction model; generating a plurality of feature pairs by matching the plurality of first features and the plurality of second features; acquiring a similarity score for each of the plurality of feature pairs by inputting two features constituting each of the plurality of feature pairs to a similarity analysis model; and determining an identity between the reference product and the comparison target product based on the similarity score.
Owner:PINOKIO LAB CORP