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3 results about "Exome" patented technology
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The exome is the part of the genome composed of exons, the sequences which, when transcribed, remain within the mature RNA after introns are removed by RNA splicing and contribute to the final protein product encoded by that gene. It consists of all DNA that is transcribed into mature RNA in cells of any type, as distinct from the transcriptome, which is the RNA that has been transcribed only in a specific cell population. The exome of the human genome consists of roughly 180,000 exons constituting about 1% of the total genome, or about 30 megabases of DNA. Though composing a very small fraction of the genome, mutations in the exome are thought to harbor 85% of mutations that have a large effect on disease. Exome sequencing has proved to be an efficient strategy to determine the genetic basis of more than two dozen Mendelian or single gene disorders.
Methods and systems for detecting an organ or a tissue impacted by a cancer or a disease, disorder or condition
Disclosed herein are methods and systems of determining a cancer status or an organ health status of a subject, the method comprising: obtaining a biological sample obtained or derived from the subject; enriching a population of cells in the biological sample, wherein the population of cells comprises stem cells and / or progenitor cells; extracting nucleic acids from the enriched population of cells; assaying the extracted nucleic acids to generate at least one of a transcriptomic profile of the subject, a genomic profile of the subject, and / or an exomic profile of the subject; computer processing the at least one of the transcriptomic profile of the subject, the genomic profile of the subject, and / or the exomic profile of the subject; and determining, based at least in part on the computer processing, the cancer status or the organ health status of the subject, wherein the cancer status or the organ health status comprises a presence or an absence of an organ and / or a tissue impacted by the cancer or impacted by a disease, disorder, or condition.
Owner:23IKIGAI PTE LTD +2
SYSTEMS AND METHODS FOR DERIVING COPY NUMBER VARIATION FOR CLINICAL DIAGNOSTICS USING COMMON LOW COVERAGE WHOLE GENOME SQUASHING AND WHOLE EXOME SQUASHING
Owner:TEMPUS AI INC
METHOD FOR LOADING EXOMES WITH SMALL NON-CODING RNAS
ActiveDE502021010149D1Microencapsulation basedMammal material medical ingredientsExonMechanical engineering
Owner:BARSUKOV ALEKSANDR PAVLOVICH +3