The invention relates to hereditary spherocytosis and a therapeutic drug thereof, belongs to the technical field of medicine and aims to solve the defects of splenectomy in surgical treatment of the hereditary spherocytosis. According to analysis, the hereditary spherocytosis is caused by congenital deficiency, liver and kidney deficiency and vital energy and blood deficiency, and patients shall take the therapeutic drug, which comprises traditional Chinese medicinal herbs with effects of tonifying spleen, liver and kidney, strengthening the essence, clearing the liver, promoting blood circulation, tonifying qi and nourishing blood, to treat the hereditary spherocytosis. The therapeutic drug comprises, by weight, 15 parts of buffalo horns, 15 parts of leeches, 20 parts of dried rehmannia roots, 10 parts of cassia seeds, 15 parts of hypericum japonicum, 15 parts of codonopsis pilosula, 10 parts of Chinese wolfberries, 18 parts of the root of bidentate achyranthes, 15 parts of turtle shells, 15 parts of astragalus membranaceus, 20 parts of yams and 7 parts of liquorice. The therapeutic drug can treat root causes of disease, has obvious therapeutic effect and is safe and stable in curative effect.