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Coagulation factor XII, also known as Hageman factor, is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC 3.4.21.38) of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by the F12 gene.
High-concentration formulation of factor XII antigen-binding protein
The present application relates to a liquid formulation comprising at least 100 mg / ml of a protein comprising an antigen-binding domain that binds to FXII (and / or its activated form), an organic acid buffer, a non-ionic surfactant, and an amino acid stabilizer, wherein the formulation has a pH of 5.0-6.5 and a viscosity of less than 30 mPa*s at 20° C. An exemplary formulation comprises the specific factor XII antibody 3F7 in a formulation comprising a histidine buffer, a polysorbate 80 surfactant, and the amino acid stabilizers arginine and proline.
Owner:CSL INNOVATION PTY LTD