43 results about "Reactive center" patented technology

In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme L-amino acid decarboxylase is encapsulated and implanted in the brain to convert L-dopa to dopamine for treatment of Parkinson's disease.

Recombinant plasminogen activator inhibitor-1 (PAI-1) isoforms which lack the reactive center loop and contain the complete heparin-binding domain or lack at least a portion of the heparin-binding domain are described. The rPAI-1 isoforms disclosed herein may be used to modulate angiogenesis through blocking release of VEGF from a VEGF-heparin complex. Furthermore the rPAI-1 proteins may be used to inhibit cell proliferation and migration, induce apoptosis, and produce proteolytic fragments corresponding to angiostatin kringles 1–3 and kringles 1–4.

The invention relates to a new method for surface modification of ultrafine inorganic solid particles. It includes under the conditions of certain temperature, mechanical stirring, nitrogen protection and the presence of catalyst, with ultrafine particles as the reaction center core, and AB x or A x One-step polycondensation reaction of monomer B occurs, and a hyperbranched polymer is grafted on the surface of ultrafine particles. The surface properties of the superfine particles modified by the hyperbranched polymer grafting obtained are greatly changed, and can be well dispersed in various resin matrices and solvents. The method is simple and easy to complete in one step, and the modified inorganic solid particles can be widely used in polymer composite materials, electronic packaging materials, plastics, coatings, rubber, antibacterial materials and other fields, and the industrial application prospect is broad.

The invention relates to a production method of chemically modified carbon black. The production of carbon black with tar as a raw material and air as a combustion enhancer is the main production method in China at present. Four cylinders are installed in the combustion chamber of the carbon black furnace and the throat of the reaction center. The silicon chloride supply pipe is introduced into silicon tetrachloride at a weight ratio of 5-10% of the carbon black output during production, and the temperature of the reaction chamber is 1600-1800°C, which can complete the chemical modification of carbon black. Compared with unmodified carbon black, the anti-corrosion resistance of modified carbon black is 15-30% higher; the yield is 0.8-4% higher than that of unmodified carbon black.

The present invention relates to procoagulant serine protease inhibitor molecules engineered to exhibit increased specificity for anticoagulant proteases by modifying P4, P2, P1 and / or P1' residues within the reactive center loop (RCL). These modified serpin molecules can be used in therapy, for example, as coagulants for the treatment of bleeding.

The invention discloses a method for synthesizing a bicyclic pyridone derivative with potential bioactivity, comprising the following steps that: 5,5-bisalkylthio-2,4-pentadienoic acid ester used as a raw material with the characteristics of being easy to prepare, having structural diversity and multiple reactive centers and a bimolecular nucleophilic reagent organic diprimary amine is subject to substitution / condensation in refluxing to synthesize the bicyclic pyridone derivative. Compared with the reported synthetic methods of the bicyclic pyridone derivative, the method disclosed in the invention has the advantages of being convenient for raw materials, simple operation, mild reaction conditions and high efficiency.

The invention discloses a polyamide-amine hyperbranched polymer, a preparation method and application thereof, and relates to the technical field of petroleum additives. The polyamide-amine hyperbranched polymer of the present invention is a polyamide-amine hyperbranched polymer with 4,4'-diaminodiphenylmethane as the reaction center and an amine terminal group. The preparation method of the present invention is simple, comprising the following steps: reacting 4,4'-diaminodiphenylmethane and methyl acrylate at room temperature for 24 hours to prepare 0.5G ester with 4,4'-diaminodiphenylmethane as the core; Then add stoichiometric ratio of ethylenediamine and methyl acrylate, and prepare the polyamide-amine demulsifier with hyperbranched structure through normal temperature reaction, staged temperature rise reaction and other steps. The polyamide-amine hyperbranched polymer of the present invention is used as a demulsifier, which can quickly demulsify the oil-in-water emulsion under the condition of 50-70°C, and realize the effective separation of oil-water. The emulsion efficiency can reach 99.5%, and it has the characteristics of fast demulsification rate, less dosage and high demulsification efficiency.