8825 results about "Glycol synthesis" patented technology

The present invention provides a dissolvable medical sealing device (3, 4; 6, 7; 9) for closing a wound in vessel. A sealing device (3, 4, 6, 7, 9) according to the invention is made of a material that dissolves by means of physical processes, rather than by means of chemical or biological processes. Such a sealing device (3, 4; 6, 7; 9) can be made of polyethylene glycol, polypropylene glycol, copolymers containing ethylene glycol and propylene glycol, polyvinyl alcohol or polyvinyl pyrolidone, or any combinations thereof.

Methods for forming nanostructures of various shapes are disclosed. Nanocubes, nanowires, nanopyramids and multiply twinned particles of silver may by formed by combining a solution of silver nitrate in ethylene glycol with a solution of poly(vinyl pyrrolidone) in ethylene glycol. Hollow nanostructures may be formed by reacting a solution of solid nanostructures comprising one of a first metal and a first metal alloy with a metal salt that can be reduced by the first metal or first metal alloy. Nanostructures comprising a core with at least one nanoshell may be formed by plating a nanostructure and reacting the plating with a metal salt.

The present invention relates to a peptide-based compound comprising a peptide moiety and a poly(ethylene glycol) moiety wherein the poly(ethylene glycol) moiety (preferably linear) has a molecular weight of more than 20 KDaltons (preferably from 20 to 60 KDaltons). The peptide moiety may be monomeric, dimeric or oligomeric. Such peptide-based compounds may optional include a linker moiety and/or a spacer moiety.

The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.

An aqueous cutting fluid which can reduce the impact on working environment and the global environment, and can achieve both preventing precipitates from becoming a hard cake and keeping high dispersibility for abrasive grains is provided. Such an aqueous cutting fluid is obtained by a method comprising dispersing abrasive grains (G) in an aqueous composition comprising a dispersion medium (M) containing a hydrophilic alcohol compound such as ethylene glycol, a lipophilic alcohol compound such as propylene glycol and water, and silica colloid particles dispersed stably in the medium. The dispersion medium (M) is odorless and not flammable. The abrasive grains (G) may settle out after a time, but they do not closely contact with one another, and therefore the resulting precipitates do not become a hard cake, which allows the re-dispersion and reuse of precipitated grains. The instant aqueous cutting fluid is inherently low viscous, and the reduction of viscosity owing to the contamination of water and the increase of viscosity owing to contamination of shavings are both moderate. As a result, the cutting fluid has a long life. And articles which have been cut using the cutting fluid can be washed with water. Further, as the dispersion medium (M) is a biodegradable low molecular weight organic compound, a waste liquid from a process using the cutting fluid can be disposed with an activated sludge.

Coatings for an implantable medical device and a method of fabricating the coatings are disclosed. The coatings comprise a fluorinated polymer and a biologically beneficial polymer, an example of which includes poly(ethylene-glycol)-block poly(butylene terephthalate)-block poly(ethylene-glycol). A biologically active agent can be additionally conjugated to the biologically beneficial polymer.

The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. In order to target a specific cell type, the nanoparticle may further be conjugated to a ligand, which is capable of binding to a cellular component associated with the specific cell type, such as a tumor marker. In one embodiment, a therapeutic agent may be attached to the nanoparticle. To permit the nanoparticle to be detectable by not only optical fluorescence imaging, but also other imaging techniques, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), computerized tomography (CT), bioluminescence imaging, and magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle.

The invention discloses a heat-dissipating double-sided adhesive tape with an ultrahigh heat conductivity coefficient. Ethylene glycol or triethylamine is added into a polyamic acid solution, the resulting mixture is put in an oven in a vacuum environment and maintained at 100 DEG C for 0.9-1.1 hours, the temperature is raised to 300 DEG C and maintained for 0.9-1.1 hours, followed by natural cooling, to produce a polyimide film; the polyimide film is heated up to 250 DEG C from room temperature and then heated up to 500 DEG C, and further heated up to 1200 DEG C at a rate of 9-11 DEG C/min, to produce a prefired carbonized film; the prefired carbonized film obtained in the step 4 is rolled by a calendar; the rolled product is heated up to 2400 DEG C at a rate of 19-21 DEG C/min and maintained for 0.9-1.1 hours and then heated up to 2900 DEG C at a rate of 19-21 DEG C/min and maintained for 1.8-2.2 hours, followed by cooling, to produce a fired graphite film; and subsequently the graphite film is rolled to obtain a graphite coating. The heat transfer performance of the double-sided adhesive tape in both the vertical and the horizontal directions are improved, so as to prevent local overheat of the adhesive tape and ensure uniformity of heat transfer performance of the adhesive tape.

The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.

This invention provides an embolization material used for blocking a blood vessel in vivo for stopping the blood flow. The most suitable embolization material has a water swelling ratio of 30% or more, is degradable in a phosphate buffered saline, is formed as virtually spherical particles, and is preferably composed of a water insoluble poly(ethylene glycol) copolymer, wherein when the film formed from said polymer is saturated with water, it has an elastic modulus in tension of 1500 MPa or less. The embolization material of this invention can reliably block a blood vessel at an intended site without causing cohesion or clogging in a catheter or in the blood vessel at other than the intended site. Thereafter, the blocked site concerned can be liberated from the embolized state by degradation, and the degraded components can be metabolized or excreted outside the body.

A process for making modified polybutylene terephthalate random copolymers from a polyethylene terephthalate component includes reacting an oligomeric diol component selected from the group consisting of bis(hydroxybutyl)terephthalate, bis(hydroxybutyl)isophthalate, hydroxybutyl-hydroxyethyl terephthalate, and combinations thereof to a reactor; (i) a polyethylene terephthalate component selected from the group consisting of polyethylene terephthalate and polyethylene terephthalate copolymers with (ii) a diol component selected from the group consisting of 1,4-butanediol, ethylene glycol, propylene glycol, and combinations thereof, in the reactor under conditions sufficient to depolymerize the polyethylene terephthalate component into a first molten mixture; combining the first molten mixture is combined with 1,4-butanediol under conditions to form a second molten mixture; and placing the second molten mixture under conditions sufficient to produce the modified polybutylene terephthalate random copolymers. Also described are compositions and articles made from the process.

The invention relates to a process for making modified polybutylene terephththalate random copolymers from a polyethylene terephthalate component. The invention relates to a three step process in which a diol component selected from the group consisting of ethylene glycol, propylene glycol, and combinations thereof reacts with a polyethylene terephthalate component under conditions sufficient to depolymerize the polyethylene terephthalate component into a first molten mixture; and where the first molten mixture is combined with 1,4-butanediol under conditions that create a second molten mixture that is subsequently placed under subatmospheric conditions that produce the modified polybutylene terephthalate random copolymers. The invention also relates to compositions made from the process.

In a composite process for subjecting ethylene to catalytic gas phase oxidation thereby obtaining ethylene oxide and causing this ethylene oxide to react with water thereby obtaining ethylene glycol, a method for producing the ethylene glycol is provided which permits effective utilization of the energy at the step for dehydrating and concentrating the resultant aqueous ethylene glycol solution. In the production of ethylene glycol by the supply of the aqueous ethylene glycol solution to a concentrating treatment at the multi-effect evaporator, the method contemplated by this invention for the production of ethylene glycol comprises utilizing as the source of heating at least one specific step the steam generated in the multi-effect evaporator.

The invention discloses a preparation method of a TiO2/ZIF-8 nanocomposite with a core-shell structure. The preparation method comprises the following steps: firstly, tetrabutyl titanate is added to an ethylene glycol solution and stirred uniformly, the mixture is added to anhydrous acetone, stirred quickly and left to stand, and TiO2 amorphous nano-beads are obtained through separation, washing and drying; the nano-beads are added to a tetramethylammonium hydroxide aqueous solution and react at 160-200 DEG C, and TiO2 nano-beads are obtained through separation, washing and drying; the prepared TiO2 nano-beads are added to a methanol solution of Zn(NO3)2*6H2O and are stirred, a methanol solution of 2-methylimidazole is then added, and the TiO2/ZIF-8 nanocomposite with the core-shell structure is obtained through separation, washing and drying. The preparation method has mild preparation conditions and simple process; the synthesized TiO2/ZIF-8 composite has uniform size and good dispersity and is expected to be applied to gas separation, photoelectric materials, photocatalytic materials and the like.