67 results about "Hydroxybenzotriazole" patented technology

The invention discloses injectable hydrogel for eye drug sustained release and a preparation method and application thereof.The method comprises the steps that a NaIO4 solution is dropwise added into a hyaluronic acid solution, after the reaction is conducted in a dark place at the room temperature, ethylene glycol is added for continuous reaction, and formylated hyaluronic acid is prepared; the preparation method comprises the following steps: adding adipic dihydrazide into a carboxymethyl cellulose solution, uniformly stirring at room temperature, adding 1-hydroxybenzotriazole and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and stirring to react, so as to prepare aminated carboxymethyl cellulose; and mixing the PBS solution of aminated carboxymethyl cellulose with the PBS solution of formylated hyaluronic acid, uniformly stirring, adding a to-be-carried drug and a FeCl3 solution, and carrying out a reaction to prepare the injectable hydrogel for sustained release of the eye drug. The hydrogel is convenient to use and high in gelation rate, effectively realizes controllable release of drugs, and has a wide application prospect in the field of biological medicines.

The present invention relates to the technical field of biodegradable sheets, and specifically discloses a bamboo crystal fiber filled biodegradable sheet, wherein the raw materials include by mass: 40-60 parts of polylactic acid, 10-20 parts of polybutylene adipate / terephthalate, 40-60 parts of bamboo, 1-5 parts of polyvinyl alcohol, 10-20 parts of glycerol, 1-5 parts of polyaspartic acid, 0.01-0.1 parts of 1-ethyl-(3-dimethylaminopropyl)carbodiimide, 0.01-0.02 parts of 1-hydroxybenzotriazole, 1-2 parts of chitosan, 1-3 parts of antioxidant, 1-3 parts of nucleating agent, 1-3 parts of coupling agent, 1-3 parts of dispersant, and 2-4 parts of talcum powder. The present invention also discloses a preparation method of the above-mentioned bamboo crystal fiber filled biodegradable sheet. The sheet obtained by the present invention has good mechanical properties, excellent aging resistance, and is easily degraded after being abandoned. After 72 days of degradation, its degradation rate can reach more than 60.5%.

The application discloses an antioxidant coating and a preparation method thereof, and relates to the technical field of coatings. The application first uses hydroxybenzotriazole to esterify and modify acrylic acid, and then uses the modified acrylic acid to prepare modified acrylic resin coating. The benzotriazole structure has high hardness and rigidity, and also has good ultraviolet absorption performance, which can reduce the degradation of the acrylic resin caused by ultraviolet rays and further improve the durability of the coating. The microcapsule wall material is modified by a hydrophobic compound, and then a new type of microcapsule wall material is prepared by coating an antioxidant. The microcapsule wall material modified by the hydrophobic compound can effectively prevent external moisture and oxygen from entering the microcapsule, improve the stability of the coating in a humid environment, and protect the antioxidant in the core material from the influence of the external environment. The antioxidant is slowly and continuously released in the coating, and the oxidation reaction of the coating is effectively inhibited for a long time. The antioxidant coating prepared by the application has the effects of wear resistance and durability.

The invention relates to a high-toughness anti-crack magnetic decorative film and a preparation method thereof. The decorative film is prepared from the following raw materials in parts by weight: 40 to 60 parts of poly (dihydrothiophene-vinyl ether) copolymer, 10 to 25 parts of shell layer self-assembly modified Fe3O4 nanosheets, 5 to 15 parts of polyether ester block elastomer, 0.5 to 2 parts of sodium dodecyl benzene sulfonate, 0.5 to 1.5 parts of fluorosilane coupling agent, 0.1 to 1.0 part of 2-hydroxybenzotriazole ultraviolet absorbent, 3 to 6 parts of bisphenol A type epoxy curing agent and 0.05 to 0.5 part of imidazole catalyst. The flexible copolymer is synthesized through copolymerization of dihydrothiophene and vinyl ether, the modified Fe3O4 nanosheets form a Fe3O4 structure through coprecipitation of ferric chloride and ferrous chloride and regulation and control of ammonia water, and shell self-assembly coating is carried out through tetraethoxysilane and a block micromolecule interface agent. The material has excellent tensile strength, elongation at break, magnetic adsorption force and cycling stability, and is suitable for the application fields of flexible magnetic films and high-adhesion decorations.

The invention discloses a deuterated lamiterone medicine as well as a preparation method and application thereof, and relates to the technical field of lamiterone, the preparation method comprises the following steps: firstly weighing deuterated propionic acid, and then adding dichloromethane, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 1-hydroxybenzotriazole to obtain white turbid liquid; dropwise adding the mixed solution into the white turbid liquid, stirring and reacting overnight, adding water for quenching, extracting twice by using dichloromethane, washing by using a saturated saline solution, drying by using anhydrous sodium sulfate, and concentrating to obtain a crude product; performing column chromatography separation on the crude product, concentrating and drying to obtain a deuterated lamiterone medicine; according to the deuterated lamiterone medicine as well as the preparation method and the application thereof, hydrogen atoms at key positions in lamiterone molecules are replaced with deuterium atoms, so that the metabolic rate of deuterated lamiterone is reduced, the half-life period of deuterated lamiterone is prolonged, and the sleep time of a patient is prolonged.

The invention discloses a modified polypeptide as well as a preparation method and application thereof, the preparation method comprises the following steps: on the basis of solid-phase synthesis of RADA16, 1-hydroxybenzotriazole and benzotriazole-N, N, N ', N'-tetramethylurea hexafluorophosphate are adopted as condensing agents, N, N-diisopropylethylamine-containing N, N-diisopropylethylamine is added into the condensing agents, and a reaction is carried out for 2-4 hours to obtain the modified polypeptide. And adding amino-terminated or carboxyl-terminated polyethylene glycol or amino-containing chitosan oligosaccharide into N, N-dimethylformamide for condensation, cutting polypeptide from the resin after the reaction is completed, precipitating, washing, re-dissolving and freeze-drying to obtain the polypeptide. The polypeptide provided by the invention has the characteristic of forming hydrogel through self-assembly in a specific medium, and the gel forming time of the polypeptide is within 21-60 seconds and is obviously faster than that of RADA peptide (gel forming in 150 seconds) under the same condition; the polypeptide modified by the polyethylene glycol or the chitosan oligosaccharide can spontaneously form gel after being injected into the blood vessel so as to embolize the blood vessel, and the embolism is long in stabilization time and stable, and meets the actual clinical requirements.

The invention discloses an anti-oxidation coating and a preparation method thereof, and relates to the technical field of coatings. Hydroxybenzotriazole is firstly used for esterifying modified acrylic acid, then the modified acrylic acid is used for preparing the modified acrylic resin coating, a benzotriazole structure has high hardness and rigidity and also has good ultraviolet absorption performance, the degradation effect of ultraviolet rays on acrylic resin can be reduced, the durability of the coating is further improved, and the service life of the coating is prolonged. The novel microcapsule wall material is prepared by modifying the microcapsule wall material with the hydrophobic compound and then coating the microcapsule wall material with the antioxidant, and the microcapsule wall material modified with the hydrophobic compound can effectively prevent external moisture and oxygen from entering the interior of the microcapsule, so that the stability of the coating in a humid environment is improved; and the coating of the microcapsule protects the core material antioxidant from being influenced by the external environment, the antioxidant is slowly and continuously released in the coating, and the oxidation reaction of the coating is effectively inhibited for a long time. The anti-oxidation coating prepared by the invention has the effects of wear resistance and durability.

The present invention provides functionalized molybdenum disulfide nanosheets and a preparation method and application thereof. The preparation method comprises the following steps: mixing a solvent, 1 part by weight of thioctic acid, and 5 to 10 parts by weight of a first compound for 2 to 4 hours to obtain a mixture; adding 0.05 to 0.1 parts by weight of 1-hydroxybenzotriazole to the mixture, mixing for 24 to 48 hours, and drying to obtain an intermediate product; and ultrasonically treating or heat-treating the raw material-solution system to obtain the functionalized nanosheets, wherein the raw material-solution system comprises 5 to 10 parts by weight of molybdenum disulfide nanosheets, 1 part by weight of the intermediate product, and brine; and the first compound comprises an oxirane group and an alkylamine chain, wherein the alkylamine chain has 12 to 18 carbon atoms and the oxirane group has 2 to 15 carbon atoms. A nanofluid prepared from the functionalized molybdenum disulfide nanosheets can reduce oil / water interfacial tension, has good stability, significantly improves the recovery rate of low-permeability oil reservoirs, and reduces costs.

The invention belongs to the field of chemical analysis and testing, and particularly relates to an aminobenzaldehyde-based coumarin fluorescent probe for preparing a reagent for detecting mercaptosuccinic acid and a preparation method of the aminobenzaldehyde-based coumarin fluorescent probe. The preparation method comprises the following steps: dissolving 2-aminobenzaldehyde and 7-(diethylamino) coumarin-3-formic acid in dichloromethane, adding 1-ethyl-(3-dimethylamino aldehyde) carbodiimide hydrochloride (EDCI) and 1-hydroxybenzotriazole (HBOT) as condensing agents, carrying out a stirring reaction at room temperature, carrying out separation and purification on the obtained crude product through a thin-layer chromatography, and carrying out recrystallization to obtain the coumarin derivative. The final yellow product, namely the aminobenzaldehyde-based coumarin fluorescent probe Y-SH, is obtained. The coumarin fluorescent probe prepared by the preparation method disclosed by the invention can be used for rapidly detecting mercaptosuccinic acid in deionized water.

The invention relates to the technical field of daily chemical industry, in particular to a washing machine tank cleaning effervescent tablet and a preparation method thereof. The washing machine tank cleaning effervescent tablet is prepared from the following raw materials in parts by weight: 40 to 60 parts of sodium percarbonate, 4 to 6 parts of tetraacetylethylenediamine, 1 to 3 parts of tetraacetyl glycoluril, 3 to 5 parts of microencapsulated sodium silicate, 12 to 18 parts of microencapsulated citric acid, 0.5 to 1.5 parts of benzotriazole, 0.5 to 1.5 parts of hydroxybenzotriazole, 1 to 2 parts of composite antibacterial agent, 3 to 5 parts of polyvinylpolypyrrolidone and 1 to 2 parts of magnesium stearate. And 0.3 to 0.7 part of essence. The washing machine tank cleaning effervescent tablet is prepared through gradient temperature control mixing and layered tabletting technologies, and has the effects of efficient cleaning, rapid disintegration, efficient antibiosis, small dosage and effective prevention of corrosion of metal parts in a low-temperature environment.

The present application relates to the technical field of paint, and discloses a preparation method of a spherical alumina-cordierite composite refractory paint composition, wherein 100 parts by weight of epoxy resin, 1-5 parts by weight of an amino-terminated polymer ultraviolet absorber, 15-28 parts by weight of a filler spherical alumina trihydrate and cordierite, 29-32 parts by weight of a curing agent and the like are stirred and uniformly mixed to obtain the spherical alumina-cordierite composite refractory paint composition.The polymer ultraviolet absorber contains an ortho-hydroxybenzotriazole group, which can improve the ultraviolet absorption characteristics and ultraviolet aging resistance of the paint.The polymer, as an absorber, contains a biphenyl structure with thermal stability, which is beneficial to improving the thermal decomposition temperature, heat resistance and water resistance after being co-cured with the epoxy resin.The addition of the spherical alumina trihydrate and cordierite improves the limiting oxygen index of the paint coating and improves the flame-retardant fire resistance.

The present invention discloses an anti-ultraviolet modified epoxy resin and a preparation method thereof, which relates to the technical field of preparation methods of functional materials. The modified epoxy resin includes hydroxyl groups, benzotriazole groups, and siloxane groups. The preparation method includes: taking epoxy resin, 2-hydroxyethyl methacrylate, and a catalyst, mixing them, heating for reaction, cooling to room temperature after completion, and separating the product; mixing the obtained product with 2-(2'-hydroxy-5'-methylphenyl) benzotriazole and a catalyst, heating for reaction, cooling and separating the product; mixing the obtained product with γ-aminopropyltriethoxysilane and a catalyst, heating for reaction, cooling and separating the product to obtain the anti-ultraviolet modified epoxy resin. The modified epoxy resin prepared by the above method is used to prepare coatings, and the coatings have excellent anti-ultraviolet performance.

The invention relates to the technical field of coatings, and discloses a preparation method of a spherical alumina-cordierite composite refractory coating composition, which comprises the following steps: uniformly stirring and mixing 100 parts by weight of epoxy resin, 1-5 parts by weight of amino-terminated polymer ultraviolet absorbent, 15-28 parts by weight of filler spherical alumina trihydrate and cordierite, 29-32 parts by weight of curing agent and the like; the spherical aluminum oxide-cordierite composite fireproof coating composition is obtained. The polymer ultraviolet absorbent contains an o-hydroxybenzotriazole group, so that the ultraviolet absorption characteristic and the ultraviolet aging resistance of the coating can be improved, and the polymer as the absorbent contains a biphenyl structure with thermal stability, so that the thermal decomposition temperature, the heat resistance and the water resistance and water resistance can be improved after the polymer is co-cured with the epoxy resin. Meanwhile, spherical alumina trihydrate and cordierite are added, so that the limit oxygen index of the coating is increased, and the flame-retardant and fire-resistant performance is improved.

The application provides a high-transparency silicone rubber material and a preparation method thereof. The silicone rubber material comprises the following raw materials in parts by mass: 100 parts of methyl vinyl phenyl rubber, 10-30 parts of modified white carbon black, 3-5 parts of vinyl MQ silicone resin, 4-6 parts of polymethyl hydrogen siloxane, 1-1.5 parts of vinyl hydroxyl silicone oil and 0.001-0.003 parts of platinum catalyst. The modified white carbon black is obtained by grafting benzotriazole silane coupling agent and silicone oil onto the modified white carbon black. The benzotriazole silane coupling agent is obtained by urethane reaction of hydroxy benzotriazole compound and isocyanate silane coupling agent. The silicone oil grafting silane coupling agent is obtained by addition reaction of hydrogen-terminated polydimethylsiloxane and vinyl silane coupling agent. The silicone rubber material has good transparency and light stability.

The invention discloses a copper-titanium etching solution, and relates to the technical field of microelectronic device manufacturing, and the copper-titanium etching solution comprises the following components by mass: 4.5-8.5% of ammonium persulfate; 1.5%-3.5% of urea peroxide; 1.0% to 2.0% of 1-hydroxybenzotriazole-5-carboxylic acid; 0.3% to 0.9% of 2-mercapto benzimidazole; 0.5% to 1.5% of sulfobutyl ether-beta-cyclodextrin; 0.8%-2.2% of L-aspartic acid-N, N-diacetic acid; 0.1% to 0.7% of iso-tridecanol polyoxyethylene ether; 0.05%-0.15% of ceric ammonium nitrate; 0.02% to 0.08% of sodium polyacrylate; and the balance of deionized water. According to the method, the matching problem of the etching rate is solved, the stability is improved, and substrate corrosion is avoided.

This invention provides an acid-resistant nutrient-carrying nanomicelles and its preparation method, comprising: (1) dissolving ursolic acid, 1-hydroxybenzotriazole, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride in a solvent and stirring to obtain an activated ester; (2) reacting an amine-containing cationic polymer with the activated ester obtained in step (1) to obtain an amphiphilic cationic polymer; (3) mixing the amphiphilic cationic polymer with a lipid-soluble active substance in a good solvent, removing the good solvent by rotary reflux in the dark to obtain nutrient-carrying nanomicelles; and (4) mixing the polyanionic polymer solution with the nutrient-carrying nanomicelles in water to obtain acid-resistant nutrient-carrying nanomicelles. The nanomicelles prepared by this invention can withstand gastric digestion and gel and aggregate in the enteritis area of ​​mice by prolonging the intestinal retention time.

The invention provides an antioxidant solution, a copper foil, a pole piece and a lithium ion battery. The antioxidant solution comprises the following components in percentage by mass: 0.05-0.5% of a first compound, 0.1-0.3% of borax, 0.05-0.2% of tannic acid, 0.1-1% of a second compound, 85-88% of ethanol and 11-14.7% of water, the first compound is prepared from 1-hydroxybenzotriazole and / or 5-chloro-2-methylbenzotriazole, and the second compound is prepared from 1-hydroxybenzotriazole and / or 5-chloro-2-methylbenzotriazole; the second compound comprises ascorbic acid and / or titanyl sulfate. The anti-oxidation liquid provided by the invention does not contain a chromium element, is simple in component and strong in anti-oxidation capability, and has excellent cycle performance and safety performance when being applied to a lithium ion battery by applying a pole piece prepared from the copper foil containing the anti-oxidation liquid to the lithium ion battery.

The application discloses modified cotton fabric and a preparation method and application thereof, and relates to the field of textile fabrics.In the preparation of the modified cotton fabric, chitosan is pretreated by 2-bromoisobutyryl bromide, then acrylic acid and methyl acrylate are grafted and polymerized by an atom transfer radical polymerization method to obtain pre-modified chitosan, then the pre-modified chitosan is sequentially reacted with oxalyl chloride and 4-hydroxybenzotriazole to prepare modified chitosan; cotton fabric is ultrasonically pretreated by a sodium dodecyl sulfate solution, then sequentially reacts with 6-chlorohexanoyl chloride and N,N-dimethylallylamine to prepare pre-modified cotton fabric, and finally, the pre-modified cotton fabric is reacted with a modified liquid prepared from modified chitosan, dimethyl phosphite and 1,4-butanediol to prepare the modified cotton fabric.The modified cotton fabric prepared by the application has excellent ultraviolet resistance, antibacterial property, wrinkle resistance and flame retardance.

The present application relates to a high temperature resistant butterfly valve, including a butterfly valve body, the surface of the butterfly valve body is coated with a thermal insulation coating, the thermal insulation coating includes: methylphenyl silicone resin, sodium alginate, dodecyltrimethylammonium chloride, valeryl dihydrazine, dicyclohexylcarbodiimide, 1-hydroxybenzotriazole, ceramic fiber, talcum powder, penetrant, polyvinyl acetate emulsion, DMF and water; a production process of a high temperature resistant butterfly valve, including the preparation, pretreatment and coating of the thermal insulation coating. The present application has the following advantages and effects: ceramic fiber and talcum powder can prevent heat conduction; the ammonium radical of dodecyltrimethylammonium chloride and the carboxylate radical in sodium alginate form a hydrogel with a three-dimensional network through ionic interaction; 1-hydroxybenzotriazole is used as an activator, and the carboxyl bonding of valeryl dihydrazine and sodium alginate is modified under the action of the condensation agent dicyclohexylcarbodiimide to form a stable entangled three-dimensional network, which effectively ensures the thermal insulation performance of the coating.

The present invention belongs to the field of chemical analysis and testing, and in particular to a fluorescent probe for identifying reduced coenzyme I and its preparation method and application. Coumarin fluorescent dye is dissolved in dichloromethane, condensing agent 1-hydroxybenzotriazole (HOBT), 1-ethyl-(3-dimethylaminoaldehyde) carbonyl diimide hydrochloride (EDCI) and trace triethylamine are added in an ice bath and stirred, and then 5-aminoindole is added and stirred at room temperature, and the resulting compound is separated and purified by column chromatography to obtain a final product. The fluorescent reagent of the present invention can realize the fluorescence selective recognition of reduced coenzyme I in PBS phosphate buffer solution.

The present invention provides a mitochondrion-targeted fenofibric acid, and the mitochondrion-targeted fenofibric acid is a triphenylphosphine fenofibric acid conjugate. A method for constructing the mitochondrion-targeted fenofibric acid is to synthesize the mitochondrion-targeted fenofibric acid by coupling aminotriphenylphosphine with fenofibric acid. The specific steps include: dissolving fenofibric acid in dichloromethane containing triethylamine; then adding aminotriphenylphosphine, 1-hydroxybenzotriazole and EDCI to obtain a mixture; washing and rotary evaporation to obtain the mitochondrion-targeted fenofibric acid. The mitochondrion-targeted fenofibric acid of the present invention can efficiently inhibit respiratory chain complex I and generate a large amount of mtROS. Its cytotoxic effect is nearly 10 times that of fenofibrate, and it shows specific killing of tumor cells. The mitochondrion-targeted fenofibric acid can also cause calreticulin membrane translocation and IFN-I secretion, induce an in-situ tumor vaccine effect, and synergistically treat tumors with immune checkpoint blockade therapy.

The invention belongs to the field of chemical analysis and testing, and particularly relates to a quinoline derivative coumarin fluorescent probe targeting tobramycin and a preparation method of the quinoline derivative coumarin fluorescent probe. The preparation method comprises the following steps: dissolving N1-(7-chloroquinoline-4-yl) ethane-1, 2-diamine and 7-(diethylamino) coumarin-3-formic acid in dichloromethane, adding condensing agents of 1-hydroxybenzotriazole (HOBT), 1-ethyl-(3-dimethylamino aldehyde) carbodiimide hydrochloride (EDCI) and triethylamine, carrying out a stirring reaction at room temperature, carrying out separation and purification on an obtained crude product through silica gel column chromatography, and carrying out recrystallization to obtain the 7-(diethylamino) coumarin-3-carboxylic acid-N-(7-chloroquinoline-4-yl) coumarin-3-carboxylic acid-N-(7-chloroquinoline-4-yl) coumarin-3-carboxylic acid-N-(7-chloroquinoline-4-yl) coumarin-3-carboxylic acid. The coumarin fluorescent probe DL containing the quinoline derivatives is obtained. The prepared coumarin fluorescent probe forms a complex under the participation of Cu < 2 + >, and tobramycin can be specifically and rapidly detected in deionized water.

The invention provides a preparation method and application of self-gelling hyaluronic acid-based physical crosslinking hydrogel, hyaluronic acid, carbonic acid dihydrazide and deionized water are mixed and dissolved, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and 1-hydroxybenzotriazole are added, a reaction is carried out, dialysis and freeze-drying are carried out, and hydrazide hyaluronic acid is obtained; the preparation method comprises the following steps: mixing and dissolving hydrazide hyaluronic acid and thymine derivative thymidine-1 acetic acid, adding 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide, adjusting the pH value, reacting, dialyzing and freeze-drying to obtain thymine modified hyaluronic acid; dissolving the thymine modified hyaluronic acid in a PBS buffer solution, homogenizing, and standing to obtain the thymine modified hyaluronic acid. Due to the property that nucleic acid bases can spontaneously form multiple hydrogen bonds, the prepared thymine grafted hyaluronic acid material realizes hydrogen bond driven self-gelation. Physical crosslinking retains good hydration ability of hyaluronic acid and endows the gel with injectability and adhesion.

The present invention belongs to the field of chemical analysis and testing, and specifically relates to a coumarin fluorescent reagent based on a tryptamine structure, and a preparation method and application thereof. Using dichloromethane as a solvent, 7-(diethylamino)coumarin-3-formic acid and tryptamine as raw materials, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) and 1-hydroxybenzotriazole (HOBT) as condensing agents, a room temperature reaction is performed to obtain a crude product. The crude product is then separated by thin layer chromatography using dichloromethane and methanol as developing agents to obtain a final yellow pure product. The fluorescent reagent obtained by the present invention has good optical properties and is 2+ With the participation of , fluorescence detection of tributyl phosphate can be achieved.

The present invention relates to a method for preparing a modified hydrophobic excipient including the following steps: Step A. obtaining intermediate I or II from a hydrophobic natural compound with one to three hydroxyl groups or a hydrophobic synthetic compound with one to three hydroxyl groups and amino acid derivatives with amino protecting groups and different chain lengths acting as raw material; Step B. obtain intermediate III from an amino acid derivative and N-hydroxysuccinimide or 1-hydroxybenzotriazole acting as raw material and a dehydrating agent; and Step C. reacting the intermediate II and the intermediate III as raw material with an acid-binding agent under a dark condition to generate a modified hydrophobic excipient.

The invention provides an antibacterial and anti-mineralization material for softening dental calculus and inhibiting formation of dental calculus, a preparation method of the antibacterial and anti-mineralization material comprises the following steps: dissolving chitosan and / or carboxymethyl chitosan and 1-hydroxybenzotriazole in deionized water under a stirring condition to obtain a solution A; under the stirring condition, an organic additive solution and a 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride solution are dropwise added into the solution A obtained in the step 1), and a solution B is obtained; performing low-temperature dialysis on the solution B obtained in the step 2), and performing freeze drying to obtain a product C; under the stirring condition, adding the product C and lysozyme into deionized water, and reacting to obtain the antibacterial and anti-mineralization material for softening dental calculus and inhibiting formation of dental calculus. The material disclosed by the invention can be combined with the surface of residual dental calculus after periodontal basic treatment, surface plaque biofilm is removed, and rapid mineralization of the material is inhibited by combining calcium ions, cell colonization is promoted, and periodontal tissue recovery is promoted.

The invention relates to a photo-initiated synthetic aminophenol compound method and application, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps: deprotonating a 1-hydroxybenzotriazole compound under an alkaline condition, and carrying out cracking reaction under the excitation of visible light to generate a high-activity biradical intermediate which is unstable and can be rapidly tautomerized into a more stable nitrosobenzene anion intermediate; the intermediate further reacts with cyclohexenone substances to synthesize the aminophenol derivative in one step. The method is simple and efficient, simple and convenient to operate, free of transition metal and additional oxidizing agents, simple and easily available in raw material reagent, high in product yield and capable of realizing large-scale synthesis, and a new method is provided for rapidly synthesizing the aminophenol compound. The synthesized aminophenol compound has good antibacterial activity, and especially has huge potential in the aspect of preventing and treating anthracnose of tea trees.

The invention belongs to the field of chemical synthesis, and particularly relates to a deprotection reagent, a kit and application of the deprotection reagent and the kit. And an organic base. According to the deprotection reagent, organic unification of mild and efficient deprotection and key side reaction inhibition is achieved through the synergistic effect of the 1-hydroxybenzotriazole and the organic base, specifically, the 1-hydroxybenzotriazole can effectively inhibit amino acid racemization, and more importantly, by capturing a beta-elimination reaction intermediate, the deprotection efficiency of the deprotection reagent is improved. And a protection mechanism aiming at phosphorylated amino acid is constructed together with organic alkali, so that a solid foundation is laid for preparing complex phosphorylated protein / polypeptide with high purity and accurate structure.

The preparation method comprises the following steps: by taking 3, 4-dihydroxyphenylacetic acid and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as raw materials, carrying out pre-activation reaction in an organic solvent, and adding 1-hydroxybenzotriazole to carry out activation reaction, so as to obtain a reaction product; slowly adding the reaction product into a protamine buffer solution, carrying out amidation coupling reaction, and purifying and drying to obtain the protamine-DOPAC conjugate. According to the protamine-DOPAC conjugate, the residence time of the exosome in a uterine cavity can be prolonged, and the action efficiency of the exosome in an endometrium can be improved. The protamine-DOPAC conjugate provided by the invention has an application prospect in the drug delivery direction.

The invention relates to the technical field of high polymer materials, in particular to a high-strength weather-resistant composite material, a preparation method and application of the high-strength weather-resistant composite material to protection of wind power generation equipment. The preparation method of the high-strength weather-resistant composite material comprises the following steps: reacting N-hydroxybenzotriazole with cyanuric chloride to prepare an intermediate A; reacting the intermediate A with biphenyl-4, 4 '-dithiol to obtain an intermediate B; and reacting the intermediate B with 4, 4 '-di [2-(1-propenyl) phenoxy] benzophenone to prepare the composite ultraviolet light absorber. Carrying out grafting reaction on the composite ultraviolet light absorber and POE (Polyolefin Elastomer) under the action of an initiator to prepare a composite modifier; the composite modifier and PA66 are subjected to melt blending, extrusion, cooling and grain-sized dicing, and the composite material is prepared. The composite material is high in strength, strong in ultraviolet aging resistance and good in weather resistance and low temperature resistance.