74 results about "Dimercaptosuccinic acid" patented technology

Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T2 contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron oxide nano contrast agents can be prepared by the steps of: coating surfaces of hydrophobic FeO nanoparticles with a coating material selected from the group consisting of polyethylene glycol-phospholipid conjugate, dextran, chitosan, dimercaptosuccinic acid and mixtures thereof in an organic solvent to form hydrophilic FeO nanoparticles having hydrophilic surfaces and dispersibility in water; dispersing the hydrophilic FeO nanoparticles in water to oxidize FeO; and exposing the oxidized hydrophilic FeO nanoparticles to an acidic buffer to dissolve and remove interior unoxidized FeO portions, and thereby to form Fe3O4 nanoparticles having an interior space.

The invention discloses a biocompatible natural polymer hydrogel and a preparation method thereof. The hydrogel is produced by the following steps: chitosan or glucan or gelatin and 1-Hydroxy benzotriazole are dispersed in the water, and stirred until transparent solution is formed; N-Acetyl-L-Cysteine or 2,3-Dimercaptosuccinic acid is added, then dripped into the water solution prepared with 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, the pH is adjusted, stirred for 2-4h; dialyzed with 5mmol / L hydrochloric acid solution containing 2Mu mol / L EDTA under lucifugal condition within 2-4 days, dialyzed with 5mmol / L hydrochloric acid solution containing 1g / L NaCl, and then dialyzed with 1mmol / L hydrochloric acid solution to achieve the desired product. The hydrogel has excellent hydrophilicity, moisture retaining property, permeability and flexibility, the degradation product has no toxic or adverse effect to the body, and can meet the requirements of modern medical science on dressing to the largest extent.

The invention relates to a preparation method and application of a sulfhydryl chitosan / activated carbon composite functional membrane, belonging to the technical fields of novel functional membrane material preparation and arsenic-polluted water treatment. The preparation method comprises the following steps: compounding chitosan and activated carbon into a membrane, adding epoxy chloropropane to carry out cross-linking to obtain a cross-linked chitosan / activated carbon composite membrane, modifying the cross-linked chitosan / activated carbon composite membrane with 2,3-dimercaptosuccinic acid, and introducing sulfhydryl group onto the chitosan framework, thereby obtaining the functional membrane. The novel functional membrane prepared by the method provided by the invention can display multiple synergic functions of chitosan, activated carbon and sulfhydryl group, is used for treating arsenic-polluted water, is applicable to wide pH range, does not need the step of preoxidation, can effectively remove As (III) and As (V), is free from the influence of coexistent competitive anions, has the advantages of favorable mechanical strength and simple treatment technique, can be used repeatedly, can greatly lower the cost, and is a new material and method having industrial application prospects.

The invention relates to a molecular probe in a medical imaging diagnostic reagent, and in particular relates to a preparation method of an MRI / PET bimodal molecular imaging probe for an atherosclerotic vulnerable plaque. According to the probe, molecular imaging can be performed on a new vessel of the atherosclerotic vulnerable plaque, and early warning of an unstable plaque is realized so as to provide a favorable new molecular imaging technology for early diagnosis and prevention of the coronary heart disease and reduction of serious cardiovascular event risk. The preparation method comprises the following step: chemically synthesizing a new vessel specific MRI / PET bimodal molecular imaging probe 68Ga-GEBP11-DMSA (dimercaptosuccinic acid)-MNPs through condensation reaction and chelating reaction by taking GEBP11 short peptide as a targeting tool and DMSA modified magnetic Fe3O4 nanoparticles (DMSA-MNPs) as carriers.

The invention relates to a chemical nickel-phosphorus alloy plating solution capable of obtaining a high-solderability plating layer. The solution comprises nickel sulfate, sodium hypophosphite, a complexing agent containing carboxylate radicals, bivalent tin ions and dimercaptosuccinic acid or dimercaptosuccinate, wherein, the complexing agent containing the carboxylate radicals is selected from one or combination of a plurality of glycollic acid, lactic acid, malonic acid, succinic acid, malic acid, tartaric acid, citric acid, gluconic acid, acetic acid, propionic acid, aminoacetic acid or corresponding salts of various acids; and the pH value of the solution is adjusted to 4-7. By adopting the chemical nickel-phosphorus alloy plating solution capable of obtaining the high-solderability plating layer, the chemical nickel-phosphorus plating layer achieves better solderability and is not restricted by the phosphorus content in the plating layer, thus solving the solderability problem of the chemical nickel-phosphorus plating layer and lowering the cost.

The invention discloses a Fe3O4-Au magnetic nano composite material, and a preparation method and an application thereof. The preparation method of the Fe3O4-Au magnetic nano composite material comprises the following steps: preparing oil-phase Fe3O4 nano particles; taking 2,3-dimercaptosuccinic acid as a phase transfer modifier, thus obtaining water-soluble Fe3O4 nano particles; and adding a reducing agent and taking chloroauric acid as the raw material to synthesize the Fe3O4-Au magnetic nano composite material through one step in the aqueous solution of Fe3O4. The preparation method is characterized in that small-particle size gold nano particles can be generated on the surface of the Fe3O4 transformed into the water phase from the oil phase through one step, the gold nano particles do not need to be extra synthesized and purified, and therefore, the experiment step is simplified and the particles obtained are even in size. In the meantime, the Fe3O4-Au magnetic nano composite material obtained by the preparation method can be applied to catalysis, biological detection, cell separation and targeted drug delivery.

The invention discloses a method for preparing magnetic iron oxide nano particles. The method comprises the following steps of: dissolving iron pentacarbonyl and a modifier into a solvent, atomizing by virtue of an ultrasonic atomizer, loading a solution into a heater by virtue of a carrier gas, carrying out gasification, decomposition and oxidation, introducing products into collected fluid, mixing, stirring, and carry outing surface reaction to obtain modified magnetic iron oxide nano particles. The modifier used in atomized liquid and the collection fluid is selected from oleic acid or oleic amine, triethylene glycol, polyethylene glycol PEG and derivates thereof, glucosan, citric acid, tetramethylammonium hydroxide, carboxylic acid polyethylene glycol and derivates thereof, polyvinylpyrrolidone (PVP) and dimercapto succinic acid or a mixture of the substances; the carrier gas is a mixed gas of oxygen gas and argon gas, and the heating process is carried out in two stages. By applying the method disclosed by the invention, the magnetic iron oxide nano particles with uniform particle sizes can be prepared while the advantages of speediness, high efficiency, continuous production and low pollution are achieved; and the prepared iron oxide nano particles can be used in the fields such as biology, medicine, catalysis and mechanical lubrication.

The invention provides a method for detecting tervalent and hexavalent chromium ions by use of 2,3-dimercaptosuccinic acid modified gold nanoparticles. The gold nanoparticles are synthesized, the surface of the gold nanoparticle is modified with 2,3-dimercaptosuccinic acid by a ligand exchange method, the pH value of solution is adjusted to be in an acid stage, chromium ion containing solution is added, the color of the gold nanoparticle solution is changed and the color change can be observed by naked eyes, so as to judge whether the chromium ions exist, the detection limit is 10nM, and no interference of other metal ions is caused; besides, the 2,3-dimercaptosuccinic acid modified gold nanoparticles also can be combined with wireless devices such as a smartphone for detection on the spot.

The invention discloses a method for preparing sulfydryl modified ferroferric oxide / silicon dioxide magnetic nanoparticles. The method comprises the following steps that 1, magnetic ferroferric oxide particles are prepared with trivalent ferric salt serving as raw materials through a solvothermal method; 2, tetraethoxysilane is adopted as a silicon source, generated silicon dioxide wraps the surfaces of the magnetic ferroferric oxide particles through a sol-gel method, and ferroferric oxide / silicon dioxide magnetic nanoparticles are formed; 3, the ferroferric oxide / silicon dioxide magnetic nanoparticles are placed in a methylbenzene solution and dispersed evenly to obtain a solution A, dimercaptosuccinate is added to a dimethyl sulfoxide solution and dispersed evenly to obtain a solution B, the solution A and the solution B are mixed and stirred and react for a period of time, then solid-liquid separation, cleaning and drying are carried out, and then the sulfydryl modified ferroferric oxide / silicon dioxide magnetic nanoparticles are obtained. The magnetic nanoparticles are good in dispersing performance, achieve good stability and biocompatibility, and has potential application value in the bio-medical field.

The invention relates to a preparation method of an efficient adsorbent for gaseous mercury sampling, and particularly relates to a preparation method of the efficient adsorbent for gaseous mercury sampling. According to the invention, except halogen and compounds thereof, iodine bromide and dimercaptosuccinic acid are used for modifying; by relevant experiment, the result shows that activated functional groups of carbonyl, halogen and the like which are increased on the surface of modified activated carbon are beneficial to chemical adsorption of the element mercury and divalent mercury, and especially a symmetrical stable structure formed by the combination of dimercaptosuccinic acid and mercury enables the adsorption capability of the modified activated carbon on mercury to be improved greatly.

The invention relates to magnetic compound bone cementand a preparation method for the same, and provides a preparation technology for preparing magnetic compound bone cement by mixing calcium phosphate bone cement serving as a substrate and zinc-doped Fe3O4 nanoparticles. The preparation method comprises the following steps: preparing DMSA (dimercaptosuccinic acid)-wrapped zinc-doped superparamagnetic Fe3O4 nanoparticles; preparing beta-TCP (beta-tricalcium phosphate); preparing bone cement solidification liquid; preparing the magnetic compound bone cement. According to the magnetic compound bone cement and the preparation method for the same, the addition of the zinc-doped Fe3O4 nanoparticles can be regulated to regulate the performance of the magnetic bone cement material, for example, the solidification time of the bone cement is prolonged, the solidification heat release temperature and the collapsibility of the bone cement are reduced, the injectability is enhanced, the compressive strength is strengthened, and the excessive degradation speed of brushite is reduced, so that the magnetic compound bone cement is favorable for repair and treatment of bones. The preparation method for the magnetic bone cement material is simple in process and high in operability, and has high popularization value, and clinical using requirements can be met better.

The invention provides a cis-platinum coordination compound which has a formula (I) structure or a formula (II) structure. The preparation method of the cis-platinum coordination compound is as follows: cis-platinum and a block copolymer with a formula (III) or a formula (IV) are subjected to coordination action in a water-based medium so as to generate the cis-platinum coordination compound. The cis-platinum coordination compound has good dissolubility and good biocompatibility and is degradable. In the water-based medium, the cis-platinum is protected by a poly (Gamma-propinyl-L-glutamate-g-dimercaptosuccinic acid) block and a polyethylene glycol block, so that the cis-platinum coordination compound has good stability. In addition, carboxyl contained in the cis-platinum coordination compound has PH-value sensibility, and in a lower PH-value environment, the carboxyl trends to be deprotonated, the releasing of the medicaments is promoted, and the curative effects of the medicaments are improved.

The invention provides dimercaptosuccinic acid solid preparations, in particular to a dimercaptosuccinic acid granular formulation, which is prepared from dimercaptosuccinic acid and auxiliary materials, wherein the auxiliary materials are taste-masking preparation and one kind or more than two kinds of the following materials which are selected from the following groups: diluent, disintegrating agent, suspending agent, sweetener and bonding agent. The dimercaptosuccinic acid granular formulation is characterized in that the taste-masking preparation is beta-cyclodextrin and liquid cream flavor essence, and is prepared into the granular formulation through the following method: after the dimercaptosuccinic acid and the liquid cream flavor essence are mixed, and then the beta-cyclodextrin is added to be uniformly mixed. The dimercaptosuccinic acid granular formulation adopts the novel taste-masking technology, the garlic like smell of the dimercaptosuccinic acid is effectively masked, and meanwhile, the formulation has the pleasant fragrance and fruity taste, and is more suitable for children to take.

The invention discloses an antimony-sulfur bulk concentrate flotation separation process and a combined inhibitor. The combined inhibitor comprises dimercaptosuccinic acid and sodium hydrosulfide in a mass ratio ranging from 1:1 to 1:2. In the antimony-sulfur bulk concentrate flotation separation process, by each ton of crude ore, 5-50g of the combined inhibitor is added each time. The combined inhibitor has the advantages of being good in action effect, small in amount and the like, and antimony and sulfur can be effectively separated.

The invention relates to a drug-deterioration discoloration indicating technology. The drug-deterioration discoloration indicating technology includes: forming light-induced or thermally-induced discoloration material through one or several kinds of II-VI compounds of CdTe, ZnO and the like, dimercaptosuccinic acid as well as mercaptoacetic acid and nitro blue tetrazolium or simple derivatives thereof or combination of the nitro blue tetrazolium with other dyes; affecting quantum character of photoelectron of the material by adding Cu<2+>, ag<+> plasma in the material or regulating material solution concentration and pH (potential of hydrogen) conditions to enable the material to produce discoloration visible to the naked eyes after the material receives light quantity or heat and the like capable of deteriorating drugs; producing the well-regulated material into thin films to be attached to drug packaging or coated on surfaces of the drugs to indicate decomposition of deterioration of the drugs through discoloration. Discoloration of special materials is synchronously induced by the aid of factors of light, heat and the like capable of inducing deterioration of relevant drugs, so that visible synchronous monitoring on deterioration of the drugs is realized, and drug safety of people is guaranteed.

The invention belongs to the field of solar cells, and discloses a high-performance environment-friendly lead-based perovskite solar cell and a preparation method thereof. According to the preparationmethod, a certain amount of a chelating agent disodium ethylene diamine tetraacetate or 2, 3-dimercaptosuccinic acid is introduced into a lead-based perovskite precursor solution so that the crystallinity and the crystal orientation of a lead-based perovskite thin film layer can be effectively optimized, the grain boundary of a perovskite thin film is passivated, and the energy conversion efficiency of the perovskite thin film is improved. Meanwhile, when the device is decomposed, the chelating agent can be combined with lead ions in time to form a stable and soluble complex, the complex canbe smoothly metabolized by a human body and discharged along with urine after being absorbed by the human body accidentally, and finally harm to the human body is remarkably reduced. Commercial development of the perovskite solar cell is facilitated, and particularly application of perovskite indoor photovoltaic as energy supply of the smart home terminal in the Internet of Things era is promoted.

The invention belongs to the nano biological technology field and particularly relates to a super-low field nano magnetic probe, a manufacturing method thereof and applications. The super-low field nano magnetic probe is a magnetic nano particle modified by a surface hydrophilic ligand; the magnetic nano particle is a ferrite magnetic nano particle or a doped ferrite magnetic nano particle, and a doping agent of the doped ferrite magnetic nano particle is at least one of zinc, cobalt and manganese; the hydrophilic ligand is 3,4-dihydroxyphenylpropionic acid, 2,3-dimercaptosuccinic acid and PEG modified by double carboxyls; at least one application of the super-low field nano magnetic probe described as 1)-3) further belongs to a protection scope of the invention, 1), cell magnetic imaging; 2), bacteria detection; and 3), preparing magnetic immunization kits on the basis of optics atom magnetic instruments. The super-low field nano magnetic probe is advantaged in that the super-low field nano magnetic probe is simple and efficient, low cost is realized, re-assembling is not needed, mass-scale production can be carried out, good monodispersion, good biological compatibility and excellent magnetic property are realized, and the super-low field nano magnetic probe has multiple applications.

The invention provides a road modified asphalt. The road modified asphalt is prepared from, by weight, 100 parts of asphalt, 8 to 15 parts of hydroxyapatite powder, 2 to 9 parts of guanidinoacetic acid, 1.1 to 3.6 parts of 2,3,4-Trihydroxybenzaldehyde, 0.6 to 0.9 part of sodium copper chlorophyll, 0.5 to 0.7 part of 2,3-dimercaptosuccinic acid, and 0.2 to 0.3 part of resorcinol. The road modified asphalt possesses excellent aging resistance and road using performance, is capable of reducing release amount of asphalt fume and waste gas in mixing and lying process of the road modified asphalt, and possesses excellent economic benefit and social benefit.

The invention relates to a preparation method for a mixed hemimicelle solid-phase extraction agent based on dimercaptosuccinic acid modified ferroferric oxide magnetic nanoparticles. The preparation process mainly comprises the four steps of preparation of ferroferric oxide magnetic nanoparticles, preparation of the dimercaptosuccinic acid modified ferroferric oxide magnetic nanoparticles, preparation of the mixed hemimicelle solid-phase extraction agent and a solid-phase extraction process. The synthetic method provided by the invention is simple and convenient, target object separation can be achieved just through little absorbing agents and short equilibrium time in the extraction process, the extraction capacity is high, lots of toxic and harmful solvents do not need to be used, and environmental friendliness is achieved; and meanwhile, influences of complex matrix effects of environmental samples can be effectively reduced, and the method is quite suitable for the rapid analyzing requirement of trace PPCPs compounds in complex matrixes.

The invention discloses a ferroferric oxide nanoparticle reinforced high thermal conductivity type epoxy resin composite material for an LED bonding layer and a preparation method technology. The composite material is characterized in that bisphenol A type epoxy resin E-51, B4C powder, Al2O3, 107 glue, dibutyltin dilaurate, ethyl orthosilicate, ferroferric oxide nanoparticles, dimercaptosuccinic acid, ethyl acetate, graphene oxide, ethylenediamine, PTS, multiwalled carbon nanotubes, methylhexahydrophthalic anhydride and emulsified silicon oil are taken as raw materials. According to the preparation technology, B4C powder and Al2O3 are taken as fillers, and KH550 surface treated thermal conductive silicon rubber is prepared; amino modification is carried out on the graphene oxide with ethylenediamine; organic silicon modified epoxy resin is prepared from PTS by adopting a chemical modification method; and a carbon nanotube reinforced epoxy resin-based composite material is prepared, and mechanical properties are excellent.

The invention discloses a bifunctional magnetic nanoparticles and a preparation method and application thereof, and belongs to the technical field of magnetic nanoparticle modification, magnetic Fe3O4 nanoparticles are used as a core, and 2, 3-dimercaptosuccinic acid is grafted on dopamine to obtain a PDA-DMSA coating which is used as a modification shell. The DMSA is 2, 3-dimercaptosuccinic acid, and the PDA is polydopamine. As a heavy metal adsorbent, the Fe3O4@PDA-DMSA nanoparticles can efficiently capture heavy metal Pb (II) and Cu (II) ions by using active sulfydryl and carboxyl on DMSA, and have wide application prospects in the field of heavy metal pollution treatment.

The invention discloses a dimercaptosuccinic acid pharmaceutical composition and medical application thereof. The dimercaptosuccinic acid pharmaceutical composition comprises dimercaptosuccinic acid and a novel-structure natural product compound (I); in single action of the dimercaptosuccinic acid and the compound (I), a treatment effect on immune thrombocytopenic purpura is achieved; in joint action of the dimercaptosuccinic acid and the compound (I), the treatment effect on immune thrombocytopenic purpura is improved remarkably. The dimercaptosuccinic acid pharmaceutical composition can be developed into medicines for treating immune thrombocytopenic purpura and has prominent substantial characteristics and remarkable progress as compared with the prior art.

The invention discloses a preparation method of dimercaptosuccinic-acid modified porous magnetic composite microspheres. The preparation method is characterized by comprising the following steps: firstly dissolving degreasing cotton and starch in 1-ethyl-3-methylimidazole diethyl phosphate, and adding nano zinc ferrite to prepare and obtain aminated porous magnetic composite microspheres; and then adopting gamma-aminopropyltrimethoxysilane to aminate the surfaces of the porous magnetic composite microspheres so as to obtain aminated porous cotton magnetic composite microspheres; finally adding the following components in percent by weight, namely 62-68% of methanol and 15-20% of dimercaptosuccinic acid, into a reactor, stirring for dissolving, adding 15-20% of aminated porous magnetic composite microspheres, stirring at a constant temperature of 60+ / -2 DEG C, stirring, reacting for 3 hours, cooling, carrying out solid-liquid separation, and drying to obtain the dimercaptosuccinic-acid modified porous magnetic composite microspheres. The dimercaptosuccinic-acid modified porous magnetic composite microspheres have high absorbing capacity for lead and mercury, is low in cost, is environment-friendly, can be repeatedly used for more than 10 times due to high mechanical strength, and is easy in separation.

The invention discloses a nanometer gamma-Fe2O3 relaxation rate standard substance and a preparation method thereof. The nanometer gamma-Fe2O3 relaxation rate standard substance is hydrophilic colloid solution of gamma-Fe2O3 nanoparticles, wherein, the relaxation rate constant value is 311.1mM<-1>.S-1, and the total uncertainty is 11.2mM<-1>.S-1. The preparation method comprises the following steps: preparing Fe3O4 nano-particles by a chemical coprecipitation process; preparing gamma-Fe2O3 nano-particles by chemically oxidizing the Fe3O4 nano-particles; and preparing dimercapto succinic acid surface modified gamma-Fe2O3 nano-particle hydrophilic colloid solution. The invention firstly provides the nanometer gamma-Fe2O3 relaxation rate standard substance which fills up home and abroad blank in the field, provides comparison standard for development, production and future application of MRI (magnetic resonance imaging) magnetic nano-particle contrast agent, and is important for development of accelerating and standardizing the field; meanwhile, the prepared nanometer gamma-Fe2O3 has high relaxation rate and stability, and has great application value as the MRI contrast agent.

The invention relates to a preparation method and application of a sulfhydryl chitosan / activated carbon composite functional membrane, belonging to the technical fields of novel functional membrane material preparation and arsenic-polluted water treatment. The preparation method comprises the following steps: compounding chitosan and activated carbon into a membrane, adding epoxy chloropropane to carry out cross-linking to obtain a cross-linked chitosan / activated carbon composite membrane, modifying the cross-linked chitosan / activated carbon composite membrane with 2,3-dimercaptosuccinic acid, and introducing sulfhydryl group onto the chitosan framework, thereby obtaining the functional membrane. The novel functional membrane prepared by the method provided by the invention can display multiple synergic functions of chitosan, activated carbon and sulfhydryl group, is used for treating arsenic-polluted water, is applicable to wide pH range, does not need the step of preoxidation, can effectively remove As (III) and As (V), is free from the influence of coexistent competitive anions, has the advantages of favorable mechanical strength and simple treatment technique, can be used repeatedly, can greatly lower the cost, and is a new material and method having industrial application prospects.

The invention relates to a medicine box used for preparing <99m>Tc complex, and a method for preparing novel <99m>Tc mixed ligand complex containing carbon monoxide (CO), 2, 3-dimercaptosuccinic acid (DMSA) and tetra (2-methoxy isobutyronitrile) cuprous (I) tetrafluoroborate complex salt (MIBI) by utilizing the medicine box. The medicine box comprises the following three medicine boxes: firstly, medicine box A which is composed of sodium carbonate, vitamin C, sodium borohydride, seignette salt, lactose and CO gas, and the weight ratio is (5-100):(5-100):(10-200):(15-300):(20-400):(10-200); secondly, medicine box B which is composed of DMSA and the vitamin C, and the weight ratio is (5-100):(5-100); and thirdly, medicine box C which is composed of tartaric acid, MIBI, and the vitamin C, and the weight ratio is (5-100):(1-20):(5-100). The preliminary biological experiments show that the mixed ligand complex <99mTc(CO)3(DMSA)(MIBI)> prepared by utilizing the medicine box has good myocardial uptake and detention, the uptake in the liver is greatly reduced, the fault that the liver uptake of the prior myocardial imaging agent <99m>Tc-MIBI is high can be overcome, and a higher heart / liver ratio can be achieved in 30 minutes after the administration, and thereby the medicine box is favorable for the myocardial imaging in the early stage.

The invention discloses a preparing method and application of a precious cultural relic, literature and history file and calligraphy and painting protective agent. The protective agent is prepared from, by weight, silicate removal water, fatty acyl monoethanolamine polyoxyethylene ether, methyl tetrahydro phthalic anhydride, N-methyl-N-nitroso para toluene sulfonamide, 4-nitro phthalimide, 1-amino-2-tectoquinone, 4-bromine-1-amination-2-sulfoacid, dimethylhydroquinone, gold nanoparticles, diphenylmethane, dimercaptosuccinic acid, 2,6-diisopropylphenylisocyanate, 2-p-benzotrifluoride-4-methyl-5-thiazole ethyl formate, methyl-1H-benzimidazole-2-base-carbamate and p-chloro-alpha-bromo-phenylacetic acid. The preparing method has the advantages that saponification of the protective agent is prevented, and elaioplast surface tension is reduced, so that the file surface protective agent can adhere more firmly; the protective agent has the advantages of being stable in chemical property, wide in application range, good in protecting effect, free of damage to files and clean in surface.

The invention provides a method for determining the dissolution rate of a DMSA (Dimercaptosuccinic Acid) preparation. The method comprises the following steps: dissolving out the DMSA preparation by utilizing a water solution containing a surfactant and an antioxidant as a solvent medium, thus obtaining a test production solution; carrying out HPLC (High Performance Liquid Chromatography) detection on the test product solution, and determining the dissolution rate of the DMSA preparation according to a detection result. According to the method provided by the invention, an important means of medicine in-vitro dissolution evaluation is supplemented, and the quality control standard is improved, so that the quality controllability of DMSA capsules is greatly increased.

The invention discloses a preparation method and application method of carboxylated magnetic polymer microspheres, and relates to the technical field of adsorption materials. The preparation method comprises the following steps: carrying out a carboxylation reaction on pretreated magnetic nanoparticles and 2,3-dimercaptosuccinic acid to obtain magnetic composite particles; dispersing the magneticcomposite particles in an alkaline buffer solution, and carrying out a stirring reaction with 2,3-dimercaptosuccinic acid at room temperature; separating a product obtained by stirring reaction underthe action of a magnetic field to obtain a solid product; removing impurities from the solid product, and drying to obtain the carboxylated magnetic polymer microspheres. The carboxylated magnetic polymer microspheres prepared by the method are good in adsorption effect and high in adsorption efficiency, can be recycled for multiple times after desorption, are environment-friendly and economical,and the production cost is reduced.