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Preparation method of MRI/PET bimodal molecular imaging probe for atherosclerotic vulnerable plaque

A technology for atherosclerosis and vulnerable plaques, applied in the field of molecular probes, can solve the problem of lack of breakthrough progress in targeting molecules, achieve clear pharmacological and toxicological metabolic processes, improve sensitivity and specificity, and be inexpensive. Effect

Active Publication Date: 2013-12-18
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
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Problems solved by technology

Previous studies have shown that the discovery of highly specific targeting molecules is the key to the progress of molecular imaging research in this field, but there has been a lack of breakthroughs in research on targeting molecules at home and abroad in recent years

Method used

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  • Preparation method of MRI/PET bimodal molecular imaging probe for atherosclerotic vulnerable plaque
  • Preparation method of MRI/PET bimodal molecular imaging probe for atherosclerotic vulnerable plaque
  • Preparation method of MRI/PET bimodal molecular imaging probe for atherosclerotic vulnerable plaque

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Embodiment 1

[0030] (1) Add 2.7 g FeCl 3 ·6H 2 O and 8.5 ml of oleic acid were dissolved in 50 mL of formaldehyde. Under continuous stirring, 100 ml of formaldehyde solution containing 1.2 g of NaOH was slowly titrated. The tan precipitate was washed with methanol and then vacuum-dried to remove the solvent. The obtained oleate can be dissolved in stearyl alcohol at 70°C, diluted to 0.39 mol / ml and can be stored stably at room temperature.

[0031] (2) Take 2 ml of the stock solution and add 8 ml of stearyl alcohol and 1 ml of oleic acid. Under the condition of nitrogen protection, heat the mixture to 320°C at a steady heating rate and keep it for 30 minutes. Add excess ethanol to cool and centrifuge Available Fe 3 o 4 Nanoparticles (MNPs).

[0032] (3) Take 200 mg of the above Fe 3 o 4 Nanoparticles were dissolved in 20 ml of chloroform, and after adding 0.1 ml of triethylamine, they were thoroughly mixed with 20 ml of dimethyl sulfoxide solution in which 100 mg of dimercaptosuccin...

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Abstract

The invention relates to a molecular probe in a medical imaging diagnostic reagent, and in particular relates to a preparation method of an MRI / PET bimodal molecular imaging probe for an atherosclerotic vulnerable plaque. According to the probe, molecular imaging can be performed on a new vessel of the atherosclerotic vulnerable plaque, and early warning of an unstable plaque is realized so as to provide a favorable new molecular imaging technology for early diagnosis and prevention of the coronary heart disease and reduction of serious cardiovascular event risk. The preparation method comprises the following step: chemically synthesizing a new vessel specific MRI / PET bimodal molecular imaging probe 68Ga-GEBP11-DMSA (dimercaptosuccinic acid)-MNPs through condensation reaction and chelating reaction by taking GEBP11 short peptide as a targeting tool and DMSA modified magnetic Fe3O4 nanoparticles (DMSA-MNPs) as carriers.

Description

1. Technical field: [0001] The invention relates to a molecular probe in a medical imaging diagnostic reagent, in particular to a preparation method for an MRI / PET dual-mode molecular imaging imaging probe for vulnerable plaques of atherosclerosis. 2. Background technology: [0002] Every year, about 20 million people die from acute cardiovascular events all over the world, and most of them have no prodromal symptoms, and it is difficult for existing diagnostic techniques to detect victims before cardiovascular events. Studies have shown that the main causes of acute cardiovascular events are atherosclerotic plaque rupture and thrombosis. Meta-analysis showed that 68% of patients had a coronary artery stenosis rate of <50% before myocardial infarction, 18% of patients had a coronary artery stenosis rate of 50%-70%, and only 14% of patients had a coronary artery stenosis rate of >70%. Current routine examination methods including arteriography can effectively identify ...

Claims

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Application Information

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IPC IPC(8): A61K49/14A61K49/00
Inventor 曹丰李家一苏涛王亚斌
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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