The invention provides
tranexamic acid-
glutathione-containing compound emulsifiable paste and a preparation method thereof.W1 / O / W
double emulsion phase structural design is adopted, reduced
glutathione is encapsulated in an acidic inner water core, an
oil phase is stabilized through hydrogenated
lecithin and
sorbitan sesquioleate, an outer water phase contains
tranexamic acid, a layered gel network is constructed, and the
tranexamic acid-
glutathione-containing compound emulsifiable paste is prepared. A submicron dispersion
system with the particle size D50 of 0.30-0.80 microns, the polydispersity index of 0.15-0.25 and the
viscosity of 2.0-8.0 Pa seconds is realized, the encapsulation efficiency of glutathione is not lower than 70%, the
oxygen content of a head space is not higher than 1.0%, and the encapsulation efficiency of glutathione is not lower than 70%. The three technical contradictions of
coupling conflict between a high-yield viscoelastic structure and low-shear damage kernel integrity, coexistence of fresh and cool low-
viscosity skin feeling and high-barrier anti-oxidation and anti-leakage and opposite low-surface-activity
sensitive skin compatibility and submicron low-PDI
dispersion stability are solved; the
traditional Chinese medicine composition has wide application values of improving
skin color unevenness,
fading color spots, brightening
skin color, soothing and repairing.