5results about How to "Scalable production" patented technology

This invention discloses a method for preparing fermented Chinese medicine wine, comprising the following steps: S1: Preparing brewing grains by weight, soaking, steaming, and treating with saccharifying enzymes to obtain saccharified grains; S2: Treating Chinese medicinal materials with compound enzymes to obtain enzymatically hydrolyzed Chinese medicinal materials; S3: Mixing the saccharified grains and enzymatically hydrolyzed Chinese medicinal materials, adding yeast for anaerobic fermentation to obtain fermented material; S4: Distilling and aging the fermented material to obtain fermented Chinese medicine wine. The advantages of this invention compared to existing technologies are: providing a method for preparing fermented Chinese medicine wine that achieves efficient release and full conversion of the effective components of Chinese medicinal materials, ensuring a mellow flavor and stable quality.

The invention belongs to the technical field of lipopeptide preparation, genetic engineering and biological medicine, and particularly relates to novel double-fat-chain lipopeptide as well as a preparation method and application thereof. According to the invention, a novel artificial gene cluster rhc is successfully constructed through precise editing and recombination of a functional module of a natural non-ribosomal lipopeptide gene cluster, and after heterologous expression of the gene cluster, a brand new double-fat-chain lipopeptide product Rhcolide A can be synthesized; the rhc gene cluster used for preparing the novel double-fat-chain lipopeptide Rhcolide A is the first artificial double-fat-chain lipopeptide synthetic gene cluster constructed through genetic engineering modification. A biological function test verifies and finds that Rhcolide A has excellent ferroptosis sensitizing activity, can be used as a ferroptosis sensitizer to be combined with a ferroptosis inducer to prepare a non-small cell carcinoma resisting drug, provides a brand new drug molecular entity for treatment of non-small cell carcinoma, and has important clinical application value and industrialization prospect.

The application belongs to the technical field of vegetable planting, and discloses an ecological planting method for big green onions, which takes a polyglutamic acid-silicate mineral grid fertilizer as a core, combines a green auxiliary prevention and control reagent and scientific field management, and specifically comprises the steps of soil pretreatment, seedling transplanting, precise fertilization in stages, green disease prevention and control, and whole-process ecological field management. The application realizes the synergistic unity of soil improvement, green disease prevention and control and yield improvement for the big green onions in a heavy-rotation plot, significantly improves the physicochemical indexes such as soil pH and bulk density, greatly reduces the number of fusarium, controls the total disease incidence of the big green onions within 7.3%, increases the yield per mu to more than 4390 kg, and is green, environmentally friendly, sustainable, simple, scalable, and suitable for the ecological planting of the big green onions in the heavy-rotation plot for more than 3 years.

The invention belongs to the technical field of electromagnetic wave regulation and control, and particularly discloses a transmission and reflection integrated beam regulation and control unit and a metasurface array system.The beam regulation and control unit is of a seven-layer structure including four metal layers and three medium / bonding layers from top to bottom, transmission and reflection mode switching is achieved through PIN diode on-off control, and the metasurface array system is formed. 180-degree phase difference can be generated in the two modes, interlayer signal transmission is achieved through plated-through holes, the electromagnetic performance is improved through inductors, and direct-current and alternating-current signals are isolated. The array system is composed of M * N units and is matched with a feed source antenna and a control module, transmission beam scanning, reflection, retroreflection and transmission and reflection cooperative work are achieved through three control methods, and directional communication and radar echo camouflage / enhancement are completed at the same aperture. The device is compact in structure, low in cost, low in power consumption, stable in phase regulation and control, adaptive to light platforms such as an unmanned aerial vehicle and capable of being applied to scenes such as cooperative communication and electronic countermeasure.

The invention discloses a Cu-Lis self-assembled nano-drug as well as a preparation method and application thereof, and belongs to the technical field of nano-medicines. The nano-drug is formed by self-assembly of Cu < 2 + > and liensinine (Liensinine, Lis) under mediation of polyvinylpyrrolidone (PVP) at room temperature, the particle size is 11.14 nm, the surface potential is-8.04 mV, and the nano-drug has good physiological stability and biological safety. According to the invention, an LCD-pyroptosis cycle injury amplification effect is utilized to cooperate with a tumor killing and immune reprogramming mechanism of copper death for the first time, osteosarcoma cells are induced to generate strong pyroptosis and immunogenic cell death, and an immunosuppression microenvironment is reconstructed. The preparation method of the Cu-Lis self-assembled nano-drug is mild in condition, raw materials are easy to obtain, large-scale production can be achieved, and the Cu-Lis self-assembled nano-drug has remarkable application prospects in the field of osteosarcoma immunotherapy.