4 results about "Molecular entity" patented technology

This specification provides systems, methods, and compositions for bioluminescence-induced photocatalytic activation of molecular entities in a proximity-dependent manner, which can be operated within biological systems. In particular, this specification provides activatable molecular entities, systems thereof, including bioluminescent proteins or complexes, their luminescent substrates, photocatalysts, and activatable molecular entities, which incorporate photoresponsive moieties that limit their activity, as well as methods for catalytically activating activatable molecular entities via bioluminescence-induced catalysis.

The invention discloses a standard compound library MetaTag database and application thereof.43120 compounds are recorded in the MetaTag database, the compounds have Xm-Yn type chemical structural characteristics, X represents an electrophilic substituent, Y represents a nucleophilic substituent, m and n represent the number of X and the number of Y respectively, the character '-' represents that X and Y form a covalent bond, and X and Y are both from endogenous metabolites; each compound is composed of a virtual part and an entity part; in the virtual part, each compound corresponds to a unique entry, and each entry comprises but is not limited to sub-entries such as a chemical information class, a biomedical information class, a related literature or an external database link; in the entity part, each compound can find a molecular entity in a mixed standard series of a MetaTag database, and the molecular entity is used for collecting LC-MS data to confirm the metabolite structure.

Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.