3 results about "Interaction site" patented technology

The invention provides a polypeptide for enhancing T cell function and application thereof, and belongs to the technical field of biological medicine. The amino acid sequence of the polypeptide disclosed by the invention is as shown in SEQ ID NO. 1. According to the invention, an interaction interface of CLDN18.2 and beta-catenin is targeted for the first time, the full D-type functional polypeptide is designed to realize high-stability and high-affinity protein-protein interaction blocking, and the problem that the interaction site is difficult to target by the traditional antibody drug or small molecule drug is broken through; the used polypeptide PC18.1 has good in-vitro stability and is suitable for subsequent clinical development; the polypeptide is easy to prepare on a large scale through a synthesis means, has the purity of more than or equal to 98%, is low in cost and convenient to modify, and can be flexibly applied to immune combined treatment schemes such as nano-carrier loading and local delivery.

A track arrangement (1) for self-driven carriages (2) in a storage rack arrangement (3) stores and accessed objects (4). A plurality of storage sites (5) are arranged in a rack extending over k storage levels (7). The track arrangement connects each storage level (7) with at least one interaction site (10) for processing stored objects and / or issuing objects to be stored and includes Z track levels, Z≥k, an entry point (27) on the mth track level for each interaction site (10), mϵ{1, . . . , Z}, and an exit point (28) on the nth track level for each interaction site, n∈{1, . . . , Z}. Each interaction site has: Z−m first one-way ramps (14) directed downward towards the entry point, m−1 second one-way ramps (16) directed upward towards the entry point, Z−n third one-way ramps (20) directed upward away from the exit point, and n−1 fourth one-way ramps (22) directed downward away from the exit point.

The application belongs to the technical field of biotechnology and three-dimensional genomics, and discloses a capture probe for targeting a promoter long-range interaction site of a whole pig genome, a kit and application thereof. The technology can efficiently enrich and accurately detect the regulatory elements in the pig genome which have long-range interaction with the promoter, significantly improves the feasibility and reliability of the long-range interaction research of the pig genome, and provides important technical support for the functional research of the pig genome, the genetic mechanism analysis of complex traits, and the innovation of molecular breeding technology.