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Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to microparticles having a high density of ligands or coupling agents, which is in the range of 1000-10,000,000, more preferably between 10,000 and 1,000,000 ligands per square micron of microparticle surface area. A general method for incorporating molecules into the surface of biocompatible polymers using materials with an HLB of less than 10, more preferably less than 5, such as fatty acids, has been developed. Because of its ease, generality and flexibility, this method has widespread utility in modifying the surface of polymeric materials for applications in drug delivery and tissue engineering, as well other other fields. Targeted polymeric microparticles have also been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and have targeting ligands directly bound to the microparticle surface. Preferred applications include use in tissue engineering matrices, wound dressings, bone repair or regeneration materials, and other applications where the microparticles are retained at the site of application or implantation. Another preferred application is in the use of microparticles to deliver anti-proliferative agents to the lining of blood vessels following angioplasty, transplantation or bypass surgery to prevent or decrease restenosis, and in cancer therapy. In still another application, the microparticles are used to treat or prevent macular degeneration when administered to the eye, where agents such as complement inhibitors are administered.

The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.

The present invention provides a gaming machine that includes multiple display devices arranged in a common line of sight. An intermediate display device or light filter may be included between the exterior display device and the interior display device. A touchscreen may also be added outside the exterior display device to facilitate player input and gaming machine interaction. The common line of sight arrangement permits a person to view video output on all the display devices simultaneously or without substantially changing their position or line of sight. The interior display device may include a digital display device that includes a curved surface.

Systems, methods and apparatus for collecting data and presenting media to a user are provided. The systems generally includes a data gathering module associated with an electronic device. The data gathering module communicates gathered data to a management module, which manages at least one user profile based on the gathered data. The management module may select media for presentation to a user based on the user profile, and the selected media may be displayed to the user via a media output device co-located with the user, such as a display of the user's mobile electronic device or a television, computer, billboard or other display co-located with the user. Related methods are also provided.

A method for presenting additional content for a word that is part of a message, and that is presented by a mobile communication device, includes the steps of: presenting the message, including emphasizing one or more words for which respective additional content is available for presenting by the mobile communication device; receiving an utterance that includes an emphasized word for which additional content is available for presenting by the mobile communication device; and presenting the additional content for the emphasized word included in the utterance received by the mobile communication device. These steps are performed by the mobile communication device.

A system and method of providing video drive-by data is provided to enable a street level view of a neighborhood surrounding a selected geographic location. The system includes a video and data server farm incorporation at least one video storage server that stores video image files containing video drive-by data that corresponds to a geographic location, a database server that processes a data query received from a user over the Internet that corresponds to a geographic location of interest, and an image processing server. In operation, the database server identifies video image files stored in the video storage server that correspond to the geographic location of interest contained in the data query, and transfers the video image files over a pre-processing network to the image processing server. The image processing server converts the video drive-by data to post processed video data corresponding to a desired image format, and transfers the post processed video data via post-processing network to the Internet response to the query.

In some embodiments, the present invention provides methods and systems for facilitating transactions between advertisers and advertisees for arranging for presentation of advertisements to users of computers or other computerized devices. Advertiser and advertisee offers, including user context conditions, are obtained. User context information is obtained, such as real-time or almost real-time information about an online user of an Internet site of the advertiser. If a match is determined between an advertiser offer, an advertisee offer, and a user context, arranging for presentation of an advertisement to the user is facilitated.

A peer-to-peer modular presentation system is disclosed for providing improved presentations. The system includes a plurality of displays. Each display is associated with an input device, processor and input/output port. The plurality of displays may include static or mobile wherein each display is aware of the displays immediately surrounding it or of the displays in a remote site during a teleconference. A propagation direction may be configured for at least two of the displays in the system. Propagation may be initiated for multiple displays by generating a gesture input at one display. The gesture input will cause content to be presented in the particular display, and initiate propagation of content along the configured direction in neighboring displays. Content may be fed to a particular display through a stack or other memory that is associated with the display.

This invention relates generally to methods and apparatus for utilizing energy, e.g., optical radiation, to treat various dermatological and cosmetic conditions. A handheld dermatological device that facilitates viewing and measuring parameters of a treatment area before, during, and after application of a treatment modality, and methods of use therefor, are disclosed. The device can include a deflective device that can steer radiation to control a target position of the radiation. The device can also include a control device to allow a user to control the radiation through manipulation of the deflective device.

Vaccines that target one or more antigens to a cell surface receptor improve the antigen-specific humoral and cellular immune response. Antigen(s) linked to a domain that binds to a cell surface receptor are internalized, carrying antigen(s) into an intracellular compartment where the antigen(s) are digested into peptides and loaded onto MHC molecules. T cells specific for the peptide antigens are activated, leading to an enhanced immune response. The vaccine may comprise antigen(s) linked to a domain that binds at least one receptor or a DNA plasmid encoding antigen(s) linked to a domain that binds at least one receptor. A preferred embodiment of the invention targets HIV-1 env antigen to the CD40 receptor, resulting in delivery of antigen to CD40 positive cells, and selective activation of the CD40 receptor on cells presenting HIV-1 env antigens to T cells.

A new display system and method is described, utilizing a cellular telephone having digital camera capability and a television linked directly over a UWB wireless signal forming a UWB wireless video pico-net. The system utilizes a digital camera unit to capture picture or video images for UWB transmission directly to the television acting as a pico-net host controller, either independently or together with the cellular telephone operating as a pico-net child. The display system comprises and one or more remote devices and a host display communicating on a UWB wireless network. The host display comprises a display for presentation of the picture or video images and a UWB transceiver for processing image data from the picture or video images, for selectively sending and receiving the image data based on a request from the child. The one or more remote devices comprise a digital camera for capturing the picture or video images and another UWB transceiver as used in the host display. The host display has a generally larger display for improved presentation of the captured picture or video images useful and amusing for group, party, wedding, and conference viewing, or simply for enhanced personal enjoyment. For picture or video image sharing, the system further facilitates downloading the current picture or video images from the host display television to a requesting cellular telephone or digital camera equipped with the UWB transceiver. The UWB display system provides sufficient bandwidth to support numerous such download requests simultaneously, while utilizing a transmission technology having minimal power consumption.

A system and or/methodology that facilitates organizing content on a portable communications device to generate a compilation (e.g., presentation) containing the organized content. The system and/or methodology includes an authoring component that associates content of a first type with a subset of other content and a sharing component that communicates and distributes the associated content. The subject invention can include a visual content input component that receives visual content and another content input component that can generate and organize other content in accordance with a user preference. The other content can include any content type known in the art including, but not limited to, visual, audible, text or the like.

Information (e.g. traffic information) is retrieved from a server. The content of the information is reviewed in order to determine which of a plurality of prestored speech files should be used to report the information. The selected speech files are concatenated to form an audio presentation. The speech files may include phrases identifying incident types, locations, severity and/or timing information, as well as other filler words that improve the audio presentation. In some embodiments, the audio presentation is accompanied by video and/or graphics that can be referenced by the audio presentation.

A computerized system and techniques facilitate the monitoring and management of online behaviorally-targeted advertising. In certain embodiments, electronic notifications related to advertising practices of members of an online advertising ecosystem are presented to users based on the discovery of elements of online content aimed at delivering targeted advertising messages to viewers of the content.

An implementation, which is described herein, facilitates a presentation of multiple miniaturized video feeds to a multimedia receiver. It further facilitates a user-interface employing multiple miniaturized video feeds to a multimedia receiver. This abstract itself is not intended to limit the scope of this patent. The scope of the present invention is pointed out in the appending claims.

An inertial sensor-based pointing device 10 is compatible with a removable USB pod 14 having a digital flash memory 32 and an integrated radio transceiver 30. Flash memory 32 can be used by a user to store software that enables a user to auto load software applications into compatible computers. Pointing device 10 is adapted to receive USB pod 14 resulting in a combined memory/transceiver and pointing device system that can be conveniently carried as a single unit in a pocket or via a belt clip.

Systems, methods and apparatus for collecting data and presenting media to a user are provided. The systems generally includes a data gathering module associated with an electronic device. The data gathering module communicates gathered data to a management module, which manages at least one user profile based on the gathered data. The management module may select media for presentation to a user based on the user profile, and the selected media may be displayed to the user via a media output device co-located with the user, such as a display of the user's mobile electronic device or a television, computer, billboard or other display co-located with the user. Related methods are also provided.

A communication apparatus has a controller (800); an interface (806; 850) adapted to receive an electronic message (852); a display (836); and a memory (802; 804). The memory is adapted to store image data representing at least one predefined icon to be presented on the display so as to indicate receipt of the electronic message. The memory (802, 804) is adapted to store an association (844, 846) between the or each predefined icon (846) and a sender (844) of electronic messages. The controller (800) is adapted to determine a sender (857) of the received electronic message (852), to match the sender thus determined with the or each predefined icon by way of the association, and to present a matching icon, if any, on the display to indicate receipt of said received electronic message as well as the sender thereof.

An apparatus and method for facilitating participation in a slot game. A display grid having a plurality of active display segments is presented. Symbols are randomly presented in each active display segment that has not expired. The active display segments that have expired in response to at least one randomly-selected expiration parameter are deactivated. The presentation of symbols in each of the active display segments, and the deactivation of active display segments that have expired, is repeated until a predetermined number of the active display segments have been deactivated through expiration.