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31results about How to "Increase molecular density" patented technology

Targeted and high density drug loaded polymeric materials

Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to microparticles having a high density of ligands or coupling agents, which is in the range of 1000-10,000,000, more preferably between 10,000 and 1,000,000 ligands per square micron of microparticle surface area. A general method for incorporating molecules into the surface of biocompatible polymers using materials with an HLB of less than 10, more preferably less than 5, such as fatty acids, has been developed. Because of its ease, generality and flexibility, this method has widespread utility in modifying the surface of polymeric materials for applications in drug delivery and tissue engineering, as well other other fields. Targeted polymeric microparticles have also been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and have targeting ligands directly bound to the microparticle surface. Preferred applications include use in tissue engineering matrices, wound dressings, bone repair or regeneration materials, and other applications where the microparticles are retained at the site of application or implantation. Another preferred application is in the use of microparticles to deliver anti-proliferative agents to the lining of blood vessels following angioplasty, transplantation or bypass surgery to prevent or decrease restenosis, and in cancer therapy. In still another application, the microparticles are used to treat or prevent macular degeneration when administered to the eye, where agents such as complement inhibitors are administered.
Owner:YALE UNIV

Nitrogen heterocyclic compound and organic light-emitting display device

The invention relates to a nitrogen heterocyclic compound, which has a structure shown in a formula (I), wherein X1-X5 are C atoms or N atoms, and at least two of X2-X4 are N atoms; m and n are respectively and independently selected from 0, 1 or 2, and the sum of the m and the n greater than or equal to 1; R1-R5 are the same or different, and R1-R5 are respectively and independently selected fromsubstituted or unsubstituted C6-C60 aryls, substituted or unsubstituted C10-C60 fused aryls, substituted or unsubstituted C4-C60 five-membered heterocyclic rings, substituted or unsubstituted C6-C60six-membered heterocyclic rings. The nitrogen heterocyclic compound, as a main material or a CPL layer material in an electroluminescent device, has a higher triplet state energy level ET and a largermolecular density as well as higher glass transition temperature and molecular thermal stability, effectively improves the balanced migration of carriers, widens an exciton recombination region, effectively improves the light extraction efficiency, and greatly improves the luminous efficiency and service life of the device, thus being better applied in the technical field of electroluminescent devices. The invention also provides an organic light emitting display device.
Owner:WUHAN TIANMA MICRO ELECTRONICS CO LTD

Cigarette lighter nozzle manufacture method and mould for the method

The invention discloses a lighter nozzle manufacturing method and a mould for the method. The manufacturing method is supported with low carbon steel tubes as raw materials; the invention comprises such steps as cutting, cold heading, horizontal hole-punching and catwalk slot machining and etc. The mould, however, comprises a support, a first mould, a resetting spring, a first staple, a second mould, a third mould and a fourth mould; the first mould is assembled inside a through-hole in the support; the interior is opened with the first through-hole in the consistent external diameter as that of the front of the end-product nozzle; the second mould is composed of the second thimble fitting with the first through-hole, so as to form the front part of the nozzle; the fourth mould inside is composed of an aperture in an identical external diameter as that of the rear of the end-product nozzle; the aperture inside is provided with the fourth thimble, in order to form the rear part and the shoulder on the nozzle. The invention method has the advantages of simple technologies, high production efficiency, low raw-material cost and manufacturing expenses, and low consumption of materials and etc; the mould has the advantages of simple structure and convenient use, and therefore, in particular adapting to the manufacturing of lighter nozzles.
Owner:徐伟明

Design preparation method of miniaturized negative ion goggles and negative ion goggles

The invention belongs to the technical fields of air purification and human health, and particularly relates to a design preparation method of a pair of miniaturized negative ion goggles and the negative ion goggles. Specifically, the method comprises the following steps: (1) supplying power to various devices in a small negative oxygen ion generator 2 by using a battery or a mobile power source 1; (2) compressing the air by an air beam source 7 in the small negative oxygen ion generator to generate an air beam and vertically illuminating to an electric field generated by a negative ion generating electrode 8 to form negative oxygen ions; and (3) flying the negative oxygen ions into an extraction field under the inertia of the air beam, and leading out to an air supply hole of the small negative oxygen ion generator by the extraction field. The structure and method of the present invention are used for rehabilitation patients and users of eye diseases, and the small negative oxygen iongenerator of the present structure is connected to the glasses through a negative oxygen ion transport tube, the small negative oxygen ion generator can be fixed to other parts of the body without the need to be fixedly connected to the glasses, and the structure is more portable.
Owner:SUZHOU UNIV OF SCI & TECH

Hub manufacturing equipment and hub manufacturing method

The embodiment of the invention discloses hub manufacturing equipment and a hub manufacturing method. In order to manufacture a hub through an extrusion forging process and effectively improve the hub performance, the hub manufacturing equipment and the hub manufacturing method are invented. The hub manufacturing equipment comprises a first male die, a flanging die, a side die and a second male die; the first male die and the second male die are oppositely arranged, the flanging die is arranged on the periphery of the first male die in a sleeving manner, and the side die is arranged between the first male die and the second male die; the first male die and the flanging die can move relative to the second male die; when the side die, the first male die and the second male die are matched, a die cavity of the hub is formed along the side die, the first male die and the second male die; when the flanging die, the side die and the second male die are matched, a flanging die cavity of the hub is formed between the inner side of the top of the side die and the flanging die; and the flanging die and the first male die simultaneously or asynchronously move relative to the second male die. The embodiment can be applied to hub manufacturing through materials such as an aluminum alloy, a magnesium alloy, carbon fibers and a composite material.
Owner:郝鑫颖

Cooking-resistant modified polyurethane adhesive and preparation method thereof

The invention discloses a steaming and boiling resistant type modified polyurethane adhesive and a preparation method of the steaming and boiling resistant type modified polyurethane adhesive, and belongs to the technical field of adhesives. The cooking-resistant modified polyurethane adhesive is prepared from the following components in parts by mass: 20 to 25 parts of oxalic acid, 10 to 15 parts of diethylene glycol, 10 to 15 parts of ethylene glycol, 8 to 10 parts of diphenylmethane diisochlorate, 3 to 5 parts of ethyl acetate, 20 to 25 parts of A-type modified epoxy resin, 20 to 25 parts of B-type modified epoxy resin, 4 to 6 parts of oxidized starch, 8 to 15 parts of deionized water, 5 to 8 parts of auxiliaries and 5 to 8 parts of filler. By adding the A-type epoxy resin for modification, the steaming and boiling resistance and toughness of the A-type epoxy resin can be effectively improved, and by adding the B-type modified resin for modification, the ablation resistance of the B-type modified resin can be effectively improved. Therefore, the problems of adhesion and reduction of shear strength caused by a high-temperature environment in the use process are further solved, and the cost waste is effectively reduced.
Owner:山东格润高分子材料有限公司
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