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269 results about "Binding energy" patented technology

In physics, binding energy (also called separation energy) is the minimum energy required to disassemble a system of particles into separate parts. This energy is equal to the mass defect minus the amount of energy, or mass, that is released when a bound system (which typically has a lower potential energy than the sum of its constituent parts) is created, and is what keeps the system together.

System and method for use of nanoparticles in imaging and temperature measurement

This invention provides a system and method that improves the sensitivity and localization capabilities of Magnetic Particle Imaging (MPI) by using combinations of time-varying and static magnetic fields. Combinations of magnetic fields can be used to distribute the signals coming from the magnetic particles among the harmonics and other frequencies in specific ways to improve sensitivity and to provide localization information to speed up or improve the signal-to-noise ratio (SNR) of imaging and / or eliminate the need for saturation fields currently used in MPI. In various embodiments, coils can be provided to extend the sub-saturation region in which nanoparticles reside; to provide a static field offset to bring nanoparticles nearer to saturation; to introduce even and odd harmonics that can be observed; and / or to introduce combinations of frequencies for more-defined observation of signals from nanoparticles. Further embodiments provide for reading of the signal produced by cyclically saturated magnetic nanoparticles in a sample so as to provide a measurement of the temperature of those nanoparticles. The spectral distribution of the signal generated provides estimates of the temperature of the nanoparticles. Related factors may also be estimated—binding energies of the nanoparticles, phase changes, bound fraction of the particles or stiffness of the materials in which the nanoparticles are imbedded.
Owner:DARTMOUTH HITCHCOCK CLINIC

Method of energy cumulative presplitting and smoothsurface blasting and special device therof

It is a special-purpose device used for two-directional energy-focusing and smooth blasting, post standard knot of multisection energy-gathering pipe which is in the double ''V'' shaped energy-accumulating groove which is set on the pipewall full of detonator, each post standard knot is linked with connection casing on which there is energy-accumulating groove, centering ring in the hole is noosed on the standard joint of the binding energy tube so that the center lines of the upper and the lower energy-gathering groove like V shape are in the same surface in the blasthole. Orifice centering rings of the two V- shaped central whose orientation is the same with V- shaped energy-gathering groove are set on the noose annulus wall at the ground end of energy -gathering pipe at orifice of blasthole, which makes the center line of each energy-gathering groove like a V shape forms a surface of centering and coinciding with blasting surface in each blasthole and among. After detonating explosive, make shaped charge jet spark along initial small crack that forms while the crack begins to form, then forms presplitting or smooth blasting surface, and finish energy-gathering presplitting and smooth blasting. The invention can enhance utilization ratio of demolishing energy and debase quantity of drilled holes, the influence of destroying rock mass kept down is little and the blasting surface is more level.
Owner:SINOHYDRO BUREAU 8 CO LTD

Enhanced Optical Gain and Lasing in Indirect Gap Semiconductor Thin Films and Nanostructures

Structures and methodologies to obtain lasing in indirect gap semiconductors such as Ge and Si are provided and involves excitonic transitions in the active layer comprising of at least one indirect gap layer. Excitonic density is increased at a given injection current level by increasing their binding energy by the use of quantum wells, wires, and dots with and without strain. Excitons are formed by holes and electrons in two different layers that are either adjacent or separated by a thin barrier layer, where at least one layer confining electrons and holes is comprised of indirect gap semiconductor such as Si and Ge, resulting in high optical gain and lasing using optical and electrical injection pumping. In other embodiment, structures are described where excitons formed in an active layer confining electrons in the direct gap layer and holes in the indirect gap layer; where layers are adjacent or separated by a thin barrier layer. The carrier injection structures are configured as p-n junctions and metal-oxide-semiconductor (MOS) field-effect transistors. The optical cavity is realized to confine photons. In the case of MOS structures, electrons from the inversion layer, formed under the gate at voltages above threshold, are injected into one or more layers comprising of quantum wells (2-d), quantum wires (1-d) and quantum dots (0-d) structures. The confinement of photons emitted upon electron-hole recombination produces lasing in active layer comprising of dots / wells. Bipolar transistor structures can also be configured as lasers.
Owner:JAIN FAQUIR C

Protein-protein interactions and methods for identifying interacting proteins and the amino acid sequence at the site of interaction

The invention relates to protein-protein interactions and methods for identifying interacting proteins and the amino acid sequence at the site of interaction. Using overlapping hexapeptides that encode for the entire amino acid sequences of the linker domains of human P-glycoprotein gene 1 and 3 (HP-gp1 and HP-gp3), a direct and specific binding between HP-gp1 and 3 linker domains and intracellular proteins was demonstrated. Three different stretches (617EKGIYFKLVTM627, (SEQ ID NO: 1) 658SRSSLIRKRSTRRSVRGSQA677 (SEQ ID NO: 2) and 694PVSFWRIMKLNLT706 (SEQ ID NO: 3) for HP-gp1 and 618LMKKEGVYFKLVNM631 (SEQ ID NO: 4), 648KAATRMAPNGWKSRLFRHSTQKNLKNS674 (SEQ ID NO: 5), and 695PVSFLKVLKLNKT707 (SEQ ID NO: 6) for HP-gp3) in linker domains bound to proteins with apparent molecular masses of ˜80 kDa, 57 kDa and 30 kDa. The binding of the 57 kDa protein was further characterized. Purification and partial N-terminal amino acid sequencing of the 57 kDa protein showed that it encodes the N-terminal amino acids of alpha and beta-tubulins. The method of the present invention was further validated with Annexin. The present invention thus demonstrates a novel concept whereby the interactions between two proteins are mediated by strings of few amino acids with high and repulsive binding energies, enabling the identification of high affinity binding sites between any interacting proteins.
Owner:GEORGES ELIAS
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