301 results about "Chemical binding" patented technology

These and other objects of this invention are achieved by providing a novel method and compositions for the clinical treatment of chronic inflammatory diseases. This invention involves use of systemically administered compositions which include primary amine derivatives of benzoic acid as carbonyl trapping agents. These primary therapeutic agents act by chemically binding to and sequestering the aldehyde and/or ketone products of lipid peroxidation. Increased levels of lipid peroxidation have been repeatedly demonstrated as a part of the non-enzymatic "inflammatory cascade" process which underlies the secondary etiology of chronic inflammatory diseases. p-Aminobenzoic acid (or PABA) is an example of the primary therapeutic agent of the present invention. PABA has a small molecular weight, is water soluble, has a primary amine group that reacts with carbonyl-containing metabolites under physiological conditions and is tolerated by the body in relatively high dosages and for extended periods. The carbonyl sequestering agents are used in combination with at least one co-agent so as to produce an additional beneficial physiological effect of an anti-inflammatory nature. Such compositions are administered systemically entirely via the oral route. Co-agents of the present invention include anti-oxidants and free radical trapping compounds (e.g., alpha-tocopherol), compounds having indirect anti-oxidant activity (e.g., selenium), vitamins (e.g., pyridoxine HCl), compounds which facilitate kidney drug elimination (e.g., glycine), metabolites at risk of depletion (e.g., pantothenic acid), sulfhydryl containing chemicals (e.g., methionine), compounds which facilitate glutathione activity (e.g., N-acetylcysteine), and non-absorbable polyamine co-agents (e.g., chitosan).

The invention belongs to the fabric water-repellent finishing and processing field, in particular relates a super hydrophobic cotton fabric and a preparation method thereof. The preparation method of the super hydrophobic cotton fabric is characterized in that the epoxy-functionalized modification is performed to the cotton fiber of fabric, then aminated nano-SiO2 and epoxy-functionalized nano-SiO2 are used to impregnate the cotton fabric in turn so as to increase the surface roughness of the fabric, finally a low-surface-energy material is adopted to perform hydrophobization treatment to the fabric; the contact angle between the prepared cotton fabric and water drops is more than 150 degrees; the method utilizes the covalent reaction of epoxy groups of cotton fabric, amino groups of nano-SiO2 and epoxy groups of nano-SiO2 to ensure the built rough surface to have good fastness; and the built surface has a large number of Si-OHs and epoxy groups so as to facilitate the chemical combination of the low-surface-energy material and the surface, thus the superhydrophobic property of the prepared fabric has excellent stability.

The present invention incorporates medicaments in the empty hard capsule shells (body and cap). The medicament is either physically/molecularly distributed and/or chemically bound to the polymer matrix of the capsule shell composition. Other medicaments in the form of drug-loaded matrices (powders, granules, beads, pellets, mini-tablets, and mini-capsules) can be filled in the drug-loaded empty, hard capsule shells. The same capsule dosage form contains medicaments in the core matrix and in the shell.

A process for chemically bonding an odor-encapsulating agent to textiles includes reacting a cyclodextrin with a cross-linking agent capable of forming ether bonds with the cyclodextrin and with the textile material, and curing the textile material treated with a mixture of the cyclodextrin and cross-linking agent. Preferably, the cross-linking agent is imidazolidone, which forms an ether bond with a hydroxyl group on the cyclodextrin and with a hydroxyl group. In textile materials containing cellulose, imidazolidone forms an ether bond with a hydroxyl group on the cellulose. An active agent can be complexed with the cyclodextrin for release. Textiles formed by such a process can comprise an article of clothing adapted to trap odors emanating from a wearer.

The invention discloses a preparation method of a novel MOFs-PVDF (Metal-Organic Frameworks-Polyvinylidene Fluoride) composite film. The preparation method is mainly characterized in that a synthesizing environment of MOFs is controlled to be consistent with a casting solution preparation condition, an organic ligand and metal ions are added into a casting solution by a simple one-step synthetic method, intermolecular acting force between the organic ligand and PVDF is regulated and controlled, the PVDF is chemically combined with the MOFs through a hydrogen bond of an 'F' atom, chemical bonding of a PVDF polymer and the MOFs is realized, and an MOFs-PVDF polymer is synthesized in the casting solution, so that the formation of a chemical bonding hole and the formation of an MOFs-PVDF novel film are performed simultaneously in a spinning process. The method is easy and efficient; moreover, the prepared film combines the advantages of an MOFs and PVDF composite film; the prepared novel MOFs-PVDF composite film has the advantages of high chemical stability, high mechanical strength, controllable aperture, large surface specific area and high porosity.

The cleaning-friendly article, such as a household kitchen appliance, which is suitable for heating food and/or directly connected with this unit, has a suitable long-lasting or permanent easily cleaned coating on its surfaces that are accessible to dirt. In order to provide this easily cleaned coating a mixture is applied to these surfaces, which contains a hydrolyzable, network-forming gel and a hydrophobic substance. The gel is preferably formed from metal oxides. such as SiO₂, Al₂O₃, Fe₂O₃, In₂O₃, SnO₂, ZrO₂, B₂O₃ and/or TiO₂. The hydrophobic substance is preferably chemically combined with the gel network. The hydrophobic substance preferably includes pre-condensed fluoroalkyl-silanes.

The invention provides a method to improve the storage stability for waste rubber powder modified asphalt. Wherein, the opposite compound comprises: 70~98.5% basic asphalt, 1~29.5% waste rubber, 0~10.0% diluent, and 0.1~5.0% coupling agent. The method comprises: adding the agents with given ratio into the waste rubber powder past 60-item screen to mix evenly; adding the treated rubber powder into asphalt to grinde for 30~190min by special device. As the alkoxy in coupling agent can form chemical bonding with inorganic filler to form organic active monomolecular layer between interfaces, this product can improve obviously the storage stability.

The invention belongs to the technical fields of materials and biology, and in particular relates to a surface-enhanced Raman scattering (SERS) tag microsphere and a preparation method thereof. The preparation method comprises the following steps of: reducing silver nitrate solution by using a reducing agent by taking a polymer microsphere of which the surface is provided with a carboxyl functional group as a template by an in-situ chemical reduction method to prepare a composite microsphere with uniform and compact surface silver nanoparticle coverage degree; and cladding a silicon dioxide shell by using a chemical adsorption Raman probe molecule and a silane coupling agent by a sol-gel method to obtain the SERS tag microsphere with high SERS activity. The SERS tag microsphere has monodispersity, high stability and high biocompatibility, a silicon dioxide surface is easily modified into functional groups such as an amino group or carboxyl and the like, and the SERS tag microsphere is chemically combined with a biomolecule and is applied to the fields of immunoassay, biomedical imaging, disease treatment and the like. The method is easy to operate, and has a controllable process and a good application prospect.

A mill blank assembly for a dental prosthesis includes a milling section and a support section for supporting the assembly in a milling machine. In certain embodiments, the milling section is adhesively bonded to the support section by a direct chemical bond that provides enhanced resistance to unintentional detachment of the milling section from the support section during a subsequent machining operation. Optionally, the support section includes a passageway that receives a quantity of flowable dental restorative material used to make the milling section, such that the restorative material that is located in the passageway provides additional resistance when hardened to unintentional detachment of the milling section from the support section.

Microarrays are made from sections of a molded block having many channels. These channels, which are formed by casting and/or embedding a rod in a moldable solid, are used to immobilize biological and chemical binding components after rod removal. The microarrays can be used in general biological assays, clinical evaluations and chemical library analyses.

The easily cleanable coated product is made by a process, in which a coating mixture including a hydrophobic and/or dirt-repellent substance uniformly distributed throughout a hydrolyzable, network-forming gel is applied to a product surface. The hydrophobic and/or dirt-repellent substance, which is a silane of the formula (CF_xH_y)—(CF_aH_b)_n—(CF_a′H_b′)_m—Si—(OR)₃, wherein R is an optionally heteroatom-containing, C₁–C₈-alkyl or aminoalkyl group and x and y each equal 0, 1, 2 or 3 and x+y=3, and a, a′ and b, b′ each equal 0.1 or 2, and a+b as well as a′+b′=2, and n and m each denote an integer from 0 to 20 and n+m equal at most 30, is chemically bound In the backbone of the gel network to form the easily cleanable coating. The gel is preferably an inorganic metal oxide gel made by a sol-gel process.

The invention belongs to the technical field of films, and in particular relates to a photocatalytic inorganic nanoparticle/polydopamine/polymer self-cleaning composite film and a preparation method thereof. According to the preparation method, photocatalytic inorganic nanoparticles are modified to the surface of the composite film by using a chemical binding method, so that the stability of the inorganic nanoparticles on the surface of the composite film is improved, and the contact of the inorganic nanoparticles with pollutants is prompted so as to improve the photo-degradation efficiency of the inorganic nanoparticles, therefore, the self-cleaning capability of the composite film is improved. In addition, as polydopamine is used as a free group quencher, a polymer matrix is effectively prevented from being degraded when being affected by the photocatalytic inorganic nanoparticles in the UV (Ultraviolet) radiation process, so that the property stability of the composite film is improved, and the service life of the composite film is prolonged. The preparation method is simple in operation process, gentle in preparation condition, low in production cost and easy for in-batch and in-scale production, and has a good industrialization production basis and a wide application prospect.

An apparatus and method of converting flue gases produced by a fossil fuel burning furnace boiler is disclosed. The flue gas is separated into its constituent parts by cooling and filtering. Carbon dioxide, the main constituent, is then converted to carbon monoxide in a laser powered gas converter in which carbon is a catalyst. The laser powered converter also produces hydrogen from steam, and the two newly produced gases are chemically combined to produce a hydrocarbon fuel product which can then be burned in the furnace boiler. In this manner no harmful greenhouse gases are permitted to escape to the atmosphere.

Fragment pairs of a Class A beta-lactamase (TEM-1 of E. coli) are disclosed that depend for their functional reassembly into the parent protein on the interaction of heterologous polypeptides or other molecules which have been genetically or chemically conjugated to the break-point termini of the fragment pairs. In addition, methods are provided for identifying fragment pairs that will optimally reassemble into a functional parent protein. Fragment pairs that comprise molecular interaction-dependent enzymes find use in (1) homogeneous assays and biosensors for any analyte having two or more independent binding sites, (2) tissue-localized activation of therapeutic and imaging reagents in vivo for early detection and treatment of cancer, chronic inflammation, atherosclerosis, amyloidosis, infection, transplant rejection, and other pathologies, (3 cell-based sensors for activation or inhibition of metabolic or signal transduction pathways for high-efficiency, high-throughput screening for agonists/antagonists of the target pathway, (4) high-throughput mapping of pair-wise protein-protein interactions within and between the proteomes of cells, tissues, and pathogenic organisms, (5) rapid selection of antibody fragments or other binding proteins which bind specifically to polypeptides of interest, (6) rapid antigen identification for anti-cell and anti-tissue antibodies, (7) rapid epitope identification for antibodies, (10) cell-based screens for high-throughput selection of inhibitors of any protein-protein interaction.

Bonded assemblies and methods for improving the bond strength of a joint are provided. The joint may be formed between bonding surfaces of a first and a second component. The first component has a bonding surface adapted to be bonded to a bonding surface of a second component. A plurality of features may be formed in at least one of the bonding surfaces. The bonding surfaces are bonded together to form the joint. A bonding material layer between the bonding surfaces may form the joint or the first and second components may be co-cured to form the joint. A chemical and mechanical bond between the bonding surfaces is formed with the plurality of features forming the mechanical bond and increasing the bond area of the chemical bond. The features may be openings and/or protrusions such as holes, slots, and bosses.

The present invention provides an integral source material, the integral source material has at least one nuclide that is an integral source material having at least one nuclide that is activatable by exposure to radiation, the nuclide is a chemically bound constituent of a polymer of the integral source material, wherein the integral source material is configured before activation to provide a device.

Disclosed is a neutrophil gelatinase-associated lipocalin (NGAL) protein level ELISA kit which is composed of a reagent I and a reagent II. The reagent I comprises a slow-release agent and a denaturant; the reagent II comprises latex particles coated with NGAL antibodies. Aggregated protein is denatured to some extent after being added with the denaturant, physical and (or) chemical binding site is exposed, chemical binding action of the chemical binding site is fractured through sulfydryl dissociation agent , while physical binding action of the physical binding site is dispersed by surface active agent, so that the aggregated protein is disaggregated. Therefore, it is quite important to choose the appropriate types and concentrations of denaturant, sulfydryl dissociation agent, and surface active agent; the aggregate is disaggregated without interference on following immunological detection. According to the method, the the appropriate types and concentrations of denaturant, sulfydryl dissociation agent and surface active agent are determined and chosen specifically, which solves the technical problem above.

The objective of the present invention is to provide chimeric phage-derived particles, that may be used as safe food grade vehicles to for presenting various factors (e.g. antigens, virulence proteins, receptors, ligands, etc.) for living cells. In addition to at least one normal phage or virus component the particles comprise at least one additional factor that is not encoded by the genetic material of the chimeric particle. Applications for such particles include, but are not limited to, vaccine development, pathogen neutralization, chemical binding and/or neutralization (e.g. toxins), and competitive exclusion. In addition, this technology may be used to extend the retention time of phage particles during phage therapy and/or specifically target a given particle for a biofilm.

The invention discloses a lamellar ordered hybrid coating film. The lamellar ordered hybrid coating film with thickness ranging from 500 nm to 40 mum is formed by alternately piling inorganic nano-particle layers with thicknesses ranging from 10 nm to 200 nm and polymer layers with thicknesses ranging from 50 nm to 5 mum; each inorganic nano-particle layer adopts a montmorillonite layer or hydrotalcite layer; the polymer layer is prepared by a polymer emulsion coating film; and the polymer emulsion is prepared by adopting the following method: adding a monomer, surface-active agent and initiating agent into deionized water to carry out polymerization reaction for 5 to 8 hours under the temperature of 50 DEG C to 80 DEG C, then cooling to room temperature after completion of reaction, and then obtaining the polymer emulsion. The lamellar ordered hybrid coating film material is prepared by adopting the alternately spincoating or spraying method, the thicknesses of the polymer layers and the norganic nano-particle layers can be controlled through the process; and in addition, the surface-active agent capable of taking part in polymerization is selected, and the chemical binding between inorganic platy particles and polymer phase can be realized, so that the mechanical property, the heat resistance, the corrosion resistance and other properties of the material are enhanced.