5 results about "Chemical library" patented technology

This disclosure provides methods for screening DNA-encoded chemical libraries using mirror images of target molecules. These methods allow for the efficient selection of compounds that bind to target molecules, even when the target molecules are able to bind to the DNA tag of the encoded compound.

The present document relates to headpieces for DNA-encoded chemical libraries and processes for preparing them, to DNA-encoded chemical libraries and DNA-supported pharmacophores or control molecules comprising the headpiece, and to uses thereof. The present document further relates to a method for generating multidimensional selection maps for a DNA-encoded library (DEL) (e.g., double-stranded or single-stranded DEL) against a single target.

The application discloses application of Biochanin A in preparation of a medicine for inhibiting or improving uterine decidua stromal cell senescence, and belongs to the field of biomedical technology. Through drug chemical library screening and experimental verification, it is found that Biochanin A can significantly alleviate the senescence phenotype of human uterine decidua stromal cells, reduce the expression of senescence-related markers, and alleviate decidua stromal cell senescence through regulation of mitochondrial energy metabolism. The application provides a brand-new drug target and intervention strategy for improving endometrial decidua function and treating related reproductive health problems in clinic, and provides application of Biochanin A in preparation of a medicine for alleviating uterine decidua stromal cell senescence.

This invention belongs to the field of compound technology, specifically a small molecule compound inhibitor antagonizing GREM1 and its application in the treatment of colorectal cancer. The specific preparation process of this small molecule compound inhibitor is as follows: First, the DEL (DNA-encoded chemical library) library is dried under vacuum, then dissolved in a protein solution containing 5-10 µM human Grem1 protein, and incubated in a DEL screening buffer system for 30 minutes; after incubation, the Grem1 protein is immobilized using 20 µl of HisPur™ Ni-NTA Magnetic Beads, and incubation continues for 15 minutes, followed by washing with 10 × 100 µl of screening buffer under shaking, and finally removing unbound library molecules by vacuum aspiration; the small molecule inhibitor screened by this application using DNA-encoded libraries (DEL) has the advantages of small size, strong permeability, tunable pharmacokinetics, and low cost, and can inhibit the migration and invasion of colorectal cancer.