180 results about "Chemical coupling" patented technology

The invention discloses a carbonatite geothermal reservoir acid fracturing evaluation method based on a heat-water-force-chemical coupling model. The carbonatite geothermal reservoir acid fracturing evaluation method specifically comprises the steps that physical and mechanical parameters of a carbonatite reservoir matrix and engineering parameters of fracture fractures are collected; according to the engineering parameters, establishing a geometric model for simulating the carbonate reservoir, and distributing variables in cracks in each field to a crack domain to obtain a computational domain; a heat transfer field, a hydraulic field, a stress field and a chemical field are added to the computational domain, the mutual coupling relation is established, and a heat-water-force-chemical coupling model covering fracture deformation is formed; the separation coupling model is solved, and acid fracturing evaluation is carried out. According to the invention, the fully-coupled THMC model of the carbonate reservoir acid fracturing process is designed, and the model integrates heat transfer, acidizing fluid flow, rock matrix and crack deformation, reaction dilution substance migration and interaction among chemical corrosion phenomena, and is used for quantifying the influence of carbonate geothermal reservoir acid fracturing.

Provided are a thermal-hydrological-mechanical-chemical coupling exploitation experimental device for a deep oil and gas reservoir, and a simulation system. The device includes a loading bin, a sample holding bin, a true triaxial pressure loading mechanism arranged on the loading bin, a temperature control system arranged on the true triaxial pressure loading mechanism, and a monitoring system having a detection element arranged in the rock sample and the sample holding bin. A sample entry port is formed in one side surface of the loading bin. The sample holding bin has one end slidably arranged in the sample entry port, can be sealed and connected with the sample entry port, and is configured for placing and fixing a rock sample. Multiple through holes are uniformly formed on an outer end cover of the sample holding bin and are configured for detecting and adding water, gas, and oil.

The embodiment of the invention relates to the technical field of simulation, in particular to an electro-hydrogen chemical coupling system planning design verification method and platform, and the method comprises the steps: building an electro-hydrogen chemical coupling system model, setting configuration parameters and a planning target for the coupling system model, and determining and executing a target planning algorithm according to the planning target to obtain a planning result, determining simulation parameters for the coupling system model according to the indication of the planning result; operating the coupling system model according to the simulation parameters to perform production simulation to obtain a corresponding production simulation result and simulation data of a plurality of equipment simulation models in the coupling system model in the simulation process; optimizing the simulation parameters according to the simulation data to obtain optimized simulation parameters, and operating the coupling system model again according to the optimized simulation parameters to perform production simulation to obtain an optimized production simulation result; and comparing the production simulation result with the optimized production simulation result, and selecting a target planning result. According to the scheme, energy conservation and consumption reduction can be realized, and the system operation stability is enhanced.

The invention relates to the field of material science, and discloses a preparation process of a softwood rubber metal composite material, which comprises the following steps: S1, cleaning the surfaces of metal, softwood and rubber; s2, plasma treatment is conducted on the surfaces of the metal, the cork and the rubber; s3, preparing a modified chemical coupling agent, and coating the modified chemical coupling agent on the surfaces of metal, cork and rubber; s4, hot press molding is carried out, and metal, rubber and cork are stacked and subjected to hot press treatment; and S5, cooling treatment is conducted, and the cork rubber metal composite material is obtained. The modified chemical coupling agent is prepared from the following components in percentage by weight: 70 to 80 percent of 3-methyl propyl triethoxy silane; 10 to 20 weight percent of diisocyanate-based silicone oil; 5 to 10 wt% of polyethylene glycol; and 2-5 wt% of dimethyl diallyl ammonium chloride. The interface bonding strength of the softwood rubber metal composite material is remarkably improved, and the overall mechanical performance is enhanced.

The invention discloses a stem cell exosome based on targeted fusion polypeptide modification, a preparation method and application of the stem cell exosome in treating male erectile dysfunction. According to the exosome, a specific targeting fusion polypeptide (sequence: EPLQLKM-GGGS-DPPV) is anchored on the surface through a chemical coupling technology, so that the targeting property of the exosome on cavernosum smooth muscle cells is enhanced; meanwhile, an anti-TrkA monoclonal antibody (TrkA-2E7-HL) is loaded through an electroporation method, and a fibrosis pathway mediated by a nerve growth factor (NGF) is inhibited. The exosome induces secretion of the umbilical cord mesenchymal stem cells by adopting an anti-oxidation culture medium, so that the anti-oxidation activity of the exosome is remarkably improved. Experiments show that in a diabetes ED rat model, the erectile function (ICP / MAP ratio) of the modified exosome is improved to 0.79 + / -0.05, the fibrosis area is reduced to 9.2 + / -1.6%, and the NO secretion level is improved by 3.5 times compared with that of a common exosome. Through triple mechanisms of polypeptide targeting, antibody synergy and oxidation resistance, effective reversion of the ED pathological process is realized, and the polypeptide has remarkable novelty and clinical transformation potential.

The invention discloses a composite material curing forming defect prediction method and system considering a flow compaction process, and relates to the technical field of composite material curing forming simulation prediction. The method comprises a data acquisition step; a data preprocessing step; obtaining a curing degree field; and a corresponding parameter obtaining step. The system comprises a thermal-chemical coupling temperature field calculation module, a component material time-varying performance calculation module and a thermal-force coupling stress field calculation and flow-compaction calculation module which are connected in sequence. According to the method, resin flowing and fiber bed compaction characteristics are considered on the basis of existing research, and accurate prediction of two molding defects of thickness out-of-tolerance and non-uniform resin content generated after curing molding of the composite material structural member is realized.

The invention relates to the technical field of material surface engineering, and discloses a plastic surface treatment process to solve the problems that in the prior art, a plastic surface coating is poor in adhesive force and single in function, and a traditional treatment method is not environmentally friendly. The process sequentially comprises the following steps: pre-treating a base material, and obtaining a clean and stress-free base material through ultrasonic cleaning and thermodynamic stress elimination; performing low-temperature plasma surface activation, performing physical bombardment and chemical modification on the plastic surface by utilizing plasma of specific process gas in a vacuum environment, introducing a large number of active functional groups, and remarkably improving the surface energy; and preparing and applying the functional nano coating, namely forming firm covalent bonds by using the coupling agent in a coating solution containing functional nano particles and a coupling agent and the anchor points, so that the chemical coupling of the functional coating and the plastic substrate is realized.

The invention relates to the technical field of wind power generation materials, in particular to a rubber insulating material and a sheath material for wind power generation. The rubber insulating material for wind power generation comprises an insulating inner layer, an interface transition layer and a sheath outer layer, in the rubber insulating material for wind power generation and the sheath material, through double mechanisms of chemical coupling of a plant-based diluent and nano-cellulose and physical adsorption of expanded graphite, the insulating inner layer has excellent heat resistance and mechanical strength on the basis of keeping the heat resistance and mechanical strength of the material; the processing viscosity of the epoxy resin system is reduced; the outer layer of the sheath improves the mechanical property and salt mist erosion resistance of the material through the chemical anchoring of plant fibers and resin and the barrier effect of the nanosheet layer; meanwhile, the natural latex-cellulose nanocrystalline composite network of the interface transition layer strengthens the interface compatibility of the insulating layer and the sheath layer, and avoids the interlayer separation risk, thereby improving the reliability and service life of the material in an extreme environment of offshore wind power equipment.

The invention belongs to the field of indoor environment health research, and particularly relates to a method for effectively representing a volatile organic compound (VOCs) release mechanism of an indoor material under long-term physical and chemical action. According to the method, accurate and effective characterization of the long-term release characteristic of the material is realized by simplifying a complex physical and chemical coupling problem and combining an aging test and a parameter determination experiment. The method comprises the following steps: designing a natural aging experiment to simulate an actual long-term release process of a material; extracting material samples with different aging times, and determining corresponding VOCs key parameters by utilizing an environment chamber experiment; and fitting the change of the key parameters along with time by using a single exponential function so as to characterize the long-term release characteristic of the VOCs in the material. The method is suitable for material-VOCs combined release research under different temperature and humidity conditions, and results can be used for long-term concentration prediction of indoor VOCs in a dynamic environment and further applied to reasonable material selection in building design, ventilation design in specific space and time, health risk assessment and the like.

The invention relates to preparation of 10-hydroxycamptothecine modified polypeptide and a research on cytotoxicity of the 10-hydroxycamptothecine modified polypeptide. The method comprises the following steps: synthesizing SA-7 polypeptide by adopting an F-moc solid-phase synthesis method, and combining the SA-7 polypeptide with 10-hydroxycamptothecine through chemical coupling reaction to obtain the SA-7-HCPT compound. C18 reversed-phase high performance liquid chromatography (RP-HPLC) is used for purification, and the molecular weight is identified to be 1898Da by using mass spectrum. A further cytotoxicity test shows that the SA-7-HCPT shows relatively strong anticancer activity to HepG2, and the toxicity of the SA-7-HCPT to HepG2 is remarkably superior to that of 10-HCPT to HepG2. Meanwhile, the toxicity of SA-7-HCPT to normal liver cells LO2 is relatively low, and the SA-7-HCPT shows good selectivity. Therefore, the SA-7-HCPT has a relatively good clinical application prospect.

The invention discloses a thermal-mechanical-chemical coupling simulation calculation method for friction-induced energetic material ignition, which comprises the following steps: S1, establishing a three-dimensional finite element model of an energetic material, and performing mesh generation on the established three-dimensional finite element model; s2, embedding a model code of the friction-induced chemical thermal decomposition reaction of the energetic material into finite element analysis software; s3, in finite element analysis software embedded with model codes, performing thermal-mechanical-chemical coupling simulation on the three-dimensional finite element model after mesh division; and S4, performing visualization post-processing on a calculation result of the coupling simulation to obtain a corresponding model temperature field. The invention provides a heat-force-chemical coupling simulation calculation method for friction-induced energetic material ignition. The critical condition of friction-induced energetic material ignition can be researched. The thermal-mechanical-chemical coupling multi-aspect physical and chemical whole process monitoring of the energetic material in the friction process is realized, and the problem of friction induced ignition of different energetic materials can be simulated and researched.

The invention relates to the technical field of electrochemistry, in particular to a supramolecular ionic liquid gel electrolyte of a solid-state zinc-iodine battery for a high-voltage platform, which is characterized in that free water in hydrogel is replaced by supramolecular interaction between ionic liquid and polyvinyl alcohol molecules to construct a water-poor ionic liquid polymer network; zinc bromide is introduced to serve as an ion carrier in a polymer network through the HofMichael effect, and preparation of the high-voltage solid-state zinc-iodine battery is finally achieved through the chemical coupling effect of bromide ions and iodide ions; the solid electrolyte is prepared from an ionic liquid and a hydrogel solution, imidazole cations of the ionic liquid have a strong electron withdrawing effect, and anions of the ionic liquid are combined with zinc ions and bromide ions to form polyanions. And the ionic liquid is used for replacing water in the hydrogel, so that the ionic liquid gel electrolyte with good chemical stability, mechanical property and electrochemical property is prepared.

The invention provides a method for measuring plasma generated by electro-chemical coupling explosion, which adopts a device for measuring plasma generated by electro-chemical coupling explosion, the device comprises an explosion cavity and an oscilloscope, and a Langmuir three-probe is arranged in the explosion cavity; and the Langmuir three-probe is connected with an oscilloscope. The Langmuir three-probe comprises a probe P1, a probe P2 and a probe P3. The device provided by the invention has the characteristics of being suitable for transient plasma diagnosis based on Langmuir three probes, simple in structure and convenient in data processing, voltage signals measured by a probe circuit are acquired and are converted into plasma electron temperature and density after being analyzed and calculated, and the electron density ne of the plasma is calculated according to the electron density ne of the plasma. Therefore, the plasma generated by the electro-chemical coupling explosion can be measured.

The invention provides an electro-chemical coupling collaborative explosion near-field shock wave pressure measuring device and method. The device comprises a fiber grating sensing system; comprising an FBG optical fiber sensor, the FBG optical fiber sensor extends into an explosion cavity, the FBG optical fiber sensor is fixed on a flange of the explosion cavity, the FBG optical fiber sensor is connected with a circulator through an optical fiber patch cord, the circulator is connected with a laser light source, and the circulator is further connected with a coupler; the coupler is connected with the signal demodulator, and optical signals of the FBG optical fiber sensor are introduced into the signal demodulator; the signal demodulator is further connected with the photoelectric detector, the coupler is further connected with the photoelectric detector, and the photoelectric detector is connected with the oscilloscope to take electricity. According to the invention, strong electromagnetic pulse interference accompanied by explosion is overcome, and the impact wave pressure generated by metal wire electric explosion and micro-explosive chemical explosion can be more accurately measured. The technical problems of strong interference signals, overlarge sensor size and the like in the measurement of the explosion impact pressure of the tiny explosive quantity in the cavity are solved.

The invention discloses a monatomic electrocatalyst of a metal polyphenol network as well as a preparation method and application of the monatomic electrocatalyst. The preparation method comprises the following steps: adding an alkaline solution of Pluronic F127; polyphenol and formaldehyde are added for a cross-linking reaction; dropwise adding a metal salt solution, stirring and mixing, carrying out a hydrothermal reaction, carrying out centrifugal separation to obtain a precipitate, and washing and drying to obtain the monatomic catalyst. According to the method, polyphenol containing a large number of hydroxyl groups is taken as a ligand, coordination with metal ions is realized through formaldehyde-assisted crosslinking, a reaction path is precisely regulated and controlled through hydrogen bond engineering, a CO2 reduction reaction path is changed from a traditional * CO path to a low-energy barrier formyl path, C-C chemical coupling and hydrogen evolution / deuterium evolution side reaction are synchronously inhibited, and the reaction efficiency is improved. The selectivity of methane or deuterated methane is obviously improved, the operation stability for ultra-long time is realized, and an effective solution is provided for synthesis of methane and deuterated methane with high additional value.

The invention relates to the technical field of ceramic glaze production, in particular to interlayer chemical coupling long-acting noctilucent ceramic glaze as well as a preparation method and application thereof. The glaze is of a multi-layer composite structure and sequentially comprises a bottom-layer combined glaze layer, a core noctilucent functional glaze layer and a photochromic protective cover glaze layer from inside to outside. The core layer adopts a glaze system containing niobium pentoxide to realize chemical coupling with the bottom layer, and adopts a core-shell structure long afterglow luminescent material to realize white light adjustability; and the protective cover glaze layer adopts a WO3 / TiO2 / CeO2 composite system. The glaze is prepared through a two-step method of high-temperature primary firing and low-temperature secondary firing, and the obtained glaze is high in interlayer bonding strength, high in weather resistance, long in luminous life, capable of adapting to ambient light and suitable for safety sign products in extreme environments.

The invention relates to an RGD (arginine-glycine-aspartic acid) peptide modified mercaptododeborane derivative and a synthesis method, the derivative utilizes RGD peptide to perform chemical coupling modification on mercaptododeborane anion salt (BSH), and the BSH and the RGD peptide are connected through a hydrophilic intermediate connector with a double bond at one end and carboxyl at the other end. A hydrophilic chain is selectively introduced to serve as an intermediate connector, a series of compounds are synthesized through a convenient and efficient sulfydryl-alkene click reaction and an amino-carboxyl amidation condensation reaction and are purified, various cationic BSH salts and RGD peptide are connected, and targeted modification of the RGD peptide on an existing boron carrying agent BSH is achieved. The derivative obtained by the invention is not reported before, has the potential to improve the tumor targeting ability of the existing boron carrying agent, and is expected to be used as a drug compound for BNCT treatment.

The invention discloses a method for detecting silicon dioxide in kaolin based on a nanoprobe. The method comprises the following steps: grinding a kaolin sample, mixing with deionized water, performing ultrasonic dispersion, and centrifuging to obtain a kaolin sample solution; the preparation method comprises the following steps: preparing titanium dioxide nano-particles with amino groups modified on the surfaces by adopting a hydrothermal method, and modifying a silane coupling agent on the surfaces of the nano-particles by adopting a chemical coupling method to form a functionalized nano-probe; adding the functionalized nanoprobe into a kaolin sample solution; the nanoprobe is combined with silicon dioxide in a sample to form a nanoprobe-silicon dioxide compound; collecting a nano probe-silicon dioxide compound; reacting the nanoprobe-silicon dioxide compound with a fluorescent marker, and combining the fluorescent marker with silicon dioxide in the compound; and detecting the fluorescence intensity, and calculating the content of silicon dioxide in the sample according to the standard curve. The method for detecting silicon dioxide in kaolin is high in sensitivity, high in selectivity, simple and convenient to operate and wide in application.

The invention provides a method for rapidly detecting fluorescently-labeled allergens for hygienic products, and relates to the technical field of detection of hygienic products. The rapid fluorescently-labeled allergen detection method for the hygienic products comprises the following steps: combining a fluorescently-labeled substance with an allergen specific antibody through a chemical coupling method to form a stable fluorescently-labeled antibody compound; fixing the fluorescence labeled antibody on the surface of a reaction chamber of a micro-fluidic chip; introducing a hygienic product sample or an extract thereof into the chip, and combining the hygienic product sample or the extract thereof with the fixed fluorescently-labeled antibody to form an'allergen-antibody-fluorescently-labeled 'immune complex; a detection area is irradiated by an excitation light source, fluorescence intensity is monitored in real time by a photoelectric sensor, and a detection result is generated by combining a data analysis module. According to the invention, the rapid and high-sensitivity detection of allergens in hygienic products is realized by combining a fluorescence labeled antibody with a microfluidic technology.

The invention belongs to the technical field of immunology, and discloses a manganese salt adjuvant system based on dextran particle capsule shrinkage and a preparation method and application thereof.The manganese salt adjuvant system comprises beta-dextran particles GPs of a hollow spherical shell structure from yeast and manganese hydroxide colloid encapsulated in the dextran particles, the preparation method comprises the following steps: soaking the GPs in a MnCl2 solution, after the inner cavity of the GPs fully absorbs the MnCl2 solution, separating the GPs adsorbing MnCl2, then adding the GPs into a NaOH solution, forming stable manganese hydroxide colloid by manganese ions in the inner cavity of the GPs, and washing after separation to obtain the dextran particle encapsulated manganese salt adjuvant system. The GPMnOH particles carry various antigens at the same time in various modes such as electrostatic adsorption, chemical coupling or hydrophobic interaction, and an ideal carrier is provided for co-delivery immunization of the antigens and adjuvants.

The invention provides a hydrogen sensor as well as a preparation method and application thereof, and particularly relates to the technical field of sensors. The hydrogen sensor comprises a ceramic substrate electrode and a gas-sensitive layer, the gas-sensitive layer is arranged on the surface of the ceramic substrate electrode, the gas-sensitive layer comprises a composite material formed by doping a semiconductor material with precious metal, the surface of the composite material is coated with a hydrophobic membrane, and the surface of the hydrophobic membrane is coated with a metal layer. The hydrophobic membrane is formed by chemical coupling reaction of hydrophobic silane and hydroxyl groups. According to the hydrogen sensor, by adopting the specific semiconductor sensing material and the hydrophobic membrane, the adaptability and the stability of the hydrogen sensor in a high-temperature alkali liquor corrosion environment are greatly improved, the hydrogen sensor can reliably work for a long time in a severe environment, the replacement frequency of the sensor is reduced, and the use cost is reduced.

The invention discloses a pulverized coal selective oxygen group alkylation modification method, which starts from fire coal, and changes the molecular configuration of pulverized coal through a mechanical force chemical coupling alkylation reagent selective modification method, thereby influencing the migration and conversion path of fuel nitrogen in raw coal, realizing the directional regulation and control of the nitrogen-containing product of the fire coal, enhancing the homogeneous and heterogeneous reduction of NOx, and improving the combustion efficiency. And finally, ultra-low nitrogen emission of the fire coal is realized.

The application discloses a preparation method and application of a conjugate targeting pelvic autonomic nerves, wherein the conjugate is NE-RH formed by coupling of rhein and norepinephrine, the conjugate can realize precise targeting of norepinephrine neurons, improve the accumulation effect of RH in the norepinephrine neurons, and further enhance the nerve protection effect of RH. The conjugate has a molecular weight of less than 1000 Da, can help to penetrate the blood-brain barrier, and can avoid the defects of being easily removed by a mononuclear phagocyte system and having a short half-life. The production process of the conjugate is simple, the chemical coupling reaction is clear, the yield can reach 38%, and the purity of the product is greater than 99%, so that the conjugate is convenient to popularize and use. The conjugate and the preparation method have important significance for the damage repair of pelvic autonomic nerves.

The present application relates to the technical field of biotechnology, and particularly relates to a D-dimer chemiluminescence assay kit. The present application provides a D-dimer chemiluminescence assay kit, which comprises a magnetic particle suspension (immunomagnetic beads) coated with D-dimer antibody 1, alkaline phosphatase-labeled D-dimer antibody 2 (enzyme-labeled antibody) and a calibrant. The immunomagnetic beads and the enzyme-labeled antibody are prepared by chemical coupling and stored in a buffer containing a soluble high molecular material, which can effectively improve the detection sensitivity and repeatability. The kit can be used in combination with a substrate solution containing a chromogenic substrate such as adamantane and its derivative AMPPD or APS-5 for a full-automatic immune test system, and the content of D-dimer in plasma or whole blood can be determined by a chemiluminescence instrument. The kit has high detection sensitivity and good repeatability.

The embodiment of the application provides a kind of high temperature contact-corrosion coupling model construction method, determine the type of high temperature contact corrosion and corrosion internal mechanism;Build force-chemical coupling theory model;Solve the force-chemical coupling theory model using finite element algorithm;Based on the result obtained by solving, build high temperature contact-corrosion coupling finite element model.The scheme, based on irreversible thermodynamics, establishes a force-chemical full-coupling high-temperature oxidation corrosion theory model considering the interaction of contact pressure, reactant (gaseous) diffusion and chemical reaction;The high-temperature corrosion model is realized by finite element using the pre-set UEL module, which can accurately simulate the corrosion evolution law, corrosion morphology characteristics, chemical reaction dynamic process in the contact area during high-temperature contact corrosion process, and the change of contact pressure with reaction process.Meanwhile, it can also accurately present the distribution of stress, strain, contact pressure, reactant and product concentration and other physical fields.

The present invention relates to a chemical coupling linker, and an antibody-drug conjugate prepared with the linker. The present invention further relates to a use of the antibody-drug conjugate in treating related disease of tumors, etc.

The invention relates to a fly ash-based hierarchical pore molecular sieve composite material as well as a preparation method and application thereof, and belongs to the technical field of molecular sieve composite materials. In order to solve the problems that an existing fly ash based molecular sieve is single in pore structure, can only adsorb single pollutants and is complex in preparation process, the invention provides a preparation method of a fly ash based hierarchical pore molecular sieve composite material. The method comprises the following steps: carrying out mechanical-chemical coupling activation on fly ash, carrying out alkali fusion activation treatment, preparing a colloidal precursor, carrying out hydrothermal crystallization treatment, carrying out post-treatment on a crystallized product, and carrying out metal ion modification treatment. A micropore-mesopore-macropore three-level pore channel is constructed, the mass transfer efficiency and the adsorption activity are improved, double active sites are formed through metal modification, heavy metal and CO2 can be synchronously adsorbed, and the CO2 capacity is improved by 10-15% through heavy metal loading. The one-step method is adopted for preparation, the process is simplified, the cost is low, high consumption of fly ash is achieved, and the benefits of solid waste recycling and multi-pollutant cooperative treatment are achieved.

The invention relates to the technical field of new energy hydrogen production and chemical coupling application, and discloses a natural gas hydrogen-doped pipeline conveying system which comprises an energy supply layer, a chemical production layer, a digital integrated platform and a dispatching control module. The energy supply layer integrates photovoltaic power, wind power, nuclear power and a power grid standby power supply through a direct-current micro-grid, is matched with a sodium ion flow battery energy storage system, and supplies energy to the water electrolysis hydrogen production system of the non-noble metal catalyst and porous electrode structure. In the chemical production layer, pipeline steel or double-layer alloy steel is selected as a hydrogen-doped pipeline according to the proportion, a hydrogen concentration monitoring and sound wave leakage detection system is arranged, the hydrogen-doped safety upper limit of high pressure of 10% and low pressure of 30% is set, and a chemical hydrogen using system is connected through a gas distribution valve set and adjusted by an intelligent module. The digital platform is based on monitoring of the Internet of Things, hydrogen doping is optimized by means of a fuzzy PID algorithm and digital twinning, and risks are early warned. The scheduling module combines wind and light prediction and real-time electricity price, optimizes the start and stop of the electrolytic cell, the hydrogen doping ratio and the conveying pressure, and achieves efficient and stable conveying.

The invention discloses a preparation method of structural color hydrogel microspheres for acute kidney injury multi-labeling detection, which comprises the following steps: S1, shearing a silicon dioxide nanoparticle solution into liquid drops, drying the obtained liquid drops, cleaning and calcining to obtain silicon dioxide photonic crystal microspheres; s2, soaking the obtained silicon dioxide photonic crystal microspheres in a hydrogel precursor solution, performing cross-linking curing by ultraviolet irradiation after full incubation, and then stripping and corroding the obtained product to obtain hydrogel structural color microspheres; s3, modifying an acute kidney injury marker antibody to the hydrogel structural color microspheres through chemical coupling, so as to obtain the structural color hydrogel microspheres for acute kidney injury multi-element marker detection. The structural color hydrogel microspheres obtained by the invention can realize simultaneous detection of various acute kidney injury markers, and can enhance fluorescence signals and sensitivity of detection at the same time.