96 results about "Chemical coupling" patented technology

The invention belongs to the technical field of immunology, and discloses a manganese salt adjuvant system based on dextran particle capsule shrinkage and a preparation method and application thereof.The manganese salt adjuvant system comprises beta-dextran particles GPs of a hollow spherical shell structure from yeast and manganese hydroxide colloid encapsulated in the dextran particles, the preparation method comprises the following steps: soaking the GPs in a MnCl2 solution, after the inner cavity of the GPs fully absorbs the MnCl2 solution, separating the GPs adsorbing MnCl2, then adding the GPs into a NaOH solution, forming stable manganese hydroxide colloid by manganese ions in the inner cavity of the GPs, and washing after separation to obtain the dextran particle encapsulated manganese salt adjuvant system. The GPMnOH particles carry various antigens at the same time in various modes such as electrostatic adsorption, chemical coupling or hydrophobic interaction, and an ideal carrier is provided for co-delivery immunization of the antigens and adjuvants.

The invention provides a hydrogen sensor as well as a preparation method and application thereof, and particularly relates to the technical field of sensors. The hydrogen sensor comprises a ceramic substrate electrode and a gas-sensitive layer, the gas-sensitive layer is arranged on the surface of the ceramic substrate electrode, the gas-sensitive layer comprises a composite material formed by doping a semiconductor material with precious metal, the surface of the composite material is coated with a hydrophobic membrane, and the surface of the hydrophobic membrane is coated with a metal layer. The hydrophobic membrane is formed by chemical coupling reaction of hydrophobic silane and hydroxyl groups. According to the hydrogen sensor, by adopting the specific semiconductor sensing material and the hydrophobic membrane, the adaptability and the stability of the hydrogen sensor in a high-temperature alkali liquor corrosion environment are greatly improved, the hydrogen sensor can reliably work for a long time in a severe environment, the replacement frequency of the sensor is reduced, and the use cost is reduced.

The application discloses a preparation method and application of a conjugate targeting pelvic autonomic nerves, wherein the conjugate is NE-RH formed by coupling of rhein and norepinephrine, the conjugate can realize precise targeting of norepinephrine neurons, improve the accumulation effect of RH in the norepinephrine neurons, and further enhance the nerve protection effect of RH. The conjugate has a molecular weight of less than 1000 Da, can help to penetrate the blood-brain barrier, and can avoid the defects of being easily removed by a mononuclear phagocyte system and having a short half-life. The production process of the conjugate is simple, the chemical coupling reaction is clear, the yield can reach 38%, and the purity of the product is greater than 99%, so that the conjugate is convenient to popularize and use. The conjugate and the preparation method have important significance for the damage repair of pelvic autonomic nerves.

The present application relates to the technical field of biotechnology, and particularly relates to a D-dimer chemiluminescence assay kit. The present application provides a D-dimer chemiluminescence assay kit, which comprises a magnetic particle suspension (immunomagnetic beads) coated with D-dimer antibody 1, alkaline phosphatase-labeled D-dimer antibody 2 (enzyme-labeled antibody) and a calibrant. The immunomagnetic beads and the enzyme-labeled antibody are prepared by chemical coupling and stored in a buffer containing a soluble high molecular material, which can effectively improve the detection sensitivity and repeatability. The kit can be used in combination with a substrate solution containing a chromogenic substrate such as adamantane and its derivative AMPPD or APS-5 for a full-automatic immune test system, and the content of D-dimer in plasma or whole blood can be determined by a chemiluminescence instrument. The kit has high detection sensitivity and good repeatability.

The present invention relates to a chemical coupling linker, and an antibody-drug conjugate prepared with the linker. The present invention further relates to a use of the antibody-drug conjugate in treating related disease of tumors, etc.

The invention relates to a fly ash-based hierarchical pore molecular sieve composite material as well as a preparation method and application thereof, and belongs to the technical field of molecular sieve composite materials. In order to solve the problems that an existing fly ash based molecular sieve is single in pore structure, can only adsorb single pollutants and is complex in preparation process, the invention provides a preparation method of a fly ash based hierarchical pore molecular sieve composite material. The method comprises the following steps: carrying out mechanical-chemical coupling activation on fly ash, carrying out alkali fusion activation treatment, preparing a colloidal precursor, carrying out hydrothermal crystallization treatment, carrying out post-treatment on a crystallized product, and carrying out metal ion modification treatment. A micropore-mesopore-macropore three-level pore channel is constructed, the mass transfer efficiency and the adsorption activity are improved, double active sites are formed through metal modification, heavy metal and CO2 can be synchronously adsorbed, and the CO2 capacity is improved by 10-15% through heavy metal loading. The one-step method is adopted for preparation, the process is simplified, the cost is low, high consumption of fly ash is achieved, and the benefits of solid waste recycling and multi-pollutant cooperative treatment are achieved.

The invention relates to the technical field of new energy hydrogen production and chemical coupling application, and discloses a natural gas hydrogen-doped pipeline conveying system which comprises an energy supply layer, a chemical production layer, a digital integrated platform and a dispatching control module. The energy supply layer integrates photovoltaic power, wind power, nuclear power and a power grid standby power supply through a direct-current micro-grid, is matched with a sodium ion flow battery energy storage system, and supplies energy to the water electrolysis hydrogen production system of the non-noble metal catalyst and porous electrode structure. In the chemical production layer, pipeline steel or double-layer alloy steel is selected as a hydrogen-doped pipeline according to the proportion, a hydrogen concentration monitoring and sound wave leakage detection system is arranged, the hydrogen-doped safety upper limit of high pressure of 10% and low pressure of 30% is set, and a chemical hydrogen using system is connected through a gas distribution valve set and adjusted by an intelligent module. The digital platform is based on monitoring of the Internet of Things, hydrogen doping is optimized by means of a fuzzy PID algorithm and digital twinning, and risks are early warned. The scheduling module combines wind and light prediction and real-time electricity price, optimizes the start and stop of the electrolytic cell, the hydrogen doping ratio and the conveying pressure, and achieves efficient and stable conveying.

The invention discloses an astaxanthin liposome-coating probiotic compound system based on an interface free radical quenching and bidirectional coupling mechanism and application of the astaxanthin liposome-coating probiotic compound system in oxidative stress protection, and belongs to the technical field of biological medicines and probiotic preparations. According to the preparation method, probiotics with an iron ion mediated sodium alginate-guar gum coating are constructed, and the probiotics and astaxanthin nano-liposomes form an interface protection layer in a hydrogen peroxide stress microenvironment. Wherein astaxanthin protects the key enzyme activity of a thallus energy metabolism pathway, and the thallus continuously consumes a hydrogen peroxide substrate in the environment through an enzyme system of the thallus. According to the composite system disclosed by the invention, under the condition of no chemical coupling, synergistic enhancement of antioxidant defense and thallus activity can be realized through physical blending, the survival rate and colonization ability of probiotics in gastrointestinal stress are remarkably improved, and an innovative solution is provided for targeted intervention of inflammatory bowel diseases and development of functional probiotic preparations.

The invention belongs to the technical field of electrochemical synthesis and isotope labeling, and particularly discloses a method for preparing a deuterated compound through electrochemical coupling and a special catalyst thereof. According to the invention, a carbon-hydrogen bond halogenation-dehalogenation deuteration process is coupled, a specific noble metal nitrogen-doped carbon catalyst is screened and applied as a cathode and anode catalytic material, a brand new electrochemical system is constructed for the first time, and under the environment-friendly reaction conditions of completely no solvent and no supporting electrolyte, through electrochemical driving, the electrochemical performance of the electrochemical system is improved. The selective halogenation of carbon-hydrogen bonds of the anode and the dehalogenation deuteration reaction of the cathode are synchronously realized, the two half reactions are successfully and efficiently coupled in the same reactor, and the deuterated organic compound with high additional value is directly synthesized. According to the method, a large amount of organic solvents and electrolyte salts used in traditional organic synthesis are abandoned, the environmental load and post-treatment difficulty of the reaction are remarkably reduced, and the method has the outstanding advantages of being simple in process, environmentally friendly and high in atom economy.

The application discloses a kind of low reflection high adhesive photo surface treatment method, successively contain photo surface plasma treatment, UV film solution coating solidification, film outer surface plasma treatment etc., core is in UV film solution adding silane coupling agent type passivator;Photo surface uses atmospheric pressure plasma treatment, film outer surface uses low temperature plasma treatment, by controlling plasma treatment power, speed, working gas etc., realize the micro-nano rough structure construction of photo and film outer surface.The application utilizes double plasma treatment to realize physical roughening and reduce reflection, realizes the stability and chemical coupling of plasma activated surface by passivator, greatly improves the bonding strength of photo and film layer, and finally prepared film encapsulation photo film layer transmittance is greater than or equal to 90%, 60 degree glossiness is 10~30GU, while realizing low reflection effect without losing transparency, also has excellent wear resistance, bending performance.

The application belongs to the technical field of molecular imaging and nanobody of tumor diagnosis and treatment, and discloses a Trop2 targeted nanobody fluorescent probe and a preparation method and application thereof. The nanobody T4 or ABDT4 capable of specifically recognizing TROP2 is connected with near-infrared two-region fluorescent dye through a chemical coupling mode to obtain a nanobody fluorescent probe with TROP2 targeting capability. The application realizes selective recognition at a molecular level by introducing the nanobody capable of specifically recognizing TROP2, which is helpful to improve the fluorescent contrast between tumors and normal tissues. Stable probe products are obtained through a controllable coupling and purification process, which is beneficial to repeated preparation and subsequent popularization and application.

The invention provides a biotinylated Angiopep-2 modified targeting nano material as well as a preparation method and application of the biotinylated Angiopep-2 modified targeting nano material. According to the preparation method of the biotinylated Angiopep-2 modified targeting nano-material, Angiopep-2 is directionally anchored through a high-affinity biotin-streptavidin system, ligand conformation inactivation caused by chemical coupling is avoided, targeting activity is maintained, the used Angiopep-2 can help nanoparticles to be specifically recognized and combined and mediate the nanoparticles to cross a blood brain barrier to enter the brain, and the targeting nano-material can be used for preparing the targeted nano-material. The drug concentration in brain tissues is increased, so that the cure rate of brain diseases is improved, the brain targeting efficiency is far higher than that of transferrin and lactoferrin, and the application value is great; by entrapping curcumin and quercetin, a hydrophilic shell is provided, so that the water solubility of curcumin and quercetin is improved, and the bioavailability of curcumin and quercetin is improved.

The application discloses a kind of magnetic nanoparticles for atherosclerosis diagnosis and treatment.It is core-shell structure, the inner core is Fe₃O₄ magnetic nano material, shell is the drug-loading layer of biodegradable polymer material, the drug-loading layer is encapsulated with analog movement polypeptide K271la, and the surface of nano particle is covalently coupled with CD36 targeting antibody.Its preparation method mainly includes: by complex emulsification-solvent volatilization method, Fe₃O₄ nanoparticle and K271la polypeptide are co-encapsulated in one step, form nanoparticle, and then CD36 antibody is modified on the surface of particle by chemical coupling.The nanoparticle of the application has the ability of active targeting (CD36 antibody) and passive targeting (magnetic response), can be efficiently enriched in plaque, and deliver therapeutic polypeptide to macrophages, activate lipophagy to remove lipid;It can be used as magnetic resonance imaging contrast agent, realizes diagnosis and treatment integration, and provides a new strategy for solving the problem of low efficiency of atherosclerosis targeted therapy and lack of effective monitoring means.

The invention provides a pollen vaccine based on an aluminum-CpG composite adjuvant and application of the pollen vaccine. The pollen vaccine comprises an aluminum-CpG chemical coupling nano adjuvant and a recombinant mugwort main allergen, the adjuvant is a substance formed by coupling an aluminum oxygen hydride nanorod and CpG through an amido bond, carboxyl on the surface of an AlOOH nanorod is activated, and then the AlOOH nanorod reacts with aminated CpG ODN to obtain the adjuvant. Stable combination of the aluminum salt nanoparticles and CpG ODN is achieved through chemical coupling, the coupling efficiency is larger than or equal to 95%, cytotoxicity is avoided, the problems that in traditional physical mixing, the aluminum salt nanoparticles and CpG ODN are not synergistic in effect and prone to dissociation are solved, and the synergistic immunoregulation effect of adjuvant components is ensured; after the adjuvant is loaded with the Artemisia pollen allergen Art v1, the IgE level can be remarkably reduced, lung inflammation can be relieved, allergic symptoms can be improved in treatment and prevention models, and a novel adjuvant platform is provided for immunotherapy of pollen allergy.

The invention discloses a water-based silicon-based nano sustained-release body and a preparation method thereof, a nano drug sustained-release body based on synergistic regulation and control of a mesoporous carrier, a responsive group and a targeting ligand is obtained, mesoporous silica nanoparticles with adjustable pore channels are synthesized by a sol-gel method, the mesoporous silica nanoparticles are used as a core load carrier, and the water-based silicon-based nano sustained-release body is prepared by a sol-gel method. The preparation method comprises the following steps: chemically bonding an element carboxymethyl chitosan with pH response and a ligand triphenylphosphine cation with biological targeting to the surface of mesoporous silica through a chemical coupling and grafting method. And then a medicinal preparation with active components is efficiently loaded into pore channels of the mesoporous silica in a dispersed stirring manner, so that the effects of environment-responsive intelligent slow release of the pesticide preparation, targeted enrichment at action targets and prolonging of the pesticide effect period are achieved.

The application specifically discloses a kind of nanovaccine for thrombosis prevention and its preparation method and application, it is related to thrombotic disease, especially related to the nanovaccine for treating thrombotic disease.The nanovaccine provided by the application has good immunogenicity without macromolecular heterologous protein carrier such as KLH;The process simplicity and repeatability are improved by reducing complex chemical coupling and purification steps;The dependence on traditional high-stimulating immune adjuvant is reduced, and the biological safety is improved;The stability of antigen in gastrointestinal environment is significantly improved;Active targeting delivery of M cells and dendritic cells is realized;Dendritic cell maturation and antigen presentation are promoted, and mucosal immunity and systemic immunity level are improved;The advantages such as effectively inhibiting thrombosis are realized, and a new type of oral antithrombotic vaccine system with high compliance suitable for long-term thrombosis prevention is constructed.

The invention discloses metal-based nanoparticles loaded with traditional Chinese medicine as well as a preparation method and application of the metal-based nanoparticles, and relates to the technical field of nano medical materials. The nano-particle is prepared by taking nickel iron zinc aluminum hydroxide as a multi-metal-based core carrier, carrying out PEG modification and cRGD peptide targeted coupling, and loading a traditional Chinese medicine active ingredient curcumin. The preparation is realized through a multi-step chemical coupling and loading process, and the multi-metal carrier can realize responsive structural disintegration and accurate controlled release of curcumin in a tumor weak acid environment. The nanoparticles have active targeting, multi-metal synergistic killing and immune regulation functions, can specifically recognize a triple negative breast cancer cell surface integrin alpha v beta 3 receptor, inhibit tumor cell proliferation, induce apoptosis, regulate BCR, IL-17 and other immune related signal channels, promote immune cell infiltration and remodel a tumor immune microenvironment. The metal-based nano-particles loaded with the traditional Chinese medicine are simple in preparation process, high in production efficiency and suitable for precise treatment of triple negative breast cancer.

The invention discloses graphene water-based heating slurry and a preparation method thereof, belongs to the technical field of graphene slurry preparation, and is used for solving the technical problem that the dispersing performance and the storage stability of graphene heating slurry in the prior art need to be further improved. According to the preparation method disclosed by the invention, a unified cooperation mechanism of interface chemical regulation and control, inorganic bridging enhancement and matrix chemical coupling is realized by constructing a multi-level cooperation system of polyphenol polyester grafted graphene oxide, silicon-titanium hetero-metal oxygen cluster composite graphene and waterborne polyurethane-acrylic emulsion; the obtained graphene water-based heating slurry is stable in dispersion and good in grinding adaptability, a continuous and compact electric conduction-heat conduction network can be formed in the film forming process, and the graphene polymer electrothermal film prepared from the slurry has excellent flexible film forming performance and uniform and stable electrothermal performance.

The application discloses a kind of magnetic capture material based on phage display, preparation method and application thereof, through the synergistic effect of specific capture and short-time proliferation, the detection limit of staphylococcus aureus is improved to 10 4 CFU / mL, reaches the detection limit of portable ATP bioluminescence instrument itself, ensures the reliability of detection result. At the same time, the whole detection process can be completed within 1 hour, only needs simple equipment such as magnetic separation frame and portable ATP detector, easy to operate, fast, suitable for food safety on-site detection, medical institution environment monitoring and various scenes. In addition, compared with traditional antibody, phage-derived binding polypeptide can be produced in large quantities by microbial fermentation, with lower cost and better batch consistency, and the directional display strategy based on T4 capsid avoids the activity loss caused by chemical coupling, further improves the stability of reagent, and has good application and promotion prospect.

The application relates to the technical field of lithium sulfide, and specifically provides a lithium sulfide material, a preparation method thereof and a solid-state battery. The lithium sulfide material comprises a matrix, the matrix is a lithium-containing crystalline sulfide; a shell layer, the shell layer covers at least part of the surface of the matrix, and the shell layer comprises lithium halide; and a transition layer, the transition layer is located between the shell layer and the matrix, and the transition layer comprises a Li-S-X bond or a Li-(P / Si)-X bond, wherein X is halogen. The transition layer realizes chemical coupling of the matrix and the lithium halide shell layer at the atomic and chemical bond levels, enhances the adhesion of the shell layer, and alleviates the problems of interface chemistry and lattice mismatch; meanwhile, the shell layer provides a transmission channel for lithium ions, plays a chemical passivation role on the surface of the matrix, thereby inhibiting the migration of soluble sulfides and the occurrence of related side reactions, so that the solid-solid interface impedance is reduced through the above structure, and the cycle stability, rate performance and environmental tolerance of the material are improved.

This invention discloses a method for preparing polytetrafluoroethylene (PTFE) copper-clad laminates using ion implantation technology, relating to the field of polymer material surface engineering technology. The method includes the following steps: sequentially dual-implanting silicon and oxygen ions into the surface of the PTFE material to form a modified transition layer; depositing a copper seed layer on the modified transition layer; and thickening the copper layer on the copper seed layer to a target thickness; wherein the modified transition layer contains SiO₂. x Si-O-Si and C-O-Si form a transition layer network structure, which chemically bonds with the copper seed layer. This invention solves the problem that existing copper-clad laminate fabrication methods cannot guarantee the stability of its operation in high-frequency transmission modes, through Si... + With O + Range matching leads to synergistic chemical reactions in the near-surface 20–100 nm range, forming ultrathin SiO₂ with controllable composition and structure. x The / Si–O–Si / C–O–Si transition layer network structure enables chemical bridging between C–O–Si and Si–O–Si, providing chemical bonding sites for metallic copper and PTFE, and significantly improving the chemical coupling adhesion at the PTFE / copper interface.

This invention provides a polyfunctional chemical conjugation molecule that has been found to be useful as a modifier for target substrates. [Solution] A polyfunctional chemical conjugation molecule is provided, comprising a localization portion, a chemical linker portion, an activator portion, a first orientation adapter that interconnects the chemical linker portion to the activator portion at one end, and optionally a second orientation adapter that interconnects the chemical linker molecule to the localization portion at a different end. The molecule provides a use for post-translational modification of a polymer that is not a natural substrate of the activator portion. Diseases or disorders may be treated or prevented by this molecule.

The invention relates to a multifunctional bacterial bio-conjugate integrating targeted delivery, oxygen generation, photodynamic therapy and immune activation and a preparation method thereof, CaO2 nanoparticles (CaO2 NPs) are synthesized through a calcium salt deposition method, a photosensitizer chlorin e6 (Ce6) is loaded on the surface of the CaO2 NPs through an ingenious design, then tannic acid (TA) is used for packaging, and the multifunctional bacterial bio-conjugate is prepared. The stable core-shell structure (TAat-CaO2 / Ce6) is obtained. A large number of phenolic hydroxyl groups, aromatic rings and galloyl groups on the surface of TA are utilized to form chemical coupling with rich functional groups on the surface of bacteria, so that the TA is loaded on the surface of the bacteria, and effective combination of a TA-coated CaO2 / Ce6 compound and fusobacterium nucleatum (Fn) is realized; and finally, the multifunctional bacterial bio-conjugate Fn-TA (at) CaO2 / Ce6 integrating targeted delivery, oxygen generation, photodynamic therapy and immune activation is successfully constructed.

A kind of mechanical and chemical coupling activated zinc-aluminum-magnesium alloy solid-gas dual-phase alternate co-permeation device, it relates to a kind of zinc-aluminum-magnesium alloy powder solid phase and gas phase periodic alternation co-permeation device.The present application is to solve the uneven thickness of the traditional zinc-aluminum-magnesium co-permeation layer, the high heating temperature, the great influence on the strength of the workpiece substrate after medium temperature tempering or / and quenching and tempering treatment, the internal penetration of complex structure workpiece such as slender tubular or deep hole is not in place and the problems such as the structure of pure gas phase co-permeation equipment is complex, cost is high.The present application includes base, is equipped with permeation box and drive system on base, is equipped with heating system in the lower part of permeation box, is connected with base through support, is equipped with tool in permeation box, and is connected with permeation box through tool spindle, is equipped with heating system in the lower part of permeation box;Permeation box spindle and tool spindle are parallel and eccentric, and drive system drives rotation of permeation box and tool and workpiece respectively.The present application belongs to the field of metal surface treatment technology.

Water-based drilling fluid improves well wall stability method and system and equipment, including the following steps: fine evaluation of formation lithology mineral component is used to conventional well logging curve;Obtain rock mechanics parameters under complex lithology background;According to the rock mechanics parameters, the present ground stress value is obtained by using the well wall fracture track inversion method;Collapse pressure calculation under the action of mud shale mechanics-chemical coupling is constructed;Drilling fluid safety mud density window determination: the lower limit and upper limit value of the window are determined, the lower limit of the window is the formation collapse pressure, and the upper limit is the formation leakage pressure;On the basis of rock mechanics parameters, ground stress, formation component content, determine the drilling fluid performance.The present application combines the analysis results of mineral component, analyzes the rheological property, thermal stability, inhibition and sealing property of different formulations of water-based drilling fluid through experiment, so as to formulate the drilling fluid formulation for different formations, finally design the drilling fluid density and performance formulation, improve the well wall stability of water-based drilling fluid, and support safe and rapid drilling.

The invention discloses a conjugate of phosphorylated Tau protein and magnetic beads as well as a preparation method and a kit of the conjugate, and relates to the technical field of immunoassay. The modified magnetic beads modified with azide groups and the modified anti-phosphorylated Tau protein antibody modified with DBCO groups are efficiently and directionally coupled in a click chemistry mode, and compared with a traditional physical adsorption or non-specific chemical coupling method, the method has the advantages of being high in coupling efficiency, high in binding stability, high in antibody activity retention rate and the like; compared with the prior art, the magnetic bead provided by the invention has the advantages that the capture efficiency and specificity of the magnetic bead on low-abundance p-Tau in blood can be obviously improved, the lower detection limit is as low as 0.3 pg / mL or below, excellent accuracy is shown in early AD diagnosis, subtle changes of p-Tau in the blood of an early AD patient can be accurately identified, and a reliable tool is provided for early screening, disease course monitoring and intervention effect evaluation of AD.

This invention discloses lysosome-targeting chimeras based on different ratios and molecular weights, their preparation methods, and applications, belonging to the field of biomedical technology. Lysosome-targeting chimera (LYTAC) molecules contain target protein ligands, linkers, and lysosome-targeting receptor ligands. The core of this invention lies in systematically regulating the molecular weight ratio (range 1:1 to 1:10) between the target protein ligand and the lysosome-targeting receptor ligand, as well as the total molecular weight of LYTAC (range 1000 Da to 5000 Da), to obtain a series of LYTAC molecules with different properties. This invention provides a method for preparing the LYTAC molecules via chemical coupling. Experiments show that by optimizing the above parameters, the LYTAC molecules prepared by this invention can significantly improve the degradation efficiency and specificity of extracellular and membrane-associated target proteins (such as PD-L1, EGFR, etc.), while optimizing their pharmacokinetic properties, showing broad application prospects in the treatment of cancer, neurodegenerative diseases, and other fields.

The application belongs to the technical field of silicon hydride addition reaction catalysts, and particularly relates to a supported platinum catalyst and a preparation method and application thereof. The application mixes ferroferric oxide, tetraethoxysilane and an organic solvent to perform a hydrolysis reaction, mixes silica-coated ferroferric oxide, organoligand functionalized trialkoxysilane and an organic solvent to perform a condensation reaction, mixes organoligand functionalized ferroferric oxide, a platinum compound and an organic solvent to perform a coordination reaction, and obtains the supported platinum catalyst. The preparation method provided by the application successfully grafts platinum complexes on the surface of ferroferric oxide by using a chemical coupling method. When the obtained supported platinum catalyst is used for a heterogeneous catalytic reaction, the catalyst is easy to separate from a reaction system, the yield of an addition reaction product is high, the catalyst has high stability, can be recycled, and has a long service life.

The application discloses a target optimization scheduling method and system based on off-grid hydrogen production and flexible chemical coupling, relates to the technical field of energy management, and comprises the following steps: analyzing a standardized data set by using a linear programming model, generating an initial hydrogen production strategy, and adjusting hydrogen production operation parameters of the initial hydrogen production strategy according to a predicted demand to generate an optimized hydrogen production strategy; identifying demand fluctuation characteristics according to the optimized hydrogen production strategy, formulating short-term and long-term energy scheduling schemes respectively, combining the two schemes, and generating a comprehensive scheduling scheme; performing energy distribution and scheduling on the comprehensive scheduling scheme, monitoring an operation state and an energy distribution process in real time, generating real-time operation data and scheduling feedback; adjusting energy distribution and hydrogen production operation parameters according to the real-time operation data and the scheduling feedback, generating an optimal scheduling scheme, performing comprehensive performance evaluation, and generating an optimization scheduling effect report. The application realizes optimization of hydrogen production efficiency and energy utilization rate.