Manufacturing method of drug vessel support with antibody immobilized on surface of support

A vascular stent and surface fixation technology, applied in the field of vascular stents, can solve the problems of promoting endothelial repair, no antibody binding active site, less antibody binding, etc., and achieve the effect of promoting endothelial cell repair and excellent treatment of restenosis.
CN102018996AInactive Publication Date: 2011-04-20INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
5 Cites 11 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Publication Date
2011-04-20
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a manufacturing method of a drug vessel support with antibody immobilized on the surface of the support. The manufacturing method comprises the following steps: 1) preparing polyester high polymer with carboxyl functional groups by using a synthesis or hydrolysis mode; 2) coating drug loading polyester high polymer on the surface of the support; and 3) immobilizing the antibody with the function of capturing endothelial progenitor cells on the surface of the support body by using a chemical coupling mode. In respect of the drug vessel support with antibody immobilized on the surface of the support, polyester high polymer with carboxyl functional groups is taken as the support drug loading coating to obtain the drug support the surface of which is subject to carboxylation, so that the surface of the support has both biocompatible compatibility and biological activity, and the carboxyl functionalized surface of the support provides abundant binding sites for loading effective dosage of antibody in the next step. Meanwhile, the support has a drug carrying function and an endothelial cell capturing function, thereby playing excellent roles in treating restenosis and promoting endothelial cell repairing.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a vascular stent, in particular to a drug vascular stent with antibodies fixed on its surface and a preparation method thereof. Background technique

[0002] Coronary atherosclerotic heart disease (CHD) is one of the major diseases that endanger human health. Coronary artery intervention (PCI) has become an important method with definite curative effect in the clinical treatment of CHD. However, in the treatment of coronary artery stent implantation, there is the problem of postoperative vascular restenosis. About 15-30% of all stent placement cases in the world have restenosis, which seriously limits the long-term effect of treatment. So far, it is still a clinical problem. Problems that need to be solved urgently. In recent years, the emergence of drug-eluting stents has become a new milestone in the history of PCI development. The widespread application of drug-eluting stents has greatly reduced the occurrence of in-stent ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More