Biodegradable stent composite material and preparation method thereof

A composite material and a biodegradable technology, applied in the field of biodegradable stent composite materials and their preparation, can solve the problems of excessive local heat generation, poor degradation controllability, accumulation of acidic degradation products, etc., and achieve a simple and practical preparation method and easy industrialization. The effect of production, increasing variety and quantity

Active Publication Date: 2011-04-13
清北高科(北京)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are still many deficiencies in the clinical application of polymer degradable stents. The main problems exposed are: (1) Insufficient mechanical support strength, which is inferior to metal stents in restricting lumen retraction. At present, it is mainly used in cardiovascular stents. However, non-vascular lumens such as esophagus, bile duct, intestinal tract, urethra, and trachea usually require greater radial support, and pure polymer materials are difficult to meet the requirements; Thermal degradation occurs. With the degradation of polymer materials in the body, the mechanical properties of the stent are significantly reduced, which cannot meet the

Method used

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  • Biodegradable stent composite material and preparation method thereof
  • Biodegradable stent composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] (1) Select high-purity magnesium metal with a purity greater than 99.9%, and carry out ultrasonic cleaning with acetone, absolute ethanol, and deionized water for 20 minutes successively to remove surface oil stains; use 280~1000# metallographic sandpaper to polish step by step, and then use them separately Ultrasonic cleaning with ionized water and absolute ethanol for 20 minutes, and then drying; soaking in 10% nitric acid-methanol solution for chemical polishing, and rinsing with deionized water after removal.

[0058] (2) Prepare 30% HF acid solution, soak magnesium metal in the solution for 24 hours, then ultrasonically clean with deionized water and absolute ethanol for 10 minutes and dry to form medical metal matrix 1 .

[0059] (3) Prepare a vinyltriethoxysilane / ethanol solution with a concentration of 1%, add acetic acid as a catalyst, and adjust the pH value to 3.5-5.5; soak the sample in the solution for 60 seconds, and put it in the Put it into an oven for h...

Embodiment 2

[0064] (1) Select a magnesium-zirconium alloy with a magnesium content of 85%, and carry out ultrasonic cleaning with acetone, absolute ethanol, and deionized water for 20 minutes in turn to remove surface oil stains; use 280~1000# Metallographic sandpaper to polish step by step, and then respectively Ultrasonic cleaning with deionized water and absolute ethanol for 20 minutes, and then drying; soaking in 10% nitric acid-methanol solution for chemical polishing, rinsed with deionized water after removal.

[0065] (2) Prepare 40% HF acid solution, soak the magnesium alloy in the solution for 24 hours, then ultrasonically clean with deionized water and absolute ethanol for 10 minutes and dry.

[0066] (3) Prepare an aminopropyltriethoxysilane / isopropanol solution with a concentration of 1%, add acetic acid as a catalyst, and adjust the pH value to 3.5-5.5; soak the sample in the solution for 60 seconds, and wait for it to dry Finally, put it into an oven for heating and aging at...

Embodiment 3

[0071] (1) Choose a magnesium-manganese alloy with a magnesium content of 95%, and use acetone, absolute ethanol, and deionized water to perform ultrasonic cleaning for 20 minutes each to remove surface oil; use 280~1000# Metallographic sandpaper to polish step by step, and then Ultrasonic cleaning with deionized water and absolute ethanol for 20 minutes, and then drying; soaking in 10% nitric acid-methanol solution for chemical polishing, rinsed with deionized water after removal.

[0072] (2) Prepare 35% HF acid solution, soak the magnesium alloy in the solution for 24 hours, then ultrasonically clean with deionized water and absolute ethanol for 10 minutes and dry.

[0073] (3) Prepare a vinyltriethoxysilane / ethanol solution with a concentration of 2%, add acetic acid as a catalyst, and adjust the pH value to 3.5-5.5; soak the sample in the solution for 60 seconds. Heat and age in an oven at 90°C for 60 minutes, then cool to room temperature with the furnace.

[0074] (4) ...

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Abstract

The invention relates to a biodegradable stent composite material and a preparation method thereof. The degradable material has a multi-gradient composite structure, and comprises a matrix made of a medical metal or an alloy thereof, a chemical coupling layer attached to the surface of the matrix, a high polymer transition layer attached to the surface of the chemical coupling layer and a degradable high polymer functional layer fixed on the surface of the high polymer transition layer. The stent composite material has high mechanical property, degradation property and biocompatibility, also can absorb and carry needed therapeutic medicaments, and meets the requirement on clinical treatment. The degradable composite material can be used as stent materials of esophagi, biliary ducts, intestinal tracts, urethrae, tracheae and other non-vessel lumens and blood vessels, and also can be used for manufacturing artificial bones, bone nails, bone connectors, bone sutures, anchors for suture, intervertebral discs, hemostatic clamps, hemostatic forceps, hemostatic plates, hemostatic screws, tissue adhesives, sealants and other medical devices and products.

Description

technical field [0001] The invention belongs to the field of medical functional materials, and relates to a biodegradable scaffold composite material and a preparation method thereof. Background technique [0002] For benign / malignant strictures and obstructions of the esophagus, bile duct, intestinal tract, urethra, trachea, etc., traditional drug therapy and surgical operations have limited effects, and stent implantation has developed into an effective minimally invasive treatment technology in recent years. It is a fast, safe, but as a "permanent stent" that remains in the body, it is also a very effective and relatively safe medical method, which opens up a new treatment approach for diseases that are incurable or refractory by traditional surgery, and improves the health of cancer patients. Lifespan and chance of cure. At present, the stents widely used in clinical medicine are mainly Ni / Ti alloy stents, stainless steel stents, plastic stents, etc. These stents have ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/50A61L31/12A61L31/14A61L17/00A61L24/10A61L24/08A61L24/06A61L24/04A61L24/02C23C22/02C23C22/50C23C22/57
Inventor 邢长民王文慧
Owner 清北高科(北京)科技有限公司
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