113 results about "Biliary ducts" patented technology

The invention relates to a biodegradable stent composite material and a preparation method thereof. The degradable material has a multi-gradient composite structure, and comprises a matrix made of a medical metal or an alloy thereof, a chemical coupling layer attached to the surface of the matrix, a high polymer transition layer attached to the surface of the chemical coupling layer and a degradable high polymer functional layer fixed on the surface of the high polymer transition layer. The stent composite material has high mechanical property, degradation property and biocompatibility, also can absorb and carry needed therapeutic medicaments, and meets the requirement on clinical treatment. The degradable composite material can be used as stent materials of esophagi, biliary ducts, intestinal tracts, urethrae, tracheae and other non-vessel lumens and blood vessels, and also can be used for manufacturing artificial bones, bone nails, bone connectors, bone sutures, anchors for suture, intervertebral discs, hemostatic clamps, hemostatic forceps, hemostatic plates, hemostatic screws, tissue adhesives, sealants and other medical devices and products.

An embodiment of the present invention is useful for identifying tumor cells in bladder cancer washes, pleural effusions, biliary tumor cells and circulating tumor cells in whole blood. Subsequent analysis may identify therapeutic treatments based on a single cell analysis of activatable elements in cell signaling pathways. This analysis can be useful for diagnosis, prognosis, therapy selection and monitoring of solid tumor diseases.

Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a bioluminescent substance or a mixture of luciferin and luciferase which produces bioluminescence, wherein a color or monochrome image of the object is constituted using the images and information based on bioluminescent emitted by the bioluminescent substance. Procedures are demonstrated which allow bioluminescent solutions to be perfused into certain tissue regions, such as but not limited to the common biliary duct, genitourinary tract, gastro-intestinal tract, cardiovascular system and lymphatic system wherein said structures may be conveniently visualized during surgery to avoid damage to these structures. Such images may also be combined with visual light images. Methods of detection of cancer cells using bioluminescence are provided. Preferred embodiments disclosed include membrane permeant coelenterazine analogs.

The invention belongs to the field of medicines, and relates to an application of a method for degrading all carbohydrate chains in the blood to be monosaccharide and detecting the monosaccharide in cancer detection. A sample in the method for degrading the blood to obtain the monosaccharide and detecting the monosaccharide is the blood, and the cancer includes lung cancer, gastric cancer, ovarian cancer, penis cancer, esophagus cancer, oral cancer, biliary duct cancer, breast cancer, adenocarcinoma perampullaire, rectal cancer and bladder cancer. The method has the characteristics of simplicity and easiness in operation steps, easiness in popularization, short detection time, low requirement on the instrument, low detection cost, less consumption of blood and the like. The result displays that based on the content of eight monosaccharides in the blood, not only can a normal person and a cancer patient be distinguished, but also different cancers can be distinguished. The method for simplifying glycomics knowledge and applying in the detection of the biomarker of blood is first created in the world.

The invention discloses a degradable biliary duct drug-eluting stent, which consists of a biliary duct stent body and a biodegradable high-molecular polymer coating arranged on the surface of the biliary duct stent body. The biliary duct stent body is formed by mixed braiding of biodegradable metal wires and biodegradable high-molecular material silk threads. The biliary duct stent body is of a tubular structure. The two ends of the biliary duct stent body are shaped like trumpets that are open outwardly. The surface of the biliary duct stent body is a netted surface. The biodegradable high-molecular polymer coating carries drugs. The degradable biliary duct drug-eluting stent plays a mechanical supporting effect in a short period, is completely degraded after a treatment effect disappears, prevents tube wall tissues from being stimulated for a long period of time, effectively prevents the wall tissues from narrowing again after an operation, enables drug loaded fiber films to evenly wrap the surface of the stent body, and makes the drugs release slowly.

A multifunctional medical magnetic metal scaffold for treating tumor and stenosis of biliary ducts, stomach and artenia coronaria is prepared from the existing medical scaffold through depositing the magnetic metal or alloy film containing medicine on its by chemical or electric plating method.

The present invention relates to a biliary tract interior support frame containing medicine and its preparation method. Said biliary tract interior support frame includes tubular supporting tube which can open cavitary tract of biliary duct and is equipped with several medicine-releasing holes. The inner wall of the invented tubular supporting tube has a layer of medicine-stored layer made up by mixing medicine and excipient. Several biliary tract interior suppert frames can be series-connected together. Said invention also provides the concrete steps of its preparation method.

Devices and methods for facilitating access to the pancreaticobiliary system are disclosed. In particular, the methods include bending a device having an elongate body with a first lumen, a second lumen, and respective first and second exit openings. The methods include inserting a first guidewire through the first lumen and out of the first exit opening to cannulate a pancreatic duct, and inserting a second guidewire through the second lumen and out of the second exit opening to cannulate a biliary duct.

The invention discloses an efficient amplifying and culturing method for biliary epithelial cells in rabbit livers and belongs to the technical field of biological medicines. The efficient amplifying and culturing method comprises the following steps of: (1) separating, purifying and culturing the epithelial cells; (2) detecting cell growth lines; and (3) identifying the epithelial cells. The efficient amplifying and culturing method for the biliary epithelial cells, disclosed by the invention, has the advantages as follows: through a multi-step separating method, biliary epithelial cells with higher purities are obtained and a long-time multiplication culturing system for the biliary epithelial cells is established; a fact that the multiplication of the biliary epithelial cells in the livers can be obviously promoted through an Rho kinase inhibitor Y-27632 is first found; and the efficient amplifying and culturing method for the biliary epithelial cells, disclosed by the invention, has the advantages of simpler operation and the like, is suitable for promotion and application and can provide a platform for researches on a plurality of disease mechanisms including biliary atresia, primary biliary cirrhosis and the like.

The invention belongs to the technical field of medical instruments, and relates to a choledochoscope guiding device for laparoscopy. The guiding device is a tubular structure formed by connecting n helical sections; the cross section structure of each helical section comprises two horizontal sections located on different planes and a transitional section connected between the two horizontal sections; a pressing piece A is arranged on the inner side of the horizontal section close to the outer side plane in an extending manner; a pressing piece B is arranged on the outer side of the horizontal section close to the inner side plane; the pressing piece A of any helical section can be pressed with the pressing piece B of the adjacent helical section; the pressing piece B of any helical section can be pressed with the pressing piece A of the adjacent helical section; a cylindrical air bag is arranged on the outer wall of the tail end of the guiding device, and is connected with an air delivery pipe; the air delivery pipe is arranged along the outer wall of the guiding device. The choledochoscope guiding device for the laparoscopy can conveniently guide a choledochoscope to enter a biliary duct through the abdominal wall, and the guiding device can ensure that the choledochoscope keeps high maneuverability all the time in a microscopic operation treatment process.

A method (200) and apparatus (1100) for generating quantitative data for biliary tree structures from volumetric medical imaging scan data. The method comprises performing segmentation (230; 300) of a volume of the medical imaging scan data to identify tubular biliary structures within the volume of the medical imaging scan data; for at least one segmented tubular biliary structure within the volume of the medical imaging scan data, computing (240; 800) at least one set of quantitative structural parameters for at least one location along the length of the tubular biliary structure; and outputting (250) quantitative biliary tree data comprising the at least one set of quantitative structural parameters for the at least one segmented tubular biliary structure.

The invention discloses vessel forceps. The vessel forceps comprise a first forceps body and a second forceps body which are hinged together, wherein the first forceps body comprises a first forceps mouth and a first forceps arm, the second forceps body comprises a second forceps mouth and a second forceps arm, the first forceps arm and the second forceps arm can be closed or opened by taking the hinging part as the moving center, and the first forceps mouth and the second forceps mouth are closed or opened under the driving of the first forceps arm and the second forceps arm; a plurality of first bulges are arranged on the closed face of the first forceps mouth, when the first forceps mouth and the second forceps mouth are closed, the plurality of first bulges contact the closed face of the second forceps mouth, when the structure is used for clamping the liver parenchymal tissue to be broken, the plurality of bulges can extrude blood vessels or biliary ducts distributed in the liver tissue to be positioned in the gaps among the bulges, so that the risk that a sharp multi-rack structure easily damages the biliary ducts or the blood vessels is reduced, and a doctor can carry out accurate clamping and dividing operations on the liver parenchyma.

The invention discloses surgical forceps for suturing. The surgical forceps are composed of a first forceps arm and a second forceps arm which are connected together through a near end; at a far end, the first forceps arm and the second forceps arm are respectively provided with a first accurate clamp and a second accurate clamp which are arc-shaped; one or more semicircular notches are respectively formed in corresponding positions of the inner sides of the first accurate clamp and the second accurate clamp, each notch extends from the upper surface to the lower surface, a chamfer is arranged on the junction of the upper surface and the inner side of each of the first accurate clamp and the second accurate clamp, and the chamfers of the first accurate clamp and the second accurate clamp are symmetrically arranged. The accurate clamps are taken as block linings, and when biliary ducts on two sides are sutured, a suture needle is not in direct contact with biliary duct walls, so that the suture needle is prevented from being sutured to the duct walls opposite to the biliary ducts which can be well sutured without enlarging the biliary duct space, and the surgical forceps do not cause adverse effect on patient's bodies.

The invention belongs to the field of the gene engineering, and particularly relates to an application of a long-chain non-coding RNA LINC00152 and a composition thereof in biliary duct cancer diagnosis and target drug treatment. In addition, the invention further relates to an application of a primer thereof for preparing a reagent of diagnosing colorectal cancer. Through researching expression of the long-chain non-coding RNA in a cellular level, a relation between the long-chain non-coding RNA and biliary duct cancer pathogenesis is disclosed. Molecular mechanisms of lncRNAs for controllingoccurrence and development of the biliary duct cancer are enriched through successful implementation of the research. It is disclosed that the LINC00152 can be used as a marker of biliary duct cancerdiagnosis and prognosis, and an experimental and theoretical basis is provided for early-stage biliary duct cancer clinical diagnosis and treatment.

Disclosed herein are hepato-biliary-pancreatic organoid (“HBPO” or “HBP organoid”) compositions, and methods of making and using hepato-biliary-pancreatic organoid compositions. The disclosed compositions may have two or more functions selected from hepatic tissue function, biliary tissue function, exocrine pancreatic function, and endocrine pancreatic tissue function. Methods of treating individuals using the hepato-biliary-pancreatic organoid compositions is also disclosed.

The invention discloses a direct-puncture-type biliary stricture dilation and drainage tube, and belongs to the technical field of medical instrument manufacturing. The direct-puncture-type biliary stricture dilation and drainage tube disclosed by the invention comprises a drainage tube body, a support pipe, and a puncture needle; a cone-shaped single-channel pipe 4 is arranged inside the drainagetube body, and has a cone-shaped inner channel; two side holes are formed in a side wall of a single-channel pipe 5; a double-channel pipe 6 has a concave surface, and is coated with a polyethylene balloon membrane of which two ends are fixed on the double-channel pipe 6; a tail part of a double-channel pipe 7 is connected with a water injection connector; a tail part of a single-channel pipe 8 is provided with a single-channel connector of which the surface is provided with threads; the head end of the support pipe is provided with a plastic resistance block, the tail end of the support pipeis provided with a cap-shaped connector, and threads are arranged on an inner wall and an outer wall of the cap-shaped connector so that the structure can be screwed onto a tail part connector of thedrainage tube body; and the tail end of the puncture needle is provided with a cap-shaped joint, and threads are arranged on an inner wall of the cap-shaped joint so that the structure can be screwedonto a tail part connector of the support pipe. The direct-puncture-type biliary stricture dilation and drainage tube has the advantages that the direct-puncture-type biliary stricture dilation and drainage tube can directly penetrate into the bile duct through the skin so as to carry out bile drainage and dilate stricture of the bile duct.