78 results about "Bile duct" patented technology

The invention discloses an intravascular adjustable ultrasonic real-time navigation TIPS puncture instrument, and relates to the technical field of medical devices, the intravascular adjustable ultrasonic real-time navigation TIPS puncture instrument comprises a catheter sheath, a core-through needle catheter, a hollow core-through needle and a solid core-through needle; the core-through needle catheter penetrates through the interior of the catheter sheath; an operating handle is arranged at one end of the through core needle catheter, a traction mechanism is installed on the operating handle, and a pull wire is arranged in the catheter sheath. Real-time ultrasonic images are obtained through the ultrasonic probe, so that an operator can clearly see a needle point path, and key organs such as hepatic artery, bile duct and gall bladder are effectively avoided. The bending-adjustable puncture needle provides the capability of real-time correction in an operation, can easily cope with complex anatomical variation, can keep certain rigidity through the hardness adjusting chain after bending adjustment, improves the penetrating power of the puncture needle, prevents unpredictable mechanical deformation during liver cirrhosis liver puncture, enhances the controllability after bending adjustment, and improves the safety of liver cirrhosis. And accurate execution of the preset angle is ensured.

The invention discloses a curative effect evaluation system for treating liver cancer by combining HDRBT with thermal ablation in multi-modal radiomics, and relates to the field of liver cancer treatment, and the system comprises a multi-modal image data acquisition module which is used for collecting multi-modal image data; the three-dimensional visual model construction module is used for reconstructing a three-dimensional structure of liver tumors, peripheral blood vessels and bile ducts through an image segmentation algorithm, and generating a visual model by fusing radiomics characteristics; the combined treatment plan generation module is used for integrating the dosimetry parameters of the HDRBT and the process parameters of the thermal ablation, optimizing a catheter implanting path, the position of a thermal ablation electrode and a treatment sequence, and generating a combined treatment scheme; and the curative effect evaluation module is used for quantitatively analyzing tumor volume change, ablation boundary integrity and residual tumor activity through accurate registration of multi-modal images before and after treatment. According to the scheme, the problems of incomplete thermal ablation and high recurrence rate of hepatocellular carcinoma can be solved, and full-chain technical support is provided for clinical precise application.

The application provides a multifunctional catheter, comprising a catheter main body and a distal tube with a multi-cavity tube structure. The distal tube comprises a soft end at the proximal end and a functional end at the distal end. The catheter main body and the soft end are provided with a working cavity and a lens cavity. The functional end is further provided with a through hole communicating with the lens cavity. The lens cavity is a circular tube cavity structure extending along the catheter main body and the soft end. The inner wall of the lens cavity is provided with a plurality of accommodation grooves for accommodating photosensitive chips in a lens assembly. The catheter provided by the application can form a space for accommodating photosensitive chips through the plurality of accommodation grooves in the lens cavity, and the lens assembly can be installed without increasing the diameter of the lens cavity, thereby reducing the overall diameter of the catheter to adapt to the more complex bile duct environment relative to the digestive tract.

The invention discloses a biliary stent for univariably regulating and controlling the dosage of an electron beam bactericide and a preparation method of the biliary stent, and belongs to the technical field of degradable biomedical materials and medical instruments. According to the stent, highly-oriented poly-L-lactic acid (PLLA) monofilaments serve as the unique raw material, and the self-expanding stent is woven after melt extrusion, solid-state thermal stretching and thermal setting; through univariate dose treatment of an electron beam sterilization (EBS) technology, the degradation rate and the degradation period can be precisely regulated and controlled in a gradient manner under the same process condition, and different clinical scenes such as gall bladder resection, biliary-intestinal anastomosis and biliary tract radiography can be matched respectively; the individual requirement of'etiological adaptation type 'is met, and a brand new normal form of single material, single variable and system one-way adjustment is provided for large-scale production and accurate application of the degradable biliary tract stent.

This invention discloses a sophoridine tricyclic derivative or its pharmaceutical salt, with the following general structural formula: R1 is selected from hydrogen, C1-C20 straight-chain alkyl, and C1-C20 branched alkyl. In vitro experiments have verified that the sophoridine tricyclic derivative can inhibit TGF-β-induced activation of hepatic stellate cells, improve CCl4- and bile duct ligation-induced liver injury and liver fibrosis in mice, inhibit TGF-β / Smads signaling pathway activation, and also inhibit diethylnitrosamine-induced primary liver cancer in mice. Therefore, this invention provides new evidence for the treatment, alleviation, or improvement of liver fibrosis or primary liver cancer using sophoridine tricyclic derivatives.

The invention relates to the technical field of active polysaccharides, in particular to an arrowroot active polysaccharide as well as a preparation method and application thereof. In an infrared spectrum of the arrowroot active polysaccharide, the arrowroot active polysaccharide at least has characteristic absorption peaks at the following positions: 3317 cm, 2911 cm, 1404 cm <-1 >, 1021 cm <-1 > and 642 cm. The polysaccharide is extracted and separated from yam beans, and the polysaccharide has a protective effect in a mouse model with hepatic fibrosis induced by ligation of bile ducts, also has a regulating effect on intestinal microbiota, and exerts anti-fibrosis activity.

The invention discloses a method for preparing a wet spinning alignment collagen membrane with high tensile strength, and relates to the technical field of biomedical material preparation, the method comprises the following steps: preparing three layers of solutions, the upper layer and the lower layer are wet spinning buffer solutions (such as a polyethylene glycol solution) with specific concentration and pH, and the middle layer is a collagen solution with specific concentration and pH; injecting the three-layer solution into three-layer flow control equipment, and controlling the flow through a collecting tube; gathering the three layers of solutions at the tail end of equipment and performing wet spinning to form a film; and axially stretching to obtain a finished product. According to the invention, by precisely regulating and controlling a solution system, adopting industrial-grade flow control equipment and flow control, optimizing a directional stretching process and stabilizing a curing environment, the problems of non-uniform film thickness, easy tearing, large mechanical property fluctuation and the like in a traditional process are solved, large-scale production of the collagen film with high tensile strength and directionally arranged molecules is realized, and the production cost is reduced. The method is suitable for artificial blood vessels, bile ducts, skin and other tissue engineering fields.

The application provides a kind of double (2,3-dihydroxy benzamide) compound and its preparation method and application, belong to medical technology field.The application obtains a series of double (2,3-dihydroxy benzamide) compound with novel structure and good inhibiting effect on cholestatic liver disease and liver fibrosis by structural modification of sporangium chelae, the compound can significantly inhibit the expression of hepatic stellate cell COL1A1 mRNA in vitro, has strong anti-liver fibrosis effect;In vivo, it can significantly alleviate the liver injury related biochemical indicators of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) induced cholestatic liver disease mouse model, inhibit the expression of liver fibrosis related genes, reduce the content of liver collagen fiber, inhibit liver inflammation and bile duct response, and can be used for treating cholestatic liver disease and liver fibrosis.

The invention discloses a novel choledochoscope without a T tube, and relates to the technical field of choledochoscopes, the novel choledochoscope comprises a forward extension structure, and the forward extension structure is arranged on the outer side of a choledochoscope pipeline in a sleeving mode; one end of the forward extending structure is connected to one end of the control handle; a displacement feedback mechanism is arranged in the front end of the choledochoscope pipeline and comprises a thin rope, one end of the thin rope is connected with an operation observation operation opening in the front end of the forward extending structure, and the other end of the thin rope is connected with the inner wall of the choledochoscope pipeline; the choledochoscope has the advantages that the forward extending structure and the displacement feedback mechanism are arranged on the basis of an original choledochoscope, the forward extending pipeline can extend forwards by a certain distance by rotating the rotary adjusting head, and by matching with the bending effect of the front end of the original choledochoscope, the purpose that the front end of the choledochoscope extends into a branch bile duct to observe and treat calculi can be achieved; the extending distance of the front end of the choledochoscope is fed back through the displacement feedback mechanism, so that the forward extending distance of instruments for subsequent calculus removal and the like is accurately controlled, and surgical operation is optimized.

The present invention relates to the compound 2-hydroxy-octadecene-9-cis-oate for use in the treatment of oncological pathologies including grade IV glioblastoma with native IDH, grade 3 glioma, embryonal tumour, pituitary tumour, meningioma, haemangiopericytoma, haemangioblastoma, mesothelioma, bile duct adenocarcinoma, exocrine pancreatic cancer, neuroendocrine pancreatic cancer, rectal cancer, urachal cancer, adenocarcinoma of the bladder and oesophageal cancer, and for the treatment of neuropathic pain caused by diabetic peripheral neuropathy, spinal cord injury, post-herpetic neuralgia, chemotherapeutic agent, antitumour agent, cancer, fibromyalgia or hepatitis. The present invention also relates to the pharmaceutical composition comprising 2-hydroxy-octadecene-9-cis-oate.

The utility model relates to the technical field of drainage, and discloses a T tube capable of being placed quickly, the T tube comprises a T tube body, an adjusting assembly is arranged in the T tube body, in order to enable the T tube to be placed more quickly, when the T tube body is installed, the two ends of a transverse straight part of the T tube body are folded towards the center, and the T tube body can be placed more quickly. The guide line is pulled, the guide line moves in the limiting ring, and the end part of the guide line pulls the fixing ring, so that the tension of the guide line can enable the fixing ring to limit the fixing rod, the two ends of the transverse straight part of the T-shaped tube body can be well folded and limited, and the folded part of the T-shaped tube body is put into the bile duct; the guide line is slowly loosened, the elastic force of the transverse straight part of the T tube body is slowly released to be opened in the bile duct, in this way, the T tube body can be placed into the bile duct more quickly, and the guide line cannot be collected into the T tube body due to the arrangement of the limiting block.

The transparent cap of the choledochoscope comprises a cap portion and a connecting portion, the tube wall of the front end, away from the connecting portion, of the cap portion is in an arc shape, and a first annular thread is arranged on the inner wall of the connecting portion. The choledochoscope tip is of a convex structure composed of a head part and a body part, the outer diameter of the head part is smaller than that of the body part, a second annular thread is arranged on the outer wall of the head part, and the second annular thread is connected with the first annular thread in a matched mode to achieve connection between the connecting part and the head part; and the outer diameter of the connecting part is the same as that of the body part. The transparent sleeve can be installed at the front end of a choledochoscope to carry out operations such as gall bladder or bile duct washing, calculus removal, stenosis expansion, gall bladder duct or Oddi sphincter exploration and the like; the transparent cap is firmly mounted and cannot fall off; the outer diameter of the connecting part of the transparent cap is consistent with the outer diameter of the choledochoscope body part, the tube wall at the front end of the cap part of the transparent cap is arc-shaped, and tissues such as fistulous tracts, gallbladders and bile duct mucosa are not damaged in the choledochoscope examination and treatment process.

The invention relates to the technical field of medical instruments, in particular to a calculus taking-out device for hepatobiliary surgery, which comprises a sleeve, a net bag structure is mounted at one end of the sleeve, a driving assembly is mounted at the other end of the sleeve, the net bag structure comprises a bag body and a distraction assembly, and the distraction assembly comprises a fixing component and a transmission component; a partition plate is fixedly connected to the middle of the inner wall of the sleeve, a through groove is formed in the partition plate, a mounting frame is arranged on one side of the partition plate, a lead screw is rotationally matched with the mounting frame, the lead screw is in threaded connection with a nut seat, the nut seat is fixedly connected with a push block, a push rod is fixedly connected to one side of the push block, and the push rod penetrates through the through groove to be fixedly connected with a side plate. The transmission part is mounted on the mounting plate; one end of the screw rod is rotationally matched with the mounting frame, and the other end is fixedly connected with the driving assembly. The calculus capturing efficiency is improved, bile duct wall injuries and postoperative infection risks are reduced, and the requirements of minimally invasive surgery for instrument accuracy, stability and safety are met.

This invention provides a choledochoscope suture removal tool, comprising: an outer tube, a connecting rod disposed inside the outer tube, a blade, and a cutting section. The head end of the connecting rod is connected to the blade, and the tail end is connected to a handle. The handle is located at the tail end of the outer tube, and the cutting section is located at the head end of the outer tube or on the blade for cutting Purlin's suture knots. This invention can be inserted through the choledochoscope's forceps channel to cut residual Purlin's suture loops at the bile duct or choledochoenterostomy site.

The utility model belongs to the field of lithotripsy devices, and particularly relates to a device for removing bile and pancreatic duct lithotripsy under an endoscope, which comprises a catheter and a handle, a support tube is fixedly connected inside the catheter, and a capillary tube is fixedly connected at one end of the support tube outside the catheter. A driving ring is fixedly connected to the end, away from the supporting tube, of the capillary tube, a guide wire is slidably connected to the interior of the supporting tube, an ultrasonic vibration head is fixedly connected to the end, away from the driving ring, of the guide wire, and a frame is fixedly connected to the upper end of the handle. The guide wire, the ultrasonic vibration head, the capillary tube and other structures are additionally arranged on the catheter, when calculus in the bile duct needs to be removed, the calculus in the bile duct can be shattered and refined through the ultrasonic vibration head, then the capillary tube is inserted into the rear portion of the calculus, and the calculus in the bile duct can be removed. And then the calculus is taken out from the interior of the bile duct through the deformed and expanded capillary tube, so that the calculus can be taken out more conveniently.

The invention provides a marker, a kit containing the marker, application of the marker and a use method of the marker. The marker comprises at least one selected from the group consisting of MUC1, MUC5AC, and Claudin18.2. The invention also relates to a method for preparing the marker. The marker and the kit containing the marker can be used for predicting prognosis of the intrahepatic cholangiocarcinoma, predicting the curative effect of targeted therapy and postoperative adjuvant therapy on the intrahepatic cholangiocarcinoma based on tumor expression states, and performing classified prediction on a big bile duct type and a small bile duct type of the intrahepatic cholangiocarcinoma. The disclosure also provides a method of cancer prognosis comprising detecting the expression of the marker and predicting the degree of benefit from post-operative adjuvant therapy in a subject, and / or the prognosis of cancer, particularly intrahepatic cholangiocarcinoma, in a subject. The present disclosure provides universal markers that can be used to predict the efficacy of postoperative adjuvant therapy, such as postoperative adjuvant chemotherapy, on intrahepatic cholangiocarcinoma.

The invention discloses an intrahepatic cholangiocarcinoma or tumor conventional ultrasonic image auxiliary diagnosis method and system based on a Vision-RWKV framework, and relates to the technical field of medical image auxiliary diagnosis. Comprising the following steps: acquiring image data information which is conventional liver ultrasonic image data of a plurality of existing patients; constructing an intrahepatic cholangiocarcinoma or tumor identification model based on a Vision-RWKV architecture, wherein the model has a linear complexity bidirectional attention mechanism; training an intrahepatic cholangiocarcinoma or tumor recognition model based on a Vision-RWKV framework by adopting the image data information; and inputting a conventional liver ultrasonic image of a patient to be identified into the trained intrahepatic cholangiocarcinoma or tumor identification model to obtain an identification result, wherein the result comprises a lesion type, lesion position calibration and credibility. The method has the advantages that ultrasonic examination is simple, economical and easy to operate, and CT / MRI examination is high in accuracy, so that more and wider crowds are covered and served, missed diagnosis and misdiagnosis are reduced, and patients obtain good prognosis and life quality.

The anti-displacement bile duct support comprises a supporting rod, a drainage tube section I, a drainage tube section II and a drainage tube section III, the drainage tube section I, the drainage tube section II and the drainage tube section III are sequentially connected from head to tail, the two ends of the supporting rod are connected with the drainage tube section I and the drainage tube section III respectively, and the drainage tube section II and the supporting rod are arranged in parallel and have elasticity. The arc-shaped spring can be relatively bounced off; communicated channels are formed in the drainage tube section I, the drainage tube section II and the drainage tube section III and are used for placing guide wires. The bile duct stent is placed in a common bile duct through an endoscope to drain bile, the drainage tube section II and the supporting tube are bounced off in an arc shape, and displacement of the bile duct stent can be avoided; and no damage is caused to the bile duct wall and the nipple mucosa in the stent taking-out process.

The invention relates to the field of metal nanopowder or plasma spraying, and particularly discloses a bile duct stent prepared by combining metal nanopowder with a plasma spraying process, and a ZrNbFeLa coating prepared by the plasma spraying process has good corrosion resistance but is poor in hemolysis rate. Furthermore, a proper amount of metal Ti is injected into the ZrNbFeLa coating, so that the biocompatibility of the ZrNbFeLa coating can be remarkably improved, and the influence on the corrosion resistance is small, so that the ZrNbFeLa coating can meet the use requirements of medical materials such as bile duct stents. It needs to be noted that the ion implantation amount of metal Ti needs to be controlled to be 2.8 * 10 < 5 > ions / cm < 2 > to 1.2 * 10 < 12 > ions / cm < 2 >, otherwise, the corrosion resistance of the ZrNbFeLa coating can be sharply reduced due to excessive titanium.

The invention provides a bis (2, 3-dihydroxybenzamide) compound as well as a preparation method and application thereof, and belongs to the technical field of medicines. A series of bis (2, 3-dihydroxybenzamide) compounds which are novel in structure and have a good inhibiting effect on cholestatic liver diseases and hepatic fibrosis are obtained by conducting structural modification on cephalochelatin, and the compounds can remarkably inhibit expression of hepatic stellate cell COL1A1 mRNA in vitro and have a very strong anti-hepatic fibrosis effect; in vivo, the traditional Chinese medicine composition can obviously relieve related biochemical indexes of cholestatic liver disease mouse model liver injury induced by 3, 5-diethoxycarbonyl-1, 4-dihydro-2, 4, 6-trimethylpyridine (DDC), inhibit expression of related genes of liver fibrosis, reduce the content of liver collagenous fibers, inhibit liver inflammation and bile duct reaction, and can be used for preventing and treating cholestatic liver diseases. The traditional Chinese medicine composition can be used for treating cholestatic liver diseases and hepatic fibrosis.

The invention is suitable for the technical field of ultrasonic puncture, and provides a non-target tissue obstacle avoidance early warning method in ultrasonic puncture, which comprises the following steps: S1, acquiring an ultrasonic image and magnetic navigation positioning data in real time; s2, identifying a non-target tissue in the ultrasonic image; s3, the real-time distance between the puncture needle and the non-target tissue is calculated; s4, an early warning signal is triggered based on the distance, the non-target tissue comprises blood vessels, nerves and bile ducts, the recognition step adopts a deep learning model to perform image segmentation, the distance calculation is based on an image-space coordinate registration algorithm, the early warning signal comprises sound, visual and tactile feedback, and the distance calculation is based on the image-space coordinate registration algorithm. By automatically identifying non-target tissues and calculating the distance in real time, subjective judgment errors of doctors are avoided, the risk that blood vessels and nerves are accidentally injured by puncture is reduced, the attention of the doctors can be quickly aroused through multi-mode early warning, the operation difficulty is reduced through obstacle avoidance suggestion visualization, and the method is suitable for doctors with different experience levels.

The utility model relates to the technical field of medical instruments, in particular to an anti-slip PTCD drainage tube fixed in a bile duct, which comprises a connector, one end of the connector is connected with a drainage tube, the surface of the connector is connected with two symmetrically arranged fixing mechanisms, each fixing mechanism comprises a connecting block, the surface of the connector is fixedly connected with the connecting block, and the connecting block is fixedly connected with the drainage tube. And one end of the connecting block is fixedly connected with a fixed plate, a limiting groove is formed in the surface of the connecting block, and a movable plate is arranged on the surface of the connecting block. The winding firmness of the suture, the drainage tube and the connector can be improved in a two-phase winding mode, so that the drainage tube is not prone to loosening relative to the suture, the suture loop is extruded and fixed through the rubber ring, and the suture head is extruded and fixed through the movable plate and the fixed plate. A section of wound suture head part can be stabilized on the connector, the knotting process is omitted, meanwhile, operation is convenient, and the stabilizing effect on the suture head part is better.

The invention discloses application of solamargine in preparation of a medicine for preventing and / or treating cholestatic liver diseases, and belongs to the field of biological medicines. By simulating a classical Mdr2- / -mouse model of clinical cholestasis pathology, the solamargine is researched and proved to treat cholestatic liver injury by improving hepatocyte injury, bile duct dysfunction and bile metabolism disorder, and the solamargine shows good application potential in clinical treatment of cholestatic liver diseases.

This product is a stent inserted into the bile duct to dilate narrowed areas. The material of this product is metal, silicone, or synthetic resin.

The present application relates to the technical field of medical devices, in particular to a dilatable sheath type endoscopic biliary mud-like stone removal device, which comprises an outer sleeve, a flushing unit, a hollow working sheath, a spiral inner core assembly, a rotary drive unit and a vibration generating unit. The flushing unit, flexible conducting rod, spiral blade and vibration generating unit work together to continuously discharge the biliary mud-like stones. The positive pressure of the flushing liquid forms a forward flow in the bile duct, and the axial conveying force of the spiral blade discharges the stones in the outward direction, effectively avoiding the stones being pushed to the distal end of the bile duct, improving the complete removal rate of the stones, overcoming the problems of the existing dredging device, such as easy adsorption to the bile duct wall when using negative pressure suction, causing mucosal vessel rupture, and possibly sucking bacteria from the duodenal papilla into the bile duct, causing infection, and greatly improving safety.

The invention relates to an electrostatic spinning-photocuring composite tubular stent. The electrostatic spinning-photocuring composite tubular stent comprises a core, a shell and a coating layer, the core comprises polylactic acid and valine acid, the shell comprises polyvinyl butyral and a YAP agonist, and the coating layer comprises methacrylated hyaluronic acid and geniposide; the shell wraps the surface of the core, and the coating layer wraps the surface of the shell; the YAP agonist comprises C381 (C381). The preparation method comprises the following steps: preparation of the core-shell tubular stent and wrapping of the coating layer. According to the electrostatic spinning-photocuring composite tubular stent, a bile duct repair integrated platform which is free of acidification degradation, high in encapsulation efficiency, bionic in surface and capable of achieving three-medicine space-time synergy is achieved for the first time, and a breakthrough tissue engineering solution capable of being sewn, degraded and actively regenerated is provided for intractable bile diseases such as PSC and bile duct atresia.

The invention discloses an application of a DHCR7 inhibitor AY9944 in treatment of cholestatic pruritus. According to the invention, a cholestatic pruritus model induced by bile duct ligation is constructed, and experiments prove that the cholestatic pruritus can be effectively relieved by adding the AY9944. According to the research results, a candidate drug with a good application prospect is provided for clinical application.

The present disclosure relates to a novel benzotriazine dioxide and a pharmaceutical composition thereof. The benzotriazine dioxide has a structure of formula (I). The benzotriazine dioxide can be used alone or in combination with other drugs to treat or alleviate benign and malignant tumor disorders in the liver, bile duct, pancreas, stomach, esophagus, kidney, colon, lung, brain (glioma), malignant glioma, breast, ovary, cervical, head and neck, skin, melanoma, prostate, fibrosarcoma, sarcoma, thyroid gland, etc.

The present invention relates to the technical field of medical devices, specifically to an inner and outer layer bile duct fixed drainage tube, which is made of latex material and has a T-shaped portion placed in the common bile duct for support and guidance, and a drainage portion that is led out of the body through the abdominal wall. The drainage bag for collecting bile is connected to the outside through the drainage portion. The T-shaped portion includes a support portion formed by cutting the end of the drainage portion along the cross-sectional diameter, and the support portion is arranged along the common bile duct for support; it also includes an operating rod with axial compression resistance and a restraining member. When the drainage tube is removed, the operating rod enters the drainage portion from one end of the drainage portion and forms a support end portion at the connection port between the drainage portion and the support portion. The restraining member drives the support portion to converge toward the support end portion and then exits the body with the drainage portion. The present invention improves the existing T-shaped drainage tube with a low-cost simple structure, and can reduce the volume when removing the tube for easy removal.

This invention provides the application of amphetamine hydrochloride in the preparation of drugs for the prevention and treatment of fibrotic diseases. The amphetamine hydrochloride provided by this invention can inhibit the synthesis of fibronectin and type I collagen in hepatic stellate cells, and exhibits significant anti-hepatic fibrosis therapeutic effects in a mouse model of liver fibrosis induced by bile duct ligation and carbon tetrachloride. This discovery provides a potential drug molecule with a new mechanism of action for the prevention and treatment of liver fibrosis.