44 results about "Bile duct" patented technology

This invention discloses a sophoridine tricyclic derivative or its pharmaceutical salt, with the following general structural formula: R1 is selected from hydrogen, C1-C20 straight-chain alkyl, and C1-C20 branched alkyl. In vitro experiments have verified that the sophoridine tricyclic derivative can inhibit TGF-β-induced activation of hepatic stellate cells, improve CCl4- and bile duct ligation-induced liver injury and liver fibrosis in mice, inhibit TGF-β / Smads signaling pathway activation, and also inhibit diethylnitrosamine-induced primary liver cancer in mice. Therefore, this invention provides new evidence for the treatment, alleviation, or improvement of liver fibrosis or primary liver cancer using sophoridine tricyclic derivatives.

The invention relates to the technical field of active polysaccharides, in particular to an arrowroot active polysaccharide as well as a preparation method and application thereof. In an infrared spectrum of the arrowroot active polysaccharide, the arrowroot active polysaccharide at least has characteristic absorption peaks at the following positions: 3317 cm, 2911 cm, 1404 cm <-1 >, 1021 cm <-1 > and 642 cm. The polysaccharide is extracted and separated from yam beans, and the polysaccharide has a protective effect in a mouse model with hepatic fibrosis induced by ligation of bile ducts, also has a regulating effect on intestinal microbiota, and exerts anti-fibrosis activity.

The present invention relates to the compound 2-hydroxy-octadecene-9-cis-oate for use in the treatment of oncological pathologies including grade IV glioblastoma with native IDH, grade 3 glioma, embryonal tumour, pituitary tumour, meningioma, haemangiopericytoma, haemangioblastoma, mesothelioma, bile duct adenocarcinoma, exocrine pancreatic cancer, neuroendocrine pancreatic cancer, rectal cancer, urachal cancer, adenocarcinoma of the bladder and oesophageal cancer, and for the treatment of neuropathic pain caused by diabetic peripheral neuropathy, spinal cord injury, post-herpetic neuralgia, chemotherapeutic agent, antitumour agent, cancer, fibromyalgia or hepatitis. The present invention also relates to the pharmaceutical composition comprising 2-hydroxy-octadecene-9-cis-oate.

The transparent cap of the choledochoscope comprises a cap portion and a connecting portion, the tube wall of the front end, away from the connecting portion, of the cap portion is in an arc shape, and a first annular thread is arranged on the inner wall of the connecting portion. The choledochoscope tip is of a convex structure composed of a head part and a body part, the outer diameter of the head part is smaller than that of the body part, a second annular thread is arranged on the outer wall of the head part, and the second annular thread is connected with the first annular thread in a matched mode to achieve connection between the connecting part and the head part; and the outer diameter of the connecting part is the same as that of the body part. The transparent sleeve can be installed at the front end of a choledochoscope to carry out operations such as gall bladder or bile duct washing, calculus removal, stenosis expansion, gall bladder duct or Oddi sphincter exploration and the like; the transparent cap is firmly mounted and cannot fall off; the outer diameter of the connecting part of the transparent cap is consistent with the outer diameter of the choledochoscope body part, the tube wall at the front end of the cap part of the transparent cap is arc-shaped, and tissues such as fistulous tracts, gallbladders and bile duct mucosa are not damaged in the choledochoscope examination and treatment process.

The invention relates to the technical field of medical instruments, in particular to a calculus taking-out device for hepatobiliary surgery, which comprises a sleeve, a net bag structure is mounted at one end of the sleeve, a driving assembly is mounted at the other end of the sleeve, the net bag structure comprises a bag body and a distraction assembly, and the distraction assembly comprises a fixing component and a transmission component; a partition plate is fixedly connected to the middle of the inner wall of the sleeve, a through groove is formed in the partition plate, a mounting frame is arranged on one side of the partition plate, a lead screw is rotationally matched with the mounting frame, the lead screw is in threaded connection with a nut seat, the nut seat is fixedly connected with a push block, a push rod is fixedly connected to one side of the push block, and the push rod penetrates through the through groove to be fixedly connected with a side plate. The transmission part is mounted on the mounting plate; one end of the screw rod is rotationally matched with the mounting frame, and the other end is fixedly connected with the driving assembly. The calculus capturing efficiency is improved, bile duct wall injuries and postoperative infection risks are reduced, and the requirements of minimally invasive surgery for instrument accuracy, stability and safety are met.

This invention provides a choledochoscope suture removal tool, comprising: an outer tube, a connecting rod disposed inside the outer tube, a blade, and a cutting section. The head end of the connecting rod is connected to the blade, and the tail end is connected to a handle. The handle is located at the tail end of the outer tube, and the cutting section is located at the head end of the outer tube or on the blade for cutting Purlin's suture knots. This invention can be inserted through the choledochoscope's forceps channel to cut residual Purlin's suture loops at the bile duct or choledochoenterostomy site.

The invention provides a marker, a kit containing the marker, application of the marker and a use method of the marker. The marker comprises at least one selected from the group consisting of MUC1, MUC5AC, and Claudin18.2. The invention also relates to a method for preparing the marker. The marker and the kit containing the marker can be used for predicting prognosis of the intrahepatic cholangiocarcinoma, predicting the curative effect of targeted therapy and postoperative adjuvant therapy on the intrahepatic cholangiocarcinoma based on tumor expression states, and performing classified prediction on a big bile duct type and a small bile duct type of the intrahepatic cholangiocarcinoma. The disclosure also provides a method of cancer prognosis comprising detecting the expression of the marker and predicting the degree of benefit from post-operative adjuvant therapy in a subject, and / or the prognosis of cancer, particularly intrahepatic cholangiocarcinoma, in a subject. The present disclosure provides universal markers that can be used to predict the efficacy of postoperative adjuvant therapy, such as postoperative adjuvant chemotherapy, on intrahepatic cholangiocarcinoma.

The invention discloses an intrahepatic cholangiocarcinoma or tumor conventional ultrasonic image auxiliary diagnosis method and system based on a Vision-RWKV framework, and relates to the technical field of medical image auxiliary diagnosis. Comprising the following steps: acquiring image data information which is conventional liver ultrasonic image data of a plurality of existing patients; constructing an intrahepatic cholangiocarcinoma or tumor identification model based on a Vision-RWKV architecture, wherein the model has a linear complexity bidirectional attention mechanism; training an intrahepatic cholangiocarcinoma or tumor recognition model based on a Vision-RWKV framework by adopting the image data information; and inputting a conventional liver ultrasonic image of a patient to be identified into the trained intrahepatic cholangiocarcinoma or tumor identification model to obtain an identification result, wherein the result comprises a lesion type, lesion position calibration and credibility. The method has the advantages that ultrasonic examination is simple, economical and easy to operate, and CT / MRI examination is high in accuracy, so that more and wider crowds are covered and served, missed diagnosis and misdiagnosis are reduced, and patients obtain good prognosis and life quality.

The anti-displacement bile duct support comprises a supporting rod, a drainage tube section I, a drainage tube section II and a drainage tube section III, the drainage tube section I, the drainage tube section II and the drainage tube section III are sequentially connected from head to tail, the two ends of the supporting rod are connected with the drainage tube section I and the drainage tube section III respectively, and the drainage tube section II and the supporting rod are arranged in parallel and have elasticity. The arc-shaped spring can be relatively bounced off; communicated channels are formed in the drainage tube section I, the drainage tube section II and the drainage tube section III and are used for placing guide wires. The bile duct stent is placed in a common bile duct through an endoscope to drain bile, the drainage tube section II and the supporting tube are bounced off in an arc shape, and displacement of the bile duct stent can be avoided; and no damage is caused to the bile duct wall and the nipple mucosa in the stent taking-out process.

The invention is suitable for the technical field of ultrasonic puncture, and provides a non-target tissue obstacle avoidance early warning method in ultrasonic puncture, which comprises the following steps: S1, acquiring an ultrasonic image and magnetic navigation positioning data in real time; s2, identifying a non-target tissue in the ultrasonic image; s3, the real-time distance between the puncture needle and the non-target tissue is calculated; s4, an early warning signal is triggered based on the distance, the non-target tissue comprises blood vessels, nerves and bile ducts, the recognition step adopts a deep learning model to perform image segmentation, the distance calculation is based on an image-space coordinate registration algorithm, the early warning signal comprises sound, visual and tactile feedback, and the distance calculation is based on the image-space coordinate registration algorithm. By automatically identifying non-target tissues and calculating the distance in real time, subjective judgment errors of doctors are avoided, the risk that blood vessels and nerves are accidentally injured by puncture is reduced, the attention of the doctors can be quickly aroused through multi-mode early warning, the operation difficulty is reduced through obstacle avoidance suggestion visualization, and the method is suitable for doctors with different experience levels.

The utility model relates to the technical field of medical instruments, in particular to an anti-slip PTCD drainage tube fixed in a bile duct, which comprises a connector, one end of the connector is connected with a drainage tube, the surface of the connector is connected with two symmetrically arranged fixing mechanisms, each fixing mechanism comprises a connecting block, the surface of the connector is fixedly connected with the connecting block, and the connecting block is fixedly connected with the drainage tube. And one end of the connecting block is fixedly connected with a fixed plate, a limiting groove is formed in the surface of the connecting block, and a movable plate is arranged on the surface of the connecting block. The winding firmness of the suture, the drainage tube and the connector can be improved in a two-phase winding mode, so that the drainage tube is not prone to loosening relative to the suture, the suture loop is extruded and fixed through the rubber ring, and the suture head is extruded and fixed through the movable plate and the fixed plate. A section of wound suture head part can be stabilized on the connector, the knotting process is omitted, meanwhile, operation is convenient, and the stabilizing effect on the suture head part is better.

The invention discloses application of solamargine in preparation of a medicine for preventing and / or treating cholestatic liver diseases, and belongs to the field of biological medicines. By simulating a classical Mdr2- / -mouse model of clinical cholestasis pathology, the solamargine is researched and proved to treat cholestatic liver injury by improving hepatocyte injury, bile duct dysfunction and bile metabolism disorder, and the solamargine shows good application potential in clinical treatment of cholestatic liver diseases.

This product is a stent inserted into the bile duct to dilate narrowed areas. The material of this product is metal, silicone, or synthetic resin.

The present application relates to the technical field of medical devices, in particular to a dilatable sheath type endoscopic biliary mud-like stone removal device, which comprises an outer sleeve, a flushing unit, a hollow working sheath, a spiral inner core assembly, a rotary drive unit and a vibration generating unit. The flushing unit, flexible conducting rod, spiral blade and vibration generating unit work together to continuously discharge the biliary mud-like stones. The positive pressure of the flushing liquid forms a forward flow in the bile duct, and the axial conveying force of the spiral blade discharges the stones in the outward direction, effectively avoiding the stones being pushed to the distal end of the bile duct, improving the complete removal rate of the stones, overcoming the problems of the existing dredging device, such as easy adsorption to the bile duct wall when using negative pressure suction, causing mucosal vessel rupture, and possibly sucking bacteria from the duodenal papilla into the bile duct, causing infection, and greatly improving safety.

The invention relates to an electrostatic spinning-photocuring composite tubular stent. The electrostatic spinning-photocuring composite tubular stent comprises a core, a shell and a coating layer, the core comprises polylactic acid and valine acid, the shell comprises polyvinyl butyral and a YAP agonist, and the coating layer comprises methacrylated hyaluronic acid and geniposide; the shell wraps the surface of the core, and the coating layer wraps the surface of the shell; the YAP agonist comprises C381 (C381). The preparation method comprises the following steps: preparation of the core-shell tubular stent and wrapping of the coating layer. According to the electrostatic spinning-photocuring composite tubular stent, a bile duct repair integrated platform which is free of acidification degradation, high in encapsulation efficiency, bionic in surface and capable of achieving three-medicine space-time synergy is achieved for the first time, and a breakthrough tissue engineering solution capable of being sewn, degraded and actively regenerated is provided for intractable bile diseases such as PSC and bile duct atresia.

This invention provides the application of amphetamine hydrochloride in the preparation of drugs for the prevention and treatment of fibrotic diseases. The amphetamine hydrochloride provided by this invention can inhibit the synthesis of fibronectin and type I collagen in hepatic stellate cells, and exhibits significant anti-hepatic fibrosis therapeutic effects in a mouse model of liver fibrosis induced by bile duct ligation and carbon tetrachloride. This discovery provides a potential drug molecule with a new mechanism of action for the prevention and treatment of liver fibrosis.

The invention relates to the technical field of magnetic resonance imaging, and discloses a thin-layer oblique coronal focusing view diffusion weighted imaging method of a magnetic resonance system, which comprises the following steps of: extracting a three-dimensional space walking path of a target bile duct based on magnetic resonance pancreaticobiliary duct water imaging and a cross section T2 weighted image, performing optimal plane fitting, and determining a personalized oblique coronal scanning plane; in the plane, diffusion weighted imaging is carried out by adopting a small visual field set according to bile duct projection, a layer thickness not higher than 3.0 mm and a low b value not higher than 100 seconds / square millimeters and a high b value not lower than 800 seconds / square millimeters, and echo time is set to a minimum value allowed by a system. Through cooperation of personalized plane positioning, thin-layer high-b-value imaging and intelligent quality control, the problems that conventional magnetic resonance imaging is incomplete in display of an extrahepatic cholangiocarcinoma lesion anatomical structure, low in signal-to-noise ratio, multiple in motion artifacts and difficult to accurately evaluate the longitudinal infiltration range of a tumor are solved.

This invention relates to the field of cell image analysis and biological cell screening technology, and discloses a method for screening liver stem cells. The method includes: acquiring original images; performing effective image screening; performing background correction, noise reduction and enhancement, and contrast compensation; performing single-cell instance segmentation; performing single-cell feature extraction and trajectory association; determining target cells using a neural network model; and outputting the liver stem cell determination result. Compared to existing screening methods that rely on manual observation or single-frame static image discrimination, especially in the case of primary hepatocyte suspensions containing mature hepatocytes, bile duct epithelial cells, stromal cells, and cell debris, this method addresses the technical problem of unstable and automated identification of liver stem cells. This application improves the accuracy and automation of liver stem cell screening by constructing a continuous processing flow of image quality gating, instance segmentation, and dual-branch feature fusion judgment.

This product is a stent inserted into the bile duct to dilate narrowed areas. The material of this product is metal, silicone, or synthetic resin.

The invention discloses a non-staining imaging liver vascular group classification method and a related product. The method comprises the following steps: acquiring a second harmonic SHG image and a two-photon fluorescence TPEF image of liver tissue; the SHG image and the TPEF image are subjected to image optimization processing, a target SHG signal image and a target TPEF signal image are obtained, each pixel value in the target SHG signal image represents the signal intensity of the SHG, and each pixel value in the target TPEF signal image represents the signal intensity of the TPEF; constructing a target candidate lumen feature vector based on the target SHG signal image and the target TPEF signal image; and inputting the target candidate lumen feature vectors into a classification model to obtain a classification result of a liver vessel group, the liver vessel group including arteries, veins and bile ducts, and the classification model being obtained by pre-training in a decision tree manner. In this way, the classification efficiency and the accuracy of the classification result can be remarkably improved, and therefore the reliability of liver blood vessel group recognition is enhanced.

The invention belongs to the technical field of biological medicine, and particularly relates to a liver organ model and an establishment method and application thereof. The establishment method comprises the following steps: pre-treating an obtained liver tissue sample to obtain a mixture containing liver tissue-derived cell clusters, and then carrying out gradient digestion treatment, filtration, lysis and centrifugation to obtain bile duct organs; performing induced culture on the bile duct organ to obtain a liver organ model; wherein the gradient digestion method comprises the step of treating the mixture containing the liver tissue-derived cell mass for 5-10 minutes by sequentially using IV type collagenase with the mass concentration of 0.1%, 0.2% and 0.3%. According to the establishment method of the liver organoid model, provided by the invention, the organoid yield is relatively high, and the prepared organoid is clear in boundary and uniform in shape. A fatty liver model constructed by using the aptamer is sensitive to drug response, can screen drugs for treating fatty liver at high throughput, and provides a basis for clinical screening of novel anti-inflammatory drugs.

The invention relates to the technical field of bile duct sampling, and discloses a bile duct biopsy sampling device which comprises a shell and a catheter, the interior of the shell is fixedly connected with a first rotating shaft, the outer wall of the first rotating shaft is rotatably connected with scissor arms, the two scissor arms are symmetrically arranged, the top ends of the scissor arms penetrate through the shell and are fixedly connected with spoon petals, and the spoon petals penetrate through the shell. The bottom ends of the scissor arms are fixedly connected with connecting rings, the connecting rings are connected with a driving mechanism, and a spring is fixedly connected between the two connecting rings. Two groups of symmetrical spoon petals are arranged, the spoon petals are spoon-shaped and can rotate and fold around a rotating shaft, samples can be clamped, the samples can be stored on the inner walls of the spoon petals, the spoon petals are folded after sampling to avoid leakage or pollution of the samples, a driving mechanism is connected with a connecting ring through a first inhaul cable, the first inhaul cable is pulled to drive a scissor arm to rotate and fold, and after the first inhaul cable is loosened, the scissor arm is driven to rotate and fold. And the spring rebounds to open the scissor arms, the structure is simple, and the operation is convenient.

The embodiment of the present application provides a rat bile duct catheter, which comprises a first catheter (1), a single knot (2) connected with the first catheter (1), a second catheter (3) connected with the single knot (2), a first double knot (4) connected with the second catheter (3), and a third catheter (5) connected with the first double knot (4). The first catheter (1) is inserted into the common bile duct and fixed through the single knot (2), the third catheter (5) is inserted into the duodenum and fixed through the first double knot (4), and the bile is taken at the second catheter (3). The first catheter is inserted into the common bile duct and fixed on the side of the common bile duct through the single knot, the third catheter is inserted into the duodenum and fixed on the side of the duodenum through the first double knot, and the second catheter is located outside the rat body, so that the bile can be taken at the second catheter. The present application conforms to the physiological structure of the rat, is not easy to fall off after being fixed, meets the requirement of long-term periodic collection of bile, and conforms to the requirement of animal welfare.

Embodiments of the disclosure encompass methods and compositions related to treatment for individuals that have bile duct paucity, such as individuals with Alagille Syndrome. The methods and compositions relate to use of inhibitory agents that target SOX4 expression to reduce it or that target SOX4 or to reduce its activity. Specific embodiments include AAV8 vectors that encode an shRNA that targets SOX4.

The invention provides a medical stent and a stent delivery device which can be placed in a bile duct in a state of sufficiently along the shape of the bile duct. This medical stent is provided with a main body having: a tubular member that extends in the longitudinal direction; and a reinforcing member wound in a spiral shape around a longitudinal axis extending in the longitudinal direction, extending in the longitudinal direction, and embedded between an inner peripheral surface of the tubular member and an outer peripheral surface of the tubular member, the main body having a first region and a second region in which winding pitches of the reinforcing member are different from each other, the second region is a region in which the reinforcer is helically wound at a winding pitch larger than that of the first region, and the second region is longer than the first region in the longitudinal direction.

What is provided is an endoscopic device including: a sheath extending in a longitudinal direction thereof; a treatment tool opening portion that communicates with a treatment tool lumen inserted through the sheath in the longitudinal direction and allows a treatment tool inserted through the treatment tool lumen to project to and retract from a distal end side of the sheath in the longitudinal direction; and a suction opening portion communicating with a suction lumen inserted through the sheath in the longitudinal direction, wherein the treatment tool opening portion and the suction opening portion are provided in an insertion region that is disposed inside bile and pancreatic ducts when the sheath is inserted into the bile and pancreatic ducts, and the suction opening portion is able to suck an inner wall of the bile and pancreatic ducts.

The utility model discloses a hepatobiliary balloon dilatation tube, and particularly relates to the technical field of medical instruments, the hepatobiliary balloon dilatation tube comprises a pressurizing tube, one end of the pressurizing tube is inserted and fixedly connected with a hepatobiliary balloon dilatation tube, one end of the hepatobiliary balloon dilatation tube is provided with a balloon body, and one end of the pressurizing tube is fixedly connected with an insertion nesting block. One end of the inserting and nesting block is inserted into the liver and gall balloon dilatation tube, an auxiliary block is fixedly connected to the outer end of the liver and gall balloon dilatation tube, a first inserting block is inserted into the outer end of the auxiliary block, and the first inserting block is fixedly connected with the pressurizing tube; through the design of the multi-layer composite material balloon, the outer layer polyimide material provides high strength and corrosion resistance, the inner layer silica gel material is soft, and damage to the bile duct wall is reduced; spiral textures on the outer wall increase friction force, prevent slippage and uniformly distribute expansion pressure; the inserting design of the pressurizing pipe and the expansion pipe realizes quick disassembly and assembly.

The utility model relates to the technical field of medicine processing auxiliary equipment, in particular to a bezoar bed which comprises a shell and a cloth bag, a convex thorn group is arranged outside the shell, one end of the shell is provided with a circular opening, the other end of the shell is provided with a connecting port, and the bottom end of the cloth bag extends into the shell and is fixedly connected with the connecting port; when the bezoar bed needs to be implanted into the cow gall bladder, a deposition medium is added into the shell, the cloth bag is folded to wrap the outer side of the shell, the cloth bag is closed below the connecting port, and then the bezoar bed is implanted into the cow gall bladder; friction force between the calculus bovis and the gall bladder can be increased, a calculus bovis bed is prevented from flowing into the intestinal canal or blocking the bile duct through the bile duct, calculus bovis crystal precipitation is facilitated, the crystal attachment surface is improved, the calculus bovis crystal adsorption capacity is better, and the calculus bovis yield is improved.

A method based on an r-IBS-introduced neural network for automatically determining the liver's condition from three common diseases—hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and fatty liver (FAT)—using liver CT images includes the following steps: First, construct an r-IBS-based training classifier. Use the classifier to determine the disease type for each liver CT image. Acquire liver CT images and process them using a snake model. Input the images into the trained classification neural network model. The neural network outputs the classification results for the aforementioned diseases.

The utility model provides a kind of double guide wire nipple sphincter incision knife, comprising: outer sheath, handle, first guide wire, second guide wire and wire, first guide wire is inserted to the inside of outer sheath through the pipe wall of outer sheath, and it is worn from the pipe wall of outer sheath;Handle is connected with the tail end of outer sheath, second guide wire is inserted to the inside of outer sheath through handle, and it is worn from the head end of outer sheath;One end of wire is fixedly connected on the pipe wall of outer sheath, the other end is inserted into the inside of outer sheath, and is connected with handle.The utility model uses, assistant can implement guide wire auxiliary nipple sphincter incision knife cannula into pancreatic duct, on the basis of not increasing nipple incision knife pipe diameter, operator can operate second guide wire and insert into common bile duct through pipe wall lateral wall, realize double person multi-angle cannulation, increase the success rate of bile duct cannulation.