154 results about "Bile duct" patented technology

The invention relates to a reconstruction method of a liver, gall and pancreas three-dimensional image. According to the technical scheme, the method comprises the following steps: introducing a segmentation network for U-Net variants of the liver, the bile duct and the pancreas, and segmenting a multi-modal image by using a convolutional neural network, including separation of the liver, the bile duct and the pancreas; a boundary enhancement module is introduced in the segmentation process; performing spatial alignment on the image data of different modalities by adopting a deep learning driven non-rigid registration algorithm; carrying out registration by utilizing anatomical feature points of the organs; according to a registration result, performing multi-modal fusion on the liver image, the bile image and the pancreas image, and constructing fusion image data by comprehensively utilizing the bone and tissue contrast ratio of CT, the soft tissue resolution ratio of MRI and the real-time dynamic characteristics of ultrasound; extracting contours of liver, gall and pancreas from the segmented image, and constructing a preliminary three-dimensional mesh model; and according to the geometrical shapes of different organs, adaptive adjustment is carried out, and the distribution of grids during reconstruction is controlled to be matched with the organ shapes.

The invention belongs to the technical field of hepatobiliary calculus treatment, and discloses a hepatobiliary calculus negative pressure suction and laser lithotripsy integrated device which comprises a wrapping mechanism, and the wrapping mechanism comprises an abutting plate, a buffer pad, a connecting ring, a shell, a first cavity, a first vent groove, an air conveying pipe and a wrapping air bag; through cooperation of the wrapping air bag, the protective air bags and other structures, the calculus can be conveniently wrapped, the calculus is wrapped through the multiple protective air bags, an isolation layer is formed, the calculus is isolated from surrounding important tissues such as bile duct walls and blood vessels, and the calculus is prevented from being damaged. In the lithotripsy process, both energy generated by laser and splashing of stone fragments are limited in the protective air bag, damage to surrounding tissue is effectively prevented, meanwhile, the stone fragments can be prevented from being diffused to the surrounding tissue in the lithotripsy process, and complications such as bile duct blockage and inflammation are avoided. And subsequent negative-pressure suction operation is facilitated to thoroughly remove the dust.

Method and systems for closing an opening formed during a medical procedure are disclosed. An example method may include advancing a needle through patient tissue to form an opening into a bile duct region, performing an intervention within the bile duct region, and advancing an embolic gel into the opening to close the opening.

The invention discloses an intravascular adjustable ultrasonic real-time navigation TIPS puncture instrument, and relates to the technical field of medical devices, the intravascular adjustable ultrasonic real-time navigation TIPS puncture instrument comprises a catheter sheath, a core-through needle catheter, a hollow core-through needle and a solid core-through needle; the core-through needle catheter penetrates through the interior of the catheter sheath; an operating handle is arranged at one end of the through core needle catheter, a traction mechanism is installed on the operating handle, and a pull wire is arranged in the catheter sheath. Real-time ultrasonic images are obtained through the ultrasonic probe, so that an operator can clearly see a needle point path, and key organs such as hepatic artery, bile duct and gall bladder are effectively avoided. The bending-adjustable puncture needle provides the capability of real-time correction in an operation, can easily cope with complex anatomical variation, can keep certain rigidity through the hardness adjusting chain after bending adjustment, improves the penetrating power of the puncture needle, prevents unpredictable mechanical deformation during liver cirrhosis liver puncture, enhances the controllability after bending adjustment, and improves the safety of liver cirrhosis. And accurate execution of the preset angle is ensured.

A surgical instrument for percutaneous transhepatic choledochoscope diagnosis and treatment is used for establishing a first-stage surgical channel of the percutaneous transhepatic choledochoscope and sinus tract forming of staging surgery, and the surgical instrument system is composed of a surgical working channel sheathing canal and a sinus tract forming drainage tube. The operation working channel sheathing canal is provided with a straight pipe, a bent pipe, an adjustable bending design and an adjustable bending device so as to adapt to all levels of bile ducts to walk, is provided with an anti-squashed pipe body or a variable-diameter material or a variable-diameter device pipe body, a controllable negative pressure connector, an endoscope insertion channel, a sealing cap and an instrument channel, and is provided with an expansion pipe, so that the sheathing canal can be conveniently and smoothly placed into the biliary tract; the sinus tract forming drainage tube body is of a reducing structure, adapts to the volume of a bile duct cavity, is provided with a pigtail-shaped anti-falling device, a fixing line and other anti-falling devices, reduces falling of the drainage tube, is provided with a side hole, can achieve the bile drainage function, is provided with a fixed Luer taper and a movable Luer taper, facilitates imbedding of the sinus tract forming drainage tube in different operation scenes, and is convenient to use. The device is used for improvement and smooth implementation of percutaneous transhepatic choledochoscope surgery.

A method of forming an access route to the bile duct includes: forming a tunnel extending from an oral ridge of a duodenal papilla, which is located on an oral side of a natural opening of a duodenal papilla, to the bile duct; and dilating a lumen of the tunnel more than when it was formed.

The invention discloses a drainage catheter for a biliary tract and a biliary tract negative pressure drainage system. The biliary tract negative pressure drainage system comprises a negative pressure instrument, a liquid storage device, a drainage catheter and a catheter fixator. Wherein the negative pressure instrument is used for providing negative pressure and carrying out pressure detection. The liquid storage device is connected with the negative pressure instrument, so that negative pressure is formed in the liquid storage device through the negative pressure instrument. The drainage catheter comprises a connector, a catheter body and a pull wire. The connector is used for being connected with a liquid storage device and used for conveying liquid into the liquid storage device. The tube body is connected with the connector and used for drainage of liquid. The stay wire is arranged in the tube body in a penetrating mode so as to pull the far end of the tube body to form a pigtail-shaped circle. The catheter fixator is connected with the catheter body of the drainage catheter and used for fixing the catheter body to the skin surface near the biliary tract. When the far end of the catheter body forms a pigtail-shaped circle, the center line of the drainage catheter and the center line of the drainage section are located in the same plane, so that the drainage tip does not protrude, and the safety of biliary tract drainage is effectively improved.

The invention discloses a curative effect evaluation system for treating liver cancer by combining HDRBT with thermal ablation in multi-modal radiomics, and relates to the field of liver cancer treatment, and the system comprises a multi-modal image data acquisition module which is used for collecting multi-modal image data; the three-dimensional visual model construction module is used for reconstructing a three-dimensional structure of liver tumors, peripheral blood vessels and bile ducts through an image segmentation algorithm, and generating a visual model by fusing radiomics characteristics; the combined treatment plan generation module is used for integrating the dosimetry parameters of the HDRBT and the process parameters of the thermal ablation, optimizing a catheter implanting path, the position of a thermal ablation electrode and a treatment sequence, and generating a combined treatment scheme; and the curative effect evaluation module is used for quantitatively analyzing tumor volume change, ablation boundary integrity and residual tumor activity through accurate registration of multi-modal images before and after treatment. According to the scheme, the problems of incomplete thermal ablation and high recurrence rate of hepatocellular carcinoma can be solved, and full-chain technical support is provided for clinical precise application.

The application provides a multifunctional catheter, comprising a catheter main body and a distal tube with a multi-cavity tube structure. The distal tube comprises a soft end at the proximal end and a functional end at the distal end. The catheter main body and the soft end are provided with a working cavity and a lens cavity. The functional end is further provided with a through hole communicating with the lens cavity. The lens cavity is a circular tube cavity structure extending along the catheter main body and the soft end. The inner wall of the lens cavity is provided with a plurality of accommodation grooves for accommodating photosensitive chips in a lens assembly. The catheter provided by the application can form a space for accommodating photosensitive chips through the plurality of accommodation grooves in the lens cavity, and the lens assembly can be installed without increasing the diameter of the lens cavity, thereby reducing the overall diameter of the catheter to adapt to the more complex bile duct environment relative to the digestive tract.

The utility model relates to a guide sheath for assisting a choledochoscope to enter and exit from a biliary tract, which comprises a guide sheath body, a guide sleeve and a guide sleeve, an inlet is arranged on one side of the guide sheath body, a channel is arranged in the guide sheath body, and a transition cambered surface is arranged between the channel and the inlet; a guide sheath tube; the connector component comprises a butt joint part and a rotating part, the guiding sheath tube is arranged on the side, away from the rotating part, of the butt joint part, a plurality of elastic pieces capable of elastically and constantly abutting against the transition cambered surface are arranged on the side, away from the butt joint part, of the rotating part, and a groove is formed in the outer side of the rotating part; and the limiting part is detachably connected with the guide sheath body and is used for blocking and limiting the butt joint part through the groove. When the guide sheath used for assisting the choledochoscope in entering and exiting from the biliary tract is used in cooperation with the choledochoscope, the angle adjustment requirement of the choledochoscope can be met, the guide sheath tube can be kept still, the situation that the guide sheath tube hurts the interior of the human body is avoided, and the guide sheath used for assisting the choledochoscope in entering and exiting from the biliary tract can be applied to a gall-stone operation.

The invention discloses a preparation method of a drug-coated stent. The preparation method comprises the following steps: preparing a NiTi alloy shape memory stent; preparing a PMEA-based drug-loaded coating suspension slurry; and coating the prepared PMEA-based drug-loaded coating suspension slurry on the outer surface of the NiTi alloy shape memory stent by adopting a liquid flame spraying mode to obtain the drug-coated stent. The invention also discloses the drug-coated stent prepared by the preparation method and application thereof. The liquid flame spraying technology is used for stent surface modification, the prepared drug-coated stent has a good effect of preventing protein adsorption, bile duct re-blockage and stent failure can be better prevented by combining the drug-coated stent with antibacterial drugs, and the drug-coated stent can be used for clinical treatment of liver and gall diseases.

The invention relates to the technical field of biomedical engineering, in particular to a bile duct for screening and developing drugs or simulating bile duct cancer fibrosis progress in vitro. The bile duct is prepared by the following steps: (1) treating a liver by using a lauryl sodium sulfate solution and a Triton X-100 solution in sequence, freeze-drying and crushing; (2) carrying out enzymolysis on the crushed tissues by using pepsin, and filtering to obtain acellular matrix hydrogel; and (3) mixing the acellular matrix hydrogel with a sodium alginate solution to obtain the composite hydrogel. The structure of the sodium alginate-acellular matrix composite hydrogel can be accurately controlled by adopting a 3D printing technology. Therefore, the hydrogel can better simulate a tumor microenvironment, and particularly can realize more real biocompatibility and tissue structure when being used for culturing bile duct cancer organs.

The utility model belongs to the technical field of medical treatment, and particularly relates to an electrocoagulation and electroresection snare under direct view of an oral cholangioscope. Comprising a core rod and a hand ring, the front end of the core rod is connected with a sheath tube, the flexible rod is arranged in the sheath tube in a penetrating mode, and the end of the flexible rod is fixedly connected with the hand ring; the electric cutting knife is arranged at the other end part of the flexible rod, and the electric cutting knife is connected with the ferrule. The diameter of the sheathing canal of the novel snare is 1 mm, the novel snare sheathing canal can be used in cooperation with a bile duct endoscope, direct and real-time observation and operation can be conducted under the bile duct endoscope, and the accuracy and timeliness of an operation are improved; the electric cutting knife is arranged, so that small and large polyps can be cut off through the electric cutting knife, or the large polyps can be cut off conveniently through the snare after being cut off; the flexible rod is provided with the cavity and is matched with the through hole, liquid medicine can be dropwise added to the cut part, and ulceration infection of the cut part is avoided.

The utility model relates to the technical field of medical instruments, in particular to a bile duct wall cell collecting device. The bile duct wall cell collection device comprises a catheter, a main guide wire, an auxiliary guide wire and a cytobrush assembly. A first channel for the main guide wire to penetrate through and a second channel for the auxiliary guide wire to penetrate through are arranged in the catheter. And the auxiliary guide wire is parallel to the main guide wire. The cytobrush assembly is arranged in the axial direction of the main guide wire. The cytobrush assembly comprises a skeleton, a connecting frame, a base and a flexible guide rod. And the plurality of frameworks are circularly arranged along the axis of the main guide wire. One end of the skeleton is connected with the main wire. Bristles for collecting are distributed on the framework. The base sleeves the main guide wire and has the degree of freedom of sliding in the axial direction of the main guide wire. The base is connected with the framework through a connecting frame. One end of the flexible guide rod is connected with the base, and the other end of the flexible guide rod is connected with the auxiliary guide wire. The bile duct wall cell collection device can conveniently penetrate through the narrow part of the bile duct, the collection difficulty is reduced, and the sampling success rate is improved.

The invention discloses CCL2, a receptor specific binding polypeptide thereof and application of the receptor specific binding polypeptide in prevention and treatment of cholestatic liver diseases, and relates to the technical field of biological medicines. The CCL2 and the receptor specific binding polypeptide thereof, which are screened by a molecular simulation technology, can be specifically bound with a key molecule CCL2 for inducing diseases and a plurality of receptors thereof in a cholestatic liver disease occurrence process, so that liver function indexes are recovered; the traditional Chinese medicine composition can be used for relieving liver pathological injury, including inhibiting bile duct hyperplasia, relieving portal vein inflammatory response and relieving portal vein fibrosis, so that the pathological development process of fibrosis and inflammation caused by the liver injury is blocked.

The invention discloses a free directional guide visual guide wire mirror device. The device mainly comprises a handheld handle, an imaging optical fiber, an illumination optical fiber, a miniature view finding objective lens group, a photoelectric conversion image acquisition group, a flexible outer sleeve and a front-end free directional guide end, and the outer diameter of the device is smaller than 0.9 mm. And through a unique free directional guiding function, the visual probe can enter a superfine lumen and a narrow part for visual exploration on the premise of not damaging the mucous membrane of the cavity. The endoscope can be applied to medical scenes such as fallopian tube cavity examination, assistance of a duodenoscope in bile duct operation and the like, the application limitation of a traditional endoscope is effectively broken through, ray radiation hazards are reduced, the cross infection risk is reduced, and an innovative technical means is provided for medical diagnosis and treatment.

The invention discloses a biliary stent for univariably regulating and controlling the dosage of an electron beam bactericide and a preparation method of the biliary stent, and belongs to the technical field of degradable biomedical materials and medical instruments. According to the stent, highly-oriented poly-L-lactic acid (PLLA) monofilaments serve as the unique raw material, and the self-expanding stent is woven after melt extrusion, solid-state thermal stretching and thermal setting; through univariate dose treatment of an electron beam sterilization (EBS) technology, the degradation rate and the degradation period can be precisely regulated and controlled in a gradient manner under the same process condition, and different clinical scenes such as gall bladder resection, biliary-intestinal anastomosis and biliary tract radiography can be matched respectively; the individual requirement of'etiological adaptation type 'is met, and a brand new normal form of single material, single variable and system one-way adjustment is provided for large-scale production and accurate application of the degradable biliary tract stent.

This invention discloses a sophoridine tricyclic derivative or its pharmaceutical salt, with the following general structural formula: R1 is selected from hydrogen, C1-C20 straight-chain alkyl, and C1-C20 branched alkyl. In vitro experiments have verified that the sophoridine tricyclic derivative can inhibit TGF-β-induced activation of hepatic stellate cells, improve CCl4- and bile duct ligation-induced liver injury and liver fibrosis in mice, inhibit TGF-β / Smads signaling pathway activation, and also inhibit diethylnitrosamine-induced primary liver cancer in mice. Therefore, this invention provides new evidence for the treatment, alleviation, or improvement of liver fibrosis or primary liver cancer using sophoridine tricyclic derivatives.

The utility model relates to a calculus removing device, which comprises an outer pipe, an inner pipe and a calculus removing basket net or a calculus crushing rod, wherein the inner pipe can be sleeved in the outer pipe; the calculus removing basket net or the calculus crushing rod can be sleeved in the inner pipe; the calculus removing device is placed into a bile duct or a gall bladder through the expanded drainage pipeline, the calculus removing basket net is placed at the position of calculus through the inner pipe and the outer pipe, the calculus is sleeved with the basket net, the catheter is fixed, the basket net with the calculus is pulled outwards, and therefore the calculus can be crushed by clamping, and the calculus which cannot be crushed by clamping can be crushed by using the calculus crushing rod. Calculus fragments can be taken out of the body through the basket net.

The invention relates to the technical field of active polysaccharides, in particular to an arrowroot active polysaccharide as well as a preparation method and application thereof. In an infrared spectrum of the arrowroot active polysaccharide, the arrowroot active polysaccharide at least has characteristic absorption peaks at the following positions: 3317 cm, 2911 cm, 1404 cm <-1 >, 1021 cm <-1 > and 642 cm. The polysaccharide is extracted and separated from yam beans, and the polysaccharide has a protective effect in a mouse model with hepatic fibrosis induced by ligation of bile ducts, also has a regulating effect on intestinal microbiota, and exerts anti-fibrosis activity.

The present invention relates to a method for reconstructing three-dimensional images of the hepatobiliary and pancreatic organs; the technical solution adopted by the present invention includes the following steps: introducing a segmentation network of a U-Net variant for the three organs of the liver, gallbladder, and pancreas, and using a convolutional neural network to segment multimodal images, including separating the liver, bile duct, and pancreas; introducing a boundary enhancement module during the segmentation process; adopting a deep learning-driven non-rigid registration algorithm to spatially align different-modal imaging data; using the anatomical feature points of the organs for registration; according to the registration results, performing multimodal fusion on the liver, gallbladder, and pancreas images, comprehensively utilizing the bone and tissue contrast of CT, the soft tissue resolution of MRI, and the real-time dynamic characteristics of ultrasound to construct fused imaging data; extracting the contours of the hepatobiliary and pancreatic organs from the segmented images to construct a preliminary three-dimensional grid model; adaptively adjusting according to the geometric shapes of different organs to control the distribution of the grid during reconstruction to match the organ morphology.

The invention provides a double-guide-wire nipple sphincter incision knife which comprises an outer sheath tube, a handle, a first guide wire, a second guide wire and a metal wire, and the first guide wire is inserted into the outer sheath tube through the tube wall of the outer sheath tube and penetrates out of the tube wall of the outer sheath tube; the handle is connected with the tail end of the outer sheath tube, and the second guide wire is inserted into the outer sheath tube through the handle and penetrates out of the head end of the outer sheath tube. One end of the metal wire is fixedly connected to the tube wall of the outer sheath tube, and the other end of the metal wire is inserted into the outer sheath tube and connected with the handle. During use, an assistant can implement the guide wire to assist the nipple sphincter incision knife in intubation into the pancreatic duct, an operator can operate the second guide wire to enter the common bile duct through intubation on the side wall of the duct wall on the basis that the duct diameter of the nipple incision knife is not increased, double-person multi-angle intubation is achieved, and the bile duct intubation success rate is increased.

The invention discloses a method for preparing a wet spinning alignment collagen membrane with high tensile strength, and relates to the technical field of biomedical material preparation, the method comprises the following steps: preparing three layers of solutions, the upper layer and the lower layer are wet spinning buffer solutions (such as a polyethylene glycol solution) with specific concentration and pH, and the middle layer is a collagen solution with specific concentration and pH; injecting the three-layer solution into three-layer flow control equipment, and controlling the flow through a collecting tube; gathering the three layers of solutions at the tail end of equipment and performing wet spinning to form a film; and axially stretching to obtain a finished product. According to the invention, by precisely regulating and controlling a solution system, adopting industrial-grade flow control equipment and flow control, optimizing a directional stretching process and stabilizing a curing environment, the problems of non-uniform film thickness, easy tearing, large mechanical property fluctuation and the like in a traditional process are solved, large-scale production of the collagen film with high tensile strength and directionally arranged molecules is realized, and the production cost is reduced. The method is suitable for artificial blood vessels, bile ducts, skin and other tissue engineering fields.

A degradable bile and pancreatic duct stent for dilating the narrowed lumen of a lesion, includes a guiding part, which has a guide passage through which a guide wire passes; and a stent main body, which is spirally distributed outside the guiding part in the lengthwise direction of the guiding part. The stent main body is capable of forming a spiral channel relative to the lumen, and the guide passage of the guiding part is in fluid communication with the spiral channel. The guiding part and the stent main body spirally have good bending and supporting performance, effectively drains bile, and prevent problems such as restenosis and occlusion in the bile and pancreatic duct. The guide passage is in communication with the spiral fluid channel, thus improving the drainage performance, and reducing the possibility of bile duct re-occlusion caused during the degradation process of the bile and pancreatic duct stent.

The application provides a kind of double (2,3-dihydroxy benzamide) compound and its preparation method and application, belong to medical technology field.The application obtains a series of double (2,3-dihydroxy benzamide) compound with novel structure and good inhibiting effect on cholestatic liver disease and liver fibrosis by structural modification of sporangium chelae, the compound can significantly inhibit the expression of hepatic stellate cell COL1A1 mRNA in vitro, has strong anti-liver fibrosis effect;In vivo, it can significantly alleviate the liver injury related biochemical indicators of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) induced cholestatic liver disease mouse model, inhibit the expression of liver fibrosis related genes, reduce the content of liver collagen fiber, inhibit liver inflammation and bile duct response, and can be used for treating cholestatic liver disease and liver fibrosis.

The invention discloses a novel choledochoscope without a T tube, and relates to the technical field of choledochoscopes, the novel choledochoscope comprises a forward extension structure, and the forward extension structure is arranged on the outer side of a choledochoscope pipeline in a sleeving mode; one end of the forward extending structure is connected to one end of the control handle; a displacement feedback mechanism is arranged in the front end of the choledochoscope pipeline and comprises a thin rope, one end of the thin rope is connected with an operation observation operation opening in the front end of the forward extending structure, and the other end of the thin rope is connected with the inner wall of the choledochoscope pipeline; the choledochoscope has the advantages that the forward extending structure and the displacement feedback mechanism are arranged on the basis of an original choledochoscope, the forward extending pipeline can extend forwards by a certain distance by rotating the rotary adjusting head, and by matching with the bending effect of the front end of the original choledochoscope, the purpose that the front end of the choledochoscope extends into a branch bile duct to observe and treat calculi can be achieved; the extending distance of the front end of the choledochoscope is fed back through the displacement feedback mechanism, so that the forward extending distance of instruments for subsequent calculus removal and the like is accurately controlled, and surgical operation is optimized.

The present invention relates to the compound 2-hydroxy-octadecene-9-cis-oate for use in the treatment of oncological pathologies including grade IV glioblastoma with native IDH, grade 3 glioma, embryonal tumour, pituitary tumour, meningioma, haemangiopericytoma, haemangioblastoma, mesothelioma, bile duct adenocarcinoma, exocrine pancreatic cancer, neuroendocrine pancreatic cancer, rectal cancer, urachal cancer, adenocarcinoma of the bladder and oesophageal cancer, and for the treatment of neuropathic pain caused by diabetic peripheral neuropathy, spinal cord injury, post-herpetic neuralgia, chemotherapeutic agent, antitumour agent, cancer, fibromyalgia or hepatitis. The present invention also relates to the pharmaceutical composition comprising 2-hydroxy-octadecene-9-cis-oate.

The utility model relates to the technical field of drainage, and discloses a T tube capable of being placed quickly, the T tube comprises a T tube body, an adjusting assembly is arranged in the T tube body, in order to enable the T tube to be placed more quickly, when the T tube body is installed, the two ends of a transverse straight part of the T tube body are folded towards the center, and the T tube body can be placed more quickly. The guide line is pulled, the guide line moves in the limiting ring, and the end part of the guide line pulls the fixing ring, so that the tension of the guide line can enable the fixing ring to limit the fixing rod, the two ends of the transverse straight part of the T-shaped tube body can be well folded and limited, and the folded part of the T-shaped tube body is put into the bile duct; the guide line is slowly loosened, the elastic force of the transverse straight part of the T tube body is slowly released to be opened in the bile duct, in this way, the T tube body can be placed into the bile duct more quickly, and the guide line cannot be collected into the T tube body due to the arrangement of the limiting block.

The invention relates to the technical field of microfluidics, and discloses a biliary duct-containing bionic liver chip and application thereof. A central vein pool, a hepatic portal vein channel and a hepatic inherent artery channel are arranged on the surface of a substrate of the bionic liver chip; a bile duct / hepatocyte U-shaped channel; and a stellate cell channel A and a stellate cell channel B, according to the liver chip, bile duct cells and a biliary tract simulation structure used for collecting bile are added while the liver chip simulates the physiological structure of the liver, interaction between the liver cells and the gall cells can be achieved, an in-vitro liver system is more bionic, and therefore the liver chip can better serve related research of biomedicine; comprising liver disease modeling, drug toxicity detection, drug effect evaluation and the like.

The present invention discloses a degradable stent suitable for end-to-end anastomosis of bile ducts during liver transplantation, comprising a transverse stent assembly, a longitudinal stent assembly and a periodically degradable connecting assembly, a transverse tube body, a retaining net, a connecting sleeve, an end sleeve, an air-avoiding hole, a longitudinal tube body, a periodically degradable sleeve, and a periodically degradable filling block. Firstly, the transverse stent can achieve docking of donor bile ducts and recipient bile ducts of different diameters, thereby improving matching and applicability. The longitudinal stent can facilitate in vitro communication in the early stage of catheterization, thereby facilitating drainage and perfusion. Secondly, the periodically degradable sleeve and the periodically degradable filling block can be continuously degraded by the patient's body secretions and decompose after a certain period of time, thereby eliminating the docking between the transverse stent assembly and the longitudinal stent assembly, separating them, and facilitating the disassembly and removal of the longitudinal stent assembly. Finally, the grid structure of the retaining net can facilitate the accumulation of bioadhesives, thereby achieving the blocking of the retaining net. After the longitudinal stent assembly is separated from the transverse stent assembly, the transverse tube body in the transverse stent assembly is in a sealed state.