4 results about "Heparin coating" patented technology

The utility model relates to the technical field of ventricular septum perforation plugging devices, and discloses a novel ventricular septum perforation plugging device which comprises a fixing column and a first disc-shaped net arranged on the outer side of the fixing column, a connecting waist part is further arranged on the outer side of the fixing column, and the connecting waist part is connected with the first disc-shaped net. A second disc-shaped net is arranged on the side, away from the first disc-shaped net, of the connecting waist part, an end is arranged on one side of the second disc-shaped net, and before use, a small screw at the front end of a transmission steel cable is used for being connected with the end, so that the whole compressed plugging device can be transmitted to a heart defect part through a pipeline; the first disc-shaped net and the second disc-shaped net are used for blocking, the defect part can be blocked, the biological membrane can make contact with the heart defect part, the sealing performance is further improved, meanwhile, the polyurethane coating has certain flexibility, friction between the polyurethane coating and the heart defect part is effectively reduced, and the service life of the heart defect part is prolonged. The heparin coating can reduce the risk of thrombus formation, so that the use risk is reduced.

The invention relates to the technical field of medical instruments, in particular to a heparin coating based on material surface ammonification modification and a preparation method thereof, and the preparation method at least comprises the following steps: carrying out ultrasonic pretreatment on a base material with purified water, and drying for later use; the preparation method comprises the following steps: performing amination modification on a base material subjected to ultrasonic pretreatment by adopting an ammoniation reagent solution, and immersing the base material into a heparin solution to prepare the base material with a heparin coating on the surface. The surface of the material is subjected to amination modification by adopting a micromolecular ammoniation reagent and / or a macromolecular ammoniation reagent system, complex pretreatment such as plasma and ultraviolet rays does not need to be carried out on a base material, specific functional group activation does not need to be carried out on heparin, and the heparin is directly reacted after being subjected to ammoniation modification; the stable covalent grafted heparin anticoagulation coating can be formed, the anticoagulation time is prolonged, and the long-term implantation requirement is met.

Disclosed herein is a method of making a medical device comprising a covalently bonded heparin coating comprising a covalently bonded heparin coating on a substrate wherein the covalently bonded heparin coating is the reaction product of: (a) an isocyanate-containing material on or covalently bonded to the substrate; and (b) a heparin molecule selected from the chemical formula of the claims, said heparin molecule being subjected to a urethane formation reaction or a thiol-isocyanate click reaction with an isocyanate-containing material.

The present application relates to the technical field of medical stents, and discloses a heparin coating and a preparation method, a vascular heparin covered stent and a preparation method, the heparin coating is prepared by introducing a photo-reactive group on a heparin molecule through substrate pretreatment, heparin modification, ultraviolet light curing and other modes, and the process does not use toxic reagents; the vascular covered stent comprises a wavy spiral, a flexible and stretchable stent body, an inner stent cylinder film and an outer silk stent covered film, a coating is coated on the inner surface of the cylinder film and the outer surface of the covered film, the vascular environment of long-distance and repeated bending of lower limbs can be met, the heparin coating is firmly combined, has long-lasting anticoagulation, effectively inhibits thrombosis, and greatly improves the safety and service life of the stent.