10 results about "Heparin coating" patented technology

The utility model relates to the technical field of ventricular septum perforation plugging devices, and discloses a novel ventricular septum perforation plugging device which comprises a fixing column and a first disc-shaped net arranged on the outer side of the fixing column, a connecting waist part is further arranged on the outer side of the fixing column, and the connecting waist part is connected with the first disc-shaped net. A second disc-shaped net is arranged on the side, away from the first disc-shaped net, of the connecting waist part, an end is arranged on one side of the second disc-shaped net, and before use, a small screw at the front end of a transmission steel cable is used for being connected with the end, so that the whole compressed plugging device can be transmitted to a heart defect part through a pipeline; the first disc-shaped net and the second disc-shaped net are used for blocking, the defect part can be blocked, the biological membrane can make contact with the heart defect part, the sealing performance is further improved, meanwhile, the polyurethane coating has certain flexibility, friction between the polyurethane coating and the heart defect part is effectively reduced, and the service life of the heart defect part is prolonged. The heparin coating can reduce the risk of thrombus formation, so that the use risk is reduced.

This invention discloses an annular capsular bag for an intraocular lens (IOL), comprising a capsular body with a mitigation structure and a heparin coating. An IOL is implanted within this capsular body, and the IOL has a strip-shaped cap made of acrylic ester around its periphery. This invention uses the mitigation structure to block epithelial cells, preventing them from migrating towards the center of the IOL via the anterior and posterior surfaces, thus avoiding opacity in the central portion of the IOL and preventing vision loss, i.e., preventing secondary cataracts. Furthermore, the strip-shaped cap on the periphery of the IOL eliminates the need for additional fixation structures, simplifying the structure, reducing surgical steps, and accelerating the surgical process. Additionally, the heparin coating on the inner surface of the capsular body reduces the adhesion of the epithelial cells at the equatorial region of the annular capsular bag to the surface of the IOL, making them less prone to adhesion and facilitating subsequent IOL replacement.

The invention relates to the technical field of medical instruments, in particular to a heparin coating based on material surface ammonification modification and a preparation method thereof, and the preparation method at least comprises the following steps: carrying out ultrasonic pretreatment on a base material with purified water, and drying for later use; the preparation method comprises the following steps: performing amination modification on a base material subjected to ultrasonic pretreatment by adopting an ammoniation reagent solution, and immersing the base material into a heparin solution to prepare the base material with a heparin coating on the surface. The surface of the material is subjected to amination modification by adopting a micromolecular ammoniation reagent and / or a macromolecular ammoniation reagent system, complex pretreatment such as plasma and ultraviolet rays does not need to be carried out on a base material, specific functional group activation does not need to be carried out on heparin, and the heparin is directly reacted after being subjected to ammoniation modification; the stable covalent grafted heparin anticoagulation coating can be formed, the anticoagulation time is prolonged, and the long-term implantation requirement is met.

The invention discloses a preparation method of a silk conical artificial blood vessel with anticoagulation / endothelialization promotion functions, which comprises the following steps: preparing an artificial blood vessel for intracavity isolation through silk and polyester yarns, and successfully constructing a phosphorylcholine / heparin bionic functional coating on the surface of the blood vessel by using dopamine hydrochloride and hexamethylenediamine. According to the method, phosphorylcholine / heparin is combined with surface coating modification, and a novel intracavitary isolated blood vessel with excellent biological functions and mechanical properties is constructed. The structure of the artificial blood vessel is more matched with the shape of the inner wall of the blood vessel, blood flow distribution and tissue regeneration are facilitated, the anticoagulant property and endothelialization ability of the artificial blood vessel are effectively improved through the phosphorylcholine / heparin coating, protein adsorption and platelet activation can be remarkably reduced, the blood coagulation cascade reaction can be blocked, endothelial cell adhesion and proliferation can be accelerated, and the risk of acute thrombus after operation can be reduced. The method provides a new technical path for design and functionalization of the conical artificial blood vessel in the intracavitary isolation operation, and has important clinical application prospects.

The application provides a heparin coating density and shedding rate detection method based on a package, and relates to the technical field of heparin quantitative detection. The heparin coating density and shedding rate detection method based on the package comprises the following steps: S1, drawing a heparin concentration-delta absorbance standard curve by using the toluidine blue method; S2, measuring the dynamic circulation and shedding amount of the heparin coating in the package; S3, measuring the residual amount of the heparin coating in the package; and S4, calculating the heparin coating density p and the coating shedding rate F at each time point in the package n The application can more truly simulate the fluid environment in the extracorporeal circulation process, realizes accurate measurement, can deeply study the coating stability under the dynamic scouring environment, and provides more accurate and effective evaluation basis for the long-term stability and service life of the long package.

The invention provides a method for detecting the density and the shedding rate of a heparin coating based on a sleeve bag, and relates to the technical field of quantitative detection of heparin. The invention discloses a method for detecting the density and the shedding rate of a heparin coating based on sheathing. The method comprises the following steps: S1, drawing a heparin concentration-absorbance standard curve by adopting a toluidine blue method; s2, measuring the dynamic circulation impact shedding amount of the heparin coating in the sleeve bag; s3, measuring the residual quantity of the heparin coating in the kit; and S4, calculating the density rho of the heparin coating in the sleeve bag and the coating shedding rate Fn at each time point. The fluid environment in the extracorporeal circulation process can be simulated more truly, accurate measurement is achieved, the coating stability in the dynamic scouring environment can be deeply researched, and a more accurate and effective judgment basis is provided for the long-term stability and the service life of the long sleeve bag.

Disclosed herein is a method of making a medical device comprising a covalently bonded heparin coating comprising a covalently bonded heparin coating on a substrate wherein the covalently bonded heparin coating is the reaction product of: (a) an isocyanate-containing material on or covalently bonded to the substrate; and (b) a heparin molecule selected from the chemical formula of the claims, said heparin molecule being subjected to a urethane formation reaction or a thiol-isocyanate click reaction with an isocyanate-containing material.

The present invention relates to the field of medical devices, and in particular to a composite heparin anticoagulant coating and a preparation method thereof. The method comprises ultraviolet light pretreatment: performing ultraviolet light pretreatment on a substrate material to induce polyethyleneimine to be grafted onto the surface of the material; directional coating: coating the surface of the substrate material with a heparin solution and fixing it with an EDC solution; and changing the coating direction midway through the coating process. The present invention introduces amino chains onto the surface of the substrate material through ultraviolet light, resulting in a positive charge on the surface, which is then combined with ionic bonds to form a heparin coating. After coating, the coating is fixed with an EDC solution, and the coating direction is changed midway through the coating process, thereby improving the stability, uniformity, hydrophilicity, and anticoagulant properties of the coating.

The utility model provides a buckle type heparin cap which comprises a rubber cap and a locking lantern ring, the clamping end of the rubber cap comprises three clamping pieces which are arranged at intervals in a surrounding mode, a pipe clamp is defined by the three clamping pieces, and when the buckle type heparin cap is used, a connecting pipe can be inserted into the pipe clamp and meshed through the pipe clamp; meanwhile, a protrusion arranged on the outer wall of the connecting pipe slides into a groove formed in the inner wall of the pipe clamp, and the protrusion and the groove are clamped in a matched mode, so that the rubber cap and the connecting pipe are detachably clamped; the locking lantern ring is arranged outside the rubber cap in a sleeving mode so that the firmness of mutual clamping connection of the protrusion and the groove can be improved. A rubber plug is arranged at the connector end of the rubber cap, the interior of the rubber cap is coated with a heparin coating, and the risk of thrombosis and infection is prevented through the heparin coating; therefore, the bayonet type heparin cap which is convenient to pick, disassemble and assemble is constructed, so that the disassembly efficiency and success rate between the heparin cap and the remaining needle are improved, and the clinical working efficiency of medical staff is further improved.

The present application relates to the technical field of medical stents, and discloses a heparin coating and a preparation method, a vascular heparin covered stent and a preparation method, the heparin coating is prepared by introducing a photo-reactive group on a heparin molecule through substrate pretreatment, heparin modification, ultraviolet light curing and other modes, and the process does not use toxic reagents; the vascular covered stent comprises a wavy spiral, a flexible and stretchable stent body, an inner stent cylinder film and an outer silk stent covered film, a coating is coated on the inner surface of the cylinder film and the outer surface of the covered film, the vascular environment of long-distance and repeated bending of lower limbs can be met, the heparin coating is firmly combined, has long-lasting anticoagulation, effectively inhibits thrombosis, and greatly improves the safety and service life of the stent.