[Topic] To design transplant materials with performance and quality more suitable for clinical medical use, a method for preparing
transplantation model animals is provided, which enables a highly reliable and reproducible
transplantation experimental system. [Solution] The evaluation method of the present invention for
transplantation materials similar to
autologous transplantation enables the preparation of transplantation model animals similar to
autologous transplantation, which enables a highly reliable and reproducible transplantation
experimental system, by including the following steps: applying a crude extract of a donor expressing a marker to a newborn recipient to obtain a recipient immune to the aforementioned donor; and
transplanting transplantation material to the immune-tolerant recipient, wherein the transplantation material comprises an artificial transplantation material covered, adhered to, infiltrated, or contained in the tissue or cells of the donor expressing the marker.