194 results about "Skeletal muscle" patented technology

The invention relates to the technical field of medical rehabilitation, and discloses a lower limb weight-bearing gait rehabilitation training system which comprises a data acquisition module, a data processing and analysis module, a patient individualized modeling module, an intelligent decision and control module, a rehabilitation execution module and a man-machine interaction and medical information interface module which are in communication connection through a network. The data acquisition module is used for acquiring multi-modal data of a patient in real time, and the multi-modal data comprises static sign data, dynamic physiological parameters, kinematics and dynamics parameters and non-motion physiological and psychological state data; and the data processing and analysis module is used for carrying out preprocessing, feature extraction and deep analysis on the original data, and outputting a structured patient individualized feature vector and an evaluation result. According to the invention, a patient three-dimensional skeletal muscle digital twinborn model is constructed through the patient individualized modeling module, and in combination with a continuous learning intelligent model library, body sign differences of different patients can be accurately adapted.

The exemplified methods and systems facilitate the quantification of cardiac cycle-variability as a metric of signal quality of an acquired signal data set and the rejection, based on that quantification, of said acquired signal data set from one or more subsequent analyses that can predict and / or estimate a metric associated with the presence, non-presence, severity, and / or localization of abnormal cardiovascular conditions or disease, including, for example, but not limited to, coronary artery disease, abnormal left ventricular end-diastolic pressure disease (LVEDP), pulmonary hypertension and subcategories thereof, heart failure (HF), among others as discussed herein. The quantification of levels of cycle-variability assessed noise such as skeletal-muscle-related-signal contamination and muscle-artifact-noise contamination, and other asynchronous-noise contamination in an acquired signal can be subsequently used for the automated rejection of such asynchronous noise from measurements of biophysical signals.

The invention discloses application of an FGF9 gene in regulation and control of growth and development of chicken skeletal muscles, and further discloses application of an overexpression vector of the FGF9 gene or an interference fragment of the overexpression vector in promotion or inhibition of proliferation and differentiation of chicken myoblasts. The invention also discloses a specific primer pair for detecting the expression quantity of the FGF9 influencing the growth and development of the chicken skeletal muscle. The invention also discloses a detection kit and a detection method thereof. The detection kit provided by the invention can be used for detecting the expression quantity of the FGF9 gene in chicken muscle tissues and myoblasts, and the detection method is simple and quick. The FGF9 gene can be used as an important gene for researching a chicken skeletal muscle growth and development regulation theory.

The invention discloses an intelligent clothing design and template generation method and system, and relates to the technical field of clothing intelligent plate making, and relates to multi-physics field modeling, dynamic simulation, reverse optimization and iterative output technologys.The method comprises the steps that a biomechanical human body model containing skeletal muscle groups and a multi-physics field coupling model of initial clothing piece templates and fabric parameters are constructed; defining a target pressure curve; driving a human body to execute preset actions, and calculating a dynamic pressure field and a wrinkle discomfort index through explicit dynamics; constructing a loss function fusing the pressure goodness of fit and the wrinkle index, solving a gradient by using an adjoint method, and accelerating reverse optimization in combination with a physical information neural network agent model; the system comprises corresponding function modules, parameters can be automatically adjusted according to the motion posture, it is ensured that the dynamic pressure is always close to a target curve, and the functionality and comfort level of clothes are improved.

The invention discloses a CircSESN1 gene as well as an overexpression vector, a specific primer pair, a detection kit and application of the CircSESN1 gene. The invention also discloses application of the CircSESN1 gene, an overexpression vector, the specific primer pair or the fluorescent quantitative detection kit in regulation and control of growth and development of chicken skeletal muscle. The invention also discloses a method for inhibiting chicken myoblast proliferation and / or promoting differentiation. The detection kit provided by the invention can be used for detecting the expression quantity of the CircSESN1 gene in chicken muscle tissues and myoblasts, and the detection method is simple and quick. The gene can be used as an important non-coding RNA for researching a regulation theory of growth and development of chicken skeletal muscles.

This invention relates to the application of oridonin in the preparation of agents that improve muscle function, specifically by improving skeletal muscle dysfunction, enhancing insulin sensitivity, promoting myoblast differentiation into myotube cells, and / or increasing myoblast insulin sensitivity. Using an in vitro C2C12 myoblast model, this invention demonstrates that oridonin can promote myoblast differentiation and growth and increase C2C12 myoblast insulin sensitivity. Through an obesity-induced skeletal muscle dysfunction model, it is demonstrated that oridonin can improve skeletal muscle dysfunction and insulin resistance by increasing muscle strength, muscle endurance, muscle mass, and reducing muscle lipid accumulation. This invention provides new insights for drug research on improving skeletal muscle dysfunction and enhancing insulin sensitivity, and also enriches the pharmacological system of oridonin.

In a method for inducing differentiation into neuromuscular junctions according to the present disclosure, the neuromuscular junctions are induced by: preculturing human pluripotent stem cells in a medium containing activin, bFGF, a WNT signal inhibitor, a BMP signal inhibitor, and a ROCK signal inhibitor; then culturing the stem cells in a medium containing bFGF, a ROCK signal inhibitor, a WNT signal activator, and a TGFβ signal inhibitor to differentiate into neuromesodermal cells; culturing the neuromesodermal cells in a medium containing a BMP signal inhibitor, a TGFβ signal inhibitor, a retinoic acid activator, and an SHH signal activator to differentiate into skeletal muscle progenitor cells and spinal motor neuron progenitor cells in the same culture dish; and culturing these progenitor cells in a medium for cell maturation containing BDNF, GDNF, AA, and dbcAMP.

A phosphodiesterase type 5 inhibitor is used in the preparation of a medicament for resisting fibrotic diseases. Experiments in animal models of ischemia-reperfusion (UIRI)-induced renal fibrosis, unilateral ureteral obstruction (UUO)-caused kidney fibrosis and idiopathic pulmonary fibrosis show that a PDE5 inhibitor such as tadalafil, sildenafil and vardenafil can significantly inhibit the expression of multiple fibrosis iconic proteins such as fibronectin, collagen I, renal injury molecule-1, and α-skeletal muscle actin in UIRI and UUO renal fibrosis lesions, improves glomerulopathy, degree of renal tubular distension, renal interstitial collagen fiber deposition and inflammatory cell infiltration, reduces the fibrotic area within the lesion, and significantly inhibits the progression of renal fibrosis; and the PDE5 inhibitor can significantly improve smooth muscle proliferation and inflammatory cell infiltration in bronchioles and pulmonary arterioles of idiopathic pulmonary fibrosis lesion, improve damage condition of alveolar tissue, and significantly inhibit the progression of pulmonary fibrosis.

The present invention addresses the problem of defining physiological significance and functions such as the influence of nicotinamide mononucleotide (NMN) contained in breast milk on the development of children. A composition for improving the athletic ability of a child is provided comprising a precursor of NAD. The improvement in athletic ability is preferably any one selected from the group consisting of promotion of skeletal muscle development and improvement in activity. A composition for reducing triglyceride levels in the blood of a child is provided comprising a precursor of NAD. A composition for reducing the blood glucose level in a child is provided comprising a precursor of NAD. A composition for inhibiting fat accumulation in children is provided, comprising a precursor of NAD.

Systems, methods, devices, and computer programs for generating personalized fitness programs are disclosed. One aspect comprises a method including inducing a release of a protein expression into the body, measuring a force generated by the body utilizing over ninety percent of skeletal muscle to generate the force, determining a force metric based on the force generated in relation to a parameter of the body, identifying a target force metric based on at least one user identified target metric, measuring at least one physical metric of the body, generating personalized training regimen based on the determined force metric and the at least one identified target metric, the developed training regimen configured to maximize conversion of type 1 muscle cells to type 2b muscle cells, and wherein the personalized training regimen is designed to be implemented by the body while the protein expression is present in the bloodstream of the body.

The application relates to a compound medicine for delaying skeletal muscle aging and application thereof, and the medicinal active components in the compound medicine composition are composed of menadione bisulfite sodium and N-acetyl cysteine, and belong to the technical field of biological medicine. A novel drug combination mode is developed, an oxidant menadione bisulfite sodium (MBS) and an antioxidant N-acetyl-L-cysteine (NAC) are combined and given in different time periods to regulate the H2O2 circadian rhythm of the skeletal muscle of old mice, the changes of the muscle strength, histopathology and aging marker protein level of the skeletal muscle of the old mice are detected, and then the precise compound medicine capable of improving the skeletal muscle function of the old mice and delaying skeletal muscle aging is determined. The application provides an effective drug combination strategy for relieving or treating the delay of skeletal muscle aging, and has very significant meaning.

The application discloses an integrin-reformed specific heart and muscle targeting AAV9 dominant mutant. The application provides an adeno-associated virus capsid protein, which comprises a targeting peptide containing an amino acid sequence as shown in any one of SEQ ID NO: 1-28. According to the RGD sequence binding with integrin, the polypeptide specific binding principle, the random amino acid carrying and the construction of the diversified AAV capsid library, and the high-throughput screening of the AAV with the suitable capsid structure, the application successfully obtains a new adeno-associated virus vector with high heart and / or muscle transduction efficiency, and the new adeno-associated virus vector exhibits better heart and / or skeletal muscle targeting and transduction efficiency in an animal model, and the off-target expression in non-target tissues is significantly reduced, and the new adeno-associated virus vector has important scientific value and commercial prospect.

The application belongs to the field of food processing and biomedical technology, and discloses a preparation method of a salty taste enhancing peptide-naringenin compound and application of the compound in improving cognitive decline. The compound is prepared by compounding salty taste enhancing peptides from soft-shelled turtle eggs and naringenin at a ratio of 20-150:1 (w:w). The preparation process comprises the following steps: soft-shelled turtle egg enzymolysis, ultrafiltration, freeze-drying to obtain salty taste enhancing peptides, mixing the salty taste enhancing peptides with a naringenin solution, concentration, and freeze-drying. The compound has good stability, salty taste enhancing and antioxidant activities, can reduce the use of salt and maintain salty taste. The compound can improve cognitive decline and anxiety caused by aging and diabetes, improve autonomous activity, memory and social skills, strengthen physical fitness, protect nerve cells and skeletal muscles, maintain brain tissue health, and can be applied to the preparation of related preparations for improving cognitive decline.

The present application relates to a method for preparing skeletal muscle organoids, comprising the steps of: inducing paraxial mesoderm stem cells (PMSCs) by directly differentiating human pluripotent stem cells (hPSCs); forming the paraxial mesoderm stem cells in a 3D shape, and then culturing same in a medium; inducing the proliferation of the paraxial mesoderm stem cells; and inducing the maturation of the paraxial mesoderm stem cells.

To provide a novel method for treating dystrophinopathy and / or a disease condition associated therewith.SOLUTION: A composition for use in treating dystrophinopathy and / or a disease condition associated therewith, the composition comprising cardiosphere-derived cells (CDCs) and / or CDC-derived exosomes.SELECTED DRAWING: Figure 4A

The invention belongs to the technical field of biological medicines, and particularly relates to application of miR-206-3p in regulation and control of skeletal muscle atrophy, and the change condition of the miR-206-3p level is measured by constructing an in-vitro cancer cachexia myotubular atrophy model; it is verified that in-vitro addition of miR-206-3p mimics relieves in-vitro myotube atrophy induced by a cancer conditioned culture medium, inhibits expression of a myotube marker gene and inhibits proteolysis and metabolism pathways and cell apoptosis of myotubes, so that myotube atrophy induced by cancer cachexia is inhibited. The invention opens up a new thought for the research of cachexia pathogenesis, and also provides a potential new target for the research and development of cachexia treatment and / or cachexia prevention drugs.

The invention belongs to the technical field of biological medicine, and particularly relates to application of LRRFIP1 serving as a bilberry extract to improvement of a target spot of insulin resistance of gestational diabetes mellitus. The insulin resistance of gestational diabetes mellitus is improved by specifically regulating and controlling a PI3K-AKT signal channel and a GLUT4 glucose transporter function in skeletal muscle based on the bilberry extract. The bilberry extract used in the invention is a natural plant source, is high in safety, and is suitable for pregnancy. PI3K-AKT signal channels can be activated at the same time, and insulin resistance and lipid metabolism disorder can be synergistically improved. The action mechanism is systematically illuminated through technical means such as proteomics, network pharmacology, molecular docking and the like. Glucose tolerance, insulin sensitivity and blood fat level of GDM rats can be remarkably improved, and no remarkable side effect exists.

The invention belongs to the technical field of microorganisms, and discloses clostridium butyricum ML5358 and application thereof.The clostridium butyricum ML5358 provided by the invention has the preservation number of CGMCC No.37000. The strain can effectively relieve mouse colitis induced by DSS and remarkably reduce expression of colon tissue inflammatory factors Il-6 and Il-1beta, and the preservation number of the clostridium butyricum ML5358 is CGMCC No.37000. The clostridium butyricum ML5358 is CGMCC No.37000. The clostridium butyricum ML5358 is CGMCC No.37000. In addition, skeletal muscle lipid metabolism can be regulated and controlled through the intestine-muscle axis, expression of fat synthesis and uptake related genes Srebf1, Acc1 and Fabp4 is specifically up-regulated, the content of intramuscular triglyceride is remarkably increased, and intramuscular fat deposition is promoted. According to the clostridium butyricum ML5358 and the application thereof, the functional limitation of traditional clostridium butyricum is broken through, and a new strain resource is provided for developing a novel microbial preparation or a feed additive capable of improving intestinal health and improving livestock and poultry meat quality.

The present application relates to the technical field of livestock feed, and particularly relates to a feed for improving muscle growth of broilers and application of a molecular marker (His-Thr-Gln-Glu) of the feed in cells, and provides a molecular marker for regulating animal skeletal muscle, and an amino acid sequence of the molecular marker is His-Thr-Gln-Glu, and the molecular marker can be applied to preparation of a product for regulating animal skeletal muscle as a target.

The invention discloses a dance posture optimization system based on real-time monitoring, and relates to the field of dance training and sports health. The system comprises the following components: a data acquisition and digital twinborn construction module, a real-time monitoring and load analysis module, a damage early warning and evaluation module, a safety substitution action generation and optimization module and an interactive feedback and collaborative management module. According to the method, the action data of the dancer is monitored in real time, the digital twinborn body and the skeletal muscle dynamics model are combined, the load condition of each part of the body of the dancer can be accurately simulated, and when the load data exceed the biomechanical limit parameters which are set in a personalized mode, the system can immediately give out early warning and point out the damaged part and the damage type; the real-time feedback mechanism helps the dancer to adjust actions in time, potential sport injuries are avoided, and meanwhile, the system can generate a safe alternative action scheme according to the physical condition and the training target of the dancer.

The present invention discloses 7-azaindole compounds, their preparation methods, and their uses, which belong to the field of drug synthesis. The present invention particularly relates to 7-azaindole compounds containing pyrazole or indole substitutions represented by general formula (I), as well as their preparation methods and pharmaceutical uses. The compounds of the present invention alleviate cancer cachexia skeletal muscle atrophy by inhibiting the ActRIIB protein in the MSTN pathway, thereby achieving significant anti-cancer cachexia effects. Experimental results show that the compounds have good anti-cachexia activity and can therefore be further used to prepare novel anti-cachexia drugs. TIFF2025537427000068.tif3144

The invention relates to a preparation method of a pharmaceutical active molecule Azurimoline. According to the present invention, the brand new synthesis method is adopted, and comprises the selective metal-catalyzed Suzuki coupling reaction, the formylation reaction and the condensation reaction, such that the synthesis of the Azaurein can be achieved, and the total yield can be increased to 32.3%. The method is simple in route, the yield is greatly improved compared with that of a traditional method, and efficient and high-selectivity synthesis of Azurimulin is achieved. The novel and efficient preparation method of the pharmaceutical active molecule skeletal muscle relaxant Azumolene and the key intermediate of the pharmaceutical active molecule skeletal muscle relaxant Azumolene is more suitable for industrial production.

The invention relates to a handheld integrated skeletal muscle function evaluation system and method and electronic equipment, and the system comprises a handheld host which comprises a handheld body, a contact end and an indentation end, and is used for collecting at least one of a contact force signal, a joint angle signal and an indentation load signal which are acted on the handheld host by a user; the measuring host is in communication connection with the handheld host, and the measuring host measures at least one of the local mechanical property of the human skeletal muscle, the relation between the passive stress and the joint angle and the active force generation capacity according to at least one of the contact force signal, the joint angle signal and the indentation load signal. Therefore, the problems that results are difficult to decouple, the interpretability is poor, information of whole joints and local tissues cannot be taken into consideration, biomechanical properties and states of skeletal muscles are difficult to comprehensively reflect, laboratory-level equipment is high in cost, the process is complex, bedside application is difficult and the like due to the fact that indexes are single, different devices are needed and the influence of operators is large in the prior art are solved.

The present invention relates to the effect of promoting muscle development and growth through inhibition of the expression of MRF4. According to the present invention, MRF4 isolated and identified from skeletal muscles of Nile tilapia showed a strong association with MyoG and MEF2 proteins, and the expression of MyoG and MEF2 was found to significantly increase when the MRF4 gene was disrupted through CRISPR / Cas9 gene editing, and thus the present invention has the effect of being able to be used for the promotion of muscle development or the treatment of muscle diseases through the inhibition of the MRF4 gene.

The invention belongs to the technical field of medical data mining and rehabilitation evaluation, and provides a skeletal muscle spasm-to-contracture evolution rule quantitative analysis method and system and application, and the method comprises the steps: preprocessing spasm contracture time sequence data, and obtaining one-dimensional feature vector data; k-means clustering is carried out, state labeling of spasm and contracture is carried out, and clustering labels are obtained; determining the change rate of the torque characteristic and the adjacent angular velocity characteristic, and generating an eight-bit pseudo-sequential sequence representing the evolution rule from the spasm state to the contracture state in combination with a state transition threshold value determined by an ROC curve; constructing a Markov chain model to calculate a transition probability matrix from a spasm state to a contracture state, and identifying torque as a key driving feature of state evolution through grouping risk ratio; and constructing a dynamic correlation model based on the key driving features to complete quantitative analysis of the evolution rule from skeletal muscle spasm to contracture. According to the method, objective division from skeletal muscle spasm to contracture state can be realized, and the transition probability and key driving factors between the skeletal muscle spasm and the contracture state can be excavated.

The invention provides a hydrogel-biological sponge composite material as well as a preparation method and application thereof, and belongs to the technical field of biological materials. The drug-loaded hydrogel is adopted to load the anti-inflammatory drug, inflammation caused by skeletal muscle injury is relieved, and the skeletal muscle healing process is promoted; a defect area is rapidly filled, and muscle-derived stem cell differentiation and muscle fiber formation are promoted; a topological structure of a skeletal muscle extracellular matrix is highly simulated by adopting biological sponge, muscle cells are effectively guided to be directionally arranged along fibers, and further myotube fusion and differentiation are promoted; the specific surface area is larger, sufficient living space is provided for cells, and adhesion and proliferation of the cells are facilitated; the biological sponge is good in mechanical property, so that the prepared hydrogel-biological sponge composite material is good in supporting property, and skeletal muscle repair is facilitated.

The present invention relates to methods of improving muscle function in a subject suffering from a disease or condition in which muscle function is impaired, the method comprising administering an effective amount of, an inhibitor of FGFR3 signaling, an NPR-B agonist or an NPR-C agonist to said subject.

The invention relates to the technical field of artificial dermis, in particular to a preparation method and application of artificial dermis based on bionic acellular matrix. The artificial dermis comprises a bionic acellular matrix component A and an auxiliary material component B, wherein the component A comprises type I collagen, type VI collagen, elastin, fibronectin, laminin, mother cell protein and glucan; the component B comprises antibacterial peptide, antibiotics and a high-molecular polymer material; the mass ratio of the component A to the component B is (4-6): (1-4). The preparation method comprises the following steps: respectively preparing procedure mother liquor of the component A and the component B, preparing hydrogel with a double-layer gradient structure through step-by-step crosslinking, and then carrying out freeze drying and sterilization treatment. The artificial dermis disclosed by the invention has good biocompatibility and antibacterial property, can effectively promote wound healing, is suitable for repairing acute and chronic wounds of four limbs, faces and trunk parts, and is particularly suitable for repairing complex wounds with exposed bones, tendons, nerves and blood vessels.

The invention relates to the technical field of medical health, in particular to an intelligent evaluation and intervention system for muscle quality of a patient with advanced solid tumors. The multi-dimensional dynamic evaluation unit is used for forming the extracted somatic cell mass, the score of the anorexia-cachexia syndrome, the standardized skeletal muscle index and the average muscle radiation attenuation value into multi-dimensional feature data, and the multi-dimensional dynamic evaluation unit is used for evaluating the quality of the somatic cells on the basis of the multi-dimensional feature data and fusing tumor treatment scheme data. Generating a multi-dimensional muscle health index and a malignant fluid risk probability through a decision tree model, and dividing patients into different risk levels; and the intervention strategy generation unit is used for outputting a comprehensive intervention scheme based on the multi-dimensional muscle health index and the malignant fluid risk probability in combination with the real-time tolerance data and the risk level of the patient. According to the system, the L3 level skeletal muscle index and the muscle radiation attenuation value can be extracted more accurately and stably, manual annotation and manual variation are reduced, and the reliability of image quantification is improved.

The invention discloses a screening method of skeletal muscle senescence markers, clock construction and a kit, and belongs to the technical field of biomedical engineering. The method comprises the following steps: acquiring multi-modal biomarker data of an individual, wherein the multi-modal biomarker data comprises an inflammatory marker, a metabolic marker, a hormone marker and a muscle function marker; inputting the data into a trained skeletal muscle biological age prediction model to obtain skeletal muscle biological age (SMBA); based on the skeletal muscle biological age (SMBA), screening out a specific methylation site set related to the skeletal muscle senescence state from the methylation sites of the whole genome; constructing a methylation aging clock model by using methylation data of the site set; and finally, accurately predicting and evaluating the skeletal muscle senescence state of an individual by using the model. According to the invention, conversion from multi-modal clinical indexes to specific single-dimensional molecular markers is realized, and the constructed senescence clock model and derivative products can be used for personalized evaluation and early risk early warning of skeletal muscle senescence.