13 results about "Limonoid" patented technology

The invention discloses a limonin compound and application thereof in preparation of a medicine for preventing and / or treating cancers. The structure of the limonin compound is shown as a formula I or II. The cancer is at least one of breast cancer, liver cancer, gastric cancer, esophageal cancer, leukemia, pancreatic cancer, glioma, osteosarcoma, prostatic cancer, nasopharynx cancer, cervical cancer, ovarian cancer, kidney cancer and skin cancer. According to the invention, activity screening is carried out on various natural product extracts, it is found for the first time that limonin compounds with structural formulas I and II have excellent inhibitory activity on various different types of human cancer cells, and an optional scheme is provided for broad-spectrum anti-cancer drugs. Related results also show that the compound provided by the invention can inhibit migration and invasion ability of breast cancer cells, promote cell apoptosis and retard a cell cycle. The limonin compound applied in the invention is derived from mallotus oblongifolius, the source is wide, and the production cost is low.

The invention relates to the field of natural products, and relates to application of limonin compounds or medicinal derivatives thereof in preparation of medicines for preventing or treating inflammation. The inventor of the invention finds for the first time that the compound I or the compound II extracted and separated from the mallotus oblongifolius can significantly inhibit the content of inflammatory factors of immune cells at an extremely low concentration, and can be used for preparing medicines for preventing or treating inflammation. Besides, the compound I or II can significantly reduce the expression level of LPS-induced inflammatory factors TNF-alpha, IL-1alpha, IL-1beta, IL-6 and IL-18 at a low concentration, and does not affect the survival of immune cells, which proves that the compound I or II can inhibit the expression of inflammatory factors and has a strong anti-inflammatory effect.

The invention discloses a compound with an anti-inflammatory effect in Enshi Sichuan amur corktree, separation and application, and belongs to the technical field of medicines. The invention particularly discloses a compound which is separated from Enshi chuan amur corktree and has an anti-inflammatory effect, a separation preparation method and application. Researches prove that the compound has an inhibition effect on the expression of inflammatory factors IL-1beta and IL-17A, can inhibit the generation and secretion of an inflammatory factor IL-6 in Th17 cells, can reduce the expression level of Caspase-1 and NLRP3 proteins in colon tissues of mice, and can reduce the inflammatory response of ulcerative colitis of DSS modeling mice in a dose-dependent manner. The compound (limonin compound) with the anti-inflammatory effect in Enshi Huangchuan amur corktree can be used as a lead compound for development of anti-inflammatory drugs, and is of great significance to comprehensive utilization and development of Enshi Huangchuan amur corktree.

The present invention relates to a novel method for obtaining the limonoid compounds of Formula IIa or IIb, and / or one or more esters and / or derivatives thereof, by culturing plant cells in a cell culture and recovering said compounds from said cells and / or cell culture. In one embodiment of the method the plant cells are obtained or originate from an explant / s of the corresponding plant. The present invention also relates to cell products of the method and the use of said products and compounds.

Disclosed herein are methods of glucosylating limonoid compounds and / or flavonoid compounds, and / or otherwise reducing levels of limonoid compounds and / or flavonoid compounds in compositions, as well as methods of reducing off-flavor in a food product / precursor. Further disclosed are compositions (i) comprising one or more glucosylated limonoid compounds and / or glucosylated flavonoid compounds, or (ii) otherwise comprising less limonoid compounds and / or flavonoid compounds, such as a food product / precursor.

The invention provides a preparation method of orange aromatic vinegar. The preparation method comprises the following steps: debitterizing green orange juice, preparing green orange wine mash, preparing orange vinegar fermentation liquor, clarifying the orange vinegar fermentation liquor, and ageing the orange vinegar fermentation liquor. In the green orange juice debitterizing step, a debitterizing agent composed of limonin dehydrogenase, limonin epoxidase and modified activated carbon according to the mass ratio of (3-5): (1-3): (10-15) is added, limonin is effectively removed, and the taste of the orange aromatic vinegar is improved. In the step of preparing the orange vinegar fermentation liquor, the immobilized acetobacter aceti is added, so that the acetobacter aceti is not easy to lose along with the fermentation liquor, the utilization rate of thalli and the fermentation stability are improved, relatively high thalli concentration and activity can be kept, and the fermentation period is shortened. In the step of ageing the orange vinegar fermentation liquor, a bamboo barrel is used for ageing, and the bamboo barrel has good air permeability, so that trace oxygen exchange of the orange vinegar fermentation liquor in the ageing process is facilitated, further fusion and development of flavor components in vinegar are promoted, and the flavor of the orange vinegar is more mellow and harmonious.

The invention discloses a series of limonin compounds as well as a preparation method and application thereof. According to the invention, two limonin compounds, namely, methyl kihadanin D and kihadanin D, are extracted and separated from dried root bark of dictamnus dasycarpus, wherein the methyl kihadanin D is a limonin compound with a novel structure. The anti-inflammatory effect of the monomeric compound is evaluated by adopting LPS-induced RAW264.7 cell NO release, and the two compounds are proved to have an obvious inhibiting effect on NO release and have a great application prospect as a potential anti-inflammatory drug.

The invention discloses medicinal granules based on active ingredients of citrus and a preparation method of the medicinal granules. According to the method, active ingredients such as flavonoid compounds, alkaloid compounds and limonin compounds are effectively extracted. The citrus peel is rich in flavonoid compounds, such as hesperidin, naringin and the like. The compounds have an anti-oxidation effect and can be used for removing free radicals in a body, so that diseases caused by oxidative stress are reduced. The alkaloid compound has anti-inflammatory, antibacterial, antiviral and other biological activities, can enhance the function of an immune system, and helps to resist diseases. The limonin compounds comprise limonin, naringenin and the like. The limonin compounds have the biological activities of regulating blood sugar, reducing blood fat and the like, and in the medicinal granules, the limonin compounds can play the roles of reducing blood sugar and blood fat and improve the drug effect of drugs.

The present invention is directed to a process for obtaining phragmarin derivatives of formula 1a, e.g. from Entandrophragma caudatum seed extract, formula (1a), in multiple steps to produce therapeutically effective limonoids and limonoid-type compounds therefrom, e.g. compounds of formula (V), together with intermediate products, e.g. of formula (III).

The present application relates to the field of natural medicine, and more particularly to a limonoid compound derived from the small alligator pear and a preparation method thereof, the limonoid compound having one of the structures of Munropin G, Munropin H, Munropin I, Munropin J, Munropin K and Munropin L. The limonoid compound extracted from the small alligator pear shows specific inhibition effect on colon cancer cells, and is obviously superior to the inhibition effect on other types of tumor cells, so that the limonoid compound extracted from the small alligator pear is expected to be developed into a new drug for treating colon cancer.

The invention relates to the field of natural medicines, in particular to a limonin compound as well as a preparation method and application thereof. The invention provides a limonin compound which has a structure as shown in any one of compounds 1-8, and data of the embodiment shows that the limonin compound provided by the invention can inhibit assembly of NLRP3 inflammasomes by inhibiting ASC oligomerization, so that generation and release of downstream inflammatory factors are reduced, and an anti-inflammatory effect is achieved.

The present invention relates to a method for obtaining a phrgamalin derivative of formula (Ia), e.g., from an extract of Azadirachta caudate seed, and thereby producing therapeutically active limonin analogs and limonin-based compounds, such as, e.g., a compound of formula (V), in a multi-step synthesis involving, e.g., an intermediate of formula (III). # imgabs0 #

This invention relates to the field of natural medicines, and particularly to a limonin compound, its preparation method, and its application. This invention provides a limonin compound having the structure shown in any of compounds 1-8. Data from the examples show that the limonin compound provided by this invention can inhibit the assembly of the NLRP3 inflammasome by inhibiting ASC oligomerization, thereby reducing the generation and release of downstream inflammatory factors and exerting an anti-inflammatory effect.