The invention belongs to the technical field of natural product extraction from oranges, and specifically relates to a method for continuously extracting natural activated products such as synephrine, hesperidin and limonin from physiological orange drops. The method comprises the following steps: using orange drops which are dried and crushed into 20-100 meshes as raw materials, adding 50-90% ethanol according to a weight/volume ratio of (1:10)-(1:50), extracting under reflux at 40-80 DEG C for 1-3 hours, filtering, recovering ethanol from the filtrate, and obtaining a concentrated solution for later use; adding a small number of chloroform crystals into the concentrated solution, adding water for layering, directly heating the water layer to 75 DEG C, filtering, adding 0.1mol/L hydrochloric acid to regulate the pH value to 3-4, and precipitating to obtain a hesperidin crude product; carrying out spin drying on the obtained chloroform layer solution, adding a right number of acetone crystals, and carrying out vacuum drying to obtain a synephrine crude product; and carrying out spin drying on the acetone solution after the crystal filtration, adding dichloromethane for dissolution, filtering, adding isopropanol into the solution according to a volume ratio of 1:2, and crystallizing to obtain a limonin crude product. Qualitative and quantitative analysis are carried out on the three resulting activated products through high-pressure liquid chromatography, and the result shows that the hesperidin has the highest purity (91.41%).