38 results about "Limonin" patented technology

The application discloses a multi-process cooperative orange peeling and juicing pretreatment machine and a pretreatment method. The machine comprises a rack, a controller installed at the upper end of the rack, and a pretreatment mechanism arranged in the rack. The pretreatment mechanism comprises a feeding assembly, a cutting and flattening assembly, a separating assembly, and a discharging assembly. The feeding assembly is used for guiding and conveying oranges to the upper end of the discharging assembly. The cutting and flattening assembly is driven by a servo motor and is provided with a cutting member and a flattening member perpendicular to each other, which are used for cutting and flattening the oranges, respectively. The separating assembly is used for cutting and separating the peel and the pulp of the flattened oranges. The discharging assembly is used for collecting the first-pressed juice generated in the flattening process and the separated peel and pulp. The four processes of feeding, cutting, flattening, and separating are cooperatively matched, the integrated pretreatment of orange peeling and first-pressed juice collection is realized, the entry of bitter substances such as limonin into the orange juice caused by juice pressing with peel is effectively avoided, and the taste quality of the orange juice is improved.

The invention relates to application of limonin as a pesticide synergistic aid in prevention and control of corn pests, which utilizes the characteristic that low-concentration limonin has a remarkable synergistic effect on chemical pesticides, 0.5-4g / mL limonin, 5% chlorantraniliprole and 25% thiamethoxam are mixed for use, so that the lethal medium concentration (LC50) of the limonin to corn borers, corn aphids and rhopalosiphum padi can be remarkably reduced; the insecticidal effect of chlorantraniliprole on corn borer and the insecticidal effect of thiamethoxam on aphid are improved. A field pesticide effect test also shows that the field prevention and control effect of the pesticide on Lepidoptera pests such as ostrinia nubilalis is remarkably improved by mixing 4 g / mL of limonin and 5% of chlorantraniliprole, the actual field dosage of chemical pesticides is reduced, the purposes of pesticide reduction and synergism are achieved, and a positive effect is achieved on comprehensive prevention and control of the field pests.

The invention provides a screening method and application of external traditional Chinese medicine anti-psoriasis active ingredients, and relates to the technical field of modern research of traditional Chinese medicines. According to the screening method disclosed by the invention, components with transdermal ability and anti-psoriasis activity are systematically excavated and screened from a traditional Chinese medicine complex system through preparation of a traditional Chinese medicine transdermal sample solution, UPLC-Q-TOF-MS component identification, network pharmacological analysis, molecular docking prediction and HaCaT psoriasis cell model verification in sequence. The method solves the problems that the traditional Chinese medicine transdermal components are unclear in pharmacodynamic material basis and low in screening efficiency, and has the advantages of being high in systematicness, high in accuracy and good in pertinence. According to the method, a plurality of effective components such as dictamnine and limonin are successfully screened from the cortex dictamni, and a clear pharmacological basis is provided for research and development of the cortex dictamni externally applied anti-psoriasis medicine.

The present invention discloses a citrus seed oil rich in limonin and a defatted citrus seed meal and their preparation methods and applications. The present invention uses the crude oil obtained from citrus seeds to re-extract limonin from citrus seed residues to obtain a defatted citrus seed meal. At the same time, the refined finished oil is rich in limonin, has nutritional and health care effects, and has a characteristic lemon-like aroma. The present invention directly uses the crude oil as an extraction agent, with a simple process, without adding exogenous functional components, without the aid of organic solvents, being green, safe, efficient, and more suitable for industrial production. The prepared citrus seed oil rich in limonin has application prospects in medicine, health food and / or beauty products. At the same time, the defatted citrus seed meal has the application potential as a feed raw material or additive.

The invention discloses application of limonin in preventing and treating bacterial wilt of cigars. According to the method, limonin is applied by adopting a foliar spraying method, so that the relative control effect of cigars on bacterial wilt can be remarkably improved, and the morbidity of the bacterial wilt of cigars is reduced.

The invention discloses a preparation method and application of an enzyme preparation for enzymatically hydrolyzing bitter substances in citrus juice. Using Aspergillus tabingensis UA13 isolated in the early stage of the laboratory and mutagenized by atmospheric and room temperature plasma (ARTP) as the starting strain, limonin in lemon peel powder is used as an inducer to induce enzyme production, and the fermentation enzyme production process of the strain and the substrate affinity of the enzyme are studied. The results show that: in a 1 L fermentor medium, under the optimal conditions of limonin addition amount of 4.0 mg / L, inoculation amount of 10% (v / v), initial pH value of 5.0, stirring speed of 250 rpm, and fermentation at 30 °C, the highest limonin debittering enzyme activity can reach 48.52 U / mL. The results of the study on the substrate affinity of the enzyme for limonin show that the Km value of the limonin debittering enzyme for limonin is 0.622 mmol / L, indicating strong affinity. At the same time, the enzyme can still efficiently hydrolyze other bitter substances such as naringin and hesperidin, has good heat resistance and acid resistance, and has very good application effects in the citrus juice processing industry.

The invention relates to the technical field of tea processing, in particular to a method for preparing special tea through compound fermentation of pansy petals and bergamot fresh leaves and application of the special tea. According to the method, the pansy petals and the bergamot fresh leaves are mixed according to a specific proportion, synergistic fermentation is performed in a high-pressure CO2 environment, and aromatic substances, anthocyanin and flavonoid compounds in the pansy petals are fully combined with citrus aromatic substances and active ingredients in the bergamot leaves by accurately controlling parameters such as temperature, humidity and CO2 concentration. The prepared tea product has the flower fragrance of the pansy and the citrus fragrance of the bergamot, is orange red and bright in soup color, is rich in nutritional ingredients such as anthocyanin, flavonoid, limonin and vitamin C, and has the effects of tranquilizing and allaying excitement, resisting oxidation, promoting digestion and relieving anxiety. The invention also relates to application of the tea product in the fields of food, health care products and cosmetics.

The invention relates to a protein feed produced by fermenting citrus peel residues as well as a preparation method and application of the protein feed. The preparation method of the protein feed produced by fermentation of the citrus peel residues comprises the following steps: (1) performing microwave enzyme deactivation on the citrus peel residues, drying to obtain dried citrus peel residues, and uniformly spraying fermentation promoting liquid on the dried citrus peel residues to obtain citrus peel residues containing a fermentation promoter; and (2) carrying out anaerobic fermentation on the citrus peel residues containing the fermentation accelerant, then turning piles, humidifying, and carrying out second-stage fermentation to obtain the high-protein feed. The protein feed prepared by the preparation method disclosed by the invention can reduce the pollution of ecological environment, improve the utilization rate of citrus, effectively improve the protein content, reduce the contents of substances such as naringin, limonin and citrus essential oil in the citrus pomace, and is beneficial to the health of animals.

The invention relates to a fruit extract preparation process based on enzymolysis and ultrasonic synergistic treatment, which comprises the following steps: S1, crushing citrus pomace, drying, sieving, adding cellulase, pectinase, beta-glucosidase and deionized water, uniformly stirring, adjusting the pH value, and carrying out enzymolysis at a constant temperature to obtain a mixture; s2, cooling the mixture, carrying out ultrasonic treatment, then heating for enzyme deactivation, centrifuging, and collecting supernate to obtain a crude extract; and S3, adsorbing the crude extract through adsorption resin, eluting, concentrating, crystallizing and drying to obtain the extract. The preparation process provided by the invention has relatively high limonin extraction rate and purity.

The invention provides application of five bitter substances in evaluation of bitter degree of hericium erinaceus and an evaluation method, and belongs to the technical field of quality monitoring. The invention provides application of five bitter substances, namely Limonin, Picrasin b, Fissinolide, Pristimulin and Samaderin a, in evaluating the bitter degree of the hericium erinaceus, the five bitter substances in the hericium erinaceus to be evaluated are extracted and separated, the content of the five bitter substances is detected, and the bitter degree of the hericium erinaceus is evaluated according to the correlation between the content of the five bitter substances and the bitter value of the hericium erinaceus. According to the method, the content of the five bitter substances and sensory evaluation are subjected to conjoint analysis, the correlation between the content of the five bitter substances and the bitter degree of the hericium erinaceus is confirmed, and a simple, convenient and scientific basis is provided for evaluating the bitter degree of the hericium erinaceus.

The invention discloses a quality detection method of smoked plum granules for stopping and benefiting, and belongs to the technical field of quality detection of traditional Chinese medicines. The method comprises the following steps: identifying a characteristic spectrum; the method comprises the following specific steps: (1) respectively preparing a hyperoside reference substance solution, a coumarin reference substance solution, a lobetyolin reference substance solution, a cinnamic acid reference substance solution, a psoralen reference substance solution, an isopsoralen reference substance solution and a limonin reference substance solution; (2) preparing a test solution from the smoked plum granules; and (3) respectively carrying out liquid chromatography detection on the seven reference substance solutions and the test solution. The quality detection method disclosed by the invention is high in accuracy, strong in specificity and reliable in detection result, realizes effective control on the quality of the smoked plum granules, is suitable for modern production requirements, and has important significance on quality detection of traditional Chinese medicines and clinical medication.

The present invention discloses a method for constructing a fingerprint of a tangerine seed and a traditional Chinese medicine preparation thereof and its application, and relates to the technical field of traditional Chinese medicine identification. The method for constructing a fingerprint of a tangerine seed and a traditional Chinese medicine preparation thereof comprises: extracting the tangerine seed or the traditional Chinese medicine preparation thereof with a first extraction solvent to obtain a test solution; dissolving or extracting a reference substance and / or a tangerine seed reference medicinal material with a second extraction solvent to obtain a reference substance solution and / or a reference medicinal material solution; measuring the test solution, the reference substance solution and / or the reference medicinal material solution with a liquid chromatograph to obtain a fingerprint of the tangerine seed or the traditional Chinese medicine preparation thereof; wherein the chromatographic column of the liquid chromatograph uses octadecylsilane bonded silica gel as the stationary phase, acetonitrile as the mobile phase A, and a phosphoric acid aqueous solution with a concentration of 0.1 vol% to 0.5 vol% as the mobile phase B for gradient elution, and the reference substances include a vecinin-2 reference substance, a hesperidin reference substance, a limonin reference substance, a nomilin reference substance, and a flavonoid reference substance; the first extraction solvent and the second extraction solvent are methanol aqueous solutions with a concentration of 30 vol% to 100 vol%. The fingerprints constructed by the present invention contain rich characteristic peak information, enabling identification from common counterfeits. Furthermore, the construction method is simple, stable, and highly specific, making it applicable to various types of tangerine seed slices and their standard decoctions and granules.

The present invention discloses a quality detection method for Wumeizhili granules, belonging to the technical field of quality detection of traditional Chinese medicines. The method includes characteristic spectrum identification, and specifically comprises the following steps: (1) preparing a reference solution of hyperoside, a reference solution of coumarin, a reference solution of codonopsis pilosula, a reference solution of cinnamic acid, a reference solution of psoralen, a reference solution of isopsoralen, and a reference solution of limonin; (2) preparing a test solution using Wumeizhili granules; and (3) performing liquid chromatography detection on the seven reference solutions and the test solution. The quality detection method of the present invention has high accuracy, strong specificity, and reliable detection results, achieving effective quality control of Wumeizhili granules, meeting the needs of modern production, and having important significance for quality detection and clinical use of traditional Chinese medicines.

This invention discloses a method for extracting limonin, comprising the following steps: S1, preparing an extract containing limonin; S2, adding macroporous resin to the extract and stirring, the macroporous resin being used to adsorb limonin in the extract; S3, removing the macroporous resin from the extract and placing it in a chromatography column to collect the eluent; S4, evaporating and concentrating the eluent to obtain a limonin extract, using ethyl acetate as a washing solvent, ultrasonically dissolving the limonin extract, then adding pure water for washing, concentrating and evaporating the washing solution to obtain a limonin sample; S5, performing TLC directional analysis on the limonin sample to check whether the limonin sample is qualified. This invention improves the extraction rate of limonin and yields a high extraction content.

The invention relates to the field of natural products, and relates to application of limonin compounds or medicinal derivatives thereof in preparation of medicines for preventing or treating inflammation. The inventor of the invention finds for the first time that the compound I or the compound II extracted and separated from the mallotus oblongifolius can significantly inhibit the content of inflammatory factors of immune cells at an extremely low concentration, and can be used for preparing medicines for preventing or treating inflammation. Besides, the compound I or II can significantly reduce the expression level of LPS-induced inflammatory factors TNF-alpha, IL-1alpha, IL-1beta, IL-6 and IL-18 at a low concentration, and does not affect the survival of immune cells, which proves that the compound I or II can inhibit the expression of inflammatory factors and has a strong anti-inflammatory effect.

The invention relates to the technical field of cosmetics, in particular to a freckle-removing and skin-whitening composition extracted from natural Chinese herbal medicines and application of the freckle-removing and skin-whitening composition in cosmetics, and the freckle-removing and skin-whitening composition is prepared from Chinese herbaceous peony stem cell extract, codonopsis pilosula extract, aloe extract, limonin extract, an accelerant and ultrapure water. The invention discloses a freckle-removing and whitening cosmetic which is prepared from the following components in parts by weight: 0.04-2.5 parts of a Chinese herbaceous peony stem cell extract, 0.85-3.1 parts of a codonopsis pilosula extract, 0.6-1.5 parts of an aloe extracting solution, 0.1-0.8 part of a limonin extracting solution, 3.5-4.8 parts of an accelerant and 35-50 parts of ultrapure water. And although the effect is obvious, the problems that stains cannot be cured, the safety is low, and the probability of adverse reactions is high are solved.

The invention provides a silica gel foam sealing material capable of preventing termite gnawing and a preparation method of the silica gel foam sealing material, and belongs to the technical field of polymer sealing materials. The raw material formula of the silica gel foam sealing material is as follows: vinyl silicone oil, a reinforcing filler, a flame-retardant filler, a contact insecticide, a bait, an odorant, a structure control agent, an inhibitor, a platinum catalyst, a foaming agent, hydroxyl silicone oil and hydrogen-containing silicone oil. Wherein the contact insecticide is one or more of pyrethroids, neonicotinoids, phenyl pyrazoles, boric acid, glycine, erythritol and fipronil; the bait agent is one or more of diatomite, talcum powder, capsaicin, dihydrocapsaicin and denatonium benzoate; the odorant is one or more of camphor oil, peppermint oil, limonin, limonene, citral, capraldehyde, octanal and nonanal. The silica gel foam sealing material disclosed by the invention has excellent flame retardant property, mechanical property and ant gnawing resistance, and the integrity of the sealing material can be well protected.

The application provides an anti-termite sealing material of silica gel foam and a preparation method thereof, and belongs to the technical field of polymer sealing materials. The raw material formula of the anti-termite sealing material of silica gel foam is as follows: vinyl silicone oil, reinforcing filler, flame-retardant filler, contact killing agent, bait agent, odor agent, structure control agent, inhibitor, platinum catalyst, foaming agent, hydroxyl silicone oil and hydrogen-containing silicone oil; wherein the contact killing agent is one or more of pyrethroid, neonicotinoid, phenylpyrazole, boric acid, glycine, erythritol and fipronil; the bait agent is one or more of diatomite, talcum powder, capsaicin, dihydrocapsaicin and denatonium benzoate; and the odor agent is one or more of camphor oil, peppermint oil, limonin, limonene, citral, decanal, octanal and nonanal. The anti-termite sealing material of silica gel foam has excellent flame-retardant performance, mechanical performance and anti-termite biting performance, and can well protect the integrity of the sealing material.

The invention discloses a series of limonin compounds as well as a preparation method and application thereof. According to the invention, two limonin compounds, namely, methyl kihadanin D and kihadanin D, are extracted and separated from dried root bark of dictamnus dasycarpus, wherein the methyl kihadanin D is a limonin compound with a novel structure. The anti-inflammatory effect of the monomeric compound is evaluated by adopting LPS-induced RAW264.7 cell NO release, and the two compounds are proved to have an obvious inhibiting effect on NO release and have a great application prospect as a potential anti-inflammatory drug.

The invention discloses a debitterizing method and debitterizing preparation for frozen pomelo cysts, and relates to the technical field of food processing.The debitterizing method comprises the steps that the pomelo cysts are placed in an ethylene diamine tetraacetic acid disodium solution with the mass concentration being 0.5-2.5% to be soaked for 15-75 min, and then freezing is conducted. By utilizing the method, the ethylene diamine tetraacetic acid can inhibit the activity of limonin D-ring lactone hydrolase, so that the generation of limonin is reduced from the source, and a relatively good debitterizing effect is achieved. On the basis, a composite debitterizing method with a better effect is further explored, that is, after soaking treatment is conducted through an ethylene diamine tetraacetic acid solution, treatment is conducted through a beta-cyclodextrin solution or treatment is conducted through a high-voltage electric field and the beta-cyclodextrin solution in sequence, and the removal rate of limonin is remarkably increased. The debitterizing method, especially the composite debitterizing method, provided by the invention is good in debitterizing effect, can be widely applied to freezing storage of pomelo cysts, and is high in production efficiency.

The invention relates to application of limonin in preparation of a medicine for resisting rheumatoid arthritis chronic pain, and belongs to the technical field of medicine application. In order to solve the problem that the existing medicine for treating the chronic pain of rheumatoid arthritis is difficult to control, the invention provides application of limonin in preparation of the medicine for treating the chronic pain of rheumatoid arthritis, and the limonin serves as an active ingredient in the medicine for treating the chronic pain of rheumatoid arthritis. The limonin is used for preparing the medicine for resisting the rheumatoid arthritis chronic pain, wherein the medicine intervenes the functions of rheumatoid arthritis synovial fibroblasts through a histamine H4R mediated mechanism. The traditional Chinese medicine can effectively solve the persistent chronic pain caused by rheumatoid arthritis, and has the advantage of good curative effect.

This invention discloses the application of limonene in the preparation of drugs for alleviating or improving vascular calcification. Intervention with limonene in CKD mouse models and primary vascular smooth muscle cells (VSMCs) significantly inhibited aortic calcification in CKD mice, significantly reduced high-phosphorus-induced osteogenic differentiation and calcium deposition in VSMCs, inhibited reactive oxygen species (ROS) production, reduced cellular iron accumulation, and alleviated ferroptosis. The findings of this application are highly likely to provide effective clinical drugs for the prevention and treatment of vascular calcification in CKD.

The invention relates to the technical field of processing of debitterized grapefruit particle cans for tea drinking, and discloses a preparation process of the debitterized grapefruit particle cans for tea drinking, and the preparation process comprises the following steps: blanching grapefruit fruits, peeling and sectioning, and then carrying out enzymolysis treatment to obtain peel-removed grapefruit peel sections; blanching the peel-removed grapefruit peel segments with hot water, dissolving limonin in the peel-removed grapefruit peel segments, and synchronously removing the limonin dissolved in the peel-removed grapefruit peel segments by using a magnetic surface molecularly imprinted polymer to obtain debittered peel-removed grapefruit peel segments; and arranging and canning the debitterized and capsule-coat-removed grapefruit capsule segments, boiling with boiling water for sterilization, injecting a sugar solution, exhausting, sealing the can, sterilizing with boiling water, and cooling to room temperature to obtain the tea drinking debitterized grapefruit particle can. The magnetic surface molecularly imprinted polymer researched and developed by the invention can be used for removing limonin in a grapefruit particle can, and experimental results show that the magnetic surface molecularly imprinted polymer has good debitterizing performance.

The invention provides a preparation method of an alkaloid composition in coptis chinensis and evodia rutaecarpa, main active substance alkaloids in coptis chinensis and evodia rutaecarpa are respectively enriched in combination with modern extraction and purification technologies, the purpose of enriching a large amount of alkaloids can be achieved, the content of limonin and other components is greatly reduced, the quality of the obtained product is more stable and controllable, and the preparation method is suitable for industrial production. Meanwhile, the drug effect of the traditional Chinese medicine is reserved. The whole preparation process is simple and convenient in flow, safe in reagent, small in usage amount, low in energy consumption and suitable for large-scale production, and the final product is stable in quality and high in safety.

The invention discloses a special organic fertilizer for preventing and controlling tobacco black shank and a preparation method thereof.The special organic fertilizer is prepared from corn straw, rice husk charcoal, a biological leavening agent, limonin, salicylic acid, plant ash, shrimp shell powder and soluble potassium silicate, and the biological leavening agent is tarlaromyces flavus powder; the preparation process comprises the following steps: acidizing the prawn shell powder, crushing and fermenting the corn straws, the rice husk charcoal and the acidized prawn shell powder, increasing the activity of the tarlaromyces flavus powder by using limonin and salicylic acid, carrying out secondary fermentation, and finally granulating and drying. The growth and development of tobacco root systems are promoted, the stress resistance of the tobacco is enhanced, and the occurrence of soil-borne diseases is reduced, so that the yield of the tobacco is increased. Meanwhile, the tobacco absorbs more comprehensive and balanced nutrients, and the internal quality of the tobacco leaves is improved.

The invention relates to the field of natural medicines, in particular to a limonin compound as well as a preparation method and application thereof. The invention provides a limonin compound which has a structure as shown in any one of compounds 1-8, and data of the embodiment shows that the limonin compound provided by the invention can inhibit assembly of NLRP3 inflammasomes by inhibiting ASC oligomerization, so that generation and release of downstream inflammatory factors are reduced, and an anti-inflammatory effect is achieved.

The present application relates to the technical field of health food, and provides a kind of nutrition food for regulating intestinal homeostasis and improving irritable bowel syndrome and its preparation process.The present application includes the following contents:(1) preparing astaxanthin nanoparticle powder by alkaline electrolytic water-ultrasonic coupling technology;(2) mixing the astaxanthin nanoparticle powder with limonin, vitamin D3, oryzanol, water or solid filler accessory in proportion to obtain a mixture;(3) homogenizing and filtering the mixture, or sieving the mixture;(4) sterilizing and filling the mixture, or tabletting and granulating the mixture to prepare a product.The present application can effectively regulate intestinal homeostasis and improve irritable bowel syndrome, and the product can be prepared into capsules, tablets, granules, oral liquids or beverages.The production process is simple, the cost is low, and the present application is suitable for large-scale industrial production.

The application relates to application of limonin as a pesticide synergist in corn pest control, and the characteristics that low-concentration limonin has a significant synergistic effect on chemical pesticides. 0.5-4 mu g / mL limonin is mixed with 5% chlorantraniliprole and 25% thiamethoxam for use, the lethal concentration (LC50) of the mixture to corn borer, corn aphid and Sitobion avenae can be significantly reduced, and the insecticidal effect of chlorantraniliprole on corn borer and thiamethoxam on aphids is improved. Field efficacy tests show that 4 mu g / mL limonin mixed with 5% chlorantraniliprole not only significantly improves the field control effect of the pesticide on lepidopterous pests such as corn borer, but also reduces the actual field use amount of the chemical pesticide, that is, the purpose of reducing the pesticide and improving the synergistic effect is achieved, and the method has a positive effect on comprehensive field pest control.

This invention provides a non-bitter, highly clarified, and flavonoid-rich pomelo rice wine and its preparation method, belonging to the field of functional rice wine technology. This invention uses pomelo juice, rice wine body, vitamin C, and citric acid as raw materials. It employs a targeted enzymatic debittering process to specifically degrade bitter precursors such as naringin and limonene, completely eliminating bitterness and astringency. A low-temperature, oxygen-free extraction technique is used to accelerate the gentle dissolution of pomelo flavor and functional components, avoiding the release of bitter substances and the degradation of heat-sensitive components. A β-cyclodextrin encapsulation technique is used to selectively encapsulate bitter substances such as naringin and limonene, achieving debittering without loss of functional components and flavor. A freeze-sedimentation process is used to fully extract unstable substances and easily crystallized components that are difficult to settle at room temperature, further improving shelf-life stability. The pomelo rice wine prepared by this invention has the advantages of a non-bitter taste, high stability, and high flavonoid content, making it easy to achieve large-scale mass production.

The invention discloses a preparation method and application of an enzyme preparation for enzymatically hydrolyzing bitter substances in citrus juice. Using Aspergillus tubingensis UA13 isolated in the early stage of the laboratory and mutagenized by atmospheric and room temperature plasma (ARTP) as the starting strain, limonin in lemon peel powder is used as an inducer to induce enzyme production, and the fermentation enzyme production process of the strain and the substrate affinity of the enzyme are studied. The results show that: in a 1 L fermentor medium, when fermenting under the optimal conditions of a limonin addition amount of 4.0 mg / L, an inoculum size of 10% (v / v), an initial pH value of 5.0, a stirring speed of 250 rpm, and a temperature of 30 °C, the maximum limonin debittering enzyme activity can reach 48.52 U / mL. The results of the study on the substrate affinity of the enzyme for limonin show that the Km value of the limonin debittering enzyme for limonin is 0.622 mmol / L, indicating a strong affinity. At the same time, the enzyme can still efficiently hydrolyze other bitter substances such as naringin and hesperidin, has good heat resistance and acid resistance, and has very good application effects in the citrus juice processing industry.