55 results about "Limonin" patented technology

The invention belongs to the technical field of food processing of pectin, and discloses limonin-pectin emulsion gel with anti-inflammatory and intestinal probiotic functions as well as preparation and application of the limonin-pectin emulsion gel. The method comprises the following steps: 1) dissolving pectin with the esterification degree of 10-40% and the RGI proportion of 20-40% in water to obtain a pectin solution; adjusting the pH value to 3-6, adding a calcium ion solution, and shearing to obtain pectin sol; 2) dissolving limonin in the oil phase to obtain an oil phase containing limonin; and adding the oil phase containing the limonin into the pectin sol, carrying out shearing treatment, and standing to obtain the pectin emulsion gel loaded with the limonin. The emulsion gel provided by the invention can be independently used as an emulsifier, can stably load limonin, and realizes relatively high embedding efficiency. The emulsion gel disclosed by the invention can be used for remarkably regulating intestinal flora and increasing the content of short-chain fatty acid, and has remarkable anti-inflammatory and prebiotic activity. The emulsion gel provided by the invention is used for anti-inflammatory and intestinal probiotic functional products.

The invention discloses a special low-conductivity cooling liquid for an electric vehicle and a preparation method thereof, and the special low-conductivity cooling liquid comprises ethylene glycol, sodium nitrate, octanoic acid, butyl phosphate, benzotriazole, a polyether modified organic silicon defoamer, triethanolamine, imidazole, pigment blue and limonin. The high-temperature-resistant and corrosion-resistant coating is prepared from the following components in percentage by mass: 95 to 100 percent of ethylene glycol, 0 to 0.05 percent of sodium nitrate, 0.2 to 0.4 percent of octanoic acid, 0 to 0.01 percent of butyl phosphate, 0.1 to 0.4 percent of benzotriazole, 0.05 to 0.1 percent of polyether modified organic silicon defoaming agent, 0.5 to 2 percent of triethanolamine, 0 to 0.3 percent of imidazole, 0.02 to 0.06 percent of pigment blue and 0.05 to 0.1 percent of limonin. On the basis of meeting the new national standard of the electric vehicle cooling liquid, the electric vehicle cooling liquid has low conductivity, fire caused by leakage of the cooling liquid can be effectively prevented, and the cooling liquid can effectively provide protection for a new energy electric vehicle system.

The invention discloses an application of an IMPDH2 inhibitor in preventing or treating inflammation. The limonin compound provided by the invention can be combined with and degrade human inosine-5 '-monophosphate dehydrogenase 2 (IMPDH2), inhibit synthesis of guanine in cells and inhibit activation of an NF-kappa B signal channel, and can be used as an IMPDH2 inhibitor; the IMPDH2 inhibitor also has a relatively good prevention or treatment effect on inflammation. Compared with the existing IMPDH2 inhibitor, the limonin compound provided by the invention can degrade IMPDH2 enzyme, and has better inhibitory activity and stronger activity of inhibiting inflammatory factors.

The application discloses a multi-process cooperative orange peeling and juicing pretreatment machine and a pretreatment method. The machine comprises a rack, a controller installed at the upper end of the rack, and a pretreatment mechanism arranged in the rack. The pretreatment mechanism comprises a feeding assembly, a cutting and flattening assembly, a separating assembly, and a discharging assembly. The feeding assembly is used for guiding and conveying oranges to the upper end of the discharging assembly. The cutting and flattening assembly is driven by a servo motor and is provided with a cutting member and a flattening member perpendicular to each other, which are used for cutting and flattening the oranges, respectively. The separating assembly is used for cutting and separating the peel and the pulp of the flattened oranges. The discharging assembly is used for collecting the first-pressed juice generated in the flattening process and the separated peel and pulp. The four processes of feeding, cutting, flattening, and separating are cooperatively matched, the integrated pretreatment of orange peeling and first-pressed juice collection is realized, the entry of bitter substances such as limonin into the orange juice caused by juice pressing with peel is effectively avoided, and the taste quality of the orange juice is improved.

The invention relates to application of limonin as a pesticide synergistic aid in prevention and control of corn pests, which utilizes the characteristic that low-concentration limonin has a remarkable synergistic effect on chemical pesticides, 0.5-4g / mL limonin, 5% chlorantraniliprole and 25% thiamethoxam are mixed for use, so that the lethal medium concentration (LC50) of the limonin to corn borers, corn aphids and rhopalosiphum padi can be remarkably reduced; the insecticidal effect of chlorantraniliprole on corn borer and the insecticidal effect of thiamethoxam on aphid are improved. A field pesticide effect test also shows that the field prevention and control effect of the pesticide on Lepidoptera pests such as ostrinia nubilalis is remarkably improved by mixing 4 g / mL of limonin and 5% of chlorantraniliprole, the actual field dosage of chemical pesticides is reduced, the purposes of pesticide reduction and synergism are achieved, and a positive effect is achieved on comprehensive prevention and control of the field pests.

The invention provides a screening method and application of external traditional Chinese medicine anti-psoriasis active ingredients, and relates to the technical field of modern research of traditional Chinese medicines. According to the screening method disclosed by the invention, components with transdermal ability and anti-psoriasis activity are systematically excavated and screened from a traditional Chinese medicine complex system through preparation of a traditional Chinese medicine transdermal sample solution, UPLC-Q-TOF-MS component identification, network pharmacological analysis, molecular docking prediction and HaCaT psoriasis cell model verification in sequence. The method solves the problems that the traditional Chinese medicine transdermal components are unclear in pharmacodynamic material basis and low in screening efficiency, and has the advantages of being high in systematicness, high in accuracy and good in pertinence. According to the method, a plurality of effective components such as dictamnine and limonin are successfully screened from the cortex dictamni, and a clear pharmacological basis is provided for research and development of the cortex dictamni externally applied anti-psoriasis medicine.

The present invention discloses a citrus seed oil rich in limonin and a defatted citrus seed meal and their preparation methods and applications. The present invention uses the crude oil obtained from citrus seeds to re-extract limonin from citrus seed residues to obtain a defatted citrus seed meal. At the same time, the refined finished oil is rich in limonin, has nutritional and health care effects, and has a characteristic lemon-like aroma. The present invention directly uses the crude oil as an extraction agent, with a simple process, without adding exogenous functional components, without the aid of organic solvents, being green, safe, efficient, and more suitable for industrial production. The prepared citrus seed oil rich in limonin has application prospects in medicine, health food and / or beauty products. At the same time, the defatted citrus seed meal has the application potential as a feed raw material or additive.

The invention discloses application of limonin in preventing and treating bacterial wilt of cigars. According to the method, limonin is applied by adopting a foliar spraying method, so that the relative control effect of cigars on bacterial wilt can be remarkably improved, and the morbidity of the bacterial wilt of cigars is reduced.

The invention discloses application of neohesperidin and limonin as markers for identifying Hu pomelo honey. The application comprises the following steps: measuring the content of neohesperidin and limonin in a honey sample to be detected; if the content of neohesperidin in the honey sample to be detected is greater than 0.14 mg / kg and the content of limonin is greater than 0.13 mg / kg, judging that the honey sample to be detected is the Huyou honey. According to the invention, neohesperidin and limonin are adopted as markers for identifying the Hu pomelo honey, a corresponding detection method is established, the Hu pomelo honey can be accurately distinguished from other honey by adopting the detection method, and the method has an application prospect in the aspects of identification, authenticity evaluation and the like of the Hu pomelo honey.

The invention discloses a preparation method and application of an enzyme preparation for enzymatically hydrolyzing bitter substances in citrus juice. Using Aspergillus tabingensis UA13 isolated in the early stage of the laboratory and mutagenized by atmospheric and room temperature plasma (ARTP) as the starting strain, limonin in lemon peel powder is used as an inducer to induce enzyme production, and the fermentation enzyme production process of the strain and the substrate affinity of the enzyme are studied. The results show that: in a 1 L fermentor medium, under the optimal conditions of limonin addition amount of 4.0 mg / L, inoculation amount of 10% (v / v), initial pH value of 5.0, stirring speed of 250 rpm, and fermentation at 30 °C, the highest limonin debittering enzyme activity can reach 48.52 U / mL. The results of the study on the substrate affinity of the enzyme for limonin show that the Km value of the limonin debittering enzyme for limonin is 0.622 mmol / L, indicating strong affinity. At the same time, the enzyme can still efficiently hydrolyze other bitter substances such as naringin and hesperidin, has good heat resistance and acid resistance, and has very good application effects in the citrus juice processing industry.

The invention relates to the technical field of tea processing, in particular to a method for preparing special tea through compound fermentation of pansy petals and bergamot fresh leaves and application of the special tea. According to the method, the pansy petals and the bergamot fresh leaves are mixed according to a specific proportion, synergistic fermentation is performed in a high-pressure CO2 environment, and aromatic substances, anthocyanin and flavonoid compounds in the pansy petals are fully combined with citrus aromatic substances and active ingredients in the bergamot leaves by accurately controlling parameters such as temperature, humidity and CO2 concentration. The prepared tea product has the flower fragrance of the pansy and the citrus fragrance of the bergamot, is orange red and bright in soup color, is rich in nutritional ingredients such as anthocyanin, flavonoid, limonin and vitamin C, and has the effects of tranquilizing and allaying excitement, resisting oxidation, promoting digestion and relieving anxiety. The invention also relates to application of the tea product in the fields of food, health care products and cosmetics.

The invention relates to a protein feed produced by fermenting citrus peel residues as well as a preparation method and application of the protein feed. The preparation method of the protein feed produced by fermentation of the citrus peel residues comprises the following steps: (1) performing microwave enzyme deactivation on the citrus peel residues, drying to obtain dried citrus peel residues, and uniformly spraying fermentation promoting liquid on the dried citrus peel residues to obtain citrus peel residues containing a fermentation promoter; and (2) carrying out anaerobic fermentation on the citrus peel residues containing the fermentation accelerant, then turning piles, humidifying, and carrying out second-stage fermentation to obtain the high-protein feed. The protein feed prepared by the preparation method disclosed by the invention can reduce the pollution of ecological environment, improve the utilization rate of citrus, effectively improve the protein content, reduce the contents of substances such as naringin, limonin and citrus essential oil in the citrus pomace, and is beneficial to the health of animals.

The invention relates to a fruit extract preparation process based on enzymolysis and ultrasonic synergistic treatment, which comprises the following steps: S1, crushing citrus pomace, drying, sieving, adding cellulase, pectinase, beta-glucosidase and deionized water, uniformly stirring, adjusting the pH value, and carrying out enzymolysis at a constant temperature to obtain a mixture; s2, cooling the mixture, carrying out ultrasonic treatment, then heating for enzyme deactivation, centrifuging, and collecting supernate to obtain a crude extract; and S3, adsorbing the crude extract through adsorption resin, eluting, concentrating, crystallizing and drying to obtain the extract. The preparation process provided by the invention has relatively high limonin extraction rate and purity.

The invention provides application of five bitter substances in evaluation of bitter degree of hericium erinaceus and an evaluation method, and belongs to the technical field of quality monitoring. The invention provides application of five bitter substances, namely Limonin, Picrasin b, Fissinolide, Pristimulin and Samaderin a, in evaluating the bitter degree of the hericium erinaceus, the five bitter substances in the hericium erinaceus to be evaluated are extracted and separated, the content of the five bitter substances is detected, and the bitter degree of the hericium erinaceus is evaluated according to the correlation between the content of the five bitter substances and the bitter value of the hericium erinaceus. According to the method, the content of the five bitter substances and sensory evaluation are subjected to conjoint analysis, the correlation between the content of the five bitter substances and the bitter degree of the hericium erinaceus is confirmed, and a simple, convenient and scientific basis is provided for evaluating the bitter degree of the hericium erinaceus.

The invention discloses a quality detection method of smoked plum granules for stopping and benefiting, and belongs to the technical field of quality detection of traditional Chinese medicines. The method comprises the following steps: identifying a characteristic spectrum; the method comprises the following specific steps: (1) respectively preparing a hyperoside reference substance solution, a coumarin reference substance solution, a lobetyolin reference substance solution, a cinnamic acid reference substance solution, a psoralen reference substance solution, an isopsoralen reference substance solution and a limonin reference substance solution; (2) preparing a test solution from the smoked plum granules; and (3) respectively carrying out liquid chromatography detection on the seven reference substance solutions and the test solution. The quality detection method disclosed by the invention is high in accuracy, strong in specificity and reliable in detection result, realizes effective control on the quality of the smoked plum granules, is suitable for modern production requirements, and has important significance on quality detection of traditional Chinese medicines and clinical medication.

The present disclosure relates generally to a process for obtaining a naturally derived composition rich in polymethoxylated flavonoids (PMFs). In some embodiments, the process results in a composition in which PMFs make up at least 90% by weight of the flavonoid content in the composition, based on the total weight of flavonoids in the composition. In certain aspects, the disclosure provides compositions resulting from the purification process and the use of such compositions to reduce bitterness, astringency, or sourness, or to enhance 0 sweetness or mouthfeel of an ingestible composition, such as a flavored food or beverage product. In some embodiments, the disclosure provides uses of the resulting composition to reduce the unpleasant taste of limonin, nomilin, or, one or more of which can be present at elevated levels in certain citrus products. naringin

The present invention discloses a method for constructing a fingerprint of a tangerine seed and a traditional Chinese medicine preparation thereof and its application, and relates to the technical field of traditional Chinese medicine identification. The method for constructing a fingerprint of a tangerine seed and a traditional Chinese medicine preparation thereof comprises: extracting the tangerine seed or the traditional Chinese medicine preparation thereof with a first extraction solvent to obtain a test solution; dissolving or extracting a reference substance and / or a tangerine seed reference medicinal material with a second extraction solvent to obtain a reference substance solution and / or a reference medicinal material solution; measuring the test solution, the reference substance solution and / or the reference medicinal material solution with a liquid chromatograph to obtain a fingerprint of the tangerine seed or the traditional Chinese medicine preparation thereof; wherein the chromatographic column of the liquid chromatograph uses octadecylsilane bonded silica gel as the stationary phase, acetonitrile as the mobile phase A, and a phosphoric acid aqueous solution with a concentration of 0.1 vol% to 0.5 vol% as the mobile phase B for gradient elution, and the reference substances include a vecinin-2 reference substance, a hesperidin reference substance, a limonin reference substance, a nomilin reference substance, and a flavonoid reference substance; the first extraction solvent and the second extraction solvent are methanol aqueous solutions with a concentration of 30 vol% to 100 vol%. The fingerprints constructed by the present invention contain rich characteristic peak information, enabling identification from common counterfeits. Furthermore, the construction method is simple, stable, and highly specific, making it applicable to various types of tangerine seed slices and their standard decoctions and granules.

The present invention discloses a quality detection method for Wumeizhili granules, belonging to the technical field of quality detection of traditional Chinese medicines. The method includes characteristic spectrum identification, and specifically comprises the following steps: (1) preparing a reference solution of hyperoside, a reference solution of coumarin, a reference solution of codonopsis pilosula, a reference solution of cinnamic acid, a reference solution of psoralen, a reference solution of isopsoralen, and a reference solution of limonin; (2) preparing a test solution using Wumeizhili granules; and (3) performing liquid chromatography detection on the seven reference solutions and the test solution. The quality detection method of the present invention has high accuracy, strong specificity, and reliable detection results, achieving effective quality control of Wumeizhili granules, meeting the needs of modern production, and having important significance for quality detection and clinical use of traditional Chinese medicines.

This invention discloses a method for extracting limonin, comprising the following steps: S1, preparing an extract containing limonin; S2, adding macroporous resin to the extract and stirring, the macroporous resin being used to adsorb limonin in the extract; S3, removing the macroporous resin from the extract and placing it in a chromatography column to collect the eluent; S4, evaporating and concentrating the eluent to obtain a limonin extract, using ethyl acetate as a washing solvent, ultrasonically dissolving the limonin extract, then adding pure water for washing, concentrating and evaporating the washing solution to obtain a limonin sample; S5, performing TLC directional analysis on the limonin sample to check whether the limonin sample is qualified. This invention improves the extraction rate of limonin and yields a high extraction content.

The invention relates to a limonin compound Aglatestate F as well as a preparation method and application thereof, and belongs to the field of chemical medicines. The compound is obtained by separating and extracting from branches and leaves of fruit of Japanese pedicularis (Aglaia edulis), and is simple to prepare and separate. The compound provided by the invention has a good effect of inhibiting dengue virus narrative hamster kidney (BHK-21) cell infection, has a good effect of inhibiting the dengue virus narrative hamster kidney (BHK-21) cell infection at a non-toxic concentration, has a dengue virus resisting effect EC50 of 1.290 + / -0.170, has a selection index higher than that of a positive antiviral drug ribavirin, and has a good application prospect. Therefore, the compound Aglatestate F has a good prospect of developing the anti-dengue-virus medicine, and a solid foundation is laid for the development of preparing the anti-dengue-virus medicine.

The invention relates to the field of natural products, and relates to application of limonin compounds or medicinal derivatives thereof in preparation of medicines for preventing or treating inflammation. The inventor of the invention finds for the first time that the compound I or the compound II extracted and separated from the mallotus oblongifolius can significantly inhibit the content of inflammatory factors of immune cells at an extremely low concentration, and can be used for preparing medicines for preventing or treating inflammation. Besides, the compound I or II can significantly reduce the expression level of LPS-induced inflammatory factors TNF-alpha, IL-1alpha, IL-1beta, IL-6 and IL-18 at a low concentration, and does not affect the survival of immune cells, which proves that the compound I or II can inhibit the expression of inflammatory factors and has a strong anti-inflammatory effect.

The invention relates to the technical field of cosmetics, in particular to a freckle-removing and skin-whitening composition extracted from natural Chinese herbal medicines and application of the freckle-removing and skin-whitening composition in cosmetics, and the freckle-removing and skin-whitening composition is prepared from Chinese herbaceous peony stem cell extract, codonopsis pilosula extract, aloe extract, limonin extract, an accelerant and ultrapure water. The invention discloses a freckle-removing and whitening cosmetic which is prepared from the following components in parts by weight: 0.04-2.5 parts of a Chinese herbaceous peony stem cell extract, 0.85-3.1 parts of a codonopsis pilosula extract, 0.6-1.5 parts of an aloe extracting solution, 0.1-0.8 part of a limonin extracting solution, 3.5-4.8 parts of an accelerant and 35-50 parts of ultrapure water. And although the effect is obvious, the problems that stains cannot be cured, the safety is low, and the probability of adverse reactions is high are solved.

The invention provides a silica gel foam sealing material capable of preventing termite gnawing and a preparation method of the silica gel foam sealing material, and belongs to the technical field of polymer sealing materials. The raw material formula of the silica gel foam sealing material is as follows: vinyl silicone oil, a reinforcing filler, a flame-retardant filler, a contact insecticide, a bait, an odorant, a structure control agent, an inhibitor, a platinum catalyst, a foaming agent, hydroxyl silicone oil and hydrogen-containing silicone oil. Wherein the contact insecticide is one or more of pyrethroids, neonicotinoids, phenyl pyrazoles, boric acid, glycine, erythritol and fipronil; the bait agent is one or more of diatomite, talcum powder, capsaicin, dihydrocapsaicin and denatonium benzoate; the odorant is one or more of camphor oil, peppermint oil, limonin, limonene, citral, capraldehyde, octanal and nonanal. The silica gel foam sealing material disclosed by the invention has excellent flame retardant property, mechanical property and ant gnawing resistance, and the integrity of the sealing material can be well protected.

The application provides an anti-termite sealing material of silica gel foam and a preparation method thereof, and belongs to the technical field of polymer sealing materials. The raw material formula of the anti-termite sealing material of silica gel foam is as follows: vinyl silicone oil, reinforcing filler, flame-retardant filler, contact killing agent, bait agent, odor agent, structure control agent, inhibitor, platinum catalyst, foaming agent, hydroxyl silicone oil and hydrogen-containing silicone oil; wherein the contact killing agent is one or more of pyrethroid, neonicotinoid, phenylpyrazole, boric acid, glycine, erythritol and fipronil; the bait agent is one or more of diatomite, talcum powder, capsaicin, dihydrocapsaicin and denatonium benzoate; and the odor agent is one or more of camphor oil, peppermint oil, limonin, limonene, citral, decanal, octanal and nonanal. The anti-termite sealing material of silica gel foam has excellent flame-retardant performance, mechanical performance and anti-termite biting performance, and can well protect the integrity of the sealing material.

The invention provides a preparation method of orange aromatic vinegar. The preparation method comprises the following steps: debitterizing green orange juice, preparing green orange wine mash, preparing orange vinegar fermentation liquor, clarifying the orange vinegar fermentation liquor, and ageing the orange vinegar fermentation liquor. In the green orange juice debitterizing step, a debitterizing agent composed of limonin dehydrogenase, limonin epoxidase and modified activated carbon according to the mass ratio of (3-5): (1-3): (10-15) is added, limonin is effectively removed, and the taste of the orange aromatic vinegar is improved. In the step of preparing the orange vinegar fermentation liquor, the immobilized acetobacter aceti is added, so that the acetobacter aceti is not easy to lose along with the fermentation liquor, the utilization rate of thalli and the fermentation stability are improved, relatively high thalli concentration and activity can be kept, and the fermentation period is shortened. In the step of ageing the orange vinegar fermentation liquor, a bamboo barrel is used for ageing, and the bamboo barrel has good air permeability, so that trace oxygen exchange of the orange vinegar fermentation liquor in the ageing process is facilitated, further fusion and development of flavor components in vinegar are promoted, and the flavor of the orange vinegar is more mellow and harmonious.

The invention discloses a series of limonin compounds as well as a preparation method and application thereof. According to the invention, two limonin compounds, namely, methyl kihadanin D and kihadanin D, are extracted and separated from dried root bark of dictamnus dasycarpus, wherein the methyl kihadanin D is a limonin compound with a novel structure. The anti-inflammatory effect of the monomeric compound is evaluated by adopting LPS-induced RAW264.7 cell NO release, and the two compounds are proved to have an obvious inhibiting effect on NO release and have a great application prospect as a potential anti-inflammatory drug.

The invention relates to the field of animal feeding feeds, in particular to a compound probiotic-containing feed additive and a preparation method thereof, and the compound probiotic-containing feed additive comprises the following raw materials: maguey extract, modified pachymaran, compound probiotics, compound vitamins, limonin, acetic acid, beta-amylase, corn and wheat bran. The maguey extract, the modified pachymaran and the compound probiotics play a role through a synergistic effect, the modified pachymaran wraps the compound probiotics and the maguey extract in the feed to form a compound, and the maguey extract provides energy for the compound probiotics, so that the loss process of substances such as the compound probiotics in the feed can be reduced; meanwhile, the effect of the compound probiotics on intestinal epithelial cells is promoted, and nutrient absorption is promoted. The maguey extract, the modified pachymaran and the compound probiotics form a dynamic balance system, and the compound probiotic feed additive which is effective to animal health is provided.

The invention discloses a debitterizing method and debitterizing preparation for frozen pomelo cysts, and relates to the technical field of food processing.The debitterizing method comprises the steps that the pomelo cysts are placed in an ethylene diamine tetraacetic acid disodium solution with the mass concentration being 0.5-2.5% to be soaked for 15-75 min, and then freezing is conducted. By utilizing the method, the ethylene diamine tetraacetic acid can inhibit the activity of limonin D-ring lactone hydrolase, so that the generation of limonin is reduced from the source, and a relatively good debitterizing effect is achieved. On the basis, a composite debitterizing method with a better effect is further explored, that is, after soaking treatment is conducted through an ethylene diamine tetraacetic acid solution, treatment is conducted through a beta-cyclodextrin solution or treatment is conducted through a high-voltage electric field and the beta-cyclodextrin solution in sequence, and the removal rate of limonin is remarkably increased. The debitterizing method, especially the composite debitterizing method, provided by the invention is good in debitterizing effect, can be widely applied to freezing storage of pomelo cysts, and is high in production efficiency.

The invention relates to application of limonin in preparation of a medicine for resisting rheumatoid arthritis chronic pain, and belongs to the technical field of medicine application. In order to solve the problem that the existing medicine for treating the chronic pain of rheumatoid arthritis is difficult to control, the invention provides application of limonin in preparation of the medicine for treating the chronic pain of rheumatoid arthritis, and the limonin serves as an active ingredient in the medicine for treating the chronic pain of rheumatoid arthritis. The limonin is used for preparing the medicine for resisting the rheumatoid arthritis chronic pain, wherein the medicine intervenes the functions of rheumatoid arthritis synovial fibroblasts through a histamine H4R mediated mechanism. The traditional Chinese medicine can effectively solve the persistent chronic pain caused by rheumatoid arthritis, and has the advantage of good curative effect.

This invention discloses the application of limonene in the preparation of drugs for alleviating or improving vascular calcification. Intervention with limonene in CKD mouse models and primary vascular smooth muscle cells (VSMCs) significantly inhibited aortic calcification in CKD mice, significantly reduced high-phosphorus-induced osteogenic differentiation and calcium deposition in VSMCs, inhibited reactive oxygen species (ROS) production, reduced cellular iron accumulation, and alleviated ferroptosis. The findings of this application are highly likely to provide effective clinical drugs for the prevention and treatment of vascular calcification in CKD.