The invention relates to the technical field of food preparation, in particular to mulberry leaf powder bread and a preparation method thereof. The mulberry leaf powder bread is mainly prepared from 60-70 parts of strong flour, 30-40 parts of mulberry leaf powder, 10-15 parts of horseradish tree leaf power, 10-15 parts of wheat germ powder, 10-15 parts of lucerne meal, 1-2 parts of tocopherol, 1-2 parts of phytic acid, 1-2 parts of xylitol, 1.5-2 parts of vanillin, 1.5-2 parts of mandarin oil, 3-5 parts of azodicarbonamide, 3-5 parts of pottasche, 7-10 parts of glucono-delta-lactone, 7-10 parts of calcium bicarbonate, 3-5 parts of table vinegar, 20-25 parts of white granulated sugar, 5-10 parts of beer yeast powder and the like. The preparation method comprises the steps of raw material treatment, mixing, kneading, cutting, baking and the like. The mulberry leaf powder bread is scientific and reasonable in raw material formula, long in shelf life, high in nutritive value, sweet and delicious in taste, leavened, tough, simple in preparation method and easy to prepare.