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Virus inactivating agent

A technology of virus inactivation and peppermint oil, applied in antiviral agents, biocides, skin diseases, etc., can solve problems such as antiviral effect and stability problems

Active Publication Date: 2021-02-26
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is revealed in Patent Document 6 that as long as the structure of the above-mentioned quaternary ammonium cation is slightly different, problems may arise in antiviral effect and stability (paragraphs 0008 and 0009)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Inactivation effect on influenza virus (Part 1)

[0082] 1) Preparation of the sample (test solution)

[0083] Samples (test solutions) of virus inactivating agents were prepared according to the formulations shown in Table 1 below.

[0084] [Table 1]

[0085]

[0086] 2) Test method

[0087] Influenza A (H1N1 / PR / 8 / 34) strain was used as the test virus strain.

[0088] Add virus liquid 0.12mL (1×10 4 pfu / mL), after reacting for 30 minutes, pass through SCDLP (Soya Casein Digest Lecithin Polysorbate, soybean casein glucose lecithin polysorbate Tween 80) medium, carry out serial dilution by 10 times, and inoculate in pre-cultured 96-well plate Canine kidney cells (MDCK), at 37°C, 5% CO 2 After culturing under the conditions, the number of phage plaques formed was measured to determine the residual virus infection titer.

[0089] 3) Test results

[0090] The results are shown in Table 2. According to the following Table 2, it can be clearly shown that in the com...

Embodiment 2

[0094] Inactivation effect on influenza virus (Part 2)

[0095] 1) Preparation of the sample (test solution)

[0096] Samples (test solutions) of virus inactivating agents were prepared according to the formulations shown in Table 3 below.

[0097] [table 3]

[0098] Specimen 9 Specimen 10 Sample 11 Sample 12 water margin margin margin margin Citric acid (food) 0.02 0.02 0.02 0.02 Sodium citrate 0.08 0.08 0.08 0.08 PEG-60 Hydrogenated Castor Oil 0.1 0.1 0.1 0.1 1,3-Butanediol 5 5 5 5 Cationized starch (*1) - 0.24 0.024 - Cationized cellulose (*2) - - - 0.1 total 100 100 100 100

[0099] (*1)Sensomer IC-50

[0100] (*2) Polymer JR-400 (manufactured by Union Carbide Corporation)

[0101] 2) Test method

[0102] According to the test method described in the above-mentioned Example 1.

[0103] 3) Test results

[0104] The results are shown in Table 4. As can be clearly seen fro...

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Abstract

The purpose of the present invention is to provide: a virus inactivating agent that exhibits an effect at an amount that does not cause skin irritation; and an external skin preparation composition containing said virus inactivating agent. The present invention relates to: a virus inactivating agent containing, as an effective component thereof, at least one selected from mint oil, eucalyptus oil,rosemary oil, sage oil, tea tree oil, shell ginger oil, peppermint oil, lemongrass oil, cajeputi oil, niaouli cineole oil, lime oil, lemon oil, lemon verbena oil, St. John's wort oil, ravintsara oil,rosewood oil, Melissa / lemon balm oil, myrrh oil, mandarin oil, vetiver oil, frankincense oil, citronella oil, cardamom oil, Angelica oil, and cationized starch; and an external skin preparation composition containing the same.

Description

technical field [0001] The invention relates to a virus inactivating agent and an external skin preparation composition containing the virus inactivating agent. , Alpine Ginger Oil, Peppermint Oil, Lemongrass Oil, Melaleuca quinquenervia Oil, Melaleuca quinquenervia Oil, Pear Berry Oil, Lemon Oil, Deodorant Wood Oil, St. John's Wort Oil, Camphor oil, rosewood oil, lemon balm / lemon balm oil, myrrh oil, orange oil, vetiver oil, frankincense tree (Boswellia carterii) oil, citronella oil, cardamom oil, angelica oil these specific essential oils 1, or 2 or more of cationized starches are used as active ingredients. Background technique [0002] It is known that some plant extracts, particularly essential oils obtained by extracting aromatic substances contained in plant extracts, exhibit an inactivating effect on various viruses including influenza virus. "Essential oil" is a kind of natural fragrance in cosmetics. In a narrow sense, it is an oil obtained by steam distillation ...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61K36/61A61K36/53A61K36/537A61K36/899A61K36/752A61K36/54A61K36/328A61K36/324A61K36/9064A61K36/9062A61K36/85A61K36/38A61K36/48A61K36/232A61K47/36A61P17/00A61P31/12A61P31/14A61P31/16A61K8/9794A61K8/9789A61K8/92A61Q19/00A61Q17/00
CPCA61P17/00A61K31/718A61K36/534A61P31/12A61K36/53A61K36/54A01N65/00A61K9/0014A61K36/537A61Q17/005A61K8/922A61K8/31A61K8/732A61K2300/00A01N31/02A01N65/22A01N65/28A61K8/06A61K8/19A61K8/34A61K8/362A61K8/416A61K8/731A61K8/8152
Inventor 有野翔子白神裕人蛭间有喜子
Owner SHISEIDO CO LTD
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