712 results about "Polygonatum" patented technology

The invention provides a strain of lactobacillus plantarum YS-AG23 with high antioxidant activity, and a rhizoma polygonati and radix angelicae sinensis fermented product obtained by fermenting rhizoma polygonati and radix angelicae sinensis with the strain of lactobacillus plantarum YS-AG23. In a D-galactose induced premature ovarian failure mouse model, the fermentation product can regulate up the levels of antioxidant and stress protection genes SOD2 and HO-1 and an anti-aging gene SIRT1 by regulating down the expression of a key gene AGER of an inflammation and oxidative stress pathway, so that the oxidative stress and inflammatory response of model mouse ovarian tissues are remarkably reduced; meanwhile, the serum hormone level can be specifically adjusted, the serum estradiol (E2) level can be increased, the follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels can be reduced to be close to the normal range, the expression of anti-mullerian hormone (AMH) and hormone regulatory gene LHR of ovarian reserve markers can be up-regulated, the proliferative activity and estrogen secretion function of follicular granulosa cells can be improved, and the effect of preventing ovarian reserve is achieved. The wet weight of atrophic uterus and ovary of the model mouse is remarkably increased, uterine and ovary atrophy is effectively reversed, and the ovarian reserve function of the D-galactose induced premature ovarian failure model mouse is recovered. Besides, in an H2O2-induced human dermal fibroblast aging model, the yeast can improve the activity of aging cells in a concentration-dependent manner and reduce the level of reactive oxygen species (ROS) in the cells; in addition, by up-regulating the expression of a collagen synthesis key gene COL1A1 and down-regulating the expression of a cell senescence marker gene p16, skin cell senescence caused by oxidative stress can be effectively improved. In conclusion, the polygonatum sibiricum and angelica sinensis leavening can synchronously improve premature ovarian failure and skin cell senescence caused by oxidative stress by accurately regulating and controlling oxidative stress, inflammatory response and tissue function related genes, and has wide application potential.

The present invention relates to the technical field of fermented Chinese medicine products, and discloses a fermented Chinese medicine product for regulating spleen and stomach function and a preparation method thereof. The fermented Chinese medicine product is prepared by a Chinese medicine extract, a fermentation medium and Lactobacillus paracasei LBR-002 of the same origin of medicine and food, and the mass ratio of the Chinese medicine extract, the fermentation medium and Lactobacillus paracasei LBR-002 is 1000:965:20-90, and the Chinese medicine extract comprises the following components in parts by weight: 25-60 parts of yam, 20-50 parts of liquorice, 20-45 parts of ganoderma lucidum, 20-42 parts of tuckahoe, 20-50 parts of polygonatum, 20-48 parts of codonopsis, 18-25 parts of dendrobium officinale, 8-17 parts of daidaihua, 8-16 parts of American ginseng, 5-20 parts of coix seeds, 6-15 parts of amomum, and 8-20 parts of hawthorn. The fermented Chinese medicine product has the characteristics of effective regulation, green safety and the like to spleen and stomach function, and can significantly improve spleen and stomach function.

The utility model relates to the technical field of grinding, in particular to a grinding device for processing rhizoma polygonati raw materials, which comprises a stainless steel grinding box, a grinding table for grinding rhizoma polygonati is arranged in the grinding box, and the bottom of the grinding table is connected with a discharging mechanism for discharging ground materials. The grinding table is composed of a first table body and a second table body, a first driving mechanism used for driving the second table body up and down is arranged on the inner wall of the bottom of the grinding box, and a second driving mechanism used for driving the second table body to rotate is arranged on the upper portion of the grinding box; the first driving mechanism comprises a driving roller rotationally arranged below the second table body, and a concave area is arranged on the surface of the driving roller. According to the polygonatum sibiricum grinding table, the to-be-ground polygonatum sibiricum materials at the end opening position of the grinding cavity can be conveniently drawn into the grinding cavity to be ground while the grinding effect of the grinding table is not affected, and therefore the grinding efficiency of the polygonatum sibiricum materials is further improved.

The invention relates to the technical field of fermented traditional Chinese medicine products, and discloses a fermented traditional Chinese medicine product for regulating spleen and stomach functions and a preparation method thereof. The fermented traditional Chinese medicine product is prepared from a traditional Chinese medicine extracting solution with homology of medicine and food, a fermentation culture medium and lactobacillus paracasei LBR-002, and the mass ratio of the traditional Chinese medicine extracting solution to the fermentation culture medium to the lactobacillus paracasei LBR-002 is 1000: 965: (20-90). The traditional Chinese medicine extracting solution comprises the following components in parts by weight: 25-60 parts of Chinese yam, 20-50 parts of liquorice, 20-45 parts of lucid ganoderma, 20-42 parts of poria cocos, 20-50 parts of rhizoma polygonati, 20-48 parts of codonopsis pilosula, 18-25 parts of dendrobium officinale, 8-17 parts of seville orange flower, 8-16 parts of American ginseng, 5-20 parts of semen coicis, 6-15 parts of fructus amomi and 8-20 parts of hawthorn. The fermented traditional Chinese medicine product has the characteristics of effective regulation on spleen and stomach functions, greenness, safety and the like, and can obviously improve the spleen and stomach functions.

The invention discloses a preparation method of polygonatum-sibiricum-sourced exosome-like nano-vesicles and application of the nano-vesicles in antitumor drugs, and relates to the technical field of biological medicines. The preparation method comprises the following steps: crushing fresh rhizoma polygonati slices, filtering and collecting to obtain a first filtrate; carrying out gradient centrifugation treatment on the first filtrate to obtain supernate; carrying out first membrane filtration treatment on the supernate to obtain second filtrate with the particle size of less than 450 nm; centrifuging the second filtrate to obtain a precipitate, and resuspending the precipitate with a PBS buffer solution to obtain a rhizoma polygonati exosome crude extract; and performing secondary membrane filtration treatment on the rhizoma polygonati exosome crude extract to obtain a third filtrate with the particle size of less than 220nm, thereby obtaining the rhizoma polygonati-derived exosome-like nano-vesicles. The polygonatum-sibiricum-sourced exosome-like nano-vesicle has remarkable inhibitory activity on tumors, provides a new strategy and means for tumor treatment, and has important scientific value and clinical application potential.

The invention discloses a traditional Chinese medicine composition for preventing / treating systemic lupus erythematosus and application thereof.The traditional Chinese medicine composition is reasonably combined according to etiology and pathogenesis of systemic lupus erythematosus, pseudo-ginseng, ginseng, glossy privet fruit and syngnathus serve as monarch drugs, and the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, nourishing the liver and tonifying the kidney and directly tonifying yin deficiency of the liver and the kidney; salvia miltiorrhiza, safflower, peach kernel, American ginseng, codonopsis pilosula, prepared rhizome of rehmannia, wolfberry, mulberry and panax japonicus are taken as ministerial drugs and are matched to assist the monarch drugs and clear stasis heat, cornu cervi pantotrichum, herba epimedii, hippocampus, pericarpium citri reticulatae, polygonum multiflorum, angelica sinensis, radix paeoniae alba, rhizoma polygonati and dog kidney are taken as adjuvant and conductant drugs and assist the monarch and ministerial drugs to harmonize yin and yang, all the drugs are matched and have a synergistic effect, and the effects of nourishing kidney and replenishing essence, reinforcing qi and nourishing yin, promoting blood circulation to remove meridian obstruction, warming yang and removing stasis can be achieved. The traditional Chinese medicine can treat both symptoms and root causes, and can effectively treat systemic lupus erythematosus.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine compound composition with a treatment effect on rapid atrial fibrillation and a preparation method of the traditional Chinese medicine compound composition. The traditional Chinese medicine composition comprises radix pseudostellariae, rhizoma polygonati, radix rehmanniae preparata, radix paeoniae alba, spina date seed, mulberry, jujube kernel, schisandra chinensis, Huai wheat, radix ophiopogonis, ligusticum wallichii, salvia miltiorrhiza, radix rehmanniae, coptis chinensis, radix paeoniae rubra, liquorice, fingered citron, calcined dragon bone, calcined oyster shell and rose. The invention aims at the basic pathogenesis of rapid atrial fibrillation dialectically belonging to insufficiency of heart yin, deficiency of essence and blood, unsmooth emotion, blood vessel stasis, stasis depression and fever which are caused by tachycardia and irregular pulse and rhythm. The clinical research proves that the traditional Chinese medicine compound composition can obviously reduce the recurrence frequency and recurrence rate of patients suffering from paroxysmal rapid atrial fibrillation and improve the symptoms of palpitation, chest distress, palpitation and the like of rapid atrial fibrillation, and has the advantages of good clinical curative effect and wide application prospect. The defects of western medicines can be well overcome.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to astragalus membranaceus and rhizoma polygonati oral liquid and a preparation method thereof. The invention provides a radix astragali and rhizoma polygonati oral liquid. The radix astragali and rhizoma polygonati oral liquid comprises the following components in parts by weight: 25-35 parts of radix astragali, 25-35 parts of rhizoma polygonati, 25-35 parts of radix asteris and 10-25 parts of radix codonopsis which are used as monarch drugs; 10-20 parts of bighead atractylodes rhizome, 25-35 parts of poria cocos, 25-35 parts of prepared rehmannia root and 15-20 parts of caffeoyl butanediamine which are used as ministerial drugs; 10-20 parts of angelica sinensis, 25-35 parts of fructus lycii and 10-20 parts of herba ecliptae are used as adjuvant drugs; and 5-10 parts of honey-fried licorice root and 10-20 parts of glossy privet fruit as conductant drugs. According to the monarch, minister, assistant and guide medication idea of traditional Chinese medicine, caffeoyl butanediamine is matched, so that the oral liquid can effectively tonify qi and enrich blood, exert the curative effect of tonifying qi and boost the spirit of a patient, and has good social benefits.

The utility model relates to the technical field of polygonatum sibiricum seed culture seedling transplanting, and discloses a special transplanting device for polygonatum sibiricum seed culture seedlings, which comprises a cutting frame, a cross rod fixedly mounted on one side, far away from the cutting frame, of a plug plate, a base plate fixedly welded on one side, far away from the cutting frame, of an inclined frame, and a sliding rod fixedly mounted on the outer wall of the top of the base plate. A transverse plate is fixedly mounted on the left outer wall of the plug plate, and a moving rod is fixedly welded to the top end of the annular frame. According to the special transplanting equipment for the polygonatum sibiricum cultivation seedlings, when the polygonatum sibiricum seedlings need to be transplanted, a cutting frame is arranged on the periphery of the polygonatum sibiricum seedlings in a sleeving mode, a pedal is treaded, the pedal can drive the cutting frame to move downwards, the cutting frame can go deep into soil, a cross rod is pushed, a plug plate can be driven by the cross rod to move downwards, the plug plate can go deep into the soil, and bottom plugging is completed; the problems that the bottom of a cylinder of an existing transplanting device is not provided with a shielding piece, soil in the cylinder is prone to falling off in the process that the cylinder is lifted upwards, and the survival rate of seedlings is low are solved.

The invention discloses granules of a composition containing rhizoma polygonati. The granules comprise the following components in percentage by weight: 30%-50% of composition dry paste powder, 38%-58% of a filling agent, 0.1%-20% of an adhesive and 0.1%-2% of a flow aid, the composition comprises rhizoma polygonati, fructus lycii, flos chrysanthemi and radix glehniae. Wherein the filling agent is dextrin; wherein the adhesive is maltodextrin or povidone; wherein the flow aid is colloidal silicon dioxide. According to the composition disclosed by the invention, proper auxiliary materials and an adding mode thereof are selected, so that the inherent properties of the original extract are improved, the extract is not easy to soften, the caking tendency caused by moisture absorption or heat absorption among particles is avoided, and the caking probability is reduced.

The invention relates to a traditional Chinese medicine composition for treating allergic dermatitis. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-35 parts of fried coix seeds, 5-35 parts of concha margaritifera, 1-30 parts of honeysuckle stems, 1-30 parts of smoked plums, 1-30 parts of fructus liquidambaris, 1-25 parts of fructus forsythiae, 1-25 parts of radix paeoniae rubra, 1-25 parts of raw sanguisorba officinalis, 1-25 parts of radix glehniae, 1-25 parts of radix ophiopogonis and 1-25 parts of raw radix polygonati officinalis. 1-25 parts by weight of talc and 1-25 parts by weight of lophatherum gracile. The traditional Chinese medicine composition has the effects of clearing heat, cooling blood without bitter cold, dispelling wind, eliminating dampness without hurting stomach, detoxifying, relieving itching and nourishing yin, is safe in clinical use, and has no adverse effect on liver and kidney.

The invention belongs to the technical field of medicines, and particularly relates to a rhizoma polygonati stem and leaf fermented feed additive and application thereof. The compound probiotics of bacillus, saccharomycetes and lactic acid bacteria are used as a feed additive, the additive for the rhizoma polygonati stem and leaf feed is provided and applied to preparation of the rhizoma polygonati stem and leaf fermented feed, the fermented feed prepared by the additive remarkably improves the dissolution of the content of total phenols and polysaccharides in the rhizoma polygonati stem and leaf feed, and the content of the total phenols and polysaccharides in the rhizoma polygonati stem and leaf feed is increased. The palatability of the feed is improved, the immunity of animals is favorably enhanced, the health and production performance of the animals are improved, the development and industrial application of medicinal and edible medicinal materials in the animal feed are promoted, and the feed has a wide prospect.

The invention relates to an anti-aging composition and application thereof. The anti-aging composition is prepared from the following raw materials: dendrobium officinale, camellia japonica and polygonatum kingianum. Dendrobium officinale, camellia japonica and polygonatum kingianum cooperate with one another to achieve a synergistic effect, secretion of type I collagen (COL-1) can be promoted, secretion of matrix metalloproteinase-1 (MMP-1) can be inhibited, and decomposition of collagen in extracellular matrixes can be slowed down. The anti-aging composition can increase skin elasticity, improve the skin barrier function, reduce the percutaneous water loss rate and delay skin aging.

The invention provides an eucheuma compound for improving lung function and a preparation method thereof. The eucheuma compound is prepared from the following raw materials in parts by weight: 25 to 35 parts of eucheuma extract, 13 to 17 parts of oyster peptide, 8 to 12 parts of fish collagen peptide, 4 to 6 parts of rhizoma polygonati, 3 to 5 parts of herba cistanche, 2 to 4 parts of semen euryales and 1 to 2 parts of longan. Secondly, the eucheuma extract rich in eucheuma polysaccharide, eucheuma polypeptide and the like is prepared through the technology. The components in the formula of the eucheuma compound have a synergistic effect, and the prepared eucheuma compound can effectively control the lung coefficient and increase of the hydroxyproline content in lung tissue and improve inflammatory infiltration and fibrohyperplasia of the lung. In addition, the compound also inhibits oxidative stress reaction and further inhibits pulmonary fibrosis; the lung lesion is effectively inhibited, the lung function is improved, and the lung health is promoted.

The invention discloses a Chinese medicine composition with the function of enhancing immune function and a preparation method thereof; the Chinese medicine composition is composed of one or more of parts A to F; wherein the weight proportions of the medicinal materials in parts A to F are as follows: part A comprises 1 to 50 parts of astragalus, 1 to 50 parts of ginseng, and 1 to 50 parts of codonopsis; part B comprises 1 to 40 parts of angelica, 1 to 40 parts of jujube, and 1 to 40 parts of longan pulp; part C comprises 1 to 30 parts of cistanche, 1 to 30 parts of eucommia leaf, 1 to 30 parts of alpinia oxyphylla, and 1 to 30 parts of ginseng seed. ~30 parts; Part D includes 1~20 parts of lily, 1~20 parts of polygonatum, 1~20 parts of wolfberry, and 1~20 parts of mulberry; Part E includes 1~20 parts of cornus and 1~20 parts of raspberry; Part F includes 1~10 parts of tuckahoe, 1~10 parts of yam, 1~10 parts of hawthorn, and 1~10 parts of tangerine peel; the Chinese medicine composition can be made into solid beverages, compressed candies, pastes, honey pills, functional jellies, biscuits, etc. in food after extraction or crushing and adding appropriate pharmaceutical excipients. The Chinese medicine composition has strong effects of strengthening the body, strengthening the spleen and lungs, and replenishing qi and blood, can effectively enhance immunity and improve physical fitness, and provides patients with a safe and effective pure Chinese medicine rehabilitation food.

The invention discloses a Lactobacillus paracasei CCFM1455 strain, a polysaccharide prepared from the Lactobacillus paracasei CCFM1455 strain for promoting gastric mucosa repair and application of the Lactobacillus paracasei CCFM1455 strain in synergism with rhizoma polygonati, and belongs to the technical field of microorganisms and medicines. According to the lactobacillus paracasei CCFM1455 exopolysaccharide disclosed by the invention, by regulating an STAT3 / SOCS3 signal channel, the levels of gastric mucosal lesion markers PGE2 and TFF3 are remarkably reduced, the expression of inflammatory factors is regulated, and gastric barrier protection and inflammation relief are realized. In addition, when the strain is used for fermenting polygonatum sibiricum, double synergistic effects can be generated: (1) macromolecular substances such as polygonatum sibiricum saponin are biologically converted, and easily absorbed micromolecular active substances such as oleanolic acid and liukucoumarin are generated; (2) polygonatum polysaccharide is converted into high-activity compound polysaccharide, so that the mucous membrane repairing synergistic effect is enhanced; therefore, the lactobacillus paracasei CCFM1455 and the fermentation derivative thereof provide an innovative solution for targeted intervention of gastric mucosal lesion and modernization of traditional Chinese medicines.

A method of preparing a Polygonatum polysaccharide composition is provided. The method includes performing a first extraction of Polygonatum material to obtain a first residue; performing a second extraction of the first residue to obtain a second residue; performing a third extraction of the second residue to obtain a supernatant, and precipitating the supernatant with a solvent to obtain crude polysaccharides; performing elution of the crude polysaccharides with a first eluent to obtain a first eluate; and performing filtration of the first eluate. A Polygonatum polysaccharide composition obtained by the method, an oral composition including the Polygonatum polysaccharide composition, a use of the Polygonatum polysaccharide composition in preparing a medicine for treatment of ulcerative colitis (UC) in a subject, and a method of treating UC in a subject are also provided. The Polygonatum polysaccharide composition comprises, consists essentially of, or is an isolated polysaccharide of a particular structure described herein.

A preparation method of a Pueraria lobata nano-silver composite hydrosol includes: dispersing Pueraria lobata powder in water, then heating to perform gelatinization, then adjusting a pH value, then sequentially adding an alkyl polyglucoside solution, a silver nitrate solution, and a sodium chloride solution, and performing a reaction by microwave heating to obtain the Pueraria lobata nano-silver composite hydrosol. The Pueraria lobata nano-silver composite hydrosol promotes seed germination of a Polygonatum Mill genus, and is applied in antibiotic detection and agricultural sterilization used as a fungicide. Organic solvents, harmful reducing agents, and dispersing agents are completely avoided to be used, and raw materials for preparing the hydrosol are safe and environment-friendly; the preparation method is simple, no harsh conditions are needed, and reaction conditions are mild; a required time is extremely short, energy is saved, consumption is reduced, and a basic principle of green chemistry is completely met.

The invention discloses a fluorescent / colorimetric dual-mode paper-based sensor for detecting cadmium ions in rhizoma polygonati as well as a preparation method and application of the fluorescent / colorimetric dual-mode paper-based sensor, and belongs to the technical field of detection of heavy metal residues in food with homology of medicine and food. PEI-UCNPs and PtNPs are loaded on a paper base and are mixed and reacted with Apt-AMNPs (at) TMB, H2O2, a PBS buffer solution and a solution containing Cd < 2 + >. The Aptamer specifically recognizes and captures Cd < 2 + >, so that the Apt-AMNPs (at) TMB is dissociated, and the TMB is released from holes of the AMNPs; the PtNPs on the paper base catalyzes colorless TMB (Tetramethylbenzidine) to generate blue oxide (oxTMB) under the action of H2O2, and the oxTMB can quench up-conversion fluorescence of PEI-UCNPs through fluorescence inner filtration. When the fluorescence / colorimetric dual-mode paper-based sensor is used for detecting the content of cadmium ions in rhizoma polygonati, the fluorescence / colorimetric dual-mode paper-based sensor has the characteristics of simplicity and convenience in operation, low detection cost, rapidness, specificity, sensitivity, portability and the like, and the fluorescence / colorimetric dual-mode paper-based sensor can be applied to on-site detection of the cadmium ions in rhizoma polygonati.

The utility model belongs to the technical field of cleaning devices, and particularly relates to a rhizoma polygonati production and processing cleaning device which comprises a cleaning device body. A motor and a discharging groove are installed on the side wall of the cleaning device body. The output end of the motor penetrates through the side wall of the cleaning device body and is fixedly connected with a rolling brush; the rolling brush is located in the cleaning device body. A rotating seat is fixedly connected to the top of the cleaning device body; the middle part of the rotating seat is rotationally connected with a cover plate; the inner side wall of the cover plate is fixedly connected with a water pipe; a plurality of water spraying heads are mounted in the middle of the water pipe; the end part of the water pipe is communicated and connected with a water delivery joint; the turnover cover plate is arranged at the top of the cleaning device body, so that liquid and rhizoma polygonati can splash when the rhizoma polygonati is cleaned by the cleaning device body, and the problem of loss caused by overflowing of the rhizoma polygonati is solved.

The invention relates to the technical field of preparation processes, and discloses ancient Huangtai liquor, which is prepared from the following components in percentage by weight: 50 to 55 percent of base liquor, 10 to 15 percent of medicinal and edible traditional Chinese medicinal material extract, 2 to 4 percent of honey, 0.1 to 2 percent of flavor regulator and the balance of purified water, the medicinal and edible traditional Chinese medicinal materials comprise at least one of angelica sinensis, lily, radix ophiopogonis, Chinese dates, Chinese wolfberry fruits, American ginseng, rhizoma polygonati, papayas, astragalus membranaceus and poria cocos, and the liqueur is prepared through the processes of stepped extraction, compound blending, ultrasonic-assisted homogenization, dynamic ageing and membrane filtration. According to the invention, through a stepped extraction process, temperature and time are regulated and controlled in stages, volatile components are preferentially extracted at low temperature, and then non-volatile substances are extracted at medium temperature, so that effective components in the traditional Chinese medicinal materials are fully extracted, the natural flavor of the traditional Chinese medicinal materials is retained, the extraction rate of the effective components is improved, and the flavor level of the liqueur is enriched.

The invention discloses a traditional Chinese medicine composition for treating hashimoto's thyroiditis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from 12-25 parts of wine-processed rhizoma polygonati, 18-30 parts of Chinese yam, 6-15 parts of pericarpium citri reticulatae, 3-12 parts of fructus amomi, 25-40 parts of semen coicis fried with bran, 8-16 parts of fried fructus gardeniae, 8-16 parts of rhizoma phragmitis, 8-16 parts of chrysanthemum, 8-16 parts of folium mori, 8-16 parts of radix polygonati officinalis, 10-15 parts of lily, 8-16 parts of honeysuckle, 12-25 parts of herba portulacae and 8-16 parts of radix angelicae. , 3-12 parts of platycodon grandiflorum and 3-12 parts of mint. The traditional Chinese medicine composition adopts the theory of syndrome differentiation and treatment, and clinical experiment results and animal experiment results show that the traditional Chinese medicine composition can improve clinical symptoms of patients with hashimoto's thyroiditis, can be used for treating hashimoto's thyroiditis, and has the advantages of remarkable treatment effect, high safety, homology of medicine and food and no toxic or side effect.

The utility model relates to the technical field of processing polygonatum, specifically a soaking device for processing polygonatum, comprising a box, the top surface of the box is hinged with a cover plate, the side of the box is connected to a liquid inlet pipe, the liquid inlet pipe is installed with a solenoid valve, and the inner wall side of the box is installed with a feedback liquid inlet mechanism; the interior of the box is slidably connected with a placement plate, both sides of the box are fixedly connected with limit plates for limiting the placement plate, and a stirring mechanism is rotatably provided between the inner walls on both sides of the box. In this soaking device for processing polygonatum, when the liquid medicine inside the box reaches a certain liquid level, the buoyancy ball will float up, overcome the elastic force of the reset spring, push the interception plate up, and block the inlet and outlet on the installation plate. On the contrary, when the liquid medicine level inside the box moves down, the elastic force of the reset spring pushes the interception plate down, and the liquid medicine can also be replenished in time, so that the soaking of polygonatum is more complete.

The invention provides a rhizoma polygonati extract as well as a preparation method and application thereof in prevention and control of glucose and lipid metabolism disorder. According to the invention, an effective component group consisting of effective parts of flavonoids and saponins is extracted from a traditional Chinese medicinal material polygonatum sibiricum, the sum of the actual contents accounts for more than 50% of the total weight of the polygonatum sibiricum extract, and meanwhile, the effective component group is used for preparing medicines for preventing and / or treating impaired glucose tolerance and glucose and lipid metabolism disorder. The traditional Chinese medicine composition is clear in curative effect, controllable in quality and easy to industrialize in preparation process, various proper dosage forms can be prepared according to clinical requirements, and a convenient, effective, stable and controllable modern traditional Chinese medicine is provided for clinical application.

The invention relates to the technical field of traditional Chinese medicines, and discloses eye drops for treating photochemically damaged eyes and a preparation method thereof. The eyedrops are prepared from the following raw materials: rhizoma polygonati, musk, flos chrysanthemi indici, semen cassiae, honeysuckle flowers, cortex phellodendri, herba houttuyniae, pearl powder, cortex fraxini, flatstem milkvetch seeds, rhizoma seu radix notopterygii and carthamin yellow. The traditional Chinese medicine composition is reasonable in component compatibility and synergistic in interaction, conforms to the traditional Chinese medicine theory, has the effects of clearing heat and purging fire, clearing liver and improving vision, clearing away heat and toxic materials and inducing diuresis to alleviate edema, can treat various eye diseases and discomfort caused by electronic equipment, and can also remarkably recover the activity of SOD and inhibit generation of MDA, so that retina lipid peroxidation caused by illumination is relieved, and the retina lipid peroxidation effect is improved. The composition has a good protection effect on the retina damaged by photochemistry, and the curative effect is remarkable.

The invention discloses a polygonatum sibiricum medicinal material species identification method based on a polygonatum sibiricum characteristic compound and application of the polygonatum sibiricum medicinal material species identification method. The invention discloses a polygonatum sibiricum medicinal material species identification method based on a polygonatum sibiricum characteristic compound. The method comprises the following steps: 1) preparing a polygonatum sibiricum rhizome sample solution; 2) analyzing different sealwort rhizome metabolites by liquid chromatography-mass spectrometry; and 3) discriminating the species of the rhizoma polygonati medicinal material, namely discriminating the species of the rhizoma polygonati medicinal material if the rhizoma polygonati rhizome metabolite contains a corresponding characteristic compound. The polygonatum sibiricum variety is polygonatum kingianum, polygonatum sibiricum, polygonatum cyrtonema and polygonatum odoratum. According to the application of the polygonatum kingianum characteristic compounds in polygonatum kingianum medicinal material species identification, each polygonatum kingianum species selects three representative characteristic compounds which are relatively high in content, have functional specificity representatives and are common in the market, the species of the polygonatum kingianum medicinal material can be identified as long as the three representative characteristic compounds are contained at the same time, the accuracy is high, the number of components to be detected is small, and the accuracy is high. The detection period is short.

The invention relates to the technical field of medicinal and edible beverages, and discloses a formula and a preparation method of a ginseng probiotic fermented beverage. The ginseng probiotic fermented beverage is prepared from ginseng, fructus lycii, rhizoma polygonati, poria cocos, fructus crataegi, honey and a compound probiotic group. The beverage comprises the following raw materials in parts by weight: 5-15 parts of ginseng; 3-8 parts of fructus lycii; 2-5 parts of rhizoma polygonati; 1-3 parts of poria cocos; 3-6 parts of hawthorn; 5-10 parts of honey; the viable count of the composite probiotic group is (1-3) * 10 < 9 > CFU / mL; according to the preparation method, the medicinal and edible raw materials are subjected to enzymolysis and three-stage temperature-controlled fermentation, so that the release rate and the stability of active ingredients such as polysaccharide and saponin are improved; through synergistic interaction of lactobacillus plantarum, lactobacillus acidophilus and bifidobacterium bifidum in a ratio of 2: 1: 1, intestinal flora regulation and immune enhancement functions are enhanced; in addition, three-stage temperature control fermentation is combined with micro-aerobic regulation and control, a flora metabolism path is optimized, micromolecular active substances are enriched, thalli and macromolecular impurities are removed through a centrifugal combined ultrafiltration process, and the purity and the absorption rate of the active ingredients can be improved.

The invention provides procyanidine C1 nanoparticles as well as a preparation method and application thereof, and relates to the technical field of food processing. The nanoparticles are prepared by using lysine as a coupling agent, polysaccharide (such as polygonatum polysaccharide, dendrobium polysaccharide and lycium barbarum polysaccharide) as an embedding wall material and procyanidine C1 as a core material through a self-assembly method. The nanoparticles can significantly improve the embedding rate and stability of the proanthocyanidins C1, enhance the anti-oxidation and anti-aging effects of the proanthocyanidins C1, can be used for constructing a nano delivery system or preparing anti-aging and anti-oxidation medicines and foods, and have wide application prospects.

The invention discloses a composite plant polypeptide composition with the effects of repairing pancreas and reducing blood sugar. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 50 parts of ginsenoside, 5 to 30 parts of radix astragali seu hedysari extract, 3 to 20 parts of radix rehmanniae polysaccharide, 2 to 15 parts of radix trichosanthis alkaloid, 5 to 25 parts of rhizoma dioscoreae polysaccharide, 5 to 30 parts of bitter gourd polypeptide, 3 to 20 parts of folium mori alkaloid, 8 to 40 parts of rhizoma polygonati polysaccharide, 5 to 25 parts of fructus hippophae flavone, 10 to 35 parts of wheat germ peptide, 2 to 15 parts of coptis berberine, 10 to 45 parts of corn stigma polysaccharide and 3 to 20 parts of saussurea involucrata polyphenol. 1-10 parts of sophora flavescens total alkaloids, 5-25 parts of a dendrobium extract, 5-30 parts of a radix puerariae extract, 8-35 parts of L-arabinose and 10-40 parts of small molecule peptides; 20 to 100 parts of collagen peptide and 15 to 80 parts of albumin peptide; 5-50 parts of microcrystalline cellulose, 3-30 parts of fructo-oligosaccharide and 0.5-5 parts of magnesium stearate; the limitation of single sugar control or simple component mixing in the prior art is broken through, a synergistic system of plant active components and functional polypeptides is constructed, and the purity and retention rate of the plant active components are improved by optimizing the extraction process.

The invention discloses a traditional Chinese medicine composition for reducing blood pressure and preventing heart diseases, and belongs to the technical field of traditional Chinese medicine preparation, and the traditional Chinese medicine composition is prepared from the following raw materials: selfheal, radix puerariae, eucommia ulmoides, salvia miltiorrhiza, ligusticum wallichii, radix paeoniae rubra, fructus trichosanthis, coptis chinensis, semen cassiae, angelica sinensis, radix paeoniae alba, rhizoma polygonati, dogwood, rhizoma atractylodis macrocephalae, poria cocos, radix cyathulae, radix curcumae, hawthorn and rheum officinale. The traditional Chinese medicine composition is suitable for people suffering from hypertension in the early stage, the middle stage and the later stage, has a good multi-target-point, targeted and broad-spectrum blood pressure lowering effect and a defecation effect, and can also protect the heart function, so that the risk of cardiovascular and cerebrovascular disease complications caused by hypertension lesion is reduced.