14 results about "Thyroiditis" patented technology

The invention discloses a traditional Chinese medicine composition for treating hashimoto's thyroiditis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from 12-25 parts of wine-processed rhizoma polygonati, 18-30 parts of Chinese yam, 6-15 parts of pericarpium citri reticulatae, 3-12 parts of fructus amomi, 25-40 parts of semen coicis fried with bran, 8-16 parts of fried fructus gardeniae, 8-16 parts of rhizoma phragmitis, 8-16 parts of chrysanthemum, 8-16 parts of folium mori, 8-16 parts of radix polygonati officinalis, 10-15 parts of lily, 8-16 parts of honeysuckle, 12-25 parts of herba portulacae and 8-16 parts of radix angelicae. , 3-12 parts of platycodon grandiflorum and 3-12 parts of mint. The traditional Chinese medicine composition adopts the theory of syndrome differentiation and treatment, and clinical experiment results and animal experiment results show that the traditional Chinese medicine composition can improve clinical symptoms of patients with hashimoto's thyroiditis, can be used for treating hashimoto's thyroiditis, and has the advantages of remarkable treatment effect, high safety, homology of medicine and food and no toxic or side effect.

This invention relates to the field of traditional Chinese medicine and natural medicines, and discloses a traditional Chinese medicine composition for treating thyroiditis, nodular goiter, and thyroid nodules, as well as its preparation method and application. The traditional Chinese medicine composition is made from raw materials in parts by weight of 1-30 parts of Prunella vulgaris, 1-30 parts of Taraxacum mongolicum, 1-30 parts of Hordeum vulgare malt, 1-20 parts of Citrus reticulata peel, 1-24 parts of Crataegus pinnatifida, and 1-24 parts of Raphanus sativus seed. It can not only significantly reduce serum TgAb and TPOAb antibody levels, inhibiting the attack of autoimmune response on the thyroid gland from the source, but also effectively reduce lymphocyte infiltration, repair damaged thyroid follicular structure and restore colloid content, thereby reversing immune damage and tissue destruction of the thyroid gland, reducing thyroid nodules, and solving the problems of existing treatments for thyroiditis, nodular goiter, and thyroid nodules that cannot reverse immune damage to the thyroid gland, destruction of follicular structure, and tissue fibrosis.

The invention provides a traditional Chinese medicine composition for detoxifying and removing stasis as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following active ingredient raw materials: selfheal, radix ranunculi ternati, rhizoma bolbostemmae, oyster, fried endothelium corneum gigeriae galli, edible tulip, vinegar turtle shell, vinegar curcuma zedoary, poria cocos, astragalus membranaceus, spina gleditsiae, radix curcumae and oldenlandia diffusa. The traditional Chinese medicine composition disclosed by the invention is used as a symptomatic medicine, is specially designed for various diseases caused by qi stagnation, phlegm coagulation and heat toxin stasis due to scientific compatibility, is suitable for patients with thyroid nodules, hashimoto's thyroiditis, hyperplasia of mammary glands and pulmonary nodules, and has no toxic or side effects. The symptoms such as emotion depression, neck and breast lumps, pharyngeal obstruction, chest distress and hypochondriac distension, breast pain and the like can be relieved.

The invention provides a traditional Chinese medicine composition for treating hashimoto's thyroiditis and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. On one hand, the invention provides a traditional Chinese medicine composition for treating hashimoto's thyroiditis, and the traditional Chinese medicine composition is prepared from the following raw material medicines: radix rehmanniae recen, fructus forsythiae, moutan bark, radix paeoniae rubra, polygonum cuspidatum, scutellaria baicalensis, cynanchum paniculatum, houttuynia cordata and pericarpium citri reticulatae; secondly, the invention provides a preparation method of the traditional Chinese medicine composition for treating hashimoto's thyroiditis. Thirdly, the invention provides a preparation method of the moutan bark and cynanchum paniculatum ethanol extraction powder. In the fourth aspect, the invention further provides application of the traditional Chinese medicine composition in preparation of a medicine for treating hashimoto's thyroiditis.

The invention relates to an application of a traditional Chinese medicine composition in preparing a medicine for treating thyroiditis, which is characterized in that the traditional Chinese medicine composition is prepared from astragalus membranaceus, dried ginger, salted morinda officinalis, cortex dictamni, calcined oyster shell, schisandra chinensis and divaricate saposhnikovia root. The composition can obviously improve the thyroid functions of mice and rats, obviously reduce the content of inflammatory factors TNF-alpha, IL-6 and IL-12 in serum of the mice, obviously increase the level of TGF-beta in serum of the rats and reduce the level of IL-17, and has a good treatment effect on autoimmune thyroiditis induced by combination of thyroglobulin and high-iodine water.

Described is a method for differentiating destructive thyroiditis, including measuring at least one of monoiodotyrosine and diiodotyrosine in a sample.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to application of a traditional Chinese medicine composition in preparation of medicine for treating thyroiditis, and the traditional Chinese medicine composition is mainly prepared from codonopsis pilosula, radix astragali preparata, poria cocos, fried rhizoma atractylodis macrocephalae, prepared polygala tenuifolia, honey-fried licorice root, fried spina date seed, longan aril, angelica sinensis, jujube, elecampane and ginger. All the medicines in the traditional Chinese medicine composition conform to the principle of compatibility of monarch, minister, assistant and guide, compatibility is scientific, clinical cases are considered, pharmacodynamic tests show that the composition can remarkably improve the basic condition of mice suffering from thyroiditis, adjust the levels of thyroid hormones T3, T4 and TSH of the mice, reduce inflammatory factors TNF-alpha and IL-10 and inhibit inflammatory reaction, and clinical tests verify that the composition has a remarkable curative effect on thyroiditis. The traditional Chinese medicine composition can effectively relieve symptoms of patients with thyroiditis, is low in toxic and side effects and good in safety, and has a wide market prospect.

This application relates to the field of otolaryngology technology, specifically a method and system for predicting the risk of papillary thyroid carcinoma. By combining multiple sets of clinical indicators and multiple imaging feature data, this application can effectively assess and predict the risk of papillary thyroid carcinoma. The scoring data provides a more intuitive determination of the severity of papillary thyroid carcinoma, thereby enabling the differentiation between atypical subacute thyroiditis and papillary thyroid carcinoma. Compared to existing technologies, the discrimination results of the embodiments in this application are more accurate.

The present invention discloses the use of puerarin in the preparation of a drug for preventing and / or treating Hashimoto's thyroiditis. Puerarin can effectively improve the Hashimoto's phenotype. The present invention proves through experiments that puerarin effectively inhibits the inflammatory damage of thyroid tissue and suppresses the level of autoantibodies, with significant differences compared with the control group, and has a good therapeutic effect on Hashimoto's thyroiditis.

The invention provides a Hashimoto's thyroiditis first work abnormity early warning method, which comprises the steps of obtaining traditional Chinese medicine symptom characteristics, an ultrasonic image and a first work index of a target user, accurately positioning key influence factors of traditional Chinese medicine related indexes on diseases according to the symptom characteristics, obtaining gland texture characteristics according to the ultrasonic image, and carrying out early warning according to the gland texture characteristics. Obtaining a quantification trend according to the first work index; mapping the current traditional Chinese medicine syndrome characteristics, the gland texture characteristics, the first work indexes and the quantitative trends of the corresponding first work indexes into state characteristics of the target user; obtaining a state transition probability of the target user based on the state feature set in a preset time period, and determining a first work abnormal inflection point of the target user based on the traditional Chinese medicine symptom feature and gland texture feature of the target user and the fluctuation condition of the quantitative trend; after the first-order work abnormal inflection point of the target user is determined, the early warning response of the target user is triggered based on the risk grading, when the first-order work abnormal inflection point of the target user occurs, the early warning response is immediately carried out, an intervention scheme is formulated for the target user in advance, and the first-order work abnormal morbidity is reduced.

The invention discloses a lactobacillus casei C7-2 and application thereof in preparation of a composition for conditioning / improving thyroiditis and brain function activity and protecting neurons. The lactobacillus casei C7-2 has the Latin literature name of Lacticaseibacillus casei, the preservation number of the lactobacillus casei C7-2 is GDMCC 63609, the preservation time of the lactobacillus casei C7-2 is June 30, 2023, and the preservation unit of the lactobacillus casei C7-2 is Guangdong Province Microbial Culture Collection Center. Compared with the prior art, the lactobacillus casei C7-2 has the advantages that the motor function and cognitive function of mice are obviously improved, and the Abeta42 level of hippocampus and cerebral cortex can be effectively reduced. In addition, the composition also can reduce the level of inflammatory factors to a certain extent, and condition / improve further deterioration of neurodegeneration and cognitive impairment. In addition, the lactobacillus casei C7-2 disclosed by the invention also has a relatively good conditioning / improving effect on thyroiditis.

Autoimmunity and (Chronic) To provide isolated monoclonal antibodies that bind to human CD38 and are useful in the treatment of diseases including inflammatory diseases such as type 1 and type 2 diabetics, thyroiditis, Graves' disease, arthritides, neuroinflammation and asthmatics.SOLUTION: There are provided antibodies binding to human CD38 in which Asp at a specific position of an amino acid sequence is substituted with Gly.EFFECT: Antibodies that bind to human CD38 are those that do not bind to the human CD38 mutant to the same extent that they bind to wild-type human CD38, and have a strong stimulatory effect on the cADPR hydrolase activity of CD38, leading to reduced levels of cADPR and inhibiting the capability of CD38 to catalyse the formation of nicotinic acid adenine dinucleotide 2 ' - phosphate (NAADP) via a base exchange reaction.SELECTED DRAWING: None

The invention relates to a traditional Chinese medicine composition for treating hashimoto's thyroiditis and a preparation method thereof. The invention provides a traditional Chinese medicine composition for treating hashimoto's thyroiditis. The traditional Chinese medicine composition comprises radix bupleuri, radix curcumae, radix asparagi, radix tetrastigme, radix paeoniae alba, rhizoma polygonati, herba epimedii and liquorice. The composition has the effects of clearing heat, eliminating goiter and supporting the healthy energy, is simple in medicine flavor, can effectively reduce the related antibody level through clinical verification, has a good clinical effect, and can relieve or even reverse the secondary thyroid dysfunction of the disease.

This invention relates to the field of traditional Chinese medicine, and particularly to a traditional Chinese medicine composition, drug, preparation method, and application for treating thyroid nodules and Hashimoto's thyroiditis. The invention uses Bupleurum chinense, stir-fried Perilla frutescens seeds, and Trichosanthes kirilowii as the principal herbs to soothe the liver, regulate qi, and resolve phlegm; Scrophularia ningpoensis, Fritillaria thunbergii, and raw oyster shell as the assistant herbs to soften and disperse nodules; and Scutellaria baicalensis to clear liver fire, and Paeonia suffruticosa to nourish the liver and clear deficiency heat. The traditional Chinese medicine composition provided by this invention has a precise formula that can significantly alleviate the clinical symptoms of patients with thyroid nodules and Hashimoto's thyroiditis, and can effectively treat these conditions. Furthermore, the traditional Chinese medicine composition of this invention has good safety, no toxic side effects, and is convenient to use, providing a new drug option for clinical practice.