The continuous preparation apparatus and process for
glucosamine sulfate or
phosphate compounds described in this invention comprises at least three
chromatographic separation units connected in a specific manner to form a continuously operable closed-loop
system. Each separation unit is connected via pipelines to a
chromatographic column, a delivery pump, a switching valve, and a
feed tank. The switching valve controls the flow direction of the feed liquid, solution, water, and waste liquid, creating a dual-function
system capable of operating independently or in conjunction with other separation units. This invention utilizes a real-time dynamic
axial compression column, significantly reducing the
dead volume at the column head, thereby improving both separation efficiency and the concentration of
glucosamine sulfate or
glucosamine phosphate solutions. The alternating use of alkali and acid, along with a matching preparation process, activates
weak base exchange groups to achieve exchange capacity similar to strong
base exchange groups, while also promptly removing impurities adsorbed on the packing material, thus improving product quality. The entire process is a closed-loop,
continuous operation via pipelines, facilitating automated control.