8 results about "Dead volume" patented technology

The utility model relates to a liquid chromatographic column, which comprises a column tube filled with filler, openings at two ends of the column tube are provided with mounting heads, each mounting head comprises an inner tube inserted on the inner side of the column tube and an outer tube sleeved on the outer side of the column tube, a sealing ring is arranged on the peripheral wall of the inner tube, and a sieve plate is arranged on one side of a limit ring far away from the column tube. A pressing sleeve is arranged on the side, away from the limiting ring, of the sieve plate, the outer circumferential wall of the pressing sleeve is in threaded connection with the inner circumferential wall of the inner pipe, a liquid guide hole coaxial with the column pipe is further formed in the pressing sleeve, an axial sliding guide piece is arranged between the outer pipe and the column pipe, and a threaded sleeve is rotationally connected to the end, away from the connecting ring, of the outer pipe and is in threaded connection with the outer circumferential wall of the column pipe. The sieve plate can be conveniently disassembled, the length of the inner tube extending into the column tube can be controlled during mounting, the distance between the sieve plate and the filler can be changed, dead volume caused by filler loss or chromatographic column collapse and the like can be compensated, and the conditions of reduction of separation degree and reduction of column efficiency of the chromatographic column are avoided.

1. Name of the product in this design: Pressure sensor (gas chromatography-liquid chromatography single / double-direction zero dead volume flow-through type). 2. Application of this design: a single / double-direction zero dead volume flow-through pressure sensor for gas chromatography, gas chromatography-mass spectrometry, liquid chromatography, pharmaceutical chemical preparation, analysis, and life science instruments. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention relates to a rapid balance calibration method and system of a gradient elution liquid chromatograph, and relates to the technical field of chromatographic instrument sample separation, and the rapid balance calibration method comprises the following steps: collecting an initial temperature and an initial dead volume of a preset chromatographic column and an initial flow velocity of a preset mobile phase; calculating a quotient between the initial dead volume and a preset target delay time to generate a target flow rate; calculating according to the initial temperature, the initial flow velocity, the target flow velocity and a preset mobile phase volume expansion coefficient to generate a target temperature; the mobile phase viscosity at the target temperature is obtained; correcting the target temperature according to the mobile phase viscosity to generate an actual target temperature; and controlling a preset chromatographic column adjusting device to adjust the temperature of the chromatographic column according to the actual target temperature so as to promote the rapid balance of the gradient elution liquid chromatograph. The method has the effect of improving the sample analysis efficiency.

The present application relates to the technical field of automation control, and discloses an At-211 elution process optimization method and system based on model predictive control, comprising the following steps: step 1, calibrating inherent dead volume and lag time; step 2, establishing a deterministic mechanism model, generating flow rate range, working condition range and valve group switching plan; step 3, using pre-washing liquid to stabilize the pre-elution stage until the conductivity and pressure are stable, and removing residual reagents; step 4, when the main elution is triggered, calculating the lag time and scheduling the valve group switching time; step 5, starting the main elution process through the high flow rate range and switching to the low flow rate range; step 6, triggering the price state locking liquid pulse, changing the At-211 price state and determining the collection termination time; and step 7, collecting the elution volume through volume segmentation, calculating the decay correction factor and converting to the unified reference time. The present application realizes the precise control of the flow rate range, working condition range and valve group switching, and improves the efficiency and consistency of the elution process.

The utility model provides a kind of chromatographic column pipe, including column pipe body, the column pipe body includes column pipe screw head and pipe body, two groups the column pipe screw head is mutually symmetrical and is connected in the both ends of the pipe body;The outside wall of one end of the pipe body is equipped with discernment slot, and the inside of the pipe body is penetrated with pipe body inner hole;The inside of the column pipe screw head is fixedly connected with sieve plate at the both end openings of the pipe body inner hole, precision line pipe hole design, reduce connection dead volume, improve separation precision and analysis result accuracy;Stainless steel sieve plate shell cooperation overall structure, withstands 150MPa, adapts high pressure chromatography analysis scene;Conical surface makes blade annular variable seal, before end chamfer polishing hand twist structure, no risk of liquid leakage under high pressure;0.1 μm roughness mirror surface inner hole, molecule is not easy to stay, significantly improve separation rate and effect;Sieve plate gives consideration to " filter macromolecular impurities " and " large flow liquid passage ", adapt to multi-flow chromatography analysis demand.

A distinctive feature of this design lies in the shape of the three-way valve for reducing dead volume through the movement of radioactive or non-radioactive solutions. 1.1) Perspective view; 1.2) Top view; 1.3) Bottom view; 1.4) Front view; 1.5) Rear view; 1.6) Left side view; 1.7) Right side view; 1.8) Perspective view; 1.9) Sectional view

This invention relates to the field of radioactive separation control technology, and discloses an intelligent switching control method and system for multi-way valves in radionuclide separation, comprising: Step 1, pushing inert liquid to determine the dead volume of the calibrated outlet section, and determining the quantitative clearing volume and the target channel pre-filling volume; Step 2, advancing pre-wetting liquid according to the preset pre-wetting volume and the target channel pre-filling volume; Step 3, advancing the feed liquid according to the sample loading volume, and executing the safety flushing volume according to the pressure signal; Step 4, purging the first and second rinsing liquids according to the quantitative clearing volume; Step 5, collecting activity signals to generate activity window entry and activity window exit signals; Step 6, responding to the signals to switch to the target collection channel according to the isolation section volume, quantitative clearing volume, and target channel pre-filling volume; Step 7, cleaning and purging, resetting the default safety position, and recording the cumulative pump advance volume. This invention realizes quantitative and time-sequential management of flow path switching during radionuclide separation.