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The invention relates to a method which utilizes blood glucose (“BG”) sampling, insulin infusion/injection records, heart rate (“HR”) information and heart rate varability (“HRV”) information to estimate BG in the near future and to estimate of the risk of the onset of hypoglycemia. The invention also relates to an apparatus for predicting BG levels and for assessing the risk of the onset of hypoglycemia in the near future. The invention is based on two predetermined bio-mathematical routines: a network model of BG fluctuations and a BG profile for assessment of the risk of hypoglycemia.

An apparatus, method and system are disclosed for visually constructing and rapidly delivering distributed applications. The system includes a virtual appliance apparatus and a composite appliance apparatus, as well as a system for virtualizing hardware resources and for provisioning, executing and scaling distributed applications.

A system loads, authenticates and uses a virtual smart card for payment of goods and/or services purchased on-line over the Internet. An online purchase and load (OPAL) server includes a virtual smart card data base that has a record of information for each smart card that it represents for a user at the behest of an issuer. The server includes a smart card emulator that emulates a smart card by using the card data base and a hardware security module. The emulator interacts with a pseudo card reader module in the server that imitates a physical card reader. The server also includes a client code module that interacts with the pseudo card reader and a remote payment or load server. A pass-through client terminal presents a user interface and passes information between the OPAL server and a merchant server, and between the OPAL server and a bank server. The Internet provides the routing functionality between the client terminal and the various servers. A merchant advertises goods on a web site. A user uses the client terminal to purchase goods and/or services from the remote merchant server. The payment server processes, confirms and replies to the merchant server. The payment server is also used to authenticate the holder of a virtual card who wishes to redeem loyalty points from a merchant. To load value, the client terminal requests a load from a user account at the bank server. The load server processes, confirms and replies to the bank server.

An improved method for delivery and play back of sound and image files is provided. This new method includes the use of sound and/or image clips, which can be snippets or full files, as alerts for a variety of electronic devices or for playing on a handheld device, and for use as a promotion to sell items associated with the files. A collection or library of uniquely selected and/or edited clips may also be provided to the consumer in a manner far more conveniently on conventional telephone equipment than previously available. Algorithms are provided for the delivery, storage and playback of the sound files, including a delivery method algorithm (500), a parametric optimization and compression algorithm (1500), and an error correction algorithm. In contrast to the conventional ring tones or musical chimes used to ring cellular phones currently on the market, the current invention provides a method for ringing cellular phones and landline telephones with real sound recordings including real music, which may be songs lifted from copyright registered CD tracks, and may comprise human voice, various instrument sounds, and other sound effects of a high quality. A software based system for encoding the hardware of existing cellular phones at the time of manufacturing with delivery, storage, and playback capabilities in accordance with the present invention is provided, such that additional hardware is not required.

An exhaust air removal system and method for use with a rack or enclosure containing equipment is provided. The system and method are configured for removal of exhaust air vented from equipment during operation to thereby remove heat from the equipment. In one aspect, the system includes a fan unit preferably configured to serve as a back door of an equipment rack or enclosure and configured to provide access to an interior of the rack or enclosure. The fan unit provides multiple fans coupled to internal exhaust ducts that are arranged to draw and to remove exhaust air vented from rack-mounted equipment. The fan unit is further configured to vent exhaust air to an area external to a rack or enclosure, such as an external exhaust duct or plenum. Removal of hot and warm exhaust air vented from rack-mounted equipment enables the equipment to operate effectively, drawing sufficient amounts of cooling air to meet its cooling requirements. The fan unit is constructed for portability and for easy attachment to and removal from a rack or enclosure, providing flexibility in handling equipment exhaust needs.

A method, system, and computer-accessible medium are provided for automating the optimization of search result relevance in a search engine. The system and method continually collect data that represent various aspects of how a search result is performing and compare that performance data to the expected performance for the search result. The system and method further diagnose the possible causes of under performing results and automatically adjust the search engine operation to optimize the search result relevance.

A device for pre-concentration and purification of analytes from biological samples, such as human serum, to be analyzed by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) and methods of use thereof are provided.

The present invention provides articles of manufacture comprising biocompatible nanostructures comprising significantly increased surface area for, e.g., organ, tissue and/or cell growth, e.g., for bone, tooth, kidney or liver growth, and uses thereof, e.g., for in vitro testing of drugs, chemicals or toxins, or as in vivo implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as drug delivery devices. The present invention provides biocompatible nanostructures with significantly increased surface area, such as with nanotube and nanopore array on the surface of metallic, ceramic, or polymer materials for enhanced cell and bone growth, for in vitro and in vivo testing, cleansing reaction, implants and therapeutics. The present invention provides optically transparent or translucent cell-culturing substrates. The present invention provides biocompatible and cell-growth-enhancing culture substrates comprising elastically compliant protruding nanostructure substrates coated with Ti, TiO₂ or related metal and metal oxide films.

The present invention is a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of denaturing due to a thermal change. The method comprises contacting the target molecule with one molecule of the multiplicity of different molecules in each of a multiplicity of containers, simultaneously heating the multiplicity of containers, measuring in each of the containers a physical change associated with the thermal denaturation of the target molecule resulting from the heating in each of the containers, generating a thermal denaturation curve for the target molecule as a function of temperature for each of the containers and determining a midpoint temperature (T.sub.m) therefrom, comparing the T.sub.m of each of the thermal denaturation curves with the T.sub.m of a thermal denaturation curve obtained for the target molecule in the absence of any of the molecules in the multiplicity of different molecules, and ranking the affinities of the multiplicity of different molecules according the change in T.sub.m of each of the thermal denaturation curves.

A transducer seal designed to seal an open aperture of a transducer housing for a therapeutic ultrasound procedure. The seal has a membrane, a retainer and a mating device for locking in place with the transducer housing. The membrane is essentially transparent to ultrasound energy while being stretched taut about the retainer. The transducer seal may be made in a disposable or re-usable form.

A decentralized cryptographic real estate transaction assistance system and method is provided to facilitate matching, engaging, contracting, and communicating between parties to a real estate and/or property rental transaction by a network-leveraged system. The decentralized cryptographic real estate transaction assistance system and method may include a property rental and real estate transaction assistance platform, database, platform components, renter component, matching component, communication component, broker-assisted component, landlord direct component, landlord management component, vendor portal, lead marketplace component, guaranteed rental income protection, renter profile validation aspect, and tenant exchange. A method for facilitating matching, engaging, contracting, and communicating between parties to a real estate and/or property rental transaction by a network-leveraged system using the decentralized cryptographic real estate transaction assistance system and method is also provided.

A pricing terminal is installed at a retail store. The pricing terminal includes an enclosure that allows a customer to be seated therein, a display screen mounted in the enclosure, a keyboard and a processor operatively connected to the display screen and the keyboard. The processor is programmed to control the display screen, receive input via the keyboard and guide the customer to perform a pricing activity. The pricing activity may include viewing an advertisement, answering survey questions, or agreeing to enter into a transaction with a third party. The customer is rewarded for performing the pricing activity by receiving a discount on a purchase transaction or another benefit.

A system and method for defining the value of a corporation by its categories of values, and determining the risk profile of the corporation by the relationship between the categories of value, termed the “Risk Signatures.” The system provides for the determination of the “Relative Values” of corporate enterprises, with the capability of dynamically monitoring and measuring the financial performance of an enterprise through the use of artificial intelligence and data mining techniques.

An injector device assembly and a method for making an injector device assembly are provided. The injector assembly includes a sterile insertion set with a housing and a hollow cannula and a device housing. A plunger is slidably received within the device housing for movement between an advanced position and a retracted position wherein the cannula is transcutaneously placed upon movement of the plunger from the advanced position to the retracted position. The device housing has a forward end defining a surface of placement against the skin of a patient with the device housing in a predetermined orientation relative to the patient's skin. The injector device assembly includes a spring for urging the plunger toward the advanced position and a releasable cover member covering the forward end. The cover member and the device housing assure sterile conditions of the insertion set within the device housing prior to removal of the cover member.