267 results about "Repertoire" patented technology

The present invention enables a cell phone or PDA user to purchase a full version of an application with a single key stroke, without switching back and forth between the application and a browser. A one click upgrade is made available which is intuitive and quicker than prior methods known in the art. Trial versions in the present invention are full versions with most of the game disabled. Upgrades to the full version are enabled by setting a flag once the customer has paid for the upgrade. The customer is able to play one level or track for a game or to play the,game for limited period of time. Once the trial limit is reached, the content or game provider offers details on how to purchase the full version.

The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a repertoire of vectors with altered antigenic properties, packaging capabilities, and / or cellular tropisms as compared with current AAV vectors.

The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

A play list manager is disclosed that can be used to create and update play lists. The play lists can be used for audio information, visual information, or a combination of audio and visual information. The user of the play list manager creates a play list and specifies certain criteria for automatically adding tracks to the play list. When a new track is added to the environment, the system tests whether the track's properties satisfy the criteria for the play list. If so, the new track is automatically added to the play list. In one alternative, a user can select a predefined play list, whose criteria has already been created. Upon selection of the predefined play list, the play list manager accesses each track and adds the track to the play list if the track's properties satisfy the criteria for the predefined play list.

The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, by compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

A system for managing academic and social life for students includes a central server connected to a wide-area network and storing a repertoire of logic functions for use by students in managing academic activities; and a plurality of computerized appliances associated with individual students, the computerized appliances connectable to the wide-area network. The students may download logic from the central server, and execute the logic to configure and manage activities related to classes and studies in a college or university, and may interact with other students through the central server. In one aspect the system further includes one or more distributed servers connected to the wide-area-network the servers adapted for network-based academic learning and for communication with the central server over the network; and one or more content servers connected to the wide-area-network, the content servers adapted to provide Web-based content and services to students through the central server.

Abstract of the Disclosure The present invention relates to methods for selecting repertoires of polypeptides using generic and target ligands. In particular, the invention relates to a library comprising a repertoire of polypeptides of the immunoglobulin superfamily, wherein the members of the repertoire have a known main chain conformation.

A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.

A system is disclosed that provides access to a large amount of content using a traditional interface. The system has many applications, one of which is for providing access to audio / visual content. Examples of audio / visual content includes compressed digital music data and video data. In one embodiment, the system receives an indication of a first mode, accesses a first playlist for the first mode, and plays tracks according to the first playlist. In this embodiment, each mode is associated with a different attribute, each mode includes one or more playlists of tracks, and each playlist of a particular mode is based on a different value for the attribute associated with the particular mode. Examples of attributes include artist, album, genre, etc. Thus, there can be an artist mode, an album node, a genre mode, etc. For example, each playlist in the artist mode is associated with a particular artist. All tracks on a given playlist in the artist mode would be associated with the same artists.

The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins / (poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.

The invention is a method for detecting and measuring T-cell receptor (TCR) repertoires from mammalian lymphocytes. The method is based on the use of the multiple sets of unique primers to amplify 22 regions of the TCR Vβ region and thereby detect clonal expansions related to antigen stimulation of the immune system. Kits containing sets of primers and specialized analytical statistical software for use in determining clonal expansion in humans and mice are disclosed. The reliability, efficiency and short assay time in using the method is well suited to monitoring immune response to vaccination and therapeutic treatments for immune disorders.

The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.

The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, by compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

The present invention discloses methods, devices, and systems for unobtrusively recognizing a user of a mobile device. Methods including the steps of: unobtrusively collecting motion data from the mobile device during normal device usage by monitoring standard authorized-user interaction with the device, without any form of challenge or device-specified action; demarcating the motion data into user motion-sequences based on changes in a motion-state or an elapsed time-period without an occurrence of the changes, wherein the motion-state refers to a placement and speed of the mobile device at a point in time; calculating user motion-characteristics from the user motion-sequences; and generating a motion-repertoire from the user motion-characteristics, whereby the motion-repertoire enables unobtrusive recognition of the user. Preferably, the method further includes the step of: detecting unidentified motion-characteristics that are not associated with the motion-repertoire, thereby enabling unobtrusive recognition of unidentified usage.

A song-matching system, which provides real-time, dynamic recognition of a song being sung and providing an audio accompaniment signal in synchronism therewith, includes a song database having a repertoire of songs, each song of the database being stored as a relative pitch template, an audio processing module operative in response to the song being sung to convert the song being sung into a digital signal, an analyzing module operative in response to the digital signal to determine a definition pattern representing a sequence of pitch intervals of the song being sung that have been captured by the audio processing module, a matching module operative to compare the definition pattern of the song being sung with the relative pitch template of each song stored in the song database to recognize one song in the song database as the song being sung, the matching module being further operative to cause the song database to download the unmatched portion of the relative pitch template of the recognized song as a digital accompaniment signal; and a synthesizer module operative to convert the digital accompaniment signal to the audio accompaniment signal that is transmitted in synchronism with the song being sung.

The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.

The present invention provides camel antibody libraries that maintain in vivo diversity of camelid antibody variable region genes. The in vivo diversity of antibody variable region genes can be accomplished by, for example, mixing genes derived from a plurality of animals or modifying gene amplification conditions. Conventional methods yield only VHHs with limited repertoire diversity. However, the present invention provides libraries comprising genes encoding functional VHHs with sufficient repertoire size. According to the present invention, libraries that enable to freely obtain VHHs against arbitrary antigens are provided. VHHs have excellent solubility and stability, and show a reactivity that usually cannot be expected from tetrameric IgGs.

A method and apparatus that permits a user to electronically make a notation of a recorded music selection that he or she would like to take a later action on. Such later actions might include purchase actions or information gathering actions as well as other actions. The user actuates a button on a portable music player that plays music stored on a removable storage medium (e.g., a minidisc) and the music player stores identifying information that identifies the currently playing track of music. By connection of the music player to a personal computer, the user can then download the marked tracks to the personal computer and carry out actions over the Internet with service providers to complete transactions or queries.

A system and method are described for permitting a telephone user to customize the identification of a call setup process. The telephone user is permitted to create a karaoke style recording by causing an underlying musical track to be mixed with the voice of the user. The karaoke style recording is stored for later use as a ringback tone and / or ringtone, as desired, to identify the call setup process.

The invention is a method for detecting and measuring T-cell receptor (TCR) repertoires from mammalian lymphocytes. The method is based on the use of the multiple sets of unique primers to amplify 22 regions of the TCR Vβ region and thereby detect clonal expansions related to antigen stimulation of the immune system. Kits containing sets of primers and specialized analytical statistical software for use in determining clonal expansion in humans and mice are disclosed. The reliability, efficiency and short assay time in using the method is well suited to monitoring immune response to vaccination and therapeutic treatments for immune disorders.

The invention discloses a health management system and implementation method thereof, belonging to the technical field of disease prevention and control. The health management system comprises a computer application module, a special testing module and a health management module. The computer application module comprises a user information acquisition module, a health risk assessment module and a disease risk assessment module. The health management repertoire includes the following steps: setting up a health risk assessment database in the health risk assessment module; and setting up a disease risk assessment database in the disease risk assessment module. The health management system and the implementation method thereof have the advantages that through the health management repertoire, the risk of an individual getting certain specific chronic disease or the outcome of the disease in the future can be simply estimated, thus helping the individual to have a fuller and more comprehensive understanding about the risk and the gravity of the threat of the disease so that the individual can take comprehensive intervention against a specific cause or high-risk factor of the disease to prevent and reverse the progress of the disease. Therefore, the health management system and the implementation method can alleviate the living and economic burdens of the families and the society.

A media data format is described, along with devices, methods, computer readable media and a propagating signal in relation to the media data format. The media data format comprises a music data portion defining a music track, and a metadata portion defining metadata associated with said music track. Said metadata comprises a tempo metadata type having a tempo class value indicating a tempo class of the music track.

The invention provides a sprayed character online visual detection method based on convolutional neural network. The sprayed character online visual detection method comprises the steps of dividing characters in an image under an offline status, classifying the characters, constructing a character repertoire, and performing training through an improved convolutional neural network learning method to form a stable classifier; shooting pictures, dividing the characters and classifying the characters in real time during online detection, and removing unqualified products. By means of the sprayed character online visual detection method, real-time performance is ensured while detection accuracy is improved greatly, and requirements for high real-time performance and accuracy of online detection process of the sprayed characters at bottoms of pop-top cans can be met.

A ball-throwing machine includes a camera connected to a computer vision unit and a microphone connected to a speech-processing unit. The computer vision unit processes images from the camera to determine a user's position, and to detect user gestures from a predetermined repertoire of gestures. The speech-processing unit recognizes user vocal commands from a predetermined repertoire of commands. A computer receives information from a control panel, from the computer vision unit, from the speech-processing unit, and from a file describing the ballistic properties of the ball to be thrown. The computer accordingly determines a ball trajectory according to the user's position and parameters indicated by a combination of control-panel settings, user gestures, and user vocal commands. The computer then adjusts the direction, elevation, ball speed, and ball spin to conform to the determined trajectory, and initiates throwing of a ball accordingly.