48 results about "Respiratory system" patented technology

The invention provides a chronic respiratory system disease risk early warning method and device based on artificial intelligence and a medium. The method comprises the following steps: firstly, acquiring physiological monitoring information of wearable equipment of a patient; inputting the physiological monitoring information into the risk prediction model to obtain a risk early warning result; wherein the risk prediction model is established according to patient medical record information, follow-up visit information and historical physiological monitoring information; the risk prediction model is a Transform-LSTM (Long Short Term Memory) double-branch integrated model. According to the method, physiological monitoring information collected by wearable equipment in real time is input into a Transform-LSTM double-branch integrated model constructed on the basis of patient medical record, follow-up visit and historical physiological monitoring multi-source information, so that a long-distance dependency relationship of multi-modal data is captured by means of a Transform branch to identify a potential risk trend in a stable period; and the time sequence dynamic characteristics of physiological monitoring information are captured through an LSTM branch to perceive short-term signal mutation in an acute exacerbation period, so that accurate early warning of the whole course risk of the chronic respiratory system disease is realized.

The present disclosure introduces an AI-based system (100) and method for predicting the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD) over three months. The system interfaces with consumer devices through REST APIs, ensuring secure communication via HTTPS. Client modules collect and pre-process raw data for integrity and compatibility. This data is then sent to the server (104) which is then transmitted to Input module, the input module (112) authenticates and validates it. The module processes personal details, respiratory history, allergies, vaccination and medication history, and demographic data for air quality analysis. The prediction module (116) uses a CART Model with 90% accuracy to evaluate COPD risk. Based on predefined thresholds, the clinical pathway module (118) and risk prediction response module (120) offer personalized treatment protocols and clinical decision support. The system complies with ISO 13485 standards for safety and reliability.

Described herein are compositions and methods for the reducing a risk of contracting a respiratory disease in a subject or reducing a risk of transmitting a respiratory disease from a first subject to a second subject. In some cases, a composition or method described herein can comprise a modulator (e.g., a pattern recognition receptor, such as a STING agonist, for instance cGAMP) In some cases, a composition or method described herein can comprise a liposome, which may be used to encapsulate one or more STING agonists. In some cases, a liposome of a composition or method described herein may comprise one or more antigens attached to, integrated into, or associated with a liposomal membrane of the liposome.

The present invention describes the synthesis and biological evaluation of new substituted pyridine derivatives as foxj1 activity enhancers. In embodiments, novel pyridine derivatives were synthesized and the ability thereof to enhance foxj1 activity was evaluated. The novel pyridine derivatives synthesized in the present invention not only exhibited excellent activity but also exhibited excellent metabolic safety and pharmacokinetic profile in a Tg (foxj1: egfp) transgenic zebrafish animal model. In addition, the novel pyridine derivatives synthesized in the present invention enhanced cilia-promoting capability in a motile ciliated cell differentiation experiment in which mouse tracheal epithelial cells (mTECs) were isolated from the airways of mice and cultured by ALI. As a result, a series of foxj1 activity enhancers with substituted pyridine skeleton has the potential to be developed as preventive and therapeutic agents for respiratory diseases.

This invention relates to the field of horticultural cultivation technology, specifically disclosing a flower and plant respiration system that combines automatic drainage, root rot prevention, and soil and water conservation functions, as well as its manufacturing method. This system innovatively adopts a modular structure consisting of an oral cavity component (1), a belly shell component (2), and a respiratory lung (3), realizing the functions of water storage, silt filtration, drainage, and soil aeration in flowerpots. It solves the problems of traditional flowerpot drainage holes leading to soil erosion, closed water storage causing root rot, and existing filters being prone to clogging and having poor aeration.

The present invention relates to nitric oxide generating compositions, kits, and combinations for the treatment, improvement, or prevention of respiratory diseases or disorders, and to methods for treating, improving, or preventing such diseases or disorders using such compositions, kits, and combinations.

This invention discloses an environmental parameter sensing and adaptive adjustment system and method based on a photoconductive film. It integrates six-dimensional environmental sensors—light intensity, ultraviolet radiation, temperature, humidity, air pressure, and air quality—at the edge of the photoconductive film, and utilizes the film's directional light guidance and stray light filtering mechanisms to reduce environmental interference. The system includes an environmental sensing module, an environmental parameter processing module, a health data interface module, a correlation analysis module, an adaptive adjustment module, and an environmental early warning module. The correlation analysis module has preset environmental-health correlation patterns such as low temperature-increased blood pressure, high humidity-decreased blood oxygen, high ultraviolet radiation-skin health, poor air quality-respiratory diseases, and sudden changes in air pressure-headaches and joint pain, set based on clinical research data. The adaptive adjustment module pairs with smart home devices through a unified identity authentication center, sending control commands via Wi-Fi / Bluetooth / infrared to automatically adjust air conditioners, humidifiers, dehumidifiers, air purifiers, and lighting according to environmental parameters. The environmental early warning module supports single-indicator early warning, correlation early warning, trend early warning, and seasonal disease early warning, with customizable thresholds. The multi-environmental data fusion module uses weighted averaging and the 3σ principle for anomaly removal, integrating data from multiple devices such as mobile phones, watches, vehicles, and smart home devices. The sensors are automatically calibrated daily using meteorological bureau data, with the calibration process simultaneously linked to health data. This invention solves the problems of scattered environmental sensing devices, disconnect from health data, and inability to proactively adjust, serving as the infrastructure for intelligent health management.

The present application relates to the technical field of pathogen detection, and particularly relates to a respiratory system infection pathogen rapid detection method based on multiplex PCR. After a baseline corrected fluorescence intensity sequence is obtained, valid fluorescence intensity sequences are screened according to whether the signal amplification trend of the baseline corrected fluorescence intensity sequence conforms to the characteristics of amplification kinetics morphology. Then, the kinetic morphology characteristics corresponding to each valid fluorescence intensity sequence are quantified through multi-dimensional morphology analysis on the basis of the frequency domain and the time domain. Furthermore, each valid fluorescence intensity sequence is quantified for a morphology determination value based on the relative deviation of the amplification morphology characteristic vector between the prior negative control hole and the prior positive control hole. Thus, the signal property is more accurately defined based on the morphology determination value, and the accuracy of the respiratory system infection pathogen detection is higher.

This invention relates to a composition with antitussive effects. By weight, the composition contains 5-25 parts of green plum, 1-20 parts of dried plum, 1-20 parts of monk fruit, 1-20 parts of platycodon root, and 1-20 parts of peppermint. The antitussive composition of this invention scientifically selects and proportions its components, which can reduce the continuous damage to the respiratory system caused by the harsh environment of high altitudes, quickly relieve coughs and dry, itchy throats, etc., shorten the course of the disease, and prevent prolongation and recurrence by prolonging the incubation period of coughs and reducing the frequency and severity of coughs. It also has the advantages of high safety, a sweet and refreshing taste, easy portability, and good patient compliance. It is particularly suitable for preventing and treating severe dry coughs, persistent coughs, and paroxysmal coughs caused by the cold, dryness, and low oxygen levels of high altitudes, maintaining the health and work capacity of personnel working at high altitudes.

Described herein are methods for treating or preventing a disease or disorder of the pulmonary system (e.g., cystic fibrosis), respiratory or digestive system in a subject, the methods comprising administering compounds or compositions comprising water soluble polyglucosamine and derivatized polyglucosamine.

The present invention relates to a composition for preventing, alleviating, or treating respiratory diseases, the composition comprising Codonopsis lanceolata, Saururus chinensis, Platycodon grandiflorum, and propolis as active ingredients. The composition according to the present invention was proven to be effective in preventing, alleviating or, treating respiratory diseases on the basis of experiments using a mouse fibroblast cell model.

Leveraging the extensive surface area of the lungs for gene therapy, inhalation route offers distinct advantages for delivery. Clinical nebulizers that employ vibrating mesh technology are the standard choice for converting liquid medicines into aerosols. However, they have limitations when it comes to delivering mRNA through inhalation, including severe damage to nanoparticles due to shearing forces. A microfluidic aerosolization platform (MAP) can preserves the structural and physicochemical integrity of lipid nanoparticles, enabling safe and efficient mRNA delivery to the respiratory system. Results demonstrated the superiority of the novel microfluidic aerosolizer over the conventional vibrating mesh nebulizer, as it avoided problems such as particle aggregation, loss of mRNA encapsulation, and deformation of nanoparticle morphology. Notably, aerosolized nanoparticles generated by the microfluidic aerosolization platform led to enhanced transfection efficiency across various cell lines. In vivo experiments with mice that inhaled these aerosolized nanoparticles revealed successful, lung-specific mRNA transfection without observable signs of toxicity. This pioneering MAP represents a significant advancement for the pulmonary gene therapy, enabling precise and effective delivery of aerosolized nanoparticles.

The application relates to the technical field of image analysis, in particular to a respiratory system lung nodule tumor cell detection method and system based on image feature fusion and a storage medium, which comprises the following steps: constructing a two-dimensional pixel gray array of a chest CT image and performing edge positioning, constructing a closed image boundary through gray difference analysis and gradient direction continuity, extracting a lung nodule candidate region image in the closed region, establishing pixel adjacency relations in horizontal, vertical and diagonal directions, constituting a direction difference image set and extracting a continuous texture region with a closed structure, generating a lung nodule edge contour connection image through spatial relationship mapping and pixel connection extension, and finally performing boundary fusion and pixel structure recombination to form a target detection image. In the application, the direction gray difference construction and boundary closure analysis are combined, the connected path judgment and pixel aggregation processing are fused, the texture structure concentration and image recognition definition are effectively enhanced, and the accuracy and readability of lung nodule detection are improved.

The invention provides a method and system for detecting the carbon utilization rate of microorganisms based on a microwell plate respiratory system, and the method comprises the following steps: pre-culturing target microorganisms, and confirming the logarithmic growth phase of the target microorganisms; the method comprises the following steps: inoculating target microorganisms into a plurality of deep holes of a microporous plate respiratory system for culture, wherein each deep hole in the microporous plate respiratory system comprises a bacterial liquid containing a specified carbon source; detecting the initial biomass in the bacterial liquid and the initial carbon dioxide value in the microplate respiratory system at the beginning of culture, and detecting the final biomass in the bacterial liquid and the final carbon dioxide value in the microplate respiratory system at the end of culture; calculating the growth rate of the target microorganisms according to the initial biomass and the end biomass; calculating the respiration rate of the target microorganism according to the initial carbon dioxide value, the end carbon dioxide value and the growth rate; and calculating the carbon utilization rate of the target microorganism according to the growth rate and the respiration rate. The problem that the carbon utilization rate of species level microorganisms is difficult to obtain is solved.

New uses of a composition containing a zinc salt and cyclo-hispro (CHP) are disclosed. The composition is suitable and effective for the prevention, alleviation, or treatment of respiratory diseases. And, a method for preventing, alleviating, or treating respiratory diseases by using the composition, wherein the composition includes a specific weight ratio of a zinc salt and cyclo-hispro as active ingredients, thereby exhibiting excellent effects of reducing allergic cytokines and decreasing mucus secretion.

The invention discloses atomization equipment for respiratory system disease treatment, and relates to the technical field of atomization treatment equipment.The atomization equipment comprises a box body, a side box is fixedly connected to one side of the box body, an exhaust pipe is fixedly connected to the top of the side box, a lifting mechanism is arranged in the side box and comprises a sliding block, and the sliding block is slidably connected to the inner surface of the side box; the interior of the sliding block is of a hollow structure and is vertically through, and an inner bin is formed in the side box. The device has the beneficial effects that the air guide groove of the device can generate negative pressure when a patient inhales, air enters from the communicating groove under the action of the negative pressure, jacks up the sliding block and compresses the spring, the metal rod makes contact with the two spiral plates, electric energy in the battery is conveyed to the atomization piece through the metal rod and the two spiral plates, and the atomization piece is powered on. The atomization piece atomizes liquid medicine and conveys the liquid medicine upwards through the air guide pipe, the sliding block moves upwards and rotates under the action of the spiral plate, and the atomized liquid medicine is inhaled by a patient through the sliding block and the exhaust pipe and is in linkage with breathing of the patient.

The invention relates to the technical field of pharmacy, in particular to a pharmaceutical and pharmacological auxiliary experiment device which comprises a shell, an air duct is fixedly arranged in the center of the upper end of the shell, an ultrasonic nebulizer is fixedly arranged at the bottom of the air duct, the air duct is connected with a fan through a pipeline, and a water injection tank is fixedly arranged at the upper end in the shell. The lower end of the water injection tank is connected with a water tank through a pipeline, the water tank is connected with a water pump through a pipeline, the water pump is connected with a ro membrane filter through a pipeline, the ro membrane filter is connected with a wastewater tank and a water filtering tank through pipelines, and an ultraviolet lamp strip is fixedly arranged on the surface of the shell. Mineral substances, impurities and harmful substances in water are effectively removed, and it is ensured that atomized water is purified water. Potential harm to the respiratory system of a patient due to the fact that mineral particles are suspended in the air is avoided, scaling inside equipment is reduced, and the service life of the equipment is prolonged.

The invention discloses a medical record time axis-based respiratory disease interactive processing analysis method and system, which can construct a real medical record-based respiratory system disease interactive intelligent auxiliary diagnosis and treatment system and improve the accuracy and practicability of respiratory system disease auxiliary diagnosis and treatment. The method comprises the following steps: (1) merging and sorting electronic medical record data of a patient into a text format for storing key-value pairs; (2) arranging the medical records into a timeline-based core information JSON file by utilizing a large language model; (3) classifying the data into a vector knowledge base by adopting a hierarchical processing architecture; (4) querying a timeline knowledge base and returning a matching result, and performing a first round of single case summarization; after summarizing, carrying out a second round of thinking and multi-case experience summarization; a return result serves as a prompt word of the final question-answer; (5) collecting guide evidences and transmitting into a large model for summarization and analysis; and (6) submitting results of multi-case summarization and guide analysis to a large language model for final question and answer, and outputting previous case summarization and experience summarization, guide recommendation summarization and comprehensive recommendation suggestions.

1. Name of the product in this design: Atomizer (JM832). 2. Purpose of this design: A nebulizer for treating respiratory diseases. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

Aspects of the present disclosure provide compositions comprising NEK10 for example, wild-type NEK10 or a hyperactive NEK10 mutant such as NEK10S684D, and methods of using such for treating a respiratory disorder such as bronchiectasis.

The invention belongs to the technical field of medical auxiliary instruments, and discloses a respiratory system nursing sputum suction device which comprises negative pressure equipment, a sputum accumulation barrel, a sputum suction pipe, a negative pressure pipe, a negative pressure detection assembly and a sputum accumulation treatment assembly, the sputum accumulation barrel is communicated with the negative pressure equipment through the negative pressure pipe, the sputum suction pipe is communicated with the sputum accumulation barrel, and the negative pressure detection assembly comprises a conduction pipe; the communicating pipe is connected with a U-shaped communicating vessel, and the two vertical communicating ends of the U-shaped communicating vessel are communicated with the communicating pipe and the outside atmosphere through a first air pipe and a second air pipe respectively. The accumulated sputum treatment assembly comprises a water tank, a fixed shell, a driving water wheel, a water pump, an outer pipe and a water guide pipe, the outer pipe and the sputum suction pipe are correspondingly provided with a first side hole and a second side hole, the outer side of the outer pipe is provided with a protrusion, and the protrusion is provided with a through hole. The negative pressure device and the sputum suction pipe are used for sucking sputum, the negative pressure in the sputum suction pipe is detected through the negative pressure detection assembly, accumulated sputum is softened and flushed through the accumulated sputum treatment assembly, the sputum suction effect is good, efficiency is high, and safety is good.

The invention belongs to the technical field of negative ion purification cabins, and particularly relates to a negative oxygen ion treatment device with a lying function for respiratory system diseases. According to the negative oxygen ion treatment device, the storage cabinet is arranged in the cabin body of the negative oxygen ion treatment device, and the foldable storage bed in linkage design with the storage cabinet is arranged in the storage cabinet. After the foldable storage bed is stretched, a complete lying surface can be formed, and the lying surface can be made of a soft package material, so that the comfort of a user during lying can be improved, and the discomfort caused by direct contact between the back and the hard bottom plate is avoided. Moreover, the cabin back plate of the negative oxygen ion treatment device is designed to be detachable, so that not only can the folding bed be detached, replaced and carried, but also the built-in components such as the negative oxygen ion generator, the air circulation system and the intelligent control system can be maintained in time, and the service life of the negative oxygen ion treatment device is ensured to be long.

The subject matter of the invention is an isolitocholic acid for use in the prevention and / or treatment of inflammatory diseases of the respiratory system and / or prevention and / or treatment of cytokine storm-associated diseases.

The invention discloses a medicinal moxa composition for preventing and treating chronic nasosinusitis and kidney stone co-disease. The medicinal moxa composition comprises asarum, gardenia jasminoides, agilawood and moxa. The medicinal moxa composition disclosed by the invention generates an external preparation with synergistic effects of smoke, medicinal gas and heating power through combustion. Volatile components of the four medicines are burnt to form a composite pharmacodynamic system which is absorbed by skin, mucous membrane and respiratory system to generate a unique treatment effect. The medicinal moxa composition can realize cold-warm balance, multi-target coordination, immunoregulation, anti-inflammatory action and diuresis metabolism regulation through the synergistic effect of heating power and volatile matters, so that the dual effects of preventing and treating nasosinusitis and kidney stone are achieved. Due to the external use characteristic, the traditional Chinese medicine composition can directly act on body surface acupuncture points and is conducted to related viscera through meridians and collaterals to form a treatment path from the outside to the inside.

This invention relates to the field of Mongolian medicine technology and discloses a Mongolian medicine composition for treating skin diseases caused by damp-heat and toxin accumulation. It aims to address the problem that existing technologies struggle to balance the efficacy of skin lesion treatment with the safety of systemic medication when treating patients with damp-heat and toxin accumulation skin diseases complicated by chronic diseases such as hypertension and asthma. This invention limits the specific weight ratio range between the heat-clearing and blood-cooling herbs and the harmonizing and strengthening herbs in the composition, and optimizes the synergistic relationship between the principal herbs and other adjuvant herbs. Under specific proportions, the composition maintains its basic effects of clearing heat and detoxifying, removing dampness and cooling blood, while enhancing its ability to clear damp-heat and toxins from the local skin. Furthermore, through the mutual restraint of the internal compatibility, it reduces potential interference with the patient's cardiovascular and respiratory systems. Therefore, this invention provides a new Mongolian medicine preparation that can safely and effectively treat skin diseases caused by damp-heat and toxin accumulation, especially suitable for patients with related chronic underlying diseases.

The application discloses a use of taibai araloside in treating hypoxic pulmonary arterial hypertension. In the use of hypoxia to induce pulmonary arterial hypertension, it is found that the taibai araloside can reduce right ventricular pressure and right heart hypertrophy index, and inhibit pulmonary arterial remodeling; the taibai araloside reduces the expression and activity of ACE in the lung in a concentration-dependent manner, and corrects the disorder of the RAS system in the lung caused by hypoxic pulmonary arterial hypertension. Moreover, a monomer component of the taibai araloside, anemarrhena asphodeloides glycoside and chizhenshan saponin IVa, has a stable combination with ACE. The results show that the taibai araloside has the potential to be developed into a drug for preventing and treating hypoxic pulmonary arterial hypertension in the clinic, and also provides a prevention and treatment strategy for interstitial lung disease, chronic obstructive pulmonary disease, sleep apnea syndrome, chronic high altitude disease and neonatal respiratory disease.

The present invention provides a mucosa-based non-invasive gene therapy with a recombinant vector. The recombinant region of the recombinant vector comprises a coding sequence of at least one therapeutic gene. The recombinant vector is administered to the respiratory system, the digestive system, the genitourinary system, and the eyes via the mucosa, for preventing and / or treating a disease.

The subject matter of the invention is a compound of the formula (I), or a salt, prodrug, solvate, hydrate, or stereoisomer thereof, wherein Rn represents groups for n=1, 2, or 3, as follows R1 represents -NHCH(CH3)2, R2 represents -CONH2, R3 represents -CH2NH2. Another subject matter of the invention is a compound according to the present invention for use in a prevention and / or treatment of inflammatory diseases of the respiratory system and / or prevention and / or treatment of cytokine storm-associated diseases.