99 results about "Respiratory system" patented technology

The invention relates to the technical field of respiratory system risk prediction, and provides a respiratory system risk prediction method and system based on a graph neural network, and the method comprises the steps: collecting the multi-modal medical data of a patient, and constructing a multilayer heterogeneous graph based on the multi-modal medical data; constructing a weighted adjacency matrix and a node feature vector through the multi-layer heterogeneous graph; matrix product operation and convolution operation are carried out based on the weighted adjacent matrix and the node feature vector, splicing combination with historical moment state information is carried out, graph state representation is obtained, weighted aggregation of time dimensions is carried out, and time sequence attention features are obtained; performing coding processing based on the clinical examination data to obtain multi-modal fusion features; and inputting the multi-modal fusion features into a risk classifier for classification calculation to obtain a respiratory system risk level prediction result, generating a risk assessment report, and outputting respiratory risk early warning information. The accuracy and clinical practicability of respiratory system risk prediction are improved.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to an innovative formula and a preparation method of a traditional Chinese medicine preparation for relieving cough and asthma, and the traditional Chinese medicine preparation comprises the following medicinal materials in parts by weight: 10-20 parts of flos farfarae, 10-20 parts of radix asteris, 5-15 parts of ephedra, 5-15 parts of almond, 5-15 parts of scutellaria baicalensis, 5-15 parts of white mulberry root-bark, 5-15 parts of radix stemonae and 3-10 parts of liquorice. Through reasonable compatibility of various traditional Chinese medicines, the traditional Chinese medicine composition acts on the respiratory system in a multi-target manner, can moisten the lung to arrest cough, can release the lung to relieve asthma, can clear heat and reduce phlegm, and has a good treatment effect on cough and asthma caused by various reasons. Animal experiments and clinical preliminary verifications prove that compared with a traditional Chinese medicine preparation for relieving cough and asthma, the preparation disclosed by the invention can more remarkably prolong the cough latency period, reduce the cough frequency, relieve the asthma symptom and improve the lung function, and the links such as reduced pressure concentration and preparation forming in the preparation process are all carried out under strict condition control, so that the traditional Chinese medicine preparation is free of toxic and side effects. The loss and degradation of effective components are reduced, and the stability and consistency of the product quality are ensured.

The invention provides a chronic respiratory system disease risk early warning method and device based on artificial intelligence and a medium. The method comprises the following steps: firstly, acquiring physiological monitoring information of wearable equipment of a patient; inputting the physiological monitoring information into the risk prediction model to obtain a risk early warning result; wherein the risk prediction model is established according to patient medical record information, follow-up visit information and historical physiological monitoring information; the risk prediction model is a Transform-LSTM (Long Short Term Memory) double-branch integrated model. According to the method, physiological monitoring information collected by wearable equipment in real time is input into a Transform-LSTM double-branch integrated model constructed on the basis of patient medical record, follow-up visit and historical physiological monitoring multi-source information, so that a long-distance dependency relationship of multi-modal data is captured by means of a Transform branch to identify a potential risk trend in a stable period; and the time sequence dynamic characteristics of physiological monitoring information are captured through an LSTM branch to perceive short-term signal mutation in an acute exacerbation period, so that accurate early warning of the whole course risk of the chronic respiratory system disease is realized.

The present disclosure introduces an AI-based system (100) and method for predicting the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD) over three months. The system interfaces with consumer devices through REST APIs, ensuring secure communication via HTTPS. Client modules collect and pre-process raw data for integrity and compatibility. This data is then sent to the server (104) which is then transmitted to Input module, the input module (112) authenticates and validates it. The module processes personal details, respiratory history, allergies, vaccination and medication history, and demographic data for air quality analysis. The prediction module (116) uses a CART Model with 90% accuracy to evaluate COPD risk. Based on predefined thresholds, the clinical pathway module (118) and risk prediction response module (120) offer personalized treatment protocols and clinical decision support. The system complies with ISO 13485 standards for safety and reliability.

The application provides a craniocerebral injury simulation man teaching model, which comprises a simulation man body provided with a head, a body and limbs; the head is internally provided with a craniocerebral simulation unit for simulating brain edema, brain hematoma, brain fracture, brain hernia and cerebrospinal fluid leakage; the body is internally provided with a urinary system simulation unit, a blood circulation system simulation unit and a respiratory system simulation unit; the controller is prearranged with control programs of reactions of the urinary system simulation unit, the blood circulation system simulation unit and the respiratory system simulation unit corresponding to different brain injuries; an operator selects different brain injuries and carries out nursing on the brain injuries and the complications of the urinary system simulation unit, the blood circulation system simulation unit and the respiratory system simulation unit. The application can not only nurse the brain injuries through the craniocerebral simulation unit, but also nurse the complications of the brain injuries through the urinary system simulation unit, the blood circulation system simulation unit and the respiratory system simulation unit, so that the application is more consistent with the actual situation and is beneficial to teaching.

Described herein are compositions and methods for the reducing a risk of contracting a respiratory disease in a subject or reducing a risk of transmitting a respiratory disease from a first subject to a second subject. In some cases, a composition or method described herein can comprise a modulator (e.g., a pattern recognition receptor, such as a STING agonist, for instance cGAMP) In some cases, a composition or method described herein can comprise a liposome, which may be used to encapsulate one or more STING agonists. In some cases, a liposome of a composition or method described herein may comprise one or more antigens attached to, integrated into, or associated with a liposomal membrane of the liposome.

The present invention describes the synthesis and biological evaluation of new substituted pyridine derivatives as foxj1 activity enhancers. In embodiments, novel pyridine derivatives were synthesized and the ability thereof to enhance foxj1 activity was evaluated. The novel pyridine derivatives synthesized in the present invention not only exhibited excellent activity but also exhibited excellent metabolic safety and pharmacokinetic profile in a Tg (foxj1: egfp) transgenic zebrafish animal model. In addition, the novel pyridine derivatives synthesized in the present invention enhanced cilia-promoting capability in a motile ciliated cell differentiation experiment in which mouse tracheal epithelial cells (mTECs) were isolated from the airways of mice and cultured by ALI. As a result, a series of foxj1 activity enhancers with substituted pyridine skeleton has the potential to be developed as preventive and therapeutic agents for respiratory diseases.

1. Name of the product in this design: Display screen panel with a graphical user interface for disease screening. 2. Purpose of this design: To display a graphical user interface. 3. The key design features of this product are its graphical user interface. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The display screen panel uses a standard design, omitting other views. 6. Purpose of the graphical user interface: Used for screening diseases after a physical examination. Human-computer interaction and state changes in the graphical user interface: The upper part of the main view displays a 3D human body model, and the "Respiratory System" button is lit. The lower part displays a floating window introducing the symptoms corresponding to the respiratory system. Swiping left or right on the 3D human body model in the main view allows you to rotate and view the model. For example, swiping left on the 3D human body model leads to state change diagram 1. Clicking the "Circulatory System" button in the main view leads to state change diagram 2. The lower part of state change diagram 2 displays a floating window introducing the symptoms corresponding to the circulatory system. Swiping up on the floating window in state change diagram 2 leads to state change diagram 3, where the floating window becomes longer. Swiping down on the longer floating window in state change diagram 3 returns you to state change diagram 2. In the interface change state diagram 3, the gray blocks represent replaceable content screens. 7. Other situations requiring explanation: This display panel can be used with desktop computers, laptops, tablets, televisions, and mobile phones.

This invention relates to the field of horticultural cultivation technology, specifically disclosing a flower and plant respiration system that combines automatic drainage, root rot prevention, and soil and water conservation functions, as well as its manufacturing method. This system innovatively adopts a modular structure consisting of an oral cavity component (1), a belly shell component (2), and a respiratory lung (3), realizing the functions of water storage, silt filtration, drainage, and soil aeration in flowerpots. It solves the problems of traditional flowerpot drainage holes leading to soil erosion, closed water storage causing root rot, and existing filters being prone to clogging and having poor aeration.

The present invention relates to nitric oxide generating compositions, kits, and combinations for the treatment, improvement, or prevention of respiratory diseases or disorders, and to methods for treating, improving, or preventing such diseases or disorders using such compositions, kits, and combinations.

This invention discloses an environmental parameter sensing and adaptive adjustment system and method based on a photoconductive film. It integrates six-dimensional environmental sensors—light intensity, ultraviolet radiation, temperature, humidity, air pressure, and air quality—at the edge of the photoconductive film, and utilizes the film's directional light guidance and stray light filtering mechanisms to reduce environmental interference. The system includes an environmental sensing module, an environmental parameter processing module, a health data interface module, a correlation analysis module, an adaptive adjustment module, and an environmental early warning module. The correlation analysis module has preset environmental-health correlation patterns such as low temperature-increased blood pressure, high humidity-decreased blood oxygen, high ultraviolet radiation-skin health, poor air quality-respiratory diseases, and sudden changes in air pressure-headaches and joint pain, set based on clinical research data. The adaptive adjustment module pairs with smart home devices through a unified identity authentication center, sending control commands via Wi-Fi / Bluetooth / infrared to automatically adjust air conditioners, humidifiers, dehumidifiers, air purifiers, and lighting according to environmental parameters. The environmental early warning module supports single-indicator early warning, correlation early warning, trend early warning, and seasonal disease early warning, with customizable thresholds. The multi-environmental data fusion module uses weighted averaging and the 3σ principle for anomaly removal, integrating data from multiple devices such as mobile phones, watches, vehicles, and smart home devices. The sensors are automatically calibrated daily using meteorological bureau data, with the calibration process simultaneously linked to health data. This invention solves the problems of scattered environmental sensing devices, disconnect from health data, and inability to proactively adjust, serving as the infrastructure for intelligent health management.

The present invention discloses a medical anesthesia air storage bag connection structure, comprising an anesthesia machine connector, a connecting shaft and an air storage bag; the connecting shaft passes through the air storage bag and is sealedly connected to the anesthesia machine connector; the connecting shaft rotates radially within the anesthesia machine connector; an oxygen channel and an atomization channel are respectively arranged along the axial direction of the connecting shaft; the connecting shaft is provided with an air inlet and air outlet connected to the oxygen channel and the atomization channel; the anesthesia machine connector is provided with an air inlet and air outlet corresponding to the oxygen channel and the atomization channel. During the inhalation anesthesia process, if the patient experiences airway constriction due to stimulation by anesthetics, or if the patient's existing respiratory system disease is stimulated, leading to bronchospasm, coughing, and wheezing, supportive treatment can be given without changing the original medical system environment; the complexity and unstable effect of the atomizer introduced in the atomization treatment during the inhalation anesthesia stage are simplified and overcome; and the complexity of positive pressure ventilation in medicine is simplified.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a medicinal composition for treating respiratory diseases and a preparation method and use thereof. The medicinal composition is prepared from raw medicinal materials of white mustard seed, asarum, cassia bark, corydalis, dried tangerine or orange peel, Szechuan lovage root, ginger and green onion white, and the components are combined to have a remarkable effect on treating respiratory diseases, and the incidence of skin discomfort or adverse reactions is significantly reduced after use. The traditional Chinese medicinal composition has a remarkable effect on treating respiratory diseases, and the incidence of skin discomfort or adverse reactions is significantly reduced after use, which is specifically manifested in that most cases do not foam after use, and only a few cases will have slight foaming, thereby reducing the risk of scarring. In particular, the safety of the medicinal composition for children is unanimously affirmed by the families of patients. In addition, the ginger and green onion white in the traditional Chinese medicinal composition can improve the absorption capacity of the medicinal composition through acupoints, and the moxibustion feeling is better, and the qi is easier to obtain and the feeling of obtaining qi is better.

The invention provides an anaesthesia evaporator and an anaesthesia machine, and the anaesthesia evaporator comprises an evaporator disc which is driven by an external force to rotate around the center of the evaporator disc; the N anesthetic evaporation containers are fixed to the evaporator disc around the center of the evaporator disc, anesthetics stored in the anesthetic evaporation containers are different in type, and N is a natural number larger than or equal to 2; by rotating the evaporator disc, the anesthetic evaporation containers to be used are driven to rotate to the same designated position, and the anesthetic evaporation containers at the designated position face a patient; when the to-be-used anesthetic evaporation container rotates to a designated position, the to-be-used anesthetic evaporation container is powered on, and the idle state is switched into the using state; two openings are formed in a shell of the evaporator disc, and one opening is communicated with the anesthetic evaporation container in a use state and is connected to a respiratory system of a patient through a respiratory loop; and the other opening is communicated with the anesthetic evaporation container in an idle state, leads to the outside and is provided with a sealing cover for updating anesthetic.

The present application relates to the technical field of pathogen detection, and particularly relates to a respiratory system infection pathogen rapid detection method based on multiplex PCR. After a baseline corrected fluorescence intensity sequence is obtained, valid fluorescence intensity sequences are screened according to whether the signal amplification trend of the baseline corrected fluorescence intensity sequence conforms to the characteristics of amplification kinetics morphology. Then, the kinetic morphology characteristics corresponding to each valid fluorescence intensity sequence are quantified through multi-dimensional morphology analysis on the basis of the frequency domain and the time domain. Furthermore, each valid fluorescence intensity sequence is quantified for a morphology determination value based on the relative deviation of the amplification morphology characteristic vector between the prior negative control hole and the prior positive control hole. Thus, the signal property is more accurately defined based on the morphology determination value, and the accuracy of the respiratory system infection pathogen detection is higher.

The invention discloses diffusion essential oil for relieving anxiety. Comprising base oil, neroli essential oil, sweet basil essential oil, bergamot essential oil, bitter orange leaf essential oil, cananga odorata essential oil, Asian sandalwood essential oil, vetiver essential oil, lavender essential oil, frankincense essential oil, valerian essential oil, Atlantic cedar essential oil, chamomile essential oil, radix bupleuri-coptis chinensis extract microcapsules, theanine nanoparticles, cyclodextrin inclusion essential oil, sodium carboxymethyl cellulose and sorbitol. The pet food has the effects of tranquilizing and allaying excitement as well as pleasant spirit, and can reduce the sensitivity of pets, so that the pets are in a pleasant, relaxed and quiet state when staying alone or facing strange and special environments or facing uncomfortable environments in a cold and quiet state, and the anxiety of the pets is effectively prevented; meanwhile, the essential oil can be quickly absorbed into the body of the pet through the nasal cavity and the respiratory system of the pet, so that the essential oil can show the medicine effect in a short time, and the anxiety of the pet can be quickly relieved.

The invention relates to the technical field of injury simulation, in particular to an injury simulation device and system.The injury simulation device comprises a simulation box body, a first door plate, an animal model and a simulation assembly, the simulation assembly comprises an elastic piece protection cover, an elastic piece launching unit, wrapping sealing cloth and a wrapping sealing unit, and elastic pieces can be prevented from splashing all around through the elastic piece protection cover; subsequent collection and treatment are facilitated; the wrapping and sealing unit is started to drive the wrapping and sealing cloth to be wound on the head of the animal model, poison gas is limited in the circulating respiratory system, then the animal model is moved to the injury simulation bin, and finally the animal model is taken out by opening the first door plate and can be used for follow-up operation simulation operation; therefore, by limiting the elastic pieces, the situation that surrounding parts are damaged due to splashing around is avoided, and collection can be facilitated; meanwhile, after poison gas simulation is finished, the head of the animal model is wrapped and sealed, poison gas leakage is avoided, the safety of workers is greatly guaranteed, and the device is more convenient for the workers to use.

The present invention relates to nitric oxide producing compositions, kits and combinations for treating, ameliorating or preventing respiratory diseases or disorders, and methods of treating, ameliorating or preventing such diseases or disorders with the compositions, kits and combinations.

The invention discloses an atomizing agent applied to an atomizer and capable of relieving dry cough and a preparation method of the atomizing agent. The effective components comprise the following raw materials: bulbus fritillariae cirrhosae extract, folium eriobotryae extract, radix asteris extract, rhizoma pinelliae extract, radix ophiopogonis extract, herba ephedrae extract, honeysuckle flower extract, radix scutellariae extract, liquorice root extract, dextromethorphan and budesonide. The atomizing agent disclosed by the invention has a good treatment effect on respiratory system disease patients with dry cough without phlegm or less phlegm symptoms, has the effects of moistening lung to arrest cough, reducing phlegm and relieving asthma, resisting inflammation and the like, and can be applied to atomizers.

The invention relates to compounds and pharmaceutically acceptable salts thereof, and to their medical use. Exemplary medical uses are the prevention and treatment of a bacterial infection, for example, a mycobacterial infection, such as a Mycobacterium tuberculosis infection, e.g., in a respiratory system and / or extrapulmonic. The invention further relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds as chemotherapeutic agents. Also, the invention relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds for inhibiting mycobacterial type VII secretion.The compounds have the following formulawhereinQ and X are, respectively, CH and C, CR2 and C, CH and N, CR2 and N, or N and C;R1 is hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms;R2 is independently selected from hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms, andR3 is optionally substituted linear or branched alkoxy having 1-6 carbon atoms, haloalkyl having 1-6 carbon atoms, n-propyl, 2-propenyl, 2-propynyl, or n-pentyl,or a pharmaceutically acceptable salt of the compound, for use in the prevention or treatment of a bacterial infection.

The respiratory system clinical suction type drug delivery device comprises a liquid storage cylinder, an ultrasonic atomizer, a charging base, a spiral conveyor and a feeding channel, the lower portion of the upper end of the liquid storage cylinder is fixedly connected with a limiting cylinder, and an open hole is formed in the upper portion of the limiting cylinder; two rotating doors are arranged at the upper end of the liquid storage cylinder, a clamping cylinder communicated with the interior of the atomizer is arranged at the lower end of the atomizer, and two bolts are arranged on the two sides of the clamping cylinder; the spiral conveyor rotationally conveys liquid medicine at the bottom of the liquid storage barrel to the upper portion of the limiting barrel, the liquid medicine falls back to the liquid level through an open hole, the atomizer is slidably inserted into the charging base for charging, the feeding channel is slidably clamped into the inner circumference of the clamping barrel, and the plug pin enters the liquid storage barrel through the rotating door and blocks the open hole; the spiral conveyor conveys the liquid medicine into the atomizer through the feeding channel in a rotating manner; by means of the device, frequent medicine supplementing of medical staff can be effectively reduced, a patient can rapidly supplement liquid medicine by himself / herself, the labor intensity of the medical staff is effectively relieved, and the medical work efficiency is improved.

The present invention provides a mutant adeno-associated virus serotype 1 (AAV1) capsid protein, wherein the mutant has an amino acid substitution at a specific position compared to the amino acid sequence of the wild-type AAV capsid protein; a nucleic acid encoding the mutant AAV1 capsid protein; a recombinant AAV1 vector comprising the nucleic acid encoding the mutant AAV1 capsid protein; and a pharmaceutical composition comprising the vector. In particular, a recombinant viral vector comprising the nucleic acid encoding the mutant AAV1 capsid protein enhances transgene expression in the lungs and bronchi when delivered in an aerosol state through the bronchi, making it useful for the prevention or treatment of respiratory diseases.

This invention relates to a composition with antitussive effects. By weight, the composition contains 5-25 parts of green plum, 1-20 parts of dried plum, 1-20 parts of monk fruit, 1-20 parts of platycodon root, and 1-20 parts of peppermint. The antitussive composition of this invention scientifically selects and proportions its components, which can reduce the continuous damage to the respiratory system caused by the harsh environment of high altitudes, quickly relieve coughs and dry, itchy throats, etc., shorten the course of the disease, and prevent prolongation and recurrence by prolonging the incubation period of coughs and reducing the frequency and severity of coughs. It also has the advantages of high safety, a sweet and refreshing taste, easy portability, and good patient compliance. It is particularly suitable for preventing and treating severe dry coughs, persistent coughs, and paroxysmal coughs caused by the cold, dryness, and low oxygen levels of high altitudes, maintaining the health and work capacity of personnel working at high altitudes.

A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C—S—C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

The application relates to a temperature difference driven air purification system, which comprises a purification shell, the purification shell is a rectangular hollow structure, a purification mechanism is installed in the middle of the purification shell, sealing plates are installed at the upper and lower ends of the purification shell, a cavity one is arranged between the upper end of the purification mechanism and the sealing plate, a cavity two is arranged between the lower end of the purification mechanism and the sealing plate, four connecting pipes are installed outside the purification shell, the four connecting pipes are symmetrically arranged at the left and right sides of the purification shell, the connecting pipe located at the upper end outside the purification shell is communicated with the cavity one, and the connecting pipe located at the lower end outside the purification shell is communicated with the cavity two; the purification mechanism provided by the application can effectively filter and purify indoor air, impurities, suspended particles and harmful bacteria in the air can be effectively removed, the phenomenon that respiratory system diseases are caused by the non-circulation of indoor air is prevented, and negative influences on the health and comfort of indoor personnel are avoided.

Described herein are methods for treating or preventing a disease or disorder of the pulmonary system (e.g., cystic fibrosis), respiratory or digestive system in a subject, the methods comprising administering compounds or compositions comprising water soluble polyglucosamine and derivatized polyglucosamine.

The invention relates to the technical field of medical instruments, in particular to atomization medical equipment for treating respiratory system diseases, which comprises a shell used for being held by a hand of a patient, one side of the shell is detachably connected with a contact piece used for spraying atomized liquid medicine, and the two sides of the shell are in sliding fit with a mounting frame. The mounting rack is detachably connected with a test tube for storing liquid medicine; an atomization mechanism communicated with the contact piece is arranged in the shell, and a liquid inlet pipe is communicated between the atomization mechanism and the test tube; the atomization mechanism comprises a compression cavity communicated with the liquid inlet pipe and the contact piece, and the compression cavity is communicated with an electric driving assembly used for electrically atomizing liquid medicine and a manual driving assembly used for manually atomizing the liquid medicine by a patient. The device is used for providing a manual pumping mode under the power failure condition, the application scene of the device is expanded, and meanwhile the disinfection effect is guaranteed.

The utility model relates to the technical field of false tooth machining, in particular to an antibacterial false tooth polishing device, and aims to solve the problem that dust causes harm to operators in the polishing process. The antibacterial false tooth polishing device comprises a rack, a tool clamp used for fixing false teeth is arranged on the rack, and a protective cover is arranged on the rack; a grinding wheel mechanism used for false tooth polishing is arranged in the protective cover shell, a shell of the protective cover shell is provided with a dust collection integrated mechanism used for adsorbing dust, the dust collection integrated mechanism comprises two dust collection pipes, an air suction pump and a treatment box, and the two dust collection pipes are symmetrically distributed on the two sides of the protective cover shell; and one ends of the two dust suction pipes communicate with the interior of the protective cover shell, the other ends of the two dust suction pipes communicate with an air suction pump, the output end of the air suction pump communicates with the interior of the treatment box, and the treatment box is arranged on the rack. The polishing device has the advantages that dust particles generated in the polishing process are effectively blocked, the scattering range is limited, and the respiratory system health risk faced by operators due to dust inhalation is reduced.

The present invention relates to a composition for preventing, alleviating, or treating respiratory diseases, the composition comprising Codonopsis lanceolata, Saururus chinensis, Platycodon grandiflorum, and propolis as active ingredients. The composition according to the present invention was proven to be effective in preventing, alleviating or, treating respiratory diseases on the basis of experiments using a mouse fibroblast cell model.

Leveraging the extensive surface area of the lungs for gene therapy, inhalation route offers distinct advantages for delivery. Clinical nebulizers that employ vibrating mesh technology are the standard choice for converting liquid medicines into aerosols. However, they have limitations when it comes to delivering mRNA through inhalation, including severe damage to nanoparticles due to shearing forces. A microfluidic aerosolization platform (MAP) can preserves the structural and physicochemical integrity of lipid nanoparticles, enabling safe and efficient mRNA delivery to the respiratory system. Results demonstrated the superiority of the novel microfluidic aerosolizer over the conventional vibrating mesh nebulizer, as it avoided problems such as particle aggregation, loss of mRNA encapsulation, and deformation of nanoparticle morphology. Notably, aerosolized nanoparticles generated by the microfluidic aerosolization platform led to enhanced transfection efficiency across various cell lines. In vivo experiments with mice that inhaled these aerosolized nanoparticles revealed successful, lung-specific mRNA transfection without observable signs of toxicity. This pioneering MAP represents a significant advancement for the pulmonary gene therapy, enabling precise and effective delivery of aerosolized nanoparticles.