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60 results about "High risk group" patented technology

High-risk group. Epidemiology A group of people in the community with a higher-than-expected risk for developing a particular disease, which may be defined on a measurable parameter–eg, an inherited genetic defect, physical attribute, lifestyle, habit, socioeconomic and/or educational feature, as well as environment.

Sudden death risk real-time evaluation system and method based on multi-mode physiological signal fusion

The invention discloses a sudden death risk real-time assessment system and method based on multi-modal physiological signal fusion, relates to the field of human physiological state monitoring and early warning, and solves the problems of low accuracy and poor real-time performance of sudden death risk assessment by single-modal signals. The system comprises a signal acquisition module, a preprocessing module, a high-dimensional feature extraction module, a multi-modal feature fusion module, a sudden death risk quantification module, a model updating engine module and an early warning feedback module, and each module integrates a self-adaptive filtering unit, a time sequence convolutional network unit, an improved multi-head self-attention mechanism unit and the like. According to the scheme, multi-mode signals such as electrocardio are synchronously collected through multiple channels, a dynamic risk index is calculated through self-adaptive noise reduction, parallel extraction of time-frequency domain nonlinear features and mutual information weighted fusion in combination with kernel density estimation, and online incremental updating and multi-stage early warning of a model are achieved; the sudden death risk can be accurately evaluated in real time, the anomaly detection sensitivity and the early warning timeliness are improved, and the method is suitable for daily health monitoring and high-risk group risk management and control.
Owner:LIFE ARK (SHENZHEN) TECHNOLOGY CO LTD

Cerebral stroke high-risk group positioning evaluation system based on multi-modal data

The invention discloses a cerebral apoplexy high risk group positioning evaluation system based on multi-modal data, and relates to the technical field of medical information science, the cerebral apoplexy high risk group positioning evaluation system comprises a cerebral apoplexy prevention and control management platform, and the cerebral apoplexy prevention and control management platform is in communication connection with the following modules: a multi-modal data acquisition and integration module, the multi-modal data collection module is used for collecting multi-modal data related to cerebral apoplexy from multiple channels and carrying out preprocessing operation on the collected multi-modal data. By integrating clinical data, image data, omics data and terminal health data, multi-dimensional information related to the cerebral apoplexy can be comprehensively captured, particularly, cerebral vessel digital twin is utilized to simulate hemodynamic characteristics, a plurality of data sources are fused in combination with a graph neural network, high-risk groups can be recognized more accurately, and the accuracy of cerebral apoplexy recognition is improved. The accuracy and reliability of risk prediction are remarkably improved, the problem of missing detection caused by dependence on a single data source in a traditional method is solved, and more powerful support is provided for early intervention.
Owner:GUILIN MEDICAL UNIVERSITY +1

MCI cognitive trajectory and bidirectional outcome dynamic prediction method based on joint model

The invention relates to the technical field of medical informatization, in particular to an MCI cognitive trajectory and bidirectional outcome dynamic prediction method based on a joint model. The method comprises the following specific steps: firstly, constructing a univariate joint model, then constructing a multivariate joint model, and then constructing a function type multivariate joint model; performing parameter estimation and statistical inference on the model; fitting evaluation is carried out on the function type multivariable joint model based on multi-longitudinal cognition and multi-state outcome; and finally, carrying out individualized dynamic prediction. According to the method, a baseline or longitudinal nerve image is processed by using a function type data analysis technology, and a change track is reconstructed; a plurality of cognitive assessments are used as longitudinal measurement indexes, covariants such as age and gender and functional nerve images are used as predictive factors, two-way outcome of MCI and occurrence time of the two-way outcome are set as survival outcomes, a joint model based on multi-longitudinal cognitive multi-state outcomes is constructed, early screening of high-risk groups is assisted, and the survival outcomes of the high-risk groups are determined. And powerful support is provided for optimal distribution of medical and medical and health resources.
Owner:SHANXI MEDICAL UNIV

Construction method and application of senile diabetic hypoglycemia risk prediction model based on data mining technology

The invention discloses a data mining technology-based construction method and application of an elderly diabetic hypoglycemia risk prediction model, and belongs to the technical field of medicines and computers. The method comprises the following steps: selecting elderly diabetic patients meeting standards, collecting demographic, disease and lifestyle factor data, dividing a training set and a verification set, comparing the performance of five data mining models, screening an optimal model, confirming the effectiveness of the model through external verification, and visualizing the result. The model can output a quantitative risk probability, is suitable for multi-scene real-time evaluation, can accurately identify high-risk groups, guides hierarchical intervention, reduces the incidence rate of hypoglycemia, and improves the management efficiency and safety of elderly diabetic patients.
Owner:张瑞婷

Tumor radiotherapy rehabilitation nursing intervention system based on artificial intelligence

The invention discloses a tumor radiotherapy rehabilitation nursing intervention system based on artificial intelligence, and relates to the technical field of tumor rehabilitation nursing. By integrating multi-dimensional data and combining clinical standards to output quantitative evaluation levels and key weak dimensions, rehabilitation weakness of a patient is accurately positioned, a targeted target is provided for the nursing intervention strategy generation module, a personalized scheme is generated, and pertinence and performability of intervention are ensured; policy execution data are captured in real time and a scheme is dynamically adjusted, so that the intervention process always adapts to the rehabilitation state change of a patient, and meanwhile, active management and control on high-risk groups are enhanced by periodically collecting core indexes and linking risk upgrading and priority intervention, so that the tumor radiotherapy rehabilitation nursing is changed from passive response to active pre-judgment, and the rehabilitation nursing efficiency is improved. And the overall quality of rehabilitation nursing after radiotherapy and the prognosis effect of a patient are optimized.
Owner:THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL

Differential privacy protection method and system based on dynamic gradient

The invention discloses a differential privacy protection method and system based on dynamic gradient, and the method comprises the steps: 1, monitoring the gradient features of back propagation in real time in the training process of a target neural network model, and calculating a dynamic sensitivity zoom factor based on the gradient features; 2, identifying the type of the network hierarchy in the target model based on a three-level progressive judgment method; and step 3, setting a noise scaling factor according to the network hierarchy, selecting a noise type according to the intensity requirement of the network hierarchy for privacy protection, obtaining a noise scale corresponding to the noise type by using the dynamic sensitivity factor and the noise scaling factor, constructing noise according to the noise scale, and injecting the constructed noise into the corresponding network hierarchy to obtain the privacy protection. Obtaining a noise-added target model; and step 4, predicting input target data based on the neural network model after noise addition. According to the method, the protection effect of the model is improved, and stealing attacks aiming at genetic privacy and high-risk group identities can be effectively defended.
Owner:Chinese People's Liberation Army Cyberspace Force Information Engineering University

Colorectal cancer and progression prediction system and equipment thereof

The invention discloses a system and equipment for predicting colorectal cancer and progression thereof. Based on the found expression level difference of AXIN2 and / or EPHB2 in colorectal cancer and the progression thereof, the invention provides a colorectal cancer and progression prediction method, system and equipment, a computer readable storage medium and a computer program product, high-risk groups can be efficiently and accurately screened out from common groups, and colonoscopy is further completed in time. While the economic burden caused by endoscopic screening is relieved, patients suffering from colorectal adenoma and early colorectal cancer are screened out, and the method has great significance in early diagnosis and treatment of colorectal tumor and further remarkable reduction of the morbidity and mortality of colorectal cancer.
Owner:THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV

Artificial Intelligence-Based Tumor Radiotherapy Rehabilitation and Nursing Intervention System

This invention discloses an artificial intelligence-based intervention system for tumor radiotherapy rehabilitation nursing, belonging to the field of tumor rehabilitation nursing technology. By integrating multi-dimensional data and combining clinical standard output quantitative assessment levels and key weakness dimensions, this invention accurately identifies patients' rehabilitation shortcomings, providing targeted objectives for the nursing intervention strategy generation module and generating personalized plans to ensure the intervention's relevance and feasibility. It captures strategy execution data in real time and dynamically adjusts the plan, ensuring the intervention process always adapts to changes in the patient's rehabilitation status. Simultaneously, by regularly collecting core indicators and linking risk escalation and priority intervention, it strengthens proactive management of high-risk groups, realizing a shift from passive response to proactive prediction in tumor radiotherapy rehabilitation nursing, thus optimizing the overall quality of post-radiotherapy rehabilitation nursing and patient prognosis.
Owner:THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL

Biomarker combination for predicting PCI postoperative LVR of STEMI patient and application of biomarker combination

The invention discloses a biomarker combination for predicting PCI postoperative LVR of an STEMI patient and application of the biomarker combination, and belongs to the technical field of biology. The research discovers that in a left ventricular remodeling (LVR) group and a non-left ventricular remodeling group after percutaneous coronary intervention (PCI) of a patient suffering from acute ST segment elevation type myocardial infarction (STEMI), a left ventricular endocardial lower myocardial overall longitudinal strain (GLS internal) value, a lung B-line integral, a serum sFRP5 level and Apelin-13 show significant differences. Through combined prediction analysis, it is found that the GLS internal value, the lung B-line integral, the serum sFRP5 and the Apelin-13 have excellent prediction performance on whether the LVR occurs after the PCI operation of the STEMI patient or not, high-risk groups, suffering from the LVR after the PCI operation, of the STEMI patient can be accurately and efficiently recognized, intervention is conducted as soon as possible, and the life quality of the patient is expected to be improved.
Owner:XUZHOU CENT HOSPITAL

Fracture risk prediction method and system

The invention discloses a fracture risk prediction method and system, and relates to the technical field of health management. According to the prediction method, serious sarcopenia is selected to diagnose and assess the sarcopenia state, the ratio of monocytes to lymphocytes reflects the immune inflammation level, the prediction model is constructed in combination with the femoral neck bone mineral density T value, and the fracture risk influence factors are comprehensively covered; and the risk identification capability on special high-risk groups with sarcopenia, immune dysfunction and the like is effectively improved. And secondly, only three target independent variables are selected, and the three target independent variables are indexes which can be directly obtained or simply calculated in clinical routine examination, so that the data collection difficulty is greatly reduced. Meanwhile, the prediction model is visualized through a column diagram, complex calculation is not needed, a clinician can quickly inquire the fracture risk score through the actual value of the target subject, and the method is suitable for being efficiently applied to conventional outpatient service, hospitalization and other scenes.
Owner:THE FIRST PEOPLES HOSPITAL OF CHANGZHOU

CT dose adaptive optimization system and method

ActiveCN122004909BCt scannersImaging quality
The application discloses a CT dose self-adaptive optimization system and method thereof, and belongs to the technical field of medical images, which comprises a CT scanner, an image data processing workstation, a high-risk population analysis device, a dose parameter self-adaptive optimization device, a dose parameter automatic adjustment device and an intelligent learning unit, and based on the theory of information geometry, the dose parameter optimization problem is promoted from the Euclidean space to the Riemannian manifold space, the dose parameter manifold and the image quality manifold are constructed, the geodesic line is calculated on the manifold through the Fisher information matrix as the Riemannian metric, and the optimal dose path is found. The system adopts a double-manifold collaborative optimization mechanism, establishes a mapping relationship between the two manifolds, and realizes accurate optimization of parameters in combination with a geometric-guided genetic algorithm, and through pre-scanning, high-risk population analysis, information geometry optimization and automatic parameter adjustment, individualized dose control is realized, the radiation dose is additionally reduced by 30-45% compared with a traditional method, the image quality is maintained or improved, and the safety of CT examination is remarkably improved.
Owner:THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL

Discrimination method for intrahepatic cholangiocarcinoma based on serum polypeptide characteristics and application thereof

PendingCN122135934AMedical data miningPreparing sample for investigationIntrahepatic CholangiocarcinomaLogistische regression
This invention discloses a method for identifying intrahepatic cholangiocarcinoma (ICC) based on serum peptide characteristics and its application. The invention collects serum samples from three groups: individuals with ICC, those with benign liver disease, and healthy controls. Peptide characteristic peaks associated with ICC are screened, and a model is constructed using a logistic regression algorithm. This model demonstrates excellent discriminative ability on both the training and independent test sets, with AUCs reaching 0.986 and 0.963, respectively, significantly outperforming traditional tumor markers CA19-9 and CEA. The peptide characteristic peak combination and the discriminative model constructed based on it can be used for early detection of ICC, differentiation between benign and malignant cases, and screening of high-risk populations. It offers advantages such as rapid detection, standardized procedures, strong early ICC identification capability, and low false positive rate, providing a highly sensitive, specific, and widely applicable non-invasive screening tool for clinical use.
Owner:THE AFFILIATED SIR RUN RUN SHAW HOSPITAL OF SCHOOL OF MEDICINE ZHEJIANG UNIV +1

Target segments S6-1, S6-2 and S6-3 for multi-cancer-species identification and application of target segments S6-1, S6-2 and S6-3

The invention provides target sections S6-1, S6-2 and S6-3 for identifying multiple cancer species and application of the target sections S6-1, S6-2 and S6-3. A group of unprecedented gene methylation sites are successfully identified through an innovative screening strategy and large-scale cross-cancer omics data analysis. The invention also comprises a detection reagent (such as a primer) and a kit for detecting the target segment of the genome. The methylation degrees of the target segment between a plurality of cancer tissues and para-carcinoma tissues have significant differences, so that the subject can be judged to belong to tumor high-risk groups. The cancer tissue and para-carcinoma tissue differential methylation state presented by the target segment can be widely applied to various different types of cancers.
Owner:SHANGHAI EPIPROBE BIOTECH CO LTD

Biomarker for diagnosing rheumatoid arthritis and application thereof

The invention relates to a biomarker for diagnosing rheumatoid arthritis and application of the biomarker, and belongs to the technical field of biological medicines. The invention finds that the concentration of lipopolysaccharide and diamine oxidase in the plasma of a patient with rheumatoid arthritis (RA) is obviously higher than that of a healthy control group; furthermore, the invention also discovers that three proteins from plasma exosomes, namely phospholipid flip enzyme 1 (PLSCR1), keratin 1 (KRT1) and complement C1Q C chain (C1QC), have a good diagnosis effect on rheumatoid arthritis, and the diagnosis accuracy of rheumatoid arthritis can be remarkably improved by performing combined diagnosis on lipopolysaccharide and diamine oxidase with the three proteins. Therefore, when the biomarker is applied to preparation of RA diagnosis products, a core basis can be provided for accurate diagnosis of RA and generation of a risk assessment system, and the biomarker has transformation application value in the aspects of early diagnosis of RA and screening and accurate prevention and treatment of high-risk groups.
Owner:SUZHOU UNIV

Method for screening left atrial appendage thrombus by using multi-mode ultrasonic technology

The invention provides a method for screening left atrial appendage thrombus by using a multi-mode ultrasonic technology, and relates to the technical field of medical ultrasonic diagnosis. According to the method for screening the left atrial appendage thrombus by using the multi-mode ultrasonic technology, through a layered screening process of noninvasive primary screening, precise secondary screening and comprehensive judgment, the technical advantages of four complementary modes of transthoracic ultrasound (TTE), transesophageal ultrasound (TEE), ultrasonic contrast (CEUS) and shear wave elastography (SWE) are integrated, primary risk stratification is completed by using noninvasive TTE, and secondary risk stratification is completed by using noninvasive TTE; tEE is combined with CEUS and SWE to achieve multi-dimensional evaluation of the structure, the blood flow and the hardness of the thrombus for high-risk groups, and finally accurate detection and stability evaluation of the thrombus are achieved based on the judgment standard of multi-modal data fusion. According to the method, the detection rate of the left auricle thrombus can be remarkably increased, the unnecessary invasive operation risk is reduced, meanwhile, thrombus stability basis is provided for formulating a clinical anticoagulation treatment scheme, and the method is suitable for conventional screening of thrombus high-risk groups such as atrial fibrillation and the like.
Owner:CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL HAINAN HOSPITAL

Biomarker based diagnosis and treatment of myeloproliferative neoplasms

PendingUS20260152800A1Health-index calculationMicrobiological testing/measurementLow risk groupDLK1
There is described herein a method of prognosing or classifying a subject with a Myeloproliferative Neoplasm (MPN) comprising: (a) determining the expression level of at least 10 genes in a test sample from the subject selected from the group consisting of SPP1, CEACAM6, GJA1, IGSF10, IGFBP2, COL4A5, LYVE1, MTIE, EMP1, XIST, DLK1, TPSAB1, TIMP3, CLC, MS4A1, ENKUR, ALOX12, KNDC1, HLA-DQB1, GAS2, CLEC2L, BEND2, CDH7, and NT5E; and (b) comparing expression of the at least 10 genes in the test sample with reference expression levels of the at least 10 genes from control samples from a reference cohort of patients; wherein a difference or similarity in the expression of the at least 10 genes in the test sample and the reference expression levels is used to prognose or classify the subject with MPN into a low risk group or a high risk group for worse survival.
Owner:UNIVERSITY HEALH NETWORK

Breast cancer risk assessment method

The invention provides a breast cancer risk assessment method which is suitable for BI-RADS compact type high-risk groups with BMI greater than or equal to 28 and estrogen greater than 50pg / mL, and the method comprises the following steps: S100, injecting a temperature-sensitive nano contrast agent which is matched with fat acoustic impedance at 37 DEG C and has tumor environment impedance mutation at 39-42 DEG C; s200, dynamically adjusting the voltage of the molybdenum target tube according to the BMI and filtering by adopting a 40keV energy spectrum; s300, based on the leptin / adiponectin ratio L, the estrogen E and the focus area A, calculating a risk score according to R = 0.7 L + 0.3 E * (1 + 50A); according to the scheme, through high-risk group limitation, temperature-sensitive contrast enhanced ultrasonic specificity, BMI self-adaptive molybdenum target penetration and a multi-parameter fusion model, the detection precision is remarkably improved, the microfocus detection sensitivity reaches 92.3%, and the specificity reaches 88.7%.
Owner:SHENZHEN PEOPLES HOSPITAL

Diagnostic application of NDUFS5 in premature ovarian insufficiency disease

PendingCN120945039AMicrobiological testing/measurementNormal ovaryDisease
The invention provides a diagnostic application of NDUFS5 in premature ovarian insufficiency disease, the NDUFS5 peripheral blood expression level (mRNA) is detected to have a significant difference between POI and a control group, the difference is verified by qPCR in an independent queue, and the result shows that the expression of the NDUFS5 gene in the premature ovarian insufficiency group is significantly reduced compared with the control group, and the NDUFS5 gene has a significant effect on the premature ovarian insufficiency disease. The trend is consistent with that of transcriptome sequencing, and meanwhile, training and verification data are combined to prove that the NDUFS5 can be applied to distinguishing normal ovarian functions and ovarian insufficiency. The kit can be used for diagnosis of premature ovarian insufficiency (premature ovarian failure and ovarian aging), solves the clinical dilemma that diagnosis is delayed by means of existing means for POI diseases in the prior art, enables high-risk groups to be capable of early prediction or early warning, and avoids the risk that irreversible fertility is lost in advance due to the fact that the optimal period of early intervention is missed.
Owner:WOMEN S HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE

A device for predicting the risk of metabolic-related fatty liver disease in children or adolescents and a storage medium

PendingCN122291028ACommunity health centerBiology
This invention discloses a risk prediction device and storage medium for metabolic-associated fatty liver disease in children or adolescents. The two-stage cascaded screening strategy and model of this invention provide a highly accurate, accessible, and scalable solution for the early identification of metabolic-associated fatty liver disease in children or adolescents. This invention utilizes different anthropometric data to identify high-risk groups in routine school physical examinations, followed by further screening using a comprehensive serological index at community health centers, thereby achieving accurate diagnosis of metabolic-associated fatty liver disease and providing clinicians with a non-invasive auxiliary diagnostic tool that combines high precision, high accuracy, and broad accessibility.
Owner:PEKING UNIV

A liver function data detection method and system for a high-risk liver cancer population

The application provides a liver function data detection method and system for a high-risk population of liver cancer, relates to the field of health management, and effectively solves the false alarm and missed alarm problems caused by the lack of context information in the prior art by creating and updating a context snapshot based on a user ID in a high-speed memory cache area in real time, combining a user diagnosis type, a medication state and a medication timestamp, and differentiating liver function data based on a preset logic tree, so that the liver function data can be differentiated according to the diagnosis type and the medication state of the user in real time, false alarms and missed alarms can be effectively avoided, and the accuracy and reliability of the alarm system are improved.
Owner:THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV

CfDNA extraction method and application of cfDNA extraction method in construction of lung cancer early screening model

The invention discloses a cfDNA extraction method and application of the cfDNA extraction method in construction of a lung cancer early screening model. The method comprises the following steps: firstly, extracting cfDNA in plasma of a patient, then carrying out whole genome sequencing on the cfDNA, and constructing a characteristic matrix for lung cancer identification by combining an epithelial cell specific open region mined by single cell chromatin open data. On the basis, a deep learning model variational self-coding and a convolutional neural network are utilized to train and predict a distribution mode of cfDNA fragments in an epithelial cell characteristic region, and high-sensitivity, low-cost and non-invasive early detection of the lung cancer is realized. According to the invention, cfDNA epithelial cell signals are creatively used as cancer recognition signals, so that the screening accuracy and coverage rate of early-stage lung cancer patients are remarkably improved. The technology is suitable for large-scale cancer population screening and high-risk population dynamic monitoring, and has wide clinical popularization and application values.
Owner:KUNMING MEDICAL UNIVERSITY

Early warning and risk assessment method for liver cancer based on intestinal microbiome

The invention provides a liver cancer early warning and risk assessment method based on intestinal microbiome, and relates to the technical field of medical auxiliary analysis, by collecting excrement and plasma samples of high-risk groups and combining 13C-cholic acid dynamics, functional gene abundance and intestinal barrier indexes, a multi-modal risk score is calculated, and dynamic monitoring is realized through longitudinal CUSUM. When the risk index exceeds a threshold value, the system can give out an early warning to assist iconography review and personalized intervention. According to the method, high-risk individuals of liver cancer can be identified in serum AFP and iconography unabnormal stages, early intervention and follow-up visit optimization are achieved, prediction sensitivity is high, interpretability is high, and the method is suitable for high-risk groups of HBV / liver cirrhosis and metabolic liver diseases and has remarkable clinical application value and generalizability.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Rapid RT-QuIC diagnostic kit for Parkinson's disease based on A30P mutant alpha-synuclein

PendingCN121955406ASolve the difficulty of insufficient accuracyimprove featuresMicroorganism based processesBiological testingMutated proteinBiochemistry
The invention provides a Parkinson's disease rapid RT-QuIC diagnostic kit based on A30P mutant alpha-synuclein, and belongs to the technical field of detection kits. The specific A30P mutant protein is used as a reaction substrate, and rapid and high-sensitivity amplification detection can be carried out on trace misfolded alpha-synuclein in a skin sample through an optimized RT-QuIC system. The kit has the characteristics of short detection period and convenience in operation, provides a new tool for molecular diagnosis of Parkinson's disease, is suitable for definite diagnosis of clinical PD suspected cases, and can also be used for screening high-risk groups. The kit has the advantages of mature preparation process, easily available raw materials, easiness in industrial production and large-scale popularization, and important clinical application value.
Owner:ZHEJIANG RUIGOU MEDICAL TECHNOLOGY CO LTD

Premature fetal membrane premature rupture prediction marker based on maternal circulation exosome microRNA and application kit

The invention belongs to the technical field of obstetrics and gynecology disease prediction, and particularly relates to a premature fetal membrane premature rupture prediction marker based on maternal circulation exosome microRNA and an application kit. According to the invention, placentas, fetal membranes and plasma exosomes of pregnant women with full-term birth and premature birth premature rupture of fetal membranes are collected for sequencing, the fetal membrane-derived exosome hsa-miR-145-3p which can be detected in the plasma exosomes is screened out in combination with a verification set, and the cell source and the premature birth promoting effect of the fetal membrane-derived exosome hsa-miR-145-3p are respectively clarified at a cell level and an animal level; and finally, by detecting the level of the plasma exosome hsa-miR-145-3p of the pregnant 12 (+ 1)-17 (+ 6) perimaternal body, the efficiency (AUC = 0.833) of the exosome in predicting the occurrence of premature rupture of fetal membranes in premature delivery is illustrated. According to the method, the high-risk crowd of the pPROM can be predicted through a noninvasive method in the early and middle stages of pregnancy, and the method has guiding significance for subsequent prevention and intervention of the high-risk crowd.
Owner:TIANJIN CENT OBSTETRICS & GYNECOLOGY HOSPITAL

Application technology for enabling screening, early auxiliary diagnosis and postoperative curative effect evaluation of gynecological cancer high-risk group by artificial intelligence algorithm

The invention provides an application technology for enabling screening, early auxiliary diagnosis and postoperative curative effect evaluation of gynecological cancer high-risk groups through an artificial intelligence algorithm, and belongs to the field of molecular biology, medical diagnosis and treatment and disease prevention. The method comprises the following steps: collecting samples of human body liquid, exosomes and the like, detecting the DNA methylation level, miRNA expression quantity, protein level and the quantity of molecular markers such as autoantibodies, exosomes, kits and the like of the gynecological cancer by virtue of a modern detection technology, and obtaining individual precision medical treatment by virtue of a model and computing power (including a software algorithm, a large model, intelligent agent application and an artificial intelligence method). The problems of screening of gynecological cancer high-risk groups, early auxiliary diagnosis, pathological typing, clinical staging, metastatic state, postoperative curative effect evaluation and poor accuracy of national approved kits are solved, and the non-destructive detection technology can be used for timely prevention, precise medical treatment and cancer development tendency analysis, and has wide social benefits and popularization and use values. And the traditional Chinese medicine also has a popularization effect on non-gynecological cancers and other cancers.
Owner:马峥

Molecular marker and MRI image fusion tumor early detection method and system

The application discloses a molecular marker and MRI image fusion tumor early detection method and system, first collects serum molecular marker detection data and multi-sequence MRI image data of a digestive tract tumor screening object, constructs a molecular feature vector and extracts high-dimensional MRI image features respectively; a tumor prior probability is calculated through a molecular pre-screening deep neural network, and an adaptive spatial attention guide weight is generated; the weight is weighted and fused with the MRI image features to realize fine feature enhancement of a high-risk area and accurate lesion detection; based on a Bayesian evidence fusion reasoning framework, molecular detection evidence and image detection evidence are combined to update a posterior probability, and finally, a lesion positioning, detection confidence and visual detection report are output. The application realizes efficient complementation of molecular evidence and image evidence, greatly improves the accuracy, sensitivity and specificity of early detection of digestive tract tumors, and is suitable for non-invasive accurate screening of high-risk groups in clinical practice.
Owner:NORTH SICHUAN MEDICAL COLLEGE

Chronic disease health-care system for institutional old-age care

The invention provides a chronic disease health-care system for institutional old-age care, and relates to the field of intelligent medical treatment. The system comprises a periodic physical examination module for performing periodic physical examination on a crowd to obtain a physical examination result; the grading and bidding module is used for dividing the crowd into low-risk, medium-risk and high-risk groups according to the physical examination result; the low-risk group, the medium-risk group and the high-risk group are managed by units of different levels; the high-risk group management module at least comprises a chronic disease special case unit and is mainly used for creating a chronic disease file for a patient and performing chronic disease management service on the patient; the chronic disease type comprises any one or more of hypertension, diabetes, cerebral apoplexy, coronary heart disease, chronic obstructive pulmonary disease and fundus disease. According to the invention, a patient-centered'Internet + chronic disease management 'mode is adopted, chronic diseases are classified, graded and bid-divided, a county hospital-community / town health center-health station integrated system network is formed, early discovery of chronic diseases is truly realized, the morbidity of high-risk groups is reduced, and the disability and fatality rates are reduced.
Owner:QINGHE COUNTY CENT HOSPITAL

Prediction model for enteral nutrition intolerance occurrence risk of serious burn adult patient and application of prediction model

The invention discloses a prediction model for enteral nutrition intolerance occurrence risk of an adult patient with severe burn and application thereof, and belongs to the field of disease risk prediction. According to the method, risk factors of enteral nutritional feeding intolerance of the serious burn patient are screened, and the EFI risk prediction model of the adult serious burn patient is established and verified based on a Logistic regression analysis method, so that a scientific basis is provided for early clinical recognition of high-risk patients and implementation of preventive intervention. Risk factors for occurrence of EFI (Extensible Firmware Index) of severe burn patients of adults are explored, the risk factors comprise the number of basic diseases of subjects, whether intestinal probiotics are used or not, the number of white blood cells within 24 hours of hospital admission, fasting blood-glucose within 24 hours of hospital admission and the total area of burn, and a risk prediction model is constructed based on the risk factors. And reference is provided for early clinical recognition of high-risk groups with intolerant enteral nutrition feeding of serious burn patients.
Owner:AFFILIATED HOSPITAL OF JIANGNAN UNIV

Parkinson's disease dysarthria early recognition method based on voiceprint features

ActiveCN121545557ASpeech analysisDysarthriaMedical diagnosis
The invention discloses a Parkinson's disease dysarthria early recognition method based on voiceprint features, and belongs to the technical field of medical diagnosis. The method comprises the following steps: performing voice analysis and voice recognition on original voice data of a to-be-recognized object, extracting pronunciation deviation and an initial feature set related to voiceprint in a fragment, screening out target features with remarkable discrimination degree for recognition of dysarthria of Parkinson's disease, and obtaining a dysarthria recognition result of the to-be-recognized object through a model. Through accurate vowel and consonant fragment extraction and pronunciation deviation recognition, in combination with association of a character sequence and voice data, accurate interception of phoneme fragments is realized, quantitative judgment of pronunciation deviation is realized, key dimensions of dysarthria recognition are reserved through feature extraction, early signals of dysarthria of Parkinson's disease are captured, and the recognition accuracy of dysarthria of Parkinson's disease is improved. High-risk groups are marked, and an early warning result is calculated and output in combination with a joint risk value, so that the problem of unobvious symptoms in a prosperous period is solved, a review interval is dynamically adjusted, and whole-process management from identification to monitoring is realized.
Owner:SECOND MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL

Intelligent self-help system for marine jellyfish sting

PendingCN122347492AJellyfish stingsEpidemiology
This invention discloses an intelligent self-rescue system for marine jellyfish stings, relating to the field of first aid technology for biological injuries. This invention establishes a basic concept popular science system by integrating information on the species, habits, geographical distribution, and hazards of marine organisms to prevent marine organism injuries. It also integrates the clinical manifestations and treatment plans for injuries caused by venomous marine organisms, establishing a training system for treatment skills to aid in the preliminary identification of injury types and improve treatment skills. Furthermore, it integrates relevant data to compile a first aid guidebook and presents relevant medicines and equipment in a modular format for on-site emergency treatment. This effectively addresses the shortcomings and deficiencies in current marine organism injury treatment. Based on the epidemiological characteristics and treatment consensus of marine jellyfish stings, it improves the awareness, treatment skills, and on-site emergency treatment efficiency of potentially high-risk groups and medical personnel regarding marine jellyfish stings, reducing the risk of aggravated injury and mortality from jellyfish stings.
Owner:THE NAVAL MEDICAL UNIV OF PLA