The invention provides a clinical auxiliary decision knowledge base platform, a configuration method and device thereof, and a medium. The method comprises the steps of configuring knowledge types anddisplay forms of labels for different knowledge, so as to form a knowledge configuration document which is convenient to store, edit and manage, inputting rules, respectively encoding the rules and knowledge in the knowledge base, and docking the rules and the knowledge through encoding matching, and according to knowledge matched with the rule, displaying in a display form of the corresponding label, and recommending to the target role. According to the method, business rules and scenes can be directly used, non-computer background business personnel are supported to carry out personalized configuration according to the requirements for the display content and form of the knowledge base, the learning cost is low, and business expression is clear, simple, convenient, verified and modified; the communication cost is reduced, the research and development speed is increased, and the friendliness optimization, agile iteration and knowledge updating of the clinical auxiliary decision system are greatly improved.