494 results about "Individualized treatment" patented technology

An efficient, objective, flexible and easily deployable system for conducting evaluations of mental and physiological state and recommending individualized treatment to improve said state is described. The method and system are based on commensurate measurement of mental functions, levels of stress and anxiety, and / or biologically active molecules such as neurotransmitters, immune markers including cytokines and hormones. The method and system are designed to assess an individual's cognitive function and the underlying physiology in order to delineate various disease processes, injuries, drug states, training stages, fatigue levels, stress levels, aging processes, predict susceptibility to stress and / or sleep deprivation, identify aptitude for training and / or characterize effects of any experimental conditions. The system and method may be used in recommending individualized treatment protocols, as well as to guide the treatment process by assessing the efficacy of such therapies in the clinical trials process.

Method and system for providing individualized healthcare to a patient having a chronic disease over the Internet are disclosed. The system includes at least a computer server for executing application programs where the computer server includes storage means for storing patient information in at least a database server and means for communicating with at least a patient computer and a medical provider computer. The system further includes means for providing individualized web pages for interacting with the patient, means for monitoring signs and symptoms of the chronic disease using inputs provided by the patient, and means for administrating an individualized treatment of the chronic disease according to the signs and symptoms provided by the patient.

An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to by physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.

The invention discloses a personalized meta search engine based on user interest and a method for processing search results. The search engine comprises a user registration / login unit, a meta search result collecting unit and a personalized processing unit, wherein, the personalized processing unit achieves screening of search results, personalized ordering and establishment and renewal of a user interest model through a search result preprocessing module, a personalized ordering processing module and a user interest renewing module. The method comprises the following steps: establishing and initializing a user interest model and then logging in a server; distributing search words input by users in the format of each search engine required; converting returning results collected into a unified format, removing reprocessing and personalized ordering in sequence, and submitting to the users; and catching search results clicked by users, changing interest types and weight size and renewing the user interest model data. The invention has the advantages that the inquiry coverage and accuracy are high, and the method for processing search results can be used for searching engine in Internet.

The invention relates to a service basic software platform, which comprises a modeling tool, a service analysis engine and a plug-in unit system, wherein the modeling tool is used for processing service universal requirements, defines a service model through property configuration and graph configuration, and catties out high-speed buffer for the service model; the service analysis engine analyzes the buffered service model and instantiates a final service system; and the plug-in unit system writes a plug-in unit in native languages, and transfers a corresponding plug-in unit to process service personalized requirements in the process of analyzing the service model by the service analysis engine. On the basis of a point of view that the service basic software platform needs to serve for developers but not non-service personnel, the service basic software platform uses model drive to reach the service universal requirements, and uses a native code plug-in unit to achieve the service personalized requirements so as to ensure that the model drive logic and the plug-in unit code achievement logic are tightly integrated, and the software developers are released from complicated software works so as to pay close attention to development works which need personalized processing, and improve the software productivity.

An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.

The invention discloses a controlled-release multilayer drug-loaded artificial bone and a preparation method thereof. The controlled-release multilayer drug-loaded artificial bone is a multilayer structure which is coated layer by layer and is composed of artificial bone carrier materials loaded with drugs or a multilayer structure which is coated layer by layer and is formed by alternately arranging the artificial bone carrier materials loaded with the drugs and artificial bone carrier materials loaded with no drugs; the outline of the controlled-release multilayer drug-loaded artificial bone can be cylindrical, cuboid, square or irregular; and the artificial bone carrier materials loaded with the drugs at different layers comprise the same or different drugs. The controlled-release multilayer drug-loaded artificial bone is prepared by adopting a three-dimensional stereoscopic printing rapid prototyping technology, and the drugs distributed at the different layers are released from outside to inside layer by layer, thereby being capable of realizing multidrug combined action, regulating the releasing sequence and time of the drugs and selecting appropriate drugs to load so as to achieve the individualized treatment goal. The invention can be applied to carrying out local chemotherapy and filling and repairing bone coloboma after eradication focuses of various infections, concretions, tumours and the like of the orthopedics department.

The invention provides a picture intercepting and sharing method of a video player to improve the quantity of screenshots of the video player and be convenient to intercept a plurality of pictures by a user in a video playing process. Abundant individual picture processing functions are provided into the player; a plurality of screenshots can be selected to carry out zoom combination splicing, and the functions of adding a watermark, zooming and processing by special effect on the pictures can be carried out. The user can combine and arrange the pictures in the player through the screenshot method provided by the invention, can arrange the pictures in a single row or double rows, also can splice the pictures according to a template frame, can change the order of the pictures at random or manually adjust the order of the pictures, can splice and combine the pictures by abundant individual processing modes, and can directly share the pictures on websites such as an SNS (social network site) and a microblog and the like, so that complicated steps that the user needs to store the pictures in a local processor for a plurality of times, and then processes or uploads the pictures to the sharing websites to be spliced are reduced, and communication of the player and a server is reduced.

The invention discloses an application program generation method and device. An application configuration request and application materials are received, the application configuration request contains application program identification, a platform type and a template type, an application program framework which corresponds to the platform type and is provided with a special directory structure is acquired according to the platform type, directory files of the application program framework are personalized according to the application program identification, the template type and the application materials, and the personalized directory files are packaged to generate an application program. Through the application program generation method and device, the application program can be generated fast, and the application development efficiency is effectively improved.

The invention relates to a three-specialist co-management graded diagnosis and treatment transfer treatment system and method for chronic disease. According to the system and method, the '1+1+X' management mode is creatively provided, in other words, a specialist physician, a general medical practitioner and multiple health managers make up a management team. A three-specialist co-management service mode is established under the '1+1+X' management mode. Firstly, the chronic disease specialist physician conducts diagnosis and complication screening on a patient and makes an individualized treatment and management scheme; the general medical practitioner is required to conduct daily disease condition management of the patient, monitor the implementation condition of the treatment scheme and get in touch with the specialist physician when the disease condition changes or relapses so that medical treatment instructions can be obtained; the health managers are required to implement the management scheme prepared by the specialist physician, conduct routine visit and health education and the like. By means of the three-specialist co-management graded diagnosis and treatment transfer treatment system and method, the patient can be transferred to a lower-grade community hospital, the patient with the disease condition stable is encouraged to conduct self management, and the pressure of departments of an upper-grade hospital is alleviated.

The invention relates to a kit for auxiliary diagnosis of multiple tumors by taking a micro ribonucleic acid (RNA) combination as a tumor marker, and a detection method of the kit. The invention belongs to the fields of genetic engineering and oncology. The detection method comprises the steps of (1) extracting RNA from serum; (2) carrying out polyadenylation on the 3' end of micro RNA; (3) purifying and recovering a tailing product; (4) carrying out an inverse transcription reaction on the tailing product; (5) testing the relative expression of the micro RNA by means of a fluorescent quantitative PCR (polymerase chain reaction); (6) analyzing the result of the fluorescent quantitative PCR. The kit has the characteristics of high conservative property, space-time specificity, stability, tissue specificity and the like, and plays an important role in the aspects such as disease pathogenesis research, early diagnosis, individualized treatment and prognosis; furthermore, the kit is simple to operate, convenient in material obtaining, safe and noninvasive, and is conveniently used for screening of a great deal of diseases.

The invention discloses a software installation package producing method. The software installation package producing method includes: A, producing a software resource file into an installation resource package by the aid of a script; B, adding individualized processing logic for the installation resource package and setting an API (application programming interface) of a Windows Installer, wherein the API is used for reading the installation resource package and the individualized processing logic for installation when the installation package is executed; and C, packaging the installation resource package, the individualized processing logic and the API into a software installation package in an executable form. The invention further discloses a software installation package device which comprises the installation resource package, an individualized processing logic module and the API. By the aid of the method and the device, software packages can be installed smoothly, and more individualized software information can be provided for users.

The invention comprises a computer-based system and method for enhanced goniometry using consumer grade data capture components coupled with software to monitor, track, and diagnose joint pain, injuries, and disorders. A video capture device is used to capture and display the movements of a patient in real time and stored in a database for review on a time-delayed basis. The patient movements are digitized by the video capture components and analyzed by the computer software program. By observing variations in joint movements and tracking the variations over time, a medical professional can monitor, evaluate, and diagnose a wide variety of joint diseases, injuries, and disorders. The medical professional can also prepare individualized treatment plans and monitor the results as the patient progresses in treatment and therapy. Additionally, the medical professional may use aggregated anonymous joint movement data to determine “best practices” for future patients, based on past results.

This invention discloses an intelligent family phone recording and prompt system based on the phone identification technology including a phone receiving module used in receiving and transmitting phone signals sent by users, a system control module used in identifying, storing and processing phones and a phone output module transmitting phone prompt to users, which can draft and identify phones of users and carries out individual process to the phone data and conveys them to the users so as to realize the function of finishing automatic word leaving, diary and booking via phones directly.

The invention discloses a prognosis marker for lung cancer, a method for anticipating lung cancer prognosis by using the marker and application of the marker. The marker comprises the following gene combinations: RP11-89K21.1, CDH17, GRIA1, CENPF, AP000438.2, HMMR, RP11-434D9.1, ADH1B, TPX2 and OR7E47P. The prognosis marker for lung cancer overcomes the defect that the difference between lung cancer treatment reaction and prognosis is big, resulting in inaccuracy and inconvenience in prognosis, and the prognosis marker for lung cancer rapidly, accurately and conveniently anticipates lung cancer prognosis through the marker and detection of the marker, realizes classification and stratification of high and low lung cancer hazards on the molecular level, and remarkably separates patients with high risk from patients with low risk, thereby guiding individualized treatment, having higher clinical application value and saving medical treatment cost.

The invention discloses an in-vitro individualized medicine test method for lung cancer and a culture medium, and belongs to the field of cell biology and pharmacology. The in-vitro individualized medicine test method and the culture medium have the advantages that the culture medium M can be applied to normal epithelial cells and primary tumor cells of human or mammals, accordingly, in-vitro culture systems for tumor cells and para-carcinoma cells of lung cancer patients can be established, and primary cells, with continuous passage and quick proliferation functions, of patient individuals can be obtained; the culture systems can be used for detecting the sensitivity and the safety of medicines or combination groups of the medicines, and accordingly stable, accurate and reliable lung cancer individualized treatment-medicine sensitivity test standard detection process systems can be established; individualized sensitive chemotherapy medicines or compositions screened by the aid of the lung cancer individualized treatment-medicine sensitivity test standard detection process systems can be combined with clinical medicine or relevant subjects, accordingly, clinical individualized treatment schemes can be formulated, and the in-vitro individualized medicine test method and the culture medium can ultimately serve for clinical application.

The invention relates to a service information pushing method and system. The service information pushing method includes the steps that a two-way data transmission mode between an intelligent terminal and a cloud server and between a manager client side and the cloud server is established through a communication network; service requests are acquired and managed by the intelligent terminal, and the acquired service requests are transmitted to the cloud server; the cloud server transmits the service requests to the manager client side, the manager client side conducts individuation processing on the service requests, and information and service feedback matched with the service requests are pushed to the intelligent terminal through the cloud server according to the individuation processing result. By the adoption of the service information pushing method and system, the defect of interaction of traditional cell service information processing and pushing is overcome, real time performance is high, the application range is wide, performance is stable, price is low, features of smart cells are enriched, and good social benefits and economic benefits are possessed.

Methods and compositions disclosed herein generally relate to methods of improving clinical and economic outcomes to address adverse effects related to anesthesia, analgesics, opioids, and inadequate pain relief. Embodiments of the invention relate to the association between genes, specific polymorphisms of genes, and non-genetic factors with inadequate pain relief and anesthesia-, analgesic, and / or opioid-related adverse effects. Embodiments of the invention can be used to determine and manage patient risk factors for development of adverse perioperative effects and can allow for personalized anesthesia and pain management for improvement of pain control and reduction of anesthesia-, analgesic-, and opioid-related adverse outcomes. These methods and compositions apply to non-surgical pain management with opioids. Therefore, patients who are genetically predisposed to risk of inadequate pain relief and / or serious side effects from anesthesia, analgesics, and / or opioids can be identified and individualized treatment plans developed for implementation by the clinician to improve clinical and economic outcomes.

The invention relates to the fields of immunology and molecular biology, in particular to a method for preparing chimeric antigen receptor-T (CAR-T) cells, and the prepared CAR-T cells and application thereof. According to the method for preparing the CAR-T cells, the CAR-T cells are obtained by enabling CD3 positive T cells to be infected by CAR-containing virus. The invention also discloses the prepared CAR-T cells and a composition containing the CAR-T cells. The method for preparing the CAR-T cells enables the CD3 positive T cells to be infected by the CAR-containing virus so as to obtain the CAR-T cells, thus being capable of realizing the industrial production and preparation of the CAR-T cells used for individualized treatment; the prepared CAR-T cells eliminate the repellency between individuals; the CAR-T cells prepared by the method are better in effectiveness and higher in safety. The invention also provides the application of the CAR-T cells in preparation of medicine for treating or preventing cancers.

The invention discloses a weight losing type gait rehabilitation training robot. The weight losing type gait rehabilitation training robot comprises a rehabilitation platform, an intelligent weight losing device and a gait simulation generating device. The intelligent weight losing device is installed at the top of the rehabilitation platform, and the gait simulation generating device is installed at the bottom of the rehabilitation platform and located below the intelligent weight losing device. The weight losing type gait rehabilitation training robot can achieve active and passive rehabilitation training and is used for rehabilitation training of trainers having dysbasia due to cerebral palsy, stroke and the like. The weight losing type gait rehabilitation training robot is controlled by a computer, is provided with a corresponding sensor and a safety device, provides different walking training modes for patients, drives the lower limbs on two sides of each patient to perform gait rehabilitation training through the gait simulation generating device, and gradually recovers the walking capability of the lower limbs of each patient. Compared with traditional weight losing gait training, the working intensity of a therapist is greatly reduced, and the weight losing type gait rehabilitation training robot is more intelligentized and provides individualized treatment.

The invention relates to an auxiliary assessment method for prognosis of nasopharynx cancer based on enhanced MRI radiomics. The auxiliary assessment method comprises the steps of: (1), performing MRIimage processing; (2), extracting imaging features; (3), screening the imaging features; (4), establishing a radiomics scoring formula; (5), screening clinical risk factors; and (6), establishing a prognostic survival model: establishing a prognostic observation model through combination of a radiomics score and the clinical risk factors of a patient with nasopharynx cancer, performing qualitative and quantitative prediction on the PFS (progression free survival) of the patient, and furthermore, assessing the performance of the prognostic survival model. The auxiliary assessment method in theinvention has little harm to the image examination of the patient; qualitative and quantitative analysis on the survival time of a specific patient is carried out; therefore, a doctor is assisted tomake an individualized treatment and follow-up visit scheme; furthermore, the doctor is assisted to assess the survival and recurrence time of the patient; simultaneously, the performance of the obtained prognostic survival model is verified; and thus, the accuracy of a prognostic prediction model is ensured.

The invention provides a circulating tumor cell detection kit and an application thereof. The circulating tumor cell detection kit is characterized by comprising a RosetteSep rare cell enriching reagent, an RNA (Ribonucleic Acid) extraction reagent, an RNA reverse transcription reagent, a fluorescence labeling Taqman probe, a specific primer and a qPCR (Quantitative Polymerase Chain Reaction) reaction system reagent. The kit can be applied to tumor patient minimally invasive liquid biopsy, early diagnosis and early warning on tumor metastasis and reappearance are achieved, the curative effect in antineoplaston and the tumor development situation are monitored, molecular subtyping based on circulating tumor cells is achieved, and sensitive medicines which specifically aim at the circulating tumor cells are selected, understanding about tumor metastasis, replase and relevant medicine resistance mechanisms is improved, and individualized treatment on tumor patients is guided, so that the total survival of tumor patients is remarkably improved, and great clinical significance is achieved.

This invention discloses a dynamic content delivery method, an personalized dynamic content enabler and a system. The method includes: generating a personalized processing policy for content subscribed or requested by a user according to user information and content information when delivering the content to the user; and sending the content to a terminal of the user after processing the content by means of the personalized processing policy if the personalized processing policy meets user requirements., which may reduce the cost of obtaining information during the process of personalizing dynamic contents and improve the efficiency of delivering the dynamic contents, thereby improving the service experience of users.

The invention belongs to the technical field of biomedical materials and particularly relates to a hydroxyapatite-based bone tissue engineering bracket and a powder 3D printing method thereof. The hydroxyapatite-based bone tissue engineering bracket takes hydroxyapatite-based composite powder as a 3D printed powder material and a water-soluble polymer solution as an adhesive; the hydroxyapatite-based composite powder is one of hydroxyapatite / gelatin compound powder, hydroxyapatite / chitosan compound powder or hydroxyapatite / gelatin / chitosan compound powder obtained according to an in-situ chemical precipitation method and in combination with a spray drying process. The hydroxyapatite-based bone tissue engineering bracket provided by the invention adopts a material pore structure, is controllable in degree of connectivity, proper in mechanical property and good in biocompatibility, has good appearance size and conforms to an individualized treatment principle; the powder 3D printing method provided by the invention is high in printing speed and high in precision.

The invention discloses an EGFR (epidermal growth factor receptor) gene mutation site detection kit which detects EGFR gene mutation sites by combining the ARMS (amplification refractory mutation system) specific mutant enrichment technology with the Taqman-MGB (minor groove binder) probe specific detection technology. The kit comprises ARMS primer pairs and corresponding Taqman-MGB probes, and the ARMS primer pairs and the corresponding Taqman-MGB probes are used for detecting the EGFR gene mutation sites. The EGFR gene mutation site detection kit is high in sensitivity, capable of detecting multiple samples simultaneously and low in cost, provides guidance for pharmacy of clinicians, realizes individualized treatment of patients suffering from tumors and is capable of reducing treatment risk and burden of the patients and wide in application prospect.

A system and a method by which a clinician may monitor and communicate with a plurality of remotely located patients. This monitoring may be facilitated using a variety of communication protocols. Modular treatments and institutionally created standards are combined with clinician-provided input and decisions to provide the patient an individualized treatment regimen.

The invention relates to the fields of biotechnology, DNA mutation detection technology and bioinformatics, in particular to a gene panel for predicting a new antigen load and detecting genome mutation. Specifically, the invention relates to the gene panel which combines 839 genes and integrates 511 gene fusion events. The gene panel provided by the invention can rapidly, efficiently and accurately predict a new antigen load, and can also detect DNA mutation of multiple sites at one time, so that an optimal individualized treatment drug and scheme can be selected according to genomic characteristics of a patient in a cancer immunotherapy process. In addition, the gene panel provided by the invention can also be used for measuring various types of biomarkers such as SNV, Indel, CNV, gene fusion, MSI, TMB and HLA.

The invention discloses a combined diagnosis marker for predicting small hepatocellular carcinoma relapse. Based on an LASSO Cox regression model, the inventor confirms and establishes a small hepatocellular carcinoma relapse prediction model based on 6 gene signatures (including CD147, IL-7, Ki67, MIF, P97 and PD-L1) through analyzing a large number of cases; the risk ratio, defined by a 6 gene signature classifier, of a high relapse risk crowd to a low relapse risk crowd is 2.721 (95% CI: 1.633-4.532; P is smaller than 0.0001); the analysis of an internal validation group and an external validation group has the same result. The experiment proves that the classifier based on the 6 gene signatures can effectively predict different relapse risks of patients suffering from small hepatocellular carcinoma, the traditional diagnosis accuracy rate, predicted through clinicopathological parameters, of small hepatocellular carcinoma relapse is increased, the relapse risk of AFP-negative patients suffering from small hepatocellular carcinoma can be well judged, and the combined diagnosis marker has potential clinical value in the individualized treatment of small hepatocellular carcinoma.

The invention provides a kit for evaluating prognostic risks of breast cancer. Big-data clinical validation test results show that 12 miRNAs are combined to be used as a molecular marker, and the molecular marker has an outstanding advantage on the aspect of evaluation of prognostic risks of ER / PR(+)HER2(-) breast cancer. The molecular marker formed by combining the 12 miRNAs is firstly applied to development of the miRNA detection kit of ER / PR(+)HER2(-) breast cancer. The breast cancer miRNA detection kit can realize prognosis evaluation of ER / PR(+)HER2(-) breast cancer on the basis of a real-time fluorogenic quantitative PCR method, and can screen patients with high relapse risks, guide clinical individualized treatment and improve treatment accuracy.