4867results about "Electronic clinical trials" patented technology

The invention discloses a chronic disease early detection method and system based on a multi-modal large model, and relates to the technical field of intelligent medical treatment and artificial intelligence, and the method comprises the steps: obtaining a multi-modal data stream of a target user in a target time window from a pathology database, and generating an original multi-modal data set; performing timestamp unification and numerical value standardization processing on the original multi-modal data set to obtain a time sequence feature sequence; inputting the time sequence feature sequence to the multi-modal large model to obtain an abnormal symptom feature; calculating the similarity between the abnormal symptom features and feature vectors of marked cases in a historical case library, and determining matched cases; a diagnosis result and a development process of the matched case are extracted, a disease risk level and a development trend corresponding to the original multi-modal data set are determined in combination with the medical knowledge graph, and a pathology assessment result is obtained; and generating an early warning signal containing the risk type and the intervention suggestion according to the pathological assessment result. By implementing the application, the accuracy of early detection of chronic diseases can be improved.

Provided is a method including obtaining a prompt, determining a prompt embedding vector representing the prompt in an embedding space, modifying the prompt embedding vector using a trained model configured to adjust prompt embedding vectors to decrease proximity to vectors of blocks in a data set from which data is retrieved to augment generation by the generative AI model, determining that the modified prompt embedding vector is within a threshold distance to vectors in the embedding space corresponding to one or more blocks in the data set, selecting the one or more blocks in the data set, generating a response using the generative AI model based on the selected one or more blocks in the data set, quantifying an amount of influence of the respective block on corresponding text in the generated response, and providing the response and a representation of the quantified amount of influence as an output.

The invention relates to the technical field of health monitoring, in particular to a cardiovascular disease data fusion and multi-dimensional health assessment method, which comprises the following steps of: acquiring multi-source data of a patient through a sensor and wearable equipment, preprocessing the acquired data, ensuring data integrity, extracting physiological features by adopting a convolutional neural network, and evaluating the health of the patient. The method comprises the steps of extracting non-physiological data features through principal component analysis, constructing a multi-dimensional feature set, identifying cardiovascular disease related risk factors through a random forest algorithm, distributing weights through a logistic regression algorithm to generate individualized risk scores, analyzing time sequence trends of the risk factors based on a long and short-term memory network model, and generating dynamic risk scores in real time. When the score exceeds a preset threshold value, an early warning mechanism is automatically triggered, and a patient and medical staff are notified through an application program; according to the method, accurate assessment and personalized intervention of cardiovascular health are realized through multi-source data fusion and dynamic analysis, and the method has high efficiency and timeliness.

Provided is a method, including obtaining data associated with clinical trials, storing the obtained data into a repository by preprocessing the data to standardize diverse input formats into unified data model and organizing the stored data into a schema designed to integrate data of diverse input formats, indexing the stored data and analyses performed on the stored data, selecting one or more visualizations responsive to the query by selecting one or more visualizations as being responsive to the query based on metadata associated with each of the one or more visualizations, determining whether the stored data is associated with a plurality of metadata requirements of each of the one or more visualizations, dynamically generating executable code configured to generate the one or more visualizations responsive to the query, executing the generated executable code, and providing a response to the query.

An apparatus and method for real-time assessment and mapping of quality of life indicators includes: selecting a set of quality of life dimensions, receiving objective quality of life indicators based on the quality of life dimensions, receiving subjective quality of life indicators based on the quality of life dimensions, performing a statistical analysis on the objective quality of life indicators and the subjective quality of life indicators, storing the objective quality of life indicators, the subjective quality of life indicators, and the results of the statistical analysis in a database, and outputting the objective quality of life indicators, the subjective quality of life indicators, and the results of the statistical analysis.

The current disclosure provides methods for an automated clinical recommendation system that generates clinical recommendations for patients of a health care system based on natural language queries submitted by care providers of the health care system. The natural language queries may be typed into a user interface (UI) of the clinical recommendation system, or submitted by voice via a microphone. The clinical recommendation system provides a clinically explainable disease state of a patient based on patient data included in a query, and recommends a next course of action (e.g., a treatment) based on clinical guidelines and population statistics, in a manner that reduces a current burden of clinicians in consulting digital clinical manuals via a series of time-consuming and cumbersome interactions with a graphical user interface (GUI) of the digital clinical manuals.

Embodiments described herein provide for a healthcare ecosystem of computing devices participating as nodes of a distributed ledger (e.g., blockchain). The distributed ledger includes NFTs representing corresponding patients, where the initial NET behaves logically as a token scaffold that represents a “digital twin” of the particular patient. The initial patient token represents personal profile data of patient personal data for the patient. The nodes may generate new data and / or new sub-tokens (or other blockchain entry type) representing new data, which the nodes associate with the token scaffold. The sub-tokens contain data for representing physical or digital specimens, health data, and data derived from the health data (e.g., cell lines, organoids, other model systems). As the nodes generate and associate new sub-tokens to the patient's token scaffold over time, the token scaffold graphs and facilitates integration of patient-specific data and evolves into a robust electronic health record (EHR) and digital twin.

The present invention provides a clinical trial full-cycle intelligent management and risk warning analysis method and an intelligent agent, which relate to the technical field of clinical trial management, including collecting clinical trial data, extracting time-frequency features through nonlinear dynamic projection, spectral decomposition network, and wavelet Hilbert transform, and obtaining key feature signals using a dynamic compressed sensing model; generating a feature association network through manifold learning, constructing a nonlinear state migration field using stochastic differential equations, and capturing risk state mutation points in combination with an adaptive sampling strategy; obtaining a risk accumulation level through a dynamic prediction system, bifurcation theory, and singular spectrum analysis; based on the risk accumulation level, setting a dynamic warning threshold using critical state theory, and when the risk enters the threshold interval, starting a multi-objective optimization decision maker to calculate the optimal intervention strategy, performing risk regulation on the state migration field through a nonlinear response function, and feeding back the intervention results to iteratively optimize the risk warning.

Systems and methods for optimizing large language models with meta learning and chain of thought. A large language model (LLM) can be fine-tuned by generating optimized prompts based on an associated score of a generated output relative to a target output of a LLM-based optimizer using tuples of questions and the prompts generated from a dataset. Core features from the dataset that obtained top-ranked associated scores for the optimized prompts can be learned by utilizing chain of thought mechanism with the LLM-based optimizer. A meta prompt from the core features can be generated with the LLM-based optimizer to perform downstream tasks with the LLM.

A computer-implemented system and method for predictive risk assessment and intervention includes a risk assessment unit that processes survey data through an integrated database architecture. The system employs machine learning algorithms to analyze relationships between community and personal risk factors, maintaining real-time correlation coefficients and reliability metrics in a geospatial database. Machine learning algorithms may process factor analysis results to generate risk prediction quotients and determine intervention thresholds. The system automatically recalibrates based on intervention outcomes, continuously updating statistical relationships while preserving geographic and demographic associations. The database architecture coordinates multiple specialized components, enabling real-time analysis of risk patterns and automated generation of evidence-based intervention recommendations. The machine learning implementation continuously improves prediction accuracy through automated learning, while maintaining statistical validity through reliability calculations and correlation analysis.

A personal health assistant (PHA) chatbot system employing large language model (LLM) to a) receive a patient query; b) prompt for a patient identifier and a personal medical inquiry record; c) create a prompt record based on a patient-specific datum stored in secure medical profile; d) creating a dynamic prompt characterized by the prompt record; and e) updating an avatar-based interface based on the dynamic prompt. Patient-specific data (e.g., medical history, medications, and allergies) associated with the patient identifier may be updated with a patient profile change retrieved from an external data source(s) across a network interface (e.g., an electronic medical record (EMR)). The system matches common health issue types (e.g., location, medications, genetics, medical history, activities, environmental exposures), as well as other pertinent variables (e.g., language, culture, age, gender, and / or ethnicity) to the patient-specific data to deliver a medical recommendation and / or a personalized health advice through a user-tailored avatar.

A computer-implemented method includes receiving patient responses over a network from a recorded screening interview, utilizing a custom Large Language Model (LLM) to generate transcriptions and insights from the audio, performing video sentiment analysis to assess emotional states, and based on these data, generating an AI model to predict risk levels for various mental health conditions. The method further comprises presenting personalized questions based on previous screening insights, creating longitudinal summaries of patient histories, continuously improving the AI models through reinforcement learning, and integrating a recommendation engine to suggest targeted interventions. Additionally, the method includes tracking outcomes over time and enabling causal inference across multiple screenings, thereby providing a comprehensive platform for mental health assessment, intervention, and outcomes tracking.

A computer implemented method for governing risk actions by an artificial intelligence (AI) browser, by classifying a proposed action by the AI browser based on a large language model (LLM) as safe or risky based on AI weights or based on policy rules; initiating a step up authentication flow for a risk action; presenting an action summary and required capabilities to the user for approval; and enforcing user configured spend or scope limits on the risk action.

A computer-implemented method is disclosed for generating structured data representations from unstructured input text sequences through a neural network-based extraction pipeline. The method involves acquiring input text sequences and processing them with an extraction neural network to produce output text sequences. Each output text sequence includes embedded delimiter tokens that annotate specific text segments, mapping them to semantic categories defined within a structured schema. The annotated text segments encapsulate semantically relevant information extracted from the input sequence. The output text sequences are subsequently processed to generate structured data records.

A system for retrieving patient information using large language models including a computing device configured to receive a natural language query as a function of a user input, input the natural language query into a large language model communicatively connected to the least a processor, receive a computer language query comprising a plurality of nodes from the large language model, map the plurality of nodes to one or more entries in a patient database, receive a database response from the patient database as a function of the mapping, generate a final database query as a function of the database response. query the patient database using the final database query, receive a user response as a function of the final database query, and transmit the user response to a graphical user interface as a function of the final database query.

The invention relates to a heart rate prediction and model training method and system, wearable equipment and a medium. The training method comprises the following steps: acquiring a training sample set and a corresponding label set; wherein each training sample of the training sample set comprises a photoelectric volume pulse wave sequence and a corresponding acceleration sequence, and the label set is a real heart rate; preprocessing each training sample to obtain a corresponding photoelectric volume pulse wave frequency spectrum sequence and an acceleration frequency spectrum sequence; all the photoelectric volume pulse wave frequency spectrum sequences and the acceleration frequency spectrum sequences are input into a heart rate prediction model to be trained, and corresponding predicted heart rates are obtained; and calculating the difference degree between the predicted heart rate and the corresponding real heart rate, and updating parameters of the heart rate prediction model based on the difference degree to obtain a trained heart rate prediction model. According to the method, the problems of high signal processing cost and high calculation complexity caused by the use of a complex adaptive filtering process in the prior art are solved, and the heart rate prediction accuracy can be remarkably improved.

The invention relates to the technical field of medical information, in particular to an intelligent prediction model and method for postoperative complications of anesthetized patients, and the method comprises the steps: collecting preoperative to postoperative complete-cycle clinical data of a patient through a medical data interface; analyzing operation codes to generate risk features, extracting vital sign dynamic features, and establishing a complication probability mapping relation through a multi-modal fusion network; combining the complication probability and pharmacokinetic parameters to construct an optimization model, and solving an individualized anesthetic dosage interval by using a gradient descent algorithm; vital signs are dynamically monitored in the operation, a dose re-optimization mechanism is triggered, the infusion rate is adjusted, and a closed-loop control link is formed; and generating a visual decision report. According to the method, through deep integration of complete-cycle clinical data and multi-modal feature modeling, preoperative physiological parameters, operation coding semantic information and intraoperative vital sign dynamic modes are subjected to fusion analysis, a nonlinear mapping relation between dosage and complication probability is constructed, and the risk prediction precision and individualized adaptability are remarkably improved.

The invention provides a multi-mode prostate cancer biochemical recurrence risk layering prediction system based on artificial intelligence. Based on an Xgboost framework, a postoperative patient pathological panoramic pathological section scanning image is analyzed through end-to-end, multi-scale, multi-center and large-sample analysis, pathological information is utilized to the maximum extent, meanwhile, the prognosis risk of a patient can be evaluated more comprehensively in combination with clinical indexes such as CAPRA-S scores, and the method has obvious advantages compared with a traditional model. The method aims at better fitting the use scene of a hospital, the risk of prostate cancer recurrence of a patient is more efficiently and accurately predicted by fusing pathological section features and clinical features after a radical operation, and the risk of recurrence of the patient within 3 years and longer time after the radical operation can be accurately predicted. And an interpretable module is further combined to assist a doctor to interpret a result, so that precise layering and personalized follow-up visit of the BCR risk of the prostatic cancer patient are realized, the risk of excessive treatment and missed diagnosis is reduced, and the method has a good application prospect.

A computer-implemented method (200) is disclosed for performing a clinical assessment, the method comprising: providing a first input (206) to a machine learning model (208), the first input comprising template data encoding a template for carrying out a part of the clinical assessment; providing a second input (210) to the machine learning model, the second input comprising assessment data recorded during the clinical assessment; wherein the first input is provided to the machine learning model to condition the machine learning model to provide an output (212) based on the second input for use in the clinical assessment; and using the output from the machine learning model to perform the clinical assessment.

The invention discloses a multi-modal medical data fusion and analysis platform, and particularly relates to the technical field of medical assistance, and the platform comprises a data collection and preprocessing module which is used for integrating, cleaning and standardizing multi-source data, and is used for efficiently fusing and safely storing the multi-modal data; the data fusion and storage module supports rapid retrieval and management; and the data analysis and modeling module is used for carrying out feature extraction and pattern recognition by utilizing a machine learning algorithm and providing deep prediction analysis. The system integrates, cleans and standardizes medical data from multiple sources through the data acquisition and preprocessing module, ensures data quality and consistency, then efficiently fuses data of different modalities into a single data set through the data fusion and storage module, supports rapid retrieval and management, and finally utilizes the data analysis and modeling module to analyze and model the medical data. And deep prediction and risk assessment of diseases are provided through feature extraction, model training and prediction analysis.

A method for providing mental health advice, a method for training a deep-learning network and a deep-learning based mental health advisory system using Acceptance and Commitment Therapy (ACT). The method for providing mental health advice comprises the steps of: receiving textual input from a user in a consultation session; processing the textual input by applying a mental health condition relationship to the textual input to identify the mental health status of the user; and providing an output associated with the mental health status of the user.

Techniques relate to generating and / or verifying content based on protocols and / or user input. The techniques can receive protocol data from an entity, including a procedure, guideline, policy, or standard. User input requesting content generation related to specific parameters can also be received. Based on the protocol data, a data request can be generated and sent to a content generation component. Machine-generated content can be received from the content generation component in response. The machine-generated content can be analyzed based on the protocol data. Output content can be generated based on the machine-generated content and provided to a computing device. In examples, this ensures that generated content aligns with entity-specific protocols and / or user-specified parameters, enabling tailored and / or compliant content delivery for various contexts.

The invention discloses a head-mounted brain body workability assessment method based on a space-time dynamic fusion network, belongs to the technical field of artificial intelligence and human body signal acquisition, and solves the problems that an existing method cannot comprehensively reflect the comprehensive state of an individual, and interaction and potential risks among multiple factors are difficult to reveal. The method comprises the steps that physiological parameter signals are collected based on wearable equipment, and an attention and fatigue prediction result is output by an LSTM prediction model; according to the method, the graph structure data packet is analyzed and processed based on the pre-constructed space-time dynamic fusion network model, the working state signal characteristics of the plateau high-risk operating personnel can be accurately evaluated, the space-time graph neural network (STGNN) can capture the complex relation, the high-dimensional topological characteristics are extracted, and the high-risk working personnel can be accurately evaluated. The dynamic event-driven pulse neural network (deSNN) can convert the pulse sequence features into pulse sequence features so as to describe feature values more accurately, iterative optimization enables the pulse sequence features and the pulse sequence features to cooperate, and the accuracy and reliability of time-space dynamic fusion network model evaluation are improved.

A surgical planning and assessment system is disclosed. The system may include a computing system having a processor, a data store, and a patient specific planning and analysis module. The system may be configured to store a patient specific target plan including a digital representation of a spinal rod having a target geometry and transform the digital representation into a curved line. The system may generate a spline data set comprising a plurality of spline segments that are sequentially linked to one another. The system may adjust, iteratively, each spline segment until the plurality of spline segments approximate the curved line. The system may generate a digital file comprising drawings for manufacturing a spinal rod based on the plurality of spline segments. In various embodiments, each spline segment may be defined by a corresponding arc or a corresponding line extending between a corresponding starting point and a corresponding ending point.

The invention discloses a traditional Chinese medicine clinical research scheme generation method and system, and relates to the field of medicine. The method comprises the following steps: aiming at traditional Chinese medicine clinical research, constructing a knowledge graph covering evidence-based evidence elements PICO; establishing a traditional Chinese medicine cue word project and an element template based on evidence-based evidence elements PICO covered by the knowledge graph; identifying element information selected in the element template by adopting a traditional Chinese medicine cue word project, and generating a cue word feature vector; retrieving data matched with the cue word feature vector from the knowledge graph by adopting a trained language model; when the feature in the cue word feature vector cannot retrieve the matched data from the knowledge graph, automatically generating the matched data by using the trained language model; and integrating the matching data automatically generated by the trained language model and the matching data retrieved from the knowledge graph to obtain a traditional Chinese medicine clinical research scheme. The preparation efficiency and quality of the traditional Chinese medicine clinical research scheme can be effectively improved.

This specification describes systems and methods for performing endoscopy, obtaining medical images for inflammatory bowel disease (IBD) and scoring severity of IBD in patients. The methods and systems are configured for using machine learning to determine measurements of various characteristics related to IBD. The methods and systems may also obtain and incorporate electronic health data of patients along with endoscopic data to use for scoring purposes.

The subject matter described herein includes methods, systems, and computer readable media for early detection of a neurodevelopmental or psychiatric disorder using scalable computational behavioral phenotyping. According to one method for early detection of a neurodevelopmental or psychiatric disorder using scalable computational behavioral phenotyping includes obtaining user related information, wherein the user related information includes metrics derived from a user interacting with one or more applications executing on at least one user device; generating, using the user related information and a machine learning based model, a user assessment report including a prediction value indicating a likelihood that the user has a neurodevelopmental or psychiatric (neurodevelopmental / psychiatric) disorder and a prediction confidence value computed using relative contributions of the metrics to the prediction value generated using the machine learning based model; and providing the user assessment report to a display or a data store.

Disclosed are methods of improving treatment adherence and compliance after discontinuation of incretin-based therapies, such as GLP-1 and / or GIP agonists, using pharmacotherapies comprising the disclosed therapeutic compounds and combinations. In some aspects, methods include treatment of psychological factors affecting other medical conditions (PFAOMC) following the administration of incretin-based therapies to treat obesity or hyperglycemia, and related disorders. In some aspects, disclosed pharmacotherapies for use in the methods include agents that modulate monoaminergic neurotransmission, administered alone or together, such as in disclosed combinations having advantageous synergistic effects.

A programmatically generated AI avatar includes a customizable personality module, acting as the embodied interface for a powerful AI “mind” that delivers personalized coaching to improve user health, well-being, and longevity. The system uses machine learning, large language models, and biometric modeling to synthesize real-time, multi-modal health data—including sleep, nutrition, glucose, mood, and activity—and generate forward-prescribed KHAs. Unlike human coaches, it continuously adapts based on context and behavior, targeting the root cause: metabolic dysfunction—namely by restoring healthy, sustainable body composition through the preservation or building of lean muscle mass and reduction of excess fat. KHAs can also be shared with friends or programmatically generated AI avatars, allowing for coordinated action, emotional support, and accountability through social connection—further reinforcing positive behavior and adherence. The system's reinforcement learning engine incorporates both individual response data and anonymized population-level insights to optimize recommendations over time, learning which interventions are most effective for users with similar physiological and behavioral profiles. First validated with Olympic athletes—resulting in measurable improvements and medal-winning outcomes—this system offers a scalable, emotionally intelligent coaching engine that exceeds human capability, designed for the ultimate purpose of supporting sustainable health, resilience, and human thriving.

The invention discloses an intelligent psychological state assessment method and system based on multi-modal alignment, and relates to the technical field of psychological assessment, and the method comprises the following steps: S1, constructing a training sample set of a psychological state assessment model; s2, preprocessing video data, voice data and text data in the training data sample set; s3, performing alignment and fusion by using multi-modal cross attention, taking the text data as a main modal, and taking the video data and the voice data as assistance of the text data to obtain multi-modal fusion features for psychological state analysis; s4, training by using the aligned and fused multi-modal fusion features to obtain a psychological state analysis model; and S5, obtaining a multi-dimensional psychological analysis result of the testee through the psychological state analysis model obtained through training. According to the method, the multi-modal deep features of the teenagers are extracted by pre-training the large model, and the feature expression ability of the data is improved by using the modal alignment technology.