The invention relates to an
advanced gastric cancer survival
prediction system based on
Lasso regression, Cox regression and an interpretable
machine learning technology, and belongs to the technical field of medical
artificial intelligence and
intelligent decision support. According to the
system, by collecting multi-
modal clinical data (including demographic information,
TNM staging, treatment
modes, tumor grading and the like) of a patient, survival-related variables are screened by adopting
Lasso regression and a Cox proportional
risk model, and an optimized
feature set is constructed. Based on the
feature set, the
system integrates various mainstream
machine learning algorithms (such as XGBoost,
Random Forest, SVM,
Logistic regression and the like) to construct a prediction model, compares the performance of each model, and selects a model with an optimal effect as a main model. And hyper-parameter tuning is performed on the model through grid search and
cross validation, so that the precision and generalization ability of the model are improved. An SHAP
interpretability analysis method is introduced into the
system, transparent interpretation is carried out on a model output result from the global level and the
individual level, and the importance and directional effect of all variables in survival prediction are determined. Finally, the model is deployed on a terminal device, a doctor is supported to automatically output the
survival probability and an explanation result after inputting
patient information, and a reference basis is provided for
clinical treatment decision and personalized management. The system has the advantages of high prediction precision, high
interpretability, convenience in use, sustainable optimization and the like, is suitable for clinical aid decision-making scenes, and has good application prospects and popularization values.