180results about How to "Useful in detection" patented technology

The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGf-1R.

The present invention is an imaging device which in one embodiment is equipped with decode functionality and is configured to operate in at least one of four user selected modes. In a first, “message only” mode, the device stores into a designated memory location a decoded-out message corresponding to a decodable indicia. In a second, “image only” mode, the device stores into a designated frame storage memory location an image representation of a scene. In a third, “image plus message” mode the device stores into a designated frame storage memory location an image representation comprising a representation of a decodable symbol and into the same or other memory location the decoded-out message decoded from the decodable indicia, or data corresponding to the same. In the fourth, “two-step message and image” mode, the device is controlled to capture an image a first time for decoding a decodable indicia and a second time for capturing an image that is associated with the decoded-out message corresponding to the decodable indicia.

This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

The present invention is an imaging device which can be equipped with decode functionality and which can be configured to operate in at least one of four user selected modes. In a first, “message only” mode, the device stores into a designated memory location a decoded-out message corresponding to a decodable indicia. In a second, “image only” mode, the device stores into a designated frame storage memory location an image representation of a scene. In a third, “omage plu message” mode the device stores into a designated frame storage memory location an image representation comprising a representation of a decodable symbol and into the same or other memory location the decoded-out message decoded from the decodable indicia, or data corresponding to the same. In the fourth, “two-step message and image” mode, the device is controlled to capture an image a first time for decoding a decodable indicia and a second time for capturing an image that is associated with the decoded-out message corresponding to the decodable indicia.

A portable, lightweight digital imaging device uses a slit scanning arrangement to obtain an image of the eye, in particular the retina. In at least one embodiment, a digital retinal imaging device includes an illumination source operable to produce a source beam, wherein the source beam defines an illumination pathway, a scanning mechanism operable to cause a scanning motion of the illumination pathway in one dimension with respect to a target, an optical element situated within the illumination pathway, the optical element operable to focus the illumination pathway into an illumination slit at a plane conjugate to the target, wherein the illumination slit is slit shaped, a first two dimensional detector array operable to detect illumination returning from the target and acquire one or more data sets from the detected illumination, wherein the returning illumination defines a detection pathway, and a shaping mechanism positioned within the illumination pathway, wherein the shaping mechanism shapes the source beam into at least one arc at a plane conjugate to the pupil. In at least one exemplary embodiment, the digital retinal imaging device is operable to minimize at least one aberration from the optical element or an unwanted reflection from the target or a reflection from a device.

This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

A microflow apparatus for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts. The posts are spaced across the width of a collection region in the flow path, extending between the upper and lower surfaces thereof; they have rectilinear surfaces, have arcuate cross-sections, and are randomly arranged so as to disrupt streamlined flow. Sequestering agents, such as Abs, are attached to all surfaces in the collection region via a hydrophilic coating, preferably a hydrogel containing isocyanate moieties or a PEG or polyglycine of substantial length, and are highly effective in capturing cells or other targeted biomolecules as a result of such streamlined flow disruption.

A method detects events in multimedia. Features are extracted from the multimedia. The features are sampled using a sliding window to obtain samples. A context model is constructed for each sample. The context models form a time series. An affinity matrix is determined from the time series models and a commutative distance metric between each pair of context models. A second generalized eigenvector is determined for the affinity matrix, and the samples are then clustered into events according to the second generalized eigenvector.

The inventors have discovered sets of proteinaceous biomarkers (“AD biomarkers”) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease. The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating the levels of the AD biomarkers.

A portable, lightweight digital imaging device uses a slit scanning arrangement to obtain an image of the eye, in particular the retina. The scanning arrangement reduces the amount of target area illuminated at a time, thereby reducing the amount of unwanted light scatter and providing a higher contrast image. A detection arrangement receives the light remitted from the retinal plane and produces an image. The device is operable under battery power and ambient light conditions, such as outdoor or room lighting. The device is noncontact and does not require that the pupil of the eye be dilated with drops. The device can be used by personnel who do not have specialized training in the eye, such as emergency personnel, pediatricians, general practitioners, or volunteer or otherwise unskilled screening personnel. Images can be viewed in the device or transmitted to a remote location. The device can also be used to provide images of the anterior segment of the eye, or other small structures. Visible wavelength light is not required to produce images of most important structures in the retina, thereby increasing the comfort and safety of the device. Flexible and moderate cost confocal and fluorescent imaging, multiply scattered light images, and image sharpening are further functionalities possible with the device.

Hafnium oxide HfO₂ scintillator compositions are doped with titanium oxide and at least an oxide of a metal selected from the group consisting of Be, Mg, and Li. The scintillator compositions can include sintering aid material such as scandium and/or tin and a rare earth metal and/or boron for improved transparency. The scintillators are characterized by high light output, reduced afterglow, short decay time, and high X-ray stopping power. The scintillators can be used as detector elements in X-ray CT systems.

A method detects events in multimedia. Features are extracted from the multimedia. The features are sampled using a sliding window to obtain samples. A context model is constructed for each sample. An affinity matrix is determined from the models and a commutative distance metric between each pair of context models. A second generation eigenvector is determined for the affinity matrix, and the samples are then clustered into events according to the second generation eigenvector.

The invention provides methods for detecting contamination in a PCR reaction. Methods of the invention are especially useful for detection of contamination in heterogeneous samples containing a rare nucleic acid to be detected.

The invention relates to a chemically-sensitive film for use in a detector for TNT, where the chemically sensitive film includes a porous, polymeric structure and a plurality of basic functional groups integral with the porous, polymeric structure, and the basic functional groups are selectively reactive with TNT. Waveguides coated with these films can be used in sensing devices that are capable of selectively detecting TNT in a sample. Methods of making the films, waveguides, and sensors are disclosed.

The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals.

A method and system are disclosed for generating and using a virus-free file certificate integrated in a file. The method, for use in a virus-free certificate authority (102), for generating a virus-free certificate (200) certifying that a file is virus-free includes the steps of: receiving (300) a virus-free certificate request for a file from a server (101) or a client (100) system, said virus-free certificate request including the file for which the virus-free certificate is requested; determining (301) whether a virus-free certificate is integrated in the file; if no virus-free certificate is integrated in the file: determining (305) whether the file is virus-free or not; if the file is declared virus-free by the virus-free certificate authority (102): generating (313, 314) a virus-free certificate (200) including a file signature (207) for certifying that said file is declared virus-free by the virus-free certificate authority (102); integrating (316) the generated virus-free certificate (200) in the file; sending (316) back in response to the virus-free certificate request the file with the integrated virus-free certificate (200). The method for use in a server (101) or client (100) system, for determining that a file is virus-free includes the steps of: determining (401) whether a virus-free certificate (200) is integrated within a file; if a virus-free certificate is integrated within the file: authenticating (415) the virus-free certificate (200), said virus-free certificate including a certificate signature (206); authenticating (407) the file, said virus-free certificate (200) including a file signature (207), said file signature certifying that said file has been declared virus-free by a virus-free certificate authority (102).

Scintillator compositions having a garnet crystal structure useful for the detection of high-energy radiation, such as X, beta, and gamma radiation, contain (1) at least one of terbium and lutetium; (2) at least one rare earth metal; and (3) at least one of Al, Ga, and In. Terbium or lutetium may be partially substituted with Y, La, Gd, and Yb. In particular, the scintillator composition contains both terbium and lutetium. The scintillators are characterized by high light output, reduced afterglow, short decay time, and high X-ray stopping power.

The invention provides a method for screening for colorectal cancer, the method comprising: screening a biological sample from an individual for one or more biomarkers selected from the group defined in Table 1 and/or Table 6, wherein the presence of or increased expression of the one or more biomarkers relative to a control sample is indicative that the individual is at risk of suffering from or is suffering from colorectal cancer. The invention also provides an array and kit suitable for use in the methods of the invention, methods of treating colorectal cancer and therapeutic agents for use in methods of treating cancer.

Methods for assembly of monolayers of nanoparticles using the Langmuir-Blodgett technique, as well as monolayers, assemblies, and devices are described. The surface properties of these monolayers are highly reproducible and well-defined as compared to other systems. These monolayers can readily be used for molecular detection in either an air-borne or a solution environment, and sensors using the monolayer could have significant implications in chemical and biological warfare detection, national and global security, as well as in medical detection applications.