742 results about "Spectroscopic detection" patented technology

The device and method disclosed herein concern detecting, identifying, and or quantifying analytes, such as nucleic acids, with high resolution and fast response times using surface enhanced coherent anti-Stokes Raman spectroscopy. In certain embodiments of the invention, a small number molecular sample of the analyte 210 such as a nucleotide, passes through a microfluidic channel, microchannel, or nanochannel 185 and sample cell 175 that contains Raman-active surfaces, and is detected by surface enhanced, coherent anti-Stokes Raman spectroscopy (SECARS). Other embodiments of the invention concern an apparatus for analyte detection.

The invention generally relates to a new gene probe biosensor employing near field surface enhanced Raman scattering (NFSERS) for direct spectroscopic detection of hybridized molecules (such as hybridized DNA) without the need for labels, and the invention also relates to methods for using the biosensor.

The device and method disclosed herein concern detecting, identifying, and or quantifying analytes, such as nucleic acids, with high resolution and fast response times using surface enhanced coherent anti-Stokes Raman spectroscopy. In certain embodiments of the invention, a small number molecular sample of the analyte 210 such as a nucleotide, passes through a microfluidic channel, microchannel, or nanochannel 185 and sample cell 175 that contains Raman-active surfaces, and is detected by surface enhanced, coherent anti-Stokes Raman spectroscopy (SECARS). Other embodiments of the invention concern an apparatus for analyte detection.

The invention discloses a non-destructive inspection method for the comprehensive quality of food and a device thereof, wherein image information reflecting characteristics of an inspected object, such as color, texture, size and shape, etc. is acquired by a machine vision system, and spectral information reflecting physical and chemical indexes of the sample such as moisture, sugar, protein, lipid and PH value, etc. is obtained by a spectrographic detection system, and the acquired image information and the spectral information undergo the preprocessing on the data layer and the information integration on the characteristic layer or the decision layer; together with a built food classification grading expert system, the quality of the inspection object is comprehensively graded. The invention comprehensively utilizes the light image information and the spectral information to inspect the appearance and inner quality of food, thereby the invention can make a quick, convenient, non-destructive and objective inspection on the comprehensive quality of food; the method and the device are widely used to classify food materials, monitor the food processing and grade the food, etc., which ensures the quality of food and contributes to the good quality and low price of food.

An apparatus and method for the remote analysis and identification of unknown compounds. A robotic arm positions a sensor on a surface. The sensor unit has a monitoring mechanism to monitor separation between the sensor unit and the surface when placed in contact with the surface to maintain the separation substantially constant. An illumination source illuminates the region of interest to produce scattered photons from an unknown compound. The scattered photons are collected by an optical system and delivered to a spectroscopic detector for analysis and identification. An algorithm is applied to the data generated by the spectroscopic detector to identify the unknown compound.

A continuous monitoring method and system wherein a porous substrate or film is used. The air from the environment is drawn through a region of the porous substrate by a simple air pump and the substances in the air are deposited or chemically adsorbed onto the surface of the substrate. The region of the substrate where the environmental air is drawn through is continuously monitored by an optical or spectrometric method. The substrate is in the form of a tape supplied by a feed reel in a reel-to-reel cartridge and taken up by a take-up reel as found in a film cartridge or a magnetic tape cartridge. The cartridge can be replaceable. A variety of materials may be employed as the substrate with an adequate surface area to effect accumulation of solid, liquid, aerosol, or gas phase compounds. An optical interrogation system is engineered such that the surface of the tape at the point where air from the environment is drawn through the substrate becomes the interaction region between the source output and the sample. As material from the environment accumulates in this region, the interaction of the source with the material is monitored by a suitable detector and supporting circuitry.

The invention relates to an integrated laser-induced enhanced plasma spectrum acquisition system and belongs to the field of laser plasma spectrum detection. The integrated laser-induced enhanced plasma spectrum acquisition system comprises a pulse laser device, a light beam lifter, a spectrometer, a domain limiting loop, a high voltage discharge electrode, an ICCD (Intensified Charge Coupled Device) camera, a focusing lens, a sample chamber, a reflector, an adjustable optical fiber optical receiving system, a sample to be detected, a three-dimensional electric control translation platform, an imaging CCD (Charge Coupled Device), a gas flow meter and a gas pressure meter. According to the integrated laser-induced enhanced plasma spectrum acquisition system, different LIBS (Laser-induced Breakdown Spectroscopy) signals are collected by utilizing control and synchronous control of internal environments of smaller independent sealed spaces so that integration is realized; a high voltage discharge enhanced and loop limited domain synchronous enhanced LIBS system with the functions of spectrum acquisition, dynamic image analysis and the like is integrated; and more accurate measurement are realized by utilizing environment stress around the sample and control of protection gas; and the system is quick and convenient, and is favorable for industrial production and application.

The invention relates to nutrient diagnosis of crops, in particular to an environment-controllable hyperspectral image detecting device for crop nutrition and moisture. The device comprises a hyperspectral imaging system and a light box system. The hyperspectral imaging system can be used for extracting and analyzing the visual image features and the reflection intensity distribution features of the crop nutrition and moisture by acquiring crop visible light-near infrared hyperspectral image data cubes. The light box system can be used for presetting and regulating standard value of detection environment parameters such as illumination, temperature, humidity and the like, providing the stable detection environment for the hyperspectral detection of the crop nutrition and moisture, and meanwhile, studying the hyperspectral image features of the crop nutrition and moisture under different environmental conditions. By optimizing the visible light-near infrared hyperspectral image features and combining environment monitoring information, error influences caused by variations of environmental factors such as light intensity and the like can be effectively reduced so as to realize the rapid detection of the crop nutrition and moisture information.

A portable system and method for measuring the concentration of multiple chemical or biological substances where an onsite analysis of such substances is needed. The new and original handheld sensor system uses a disposable optical test element and a spectroscopic detector that measures the test element response to specific analytes through a change in light absorbance, luminescence, and other forms of light-based response. In this way, reflection light intensities indicative of the test element response can be used to measure the concentration of the target analytes. The sensor system is also capable of being interfaced to an information processing unit or computer so that analytical data can be manipulated or stored electronically.

The present invention relates to a method for measuring the characteristics of a downhole fluid. The method for measuring the characteristics of a downhole fluid includes passing a downhole fluid sample through an analyzer, analyzing the downhole fluid sample by illuminating the downhole fluid sample with light from a light source and detecting light that interacts with the fluid sample. The method is applicable to detecting carbon dioxide and / or hydrogen sulfide directly in a downhole environment.

The present invention relates to the technical field of laser spectrum detection and gas detection, and in particular relates to a two quantum cascade laser spectrum-based multicomponent gas simultaneous detection device and method. An arbitrary waveform function generator outputs a periodic signal which only superposes high-frequency modulation signals in any half period to be used as a laser current signal, a room temperature continuous mode mid-infrared quantum cascade laser is driven by a current control unit, the laser emits a laser signal, the laser signal passes sequentially through a focusing collimating three-dimensional adjustment system, a first mirror, a sample absorption pool and a off-axis parabolic mirror to be reflected to a first detector, the first detector passes the laser signal through a data acquisition unit to convert into an electrical signal and transmit to a computer, and information of the gas to be measured can be obtained by analysis and processing of the electrical signal by the computer. The devices simultaneously utilizes two spectrums for gas detection, and has the advantages of high detection sensitivity, high detection accuracy, no need of external standard gas calibration, simple optical path adjustment, fast response, and stability, and the like.

Improved methods for the detection and quantitation of labeled biological materials in a sample using elemental spectroscopic detection are described. Element-labeled biologically active materials, comprising antibodies, antigens, growth factors, hormones, receptors and other biologically active materials covalently attached to a stable elemental tag, can be used in specific binding assays and measured by elemental spectroscopic detection. Also described are methods for the determination of metals in samples of interest using specific antibodies to isolate the target metals and elemental spectroscopy for detection and quantitation.

Textile fibers and other fibrous substrates functionalized with particles are provided for use in the detection of targets of interest by spectroscopic methods. In one embodiment, a substrate is provided that comprises a conformal coating on its surface, wherein the coating comprises a plurality of chemically functional particles that are spectroscopically enhancing. Methods for producing such functionalized textile fibers are also provided. These textiles can be used as platforms for spectroscopic detection, including surface-enhanced Raman scattering (SERS), surface-enhanced infrared absorption (SEIRA), and surface-enhanced fluorescence (SEF). Functionalized textile fibers for use in the signature detection methods are produced by performing layer-by-layer self-assembly of particles on natural and synthetic textile substrates.

Methods and related apparatuses and mixtures are described for detecting hydrogen sulfide in a formation fluid downhole. A detection mixture is combined with the formation fluid downhole. The detection mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and charged nanoparticles sized so as to inhibit significant aggregation of the metal sulfide so as to enable spectroscopic detection of the metal sulfide downhole. The combined mixture and formation fluid is then spectroscopically interrogated so as to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the formation fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions.

Structures are characterized by exposing a sample to optical radiation, measuring a spectrum associated with the exposure, detecting at least one characteristic parameter in the measured spectrum, and computing at least one structural parameter based on the at least one characteristic parameter.

A method of particle detection includes optically trapping a single particle having an averaged linear dimension of between 0.10 microns and 50 microns in a focal region optical trap formed from a trap visible to near-infrared wavelength. The trap is proximal to a substrate having a discontinuous metal coating so as to exploit a surface plasmon resonance generated electric field caused by irradiation of the metal coating. The single particle is then exposed to an interrogation wavelength to yield scattering spectrum relating to the particle. A particle identification digital database containing scattering spectra from a variety of different single particles that vary in spectral features facilitates identification of unknown spectra. A microfluidic cell is detailed to facilitate the automated scanning of numerous particles from a sample.

The invention belongs to the micro-spectrum imaging technical field and relates to a differential confocal raman spectral test method. The method integrates the technical characteristics of the differential confocal detection method and the raman spectral detection method, forms a test method capable of realizing sample microarea spectral detection, precisely catches focus positions of excitation light beams through the differential confocal technology, detects raman spectra of corresponding positions, simultaneously adopts a designed pupil filter, sharpens Airy disc major lobes of a differential confocal raman spectral system, improves the microarea raman spectral detectability and precisely acquires microarea space spectrum information which comprises spectral information and position information of microarea samples. The method obviously improves the microarea spectral detectability of a confocal raman spectromicroscope, has absolute tracking zero points and bipolar tracking characteristics, realizes absolute measurement of physical dimension, can be widely applied in the technical fields such as biomedicine, life sciences, biophysics, biochemistry, industrial precision detection and so on to perform high-precision detection of geometric positions and spectral characteristics of microareas, and has very important application prospect.

This invention provides a system and method that enables the use of incoherent light sources, such as light emitting diodes, to provide for the detection of gaseous species which exhibit broadband absorption features (e.g., nitrogen dioxide and the halogen gases). The light emitting diode (LED) is an ideal light source for such an arrangement in that it can be modulated at high frequencies (allowing for omission of external modulation equipment) and provides sufficient illumination within a reasonably narrow wavelength band as compared to, for instance, an incandescent light source. A further advantage of a LED as a light source compared to alternatives such as a gas discharge or arc lamp is that the light output of the LED is highly stable, limited by the stability of the current source used to drive it. Use of a confocal or near-confocal resonant optical cavity maximizes coupling of the light source to the cavity.

The present invention provides a method, a system or device system for examining medicine component on-line in the process of pharmacy. The present method employs electric controller, dynamic dilution mixed system and mini-type ultraviolet / visible light spectrometer to examine chemistry component. The device system main comprises valve control technique, multi-streaming precise proportional dilution technique and spectrum measuring technique. The detecting device comprises valve controller, electric controller, precision variable peristalsis pump, precision dynamic mixed device, dynamic flow-through cell, multi-join sampling pipeline and precision UV-VIS fiber spectrum detector. The detecting device on-line detects the medicine component or Chinese traditional medicine active component on-line automatically in the process of pharmacy, and provides gist for pharmacy process control and efficiency direction.

The invention discloses a method and a device for detecting CO2 carbon isotope by infrared spectrum; and the device comprises a reflecting pool, an infrared source, an off-axis parabolic mirror, an interferometer, an infrared detector connected with a computer, a target gas input gas circuit used for inputting CO2-containing target gas, and a standard gas input gas circuit used for inputting standard CO2 gas with the known delta 13 CO2 value. The method and the device can be used for obtaining the delta 13 CO2 value of the detected gas according to the infrared spectrum acquired by the infrared detector.

An integrated chromatography-immunoassay system for integrated chromatography-immunoassay system includes a chromatographic unit that receives labeled nano-structured probes comprising nano particles and antibodies attached to the nano particles, and a test membrane comprising coating antigens. The chromatographic unit allows the labeled nano-structured probes to diffuse there through and into the test membrane, wherein the antibodies on the nano particles are bound to the coating antigens. A laser device emits a laser light to illuminate the labeled nano-structured probes having the antibodies bound to the coating antigens on the test membrane. A spectral analyzer obtains a Raman spectrum from light scattered from the labeled nano-structured probes having the antibodies bound to the coating antigens on the test membrane, and to identify a spectral signature in the Raman spectrum associated with the antibody-antigen pair, which enables detection and identification of the antibody.

The invention relates to a method and device for detecting liquid samples by using breakdown spectroscopy. The device utilizes the ultrasonic atomization method to atomize the liquid samples to form massive and dense droplets in the air, breaks down and induces plasma and radiates an emission spectra signal. The method comprises the following steps: high-frequency oscillation is generated by the ultrasonic transducer (3) of the device of the invention to ensure that the liquid samples (4) in a sample cell (5) generate fog droplets, with the aid of a supply fan and an exhaust fan (13), columnar mist is generated above an air duct (6); plasma is generated at the edge of the columnar mist through breakdown, the plasma emission spectra signal is collected by a collection lens (7) and enters a spectrograph (9) through optical fiber (8) to split light; and finally a photoelectric sensor (11) fits with an ICCD detector (10) to collect spectral data. The method of the invention can reduce the breakdown threshold, increase the ablation efficiency and prolong the life of plasma. The detection device is applicable to the field component detection analysis field of the environment and mineral resources and the detection method has higher signal-to-background ratio and lower cost compared with the similar methods.

A spectroscopic method for spectroscopic detection and identification of bacteria in culture is disclosed. The method incorporates construction of at least one data set, which may be a spectrum, interference pattern, or scattering pattern, from a cultured sample suspected of containing said bacteria. The data set is corrected for the presence of water in the sample, spectral features are extracted using a principal components analysis, and the features are classified using a learning algorithm. In some embodiments of the invention, for example, to differentiate MRS A from MSSA, a multimodal analysis is performed in which identification of the bacteria is made based on a spectrum of the sample, an interference pattern used to determine cell wall thickness, and a scattering pattern used to determine cell wall roughness. An apparatus for performing the method is also disclosed, one embodiment of which incorporates a multiple sample analyzer.

The invention provides a cloud spectrum database-based miniature spectrometer and a spectrum detection method. The miniature spectrometer comprises a power supply, a light source, a spectroscopic imaging module, a control module, a communication module, and an intelligent mobile terminal provided with a display assembly, the intelligent mobile terminal is connected with the communication module to communicate with the control module and is suitable for connecting with a cloud processor including a cloud spectrum database, spectrum information of a sample on the cloud processor is compared with the spectrum database, and a comparison result is displayed on the display module of the intelligent mobile terminal. The spectrum database is arranged on the cloud processor, so the spectrum database chip and the processing module group of the miniature spectrometer have small size, and the dimension of the miniature spectrometer is shortened, thereby the miniature spectrometer is convenient to carry.

The invention discloses a coherent anti-stokes raman scattering (CARS) optical comb spectrum detection method for improving the precision. The method comprises the steps of: after two femtosecond optical comb generators as a pumping-detecting light source and a stokes light source of a CARS system pass a CARS spectral measurement system, performing beat frequency and double-optical comb optical heterodyne detection on generated anti-stokes signal light and reference optical combs; eliminating the interference introduced by pumping light by utilizing a polarization dependent balance detection technology at a detecting part so as to realize the quick and real-time CARS optical spectrum detection with high sensitivity and high frequency resolution precision. The method provided by the invention can be used for effectively improving the resolution precision of spectral measurement, realizing the high-precision optical comb imaging within a wide spectral range, effectively inhibiting the environmental noises, eliminating the non-resonant background noise introduced by the pumping light, improving the time and frequency resolution precision and realizing the quick and real-time spectral detection.

Microflow controlled chip 14 is prepared by sticking etched two layers of sheets. Chunnel 21 in decussation is fluted between the said sheets. There are inhalant pore 17 of sample, opposite two inhalant pores 18 for buffer solution, and flowout pore for waste fluid at end point of channel 21 connected to outside. One electrode is inserted into the four pores respectively. Laser emitted from laser source 1 is focused on testing point 24 on the channel 21 in decussation. Fluorescence emitted from matter in channel 21 and received by optical fiber is transferred to spectrum detection system 16 composed of CCD spectrographic detector. The invention possesses features of small size, lightweight, compact structure, and simple operation, as well as optional fluorescent reagent, fast response speed and fluorescence intensities in multiple wavelengths obtained. The invention is applicable to areas such as analyzing biochemistry matter, drug screening and clinical diagnosis.