The invention discloses an unmanned aerial vehicle prevention and control method. The method comprises the following steps of S1, carrying out the full-band scanning of an unmanned aerial vehicle signal; S2, discovering a target by using a radar detection device, and recognizing the target by using a photoelectric video image; S3, performing frequency writing interference, and starting navigation interference; S4, if full-band radio detection equipment cannot detect, discovering the unmanned aerial vehicle by using the radar detection equipment, and recognizing the target by using the photoelectric video image; and S5, starting a composite interception strategy. The invention further discloses an unmanned aerial vehicle prevention and control system. A cluster unmanned aerial vehicle prevention and control command subsystem comprises a radio detection and recognition module, a passive radar photoelectric guiding module, a radio interference steering module, an active radar photoelectric guiding module, and a composite interception strategy module. According to the Unmanned aerial vehicle prevention and control method and system, accurate detection identification and rapid command decision making are achieved for incoming cluster unmanned aerial vehicles, soft and hard killing measures are taken in an auxiliary mode, the cluster unmanned aerial vehicle interception disposal success rate and disposal efficiency are improved, and the method and the system can be widely applied to the field of unmanned aerial vehicle prevention and control.