The invention provides a multimodal amphibious bio-robot, which comprises a head, a replaceable wheel paddle/flipper mechanism, a propelling unit and a caudal peduncle compound drive mechanism. In water, the propelling unit and the caudal peduncle compound drive mechanism oscillate back and forth to propel by imitating a fish in the plane, and a rotating mechanism rotates the propelling unit and the caudal peduncle compound drive mechanism for 90 degrees, and switches the moving mode of propelling by imitating a fish into that of swimming by imitating a dolphin; and the flipper mechanism assists the tail propelling to accomplish actions of moving forward, moving backward, turning and pitching, and the paddle mechanism assists the robot turning. On land, the flipper mechanism rotates continuously to make the robot creep on the ground, imitates the movement of a wheel mechanism when rotating continuously, thereby the robot improves the speed of the movement, has obstacle-climbing capability, and a driven wheel reduces the resistance of the movement on the land. The robot can induce the own environment in real time by two liquid level sensors arranged at the head and the propelling unit respectively; and when the land and water environments are changed, according to the information of the liquid level sensors, a main control panel uses corresponding movement policies to accomplish the intelligent switching between the modes of moving on the land and in the water.