The invention provides a vertical and horizontal shearing combination production line for high-strength thick steel plates based on the advantage of multifunction of an existing vertical and horizontal shearing combination production line, so that vertical shearing and horizontal shearing functions are organically combined, various machining processes are realized, and production requirements on high efficiency and high quality are met. The vertical and horizontal shearing combination production line for the high-strength thick steel plates comprises a vertical shearing line and a horizontal shearing line which are controlled by an electric control system and a hydraulic pneumatic lubricating system, a second uncoiler is arranged on the horizontal shearing line, and a transition bench is arranged between the vertical shearing line and the horizontal shearing line. The vertical shearing line has independent functions of uncoiling, vertical shearing and coiling, the horizontal shearing line has independent functions of uncoiling, leveling, horizontal shearing and stacking, the whole vertical and horizontal shearing combination production line has the functions of uncoiling, leveling, vertical shearing and coiling, leveling and horizontal shearing, multi-strip horizontal shearing and automatic stacking, the requirements of various high-strength thick steel plates on various machining processes are met, the vertical and horizontal shearing combination production line is high in utilization rate, multifunctional and high in automation degree, and the production requirements on high efficiency and high quality are met.