The invention discloses a design and configuration integrated system for an intelligent substation, which is technically convenient for information management for the intelligent substation in design, construction, operation and maintenance stages to reduce workload for checking staff. The design and configuration integrated system is arranged in a personal computer which is networked with switches of an electric power designing institute, an intelligent substation construction organization, an electricity authority, an intelligent substation operating maintenance department and a secondary equipment manufacturer. The system is provided with an intelligent substation design drawings module, a configuration management module, a model base module, a drawings management module, a retrieval module, a permission management module, a verification module, a database module and a version management module. Compared with the prior art, the design and configuration integrated system has the advantages that design and configuration are integrated, risks of errors of design and configuration are lowered, design and configuration efficiency of the intelligent substation is improved while an effective secondary data management tool is provided for operation and maintenance, repeated operations are avoided, and workload is greatly reduced for the checking staff.