25results about How to "Speed ​​up the development process" patented technology

The invention relates to the technical field of biology, and discloses a chemically modified small nucleic acid drug zero sample prediction method and system based on a large language model and multi-view deep learning. The method comprises the following steps: collecting chemically modified RNA data; performing Token conversion by using an SMILES token regular expression, and performing embedding by using a pre-trained large language model; chemical modification position information is obtained and combined with SMILES in an embedded mode; the RNA sequence is embedded; processing the comprehensive embedded vector by using a self-attention mechanism; fusing RNA sequence embedding and comprehensive embedding by adopting a cross attention mechanism; performing feature extraction and dimension reduction by using a three-dimensional convolutional neural network; and inputting the features into a full-connection layer to predict the drug efficiency. According to the method, high-precision zero-sample prediction of novel chemical modification is realized, the generalization ability and prediction precision of the model are remarkably improved, and a flexible, efficient and accurate method is provided for design and development of RNAi drugs.

The invention provides a method for determining a mixing ratio, a storage medium and an electronic device, and the method comprises the steps: determining particle attribute parameters of a target material, and obtaining the particle attribute parameters of the target material under the condition of obtaining simulation data corresponding to mixing equipment; determining a first contact parameter of the target material and the mixing equipment based on an equipment intrinsic parameter and a particle attribute parameter in the simulation data, and determining a target mechanical basic model of the target material matched with a motion attribute under the condition that the motion attribute of the mixing equipment input by the target object is received, inputting the particle attribute parameter, the first contact parameter and the target mechanical basic model into a preset engineering application, and setting a particle generation strategy corresponding to the mixing equipment based on the mixing demand of the target object in the preset engineering application to obtain a to-be-operated simulation engineering application file, and operating the to-be-operated simulation engineering application file. And generating the target ratio parameter of each sub-strategy in the particle generation strategy. The problem that the coating is not uniform due to inappropriate ratio in the related technology is solved.

The invention provides a whole vehicle fatigue analysis method based on VPG and modal stress recovery, an analysis terminal and a storage medium, and belongs to the technical field of whole vehicle fatigue analysis. Configuring a vehicle body finite element model, and performing modal analysis to obtain a modal neutral file and a modal result file; coupling the modal neutral file with the vehicle dynamics model to generate a rigid-flexible coupling model; carrying out vehicle dynamics analysis by taking the actual test field virtual road surface as input, and outputting a modal coordinate file; stress recovery and fatigue life prediction are carried out based on a fatigue analysis algorithm, the equivalent fatigue stress of the whole vehicle body is obtained, and fatigue analysis of the vehicle body is completed in combination with an S-N curve. According to the method, the vibration relation between the external load frequency and the inherent frequency of the structure can be effectively considered, the more accurate fatigue life is further obtained, and the method has good application value in engineering.

The invention belongs to the technical field of material science, and discloses a shape optimization method for a high-temperature alloy disc type pre-forged piece. According to the method, finite element numerical simulation, a support vector machine and a genetic algorithm are combined, a GA-SVR prediction model between an input variable and a target function is established, the optimal value of the target function is predicted, and the optimal geometric parameter combination of the pre-forged piece is obtained. Firstly, the shape of a pre-forged piece is preliminarily designed through experience, then a finite element simulation result is extracted to establish a data set, parameters of a support vector machine model serve as a target function of a genetic algorithm by means of the data set, the parameters of the support vector machine model are optimized by means of the genetic algorithm, and an optimal prediction model is obtained. And for the size parameter combination of the pre-forged piece when the best deformation uniformity evaluation index is obtained, the deformation uniformity of finish forging is effectively improved through global optimization of the genetic algorithm, so that the final performance of the forged piece is improved.

The invention discloses an additive molecule screening design method for optimizing the performance of ester-based insulating oil, and relates to the technical field of electrical insulating materials. The invention provides an additive molecule design method combined with a deep molecule generation model, aiming at solving the problems that the breakdown voltage performance is insufficient due to the fact that ester-based insulating oil is easy to generate rapid streamer under high-strength lightning impulse, and time and labor are consumed when an appropriate additive is found through an experiment. The method comprises the following steps: acquiring molecular data with target electronic attributes; taking the fragment of the molecular structure as the input of the model, and designing a new additive molecular structure by utilizing the molecular generation model; performing molecular screening according to target characteristics; and the performance of the screened molecules is verified through streamer discharge simulation. According to the method, generative design of ester-based insulating oil additive molecules is realized by using the deep autoregressive neural network, the molecular screening efficiency is remarkably improved, and a new technical route is provided for improving the breakdown voltage performance of the ester-based insulating oil.

The invention relates to the technical field of medicine detection, in particular to a detection method of sildenafil citrate tablets, which comprises the following steps: S1, placing contents and target samples with different water contents in a plurality of containers; s2, determining the drug concentration of each region based on the color development characteristics of the diffused image of the target sample in the container at different detection time points, and calculating the concentration gradient component and diffusion concentration gradient of the target sample; s3, measuring the total amount or the concentration of the residual medicine of the target sample in the plurality of containers in a preset time period so as to determine the residual degree of the target sample; and S4, determining the diffusion difference degree based on the diffusion concentration gradient and the residual degree, and evaluating the diffusion adaptability of the target sample based on the diffusion difference degree. The accuracy and depth of drug diffusion performance research are improved, reliable data support is further provided for drug research and development and quality control, and drug quality can be improved.

The invention discloses a software research and development method based on a PBC assembled architecture, and the method comprises the steps: providing an overall view of a business field oriented to a manager or an architect, and meanwhile, generating linkage with a specific business field to realize a basic drill-down capability; a default engineering scaffold or a user-defined engineering scaffold is supported to generate a code framework; the precipitated asset capabilities of technical components, business components and the like are reused; executing service component custom configuration and generating a service related code path and basic function logic; according to the current situation and the service characteristics, the application selects to add code logic under the condition of cutting or not adjusting stock code logic, so that the scenarized ability is improved; realizing assembly and arrangement of technical components and business components, and performing scene interface development through a visual designer; and breaking through with a DevOps tool chain. According to the technical scheme, an enterprise can accelerate asset precipitation, the delivery efficiency is improved, and the capacity of quickly responding to market requirements is achieved.

The invention discloses an open source component security scheduling method, which comprises the following steps: acquiring a task demand of a target system, and screening an open source component cluster matched with the task demand function from a preset component library according to a semantic similarity algorithm; extracting a risk assessment index of each open source component in each open source component cluster by using a software component analysis tool; inputting the risk assessment index into a pre-trained risk assessment model for prediction to obtain a risk assessment result corresponding to each open source component; constructing a scheduling strategy according to the task demand and the risk assessment result; in the actual scheduling process, the real-time task request is scheduled based on the scheduling strategy. According to the open source component security scheduling method provided by the embodiment of the invention, the open source component is automatically screened and evaluated, so that the time cost of manual screening and testing is reduced.

The invention discloses a method for improving SPA application development performance. The method comprises the steps that an npm package installer is adopted to initialize an SPA application so as to manage application dependency in a unified mode; splitting dependent packages and codes with high computing power in the SPA application so as to reduce the number of files when an npm package manager compiles and packages; performing a Wasm conversion test and conversion on the high-computing-power code, and performing Wasm compilation on the dependent package to improve the compilation speed; judging updating of the dependent package in the application installation directory by adopting a package detector so as to re-execute the compiling work of the dependent package; and integrating the front-end framework with the Wasm through SPA application configuration so as to realize shunt loading of the framework structure. According to the method, front-end dependence rapid compiling and loading can be achieved, the construction performance and the construction speed are improved as much as possible, the pressure of an npm package manager is relieved, meanwhile, the compiling speed is improved, and the limitation of traditional SPA application compiling and packaging is solved.

The invention relates to a method for detecting a near space wind field, temperature and density based on iron atom resonance fluorescence. The method comprises the following steps: emitting 372 nm laser to a near space, and receiving an iron atom resonance fluorescence echo signal generated by a UMLT region and a Rayleigh back scattering echo signal generated by a region below the UMLT; according to the iron atom resonance fluorescence echo signal, an atmospheric temperature response function and a wind speed response function are defined, and the atmospheric temperature and the wind speed of a UMLT area are calculated according to the atmospheric temperature response function and the wind speed response function; and according to the Rayleigh backscattering echo signal of the predetermined wavelength laser, using a normalization algorithm to invert the atmospheric molecular density of the area below the UMLT, and then according to the atmospheric molecular density, inverting the atmospheric temperature of the area below the UMLT. According to the invention, the atmospheric temperature and wind speed of the UMLT region and the atmospheric molecular density and atmospheric temperature of the region below the UMLT region can be detected, and the wind field, temperature and density profile information can be obtained all day long and all day long with high precision.

The invention discloses a self-elevating platform pile pitching operation slippage semi-quantitative judgment method which comprises the following steps: investigating the form of an old pile pit; old pile pit survey parameters are analyzed; a self-elevating platform in-place scheme is designed, and the position of the self-elevating platform is determined; judging the area coincidence ratio of the pile shoe to the old pile pit; analyzing the slope degree of the old pile pit and performing collapse backfilling; analyzing the pile center distance; the comparison value of the pile shoe diameter of the in-place pile pitching self-elevating platform and the old pile pit and the comparison value of the predicted depth and the depth of the old pile pit are determined; analyzing the self-weight and the full-load ballast of the self-elevating platform; analyzing the overall slippage trend of the three piles; forming an instrumentation slip influence factor and slip risk grade table; and a slip semi-quantitative determination result is obtained. The self-elevating platform multi-time pile pitching operation slippage risk judgment, pile pitching operation safety early warning and pile pitching operation plan making are facilitated, the in-place pile pitching operation safety of the self-elevating platform is guaranteed, the slippage risk is reduced to the maximum degree, the safety of large facilities and personnel is guaranteed, and the offshore oilfield development process is promoted.

The application discloses a non-singular fast terminal sliding mode vibration active control method based on a compensation function observer, 1) according to elastic dynamics, a fourth-order modal equation of a four-side fixed support plate structure driven by an electromagnetic inertial actuator is established; 2) in view of external unknown interference and modeling uncertainty existing in the system, a compensation function observer is designed to realize real-time estimation and compensation; 3) a non-singular fast terminal sliding mode surface is constructed, and a sliding mode control law is designed in combination with the observer output, so that the singularity problem of a traditional terminal sliding mode is solved, and the time for system state to reach a balance point is shortened through a fast convergence term; 4) a comparison experiment is designed, and the composite control method designed in the application can significantly reduce the vibration amplitude of the four-side fixed support plate while guaranteeing the finite time stability of the system, and has stronger anti-interference ability and higher vibration suppression precision compared with the traditional sliding mode control.

The invention discloses a cell-based new drug screening method for inhibiting lipid accumulation. The method comprises the following steps: culturing a hepatocyte line, inoculating the hepatocyte line into a culture plate, and adhering the hepatocyte line to the wall for overnight; adding free fatty acid and to-be-detected compounds with different concentrations or an equal amount of solvent into the culture plate for incubation; the method comprises the following steps of: firstly, incubating cells with D-PBS (D-Phosphate Buffer Solution), fixing the cells with paraformaldehyde, washing the cells with D-PBS, incubating the cells with D-PBS containing BODIPY 493 / 503 and DAPI in a dark place, washing the cells with D-PBS, and finally measuring the fluorescence intensity of BODIPY 493 / 503 and the fluorescence intensity of DAPI by using a microplate reader; calculating the ratio of the BODIPY 493 / 503 fluorescence intensity to the DAPI fluorescence intensity, and evaluating the lipid content according to the ratio; and comparing the lipid content of the experimental group with the lipid content of the control group to screen out the drug for inhibiting lipid accumulation. The method is simple and easy to implement, does not depend on expensive instruments and equipment, and can be widely applied to different laboratories and under different conditions.

The invention discloses a code increment testing method and device, computer equipment and a storage medium, and relates to the technical field of data research and development management, the method is applied to software code increment testing scenes related to financial services, and the method comprises the steps that a Git Diff command is used for detecting the change situation of a code library of target software after the last successful construction; based on the change condition detection result of the code library, obtaining an incremental Java file of the code library; a target source code class needing to be subjected to unit testing is screened out from the incremental Java file; according to a standard Maven project structure, determining a unit test class corresponding to the target source code class; and constructing a unit test command according to the unit test class, and executing the unit test command to realize an incremental test of the target software. According to the method, only the incremental code of the target software is subjected to the unit test instead of the unit test of the whole code library, so that the execution time of the unit test during iteration of the target software can be effectively shortened.

The utility model relates to injection moulding processing mould technical field especially relates to a kind of injection molding part quick -wired mould. Including: top plate, top block being arranged in the top plate below, intermediate block being arranged in the top block below, several bottom blocks being arranged in the intermediate block below and bottom plate being arranged in the bottom block below, the inside detachable connection of the top block has mould core;The middle part of the top plate is provided with main flow pipeline, and the main flow pipeline is communicated with the mould core. The utility model provides a kind of injection molding part quick -wired mould with the advantages of high work efficiency, good product quality, long service life, low cost, simple structure and easy to disassemble and assemble.

The present invention provides a front-end and back-end code generation and deployment system based on a text AI model, which belongs to the field of information technology. The system includes a data acquisition module, which is responsible for collecting user demand descriptions, reference front-end codes, reference back-end codes and corresponding test cases; a data embedding module embeds the collected information and generates a reference test combination; a generation module automatically generates a predicted front-end code and its test cases according to the reference test combination; an evaluation module uses the generated test cases to perform an accuracy test on the generated front-end code, and compares the performance with the reference code, and selects the code with excellent performance as the output candidate. Finally, the output module annotates the predicted front-end code to be output through an artificial intelligence text large model to enhance the readability and maintainability of the code, outputs the annotated front-end code, and the deployment module is responsible for deploying it to the production environment.

A multi-thread lock overhead evaluation method based on a linux system comprises the steps that S1, a mutual exclusion lock to be tracked is determined, and a layer of lock packaging function is added to a locking function and an unlocking function of the mutual exclusion lock respectively; s2, acquiring a symbol address of the lock encapsulation function in the step S1 by using a readelf-s instruction; s3, in a debugfs directory, registering the symbol address of the lock encapsulation function obtained in the previous step into an uprobe event; s4, opening a trace function, and importing trace information into the log file after running the program for a period of time; s5, according to at least one thread id to be tracked, using an awk command to process the log file to obtain at least one log file of the thread id to be tracked; and S6, acquiring timestamps of each locking and unlocking of the mutual exclusion lock in each log file by using an awk command, then calculating a time difference value between each unlocking and each locking of the mutual exclusion lock, and calculating an average value of a plurality of obtained time difference values.

The invention provides a method and a device for developing a self-defined annular progress bar component based on Element Plus and a medium, and belongs to the technical field of front-end development. The method comprises the following steps: based on an el-process component of Element Plus, creating an annular progress bar by setting an attribute that type is equal to'circle '; expanding configurable attributes of the annular progress bar; compiling a template of the component; compiling a script of the component; the appearance of the annular progress bar is customized through a CSS or inline style. By adding the configurable attributes, the flexibility of the annular progress bar is greatly enhanced, so that the annular progress bar can meet the requirements under different development scenes. The color, the line width, the size, the text format and the decoration elements of the progress bar can be self-defined according to needs, so that the component is more personalized. Through flexible configuration options and powerful functions, developers can quickly complete the design and implementation of the progress bar, so that the development process of a project is accelerated.

The invention relates to an indole derivative obtained by converting quinoline nitrogen-oxide and a synthesis method thereof. The chemical structural formula of the derivative is as shown in formula 2. The synthesis method comprises the following steps: adding a compound quinoline nitrogen-oxide as shown in a formula 1, dimethyl butynedioate and water serving as reaction raw materials into a 1, 2-dichloroethane solvent, carrying out a first heating and stirring reaction under the catalytic action of diphenyl phosphate, and after TLC monitors that the compound quinoline nitrogen-oxide as shown in the formula 1 is completely converted, carrying out a second heating and stirring reaction; and adding trichloroacetic acid and a dehydrating agent # imgabs0 # molecular sieve, carrying out a second heating and stirring reaction, monitoring the reaction by TLC until the reaction is complete, evaporating out the solvent, and purifying to obtain the product. The method has the advantages of being high in atom economy, mild in reaction condition, green, low in cost, high in conversion rate and the like, meanwhile, the method is a carbon recombination strategy for directly editing a molecular skeleton, and a new thought can be provided for later design optimization of drug molecules. The method can accelerate the drug discovery and development process, and has good theoretical value and application prospect. # imgabs1 #

The utility model discloses a clamping sleeve device for preparing a radionuclide labeled cell preparation, and relates to the technical field of radioactive biological medicines. The clamping sleeve device comprises a filtering assembly, a conveying assembly, a cleaning assembly, a waste liquid collecting bottle, a marking assembly, a cell preserving fluid assembly and a preparation collecting bottle, and a first three-way valve, a second three-way valve, a third three-way valve, a fourth three-way valve, a fifth three-way valve and a sixth three-way valve which are arranged corresponding to the assemblies respectively. According to the clamping sleeve device, automatic preparation of the radionuclide labeled cell preparation can be realized, and the product can be prevented from being polluted while the preparation efficiency is improved.

This invention belongs to the field of plasmid and mRNA quality control technology, specifically disclosing a method for characterizing plasmid quality. Existing plasmid quality control systems cannot effectively predict mRNA product quality and do not focus on the purity of the PolyA tail. This invention establishes a positive correlation between the purity of the PolyA region in the plasmid and the quality of the mRNA product by detecting its purity, thus achieving early mRNA quality prediction. The prediction method includes the following steps: plasmid sample enzyme digestion, analysis of PolyA fragment purity using capillary gel electrophoresis, and substituting the PolyA fragment purity into a correlation curve to obtain mRNA purity. Based on this, this invention effectively shortens the production cycle, reduces costs, and provides a new evaluation dimension for plasmid quality control by screening plasmids with acceptable PolyA purity for mRNA production.

The invention provides an equivalent frequency device, a compressor and a method, and solves the technical problems that high-frequency large-current automatic frequency reduction of the compressor cannot be carried out, and a high-frequency reliability test cannot be carried out. The equivalent frequency device comprises a driving shaft, a first transmission shaft, a second transmission shaft, a relay, a piezoelectric crystal, a first transmission assembly and a second transmission assembly, a relay is arranged between the driving shaft and the second transmission shaft; the first transmission shaft is in transmission connection with the driving shaft through a first transmission assembly which can be closed and opened; the second transmission shaft and the first transmission shaft are in transmission connection through a second transmission assembly capable of being closed and opened. The piezoelectric crystal is arranged on the first transmission shaft and used for controlling the first transmission assembly and the second transmission assembly to be connected or disconnected. The transmission ratio of the first transmission assembly is 1; the transmission ratio of the second transmission assembly is N2 / N1. According to the invention, the structural part can still operate according to the target frequency when the compressor is subjected to frequency reduction due to large current in high-frequency heavy load.

The invention relates to a plug-in automatic report generation system, which comprises an automatic test tool which is deployed on a PC (Personal Computer) terminal for service execution and is used for executing a specific test case and submitting test result data to an interface of a back-end server in a JSON (JavaScript Object Notation) format after the test case is executed or in the execution process; a test report plug-in installation interface, a plug-in unloading interface and a report generation interface are arranged in the Web back-end server, and the Web back-end server is used for processing the received test data and generating a test report according to the corresponding test report plug-in; the Web front-end server is used for providing static files for a user browser for reference and comprises pages of html (Hypertext Markup Language), css (Data Service) and javascript; the database server is used for storing plug-in information and test data information of related reports; and the MQTT Broker / Websocket agent is used for providing a coordination agent for the automatic test tool, the Web back-end server and the Web front-end server, and distributing the message of the specific theme to each subscriber.

This invention provides a method, apparatus, equipment, and medium for controlling alternating gas-water injection and production, belonging to the field of petroleum development technology. The method includes: acquiring multiple sets of different injection and development parameters; calling a reservoir development gas-water alternating injection and production model; employing orthogonal design to select the optimal injection parameters from the multiple sets of injection parameters, and calculating the corresponding optimal gas-water ratio, gas slug size, and water slug size. By fixing these optimal parameters and inputting different development parameters into the gas-water alternating injection and production model, the optimal development parameters that maximize reservoir recovery are determined; finally, a gas-water alternating injection and production strategy is generated based on these optimal parameters to guide reservoir development. This invention significantly improves reservoir recovery and development efficiency by optimizing injection and development parameters, while reducing costs and enhancing operational flexibility.

The embodiment of the invention discloses a theme configuration method, device and equipment. According to the scheme, the method comprises the steps of defining rendering rule configuration based on a theme configuration layer to obtain a rendering rule list; collecting design data corresponding to the current theme configuration; based on rendering rules contained in the rendering rule list, performing rendering logic calculation on the design data to generate a corresponding semantic structure result set; and according to the semantic structure result set, generating a corresponding semantic structure entity for executing theme rendering.